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bioactivity.txt
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bioactivity.txt
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CMPD_CHEMBLID MOLREGNO PARENT_CMPD_CHEMBLID PARENT_MOLREGNO MOL_PREF_NAME COMPOUND_KEY MOLWEIGHT ALOGP PSA NUM_RO5_VIOLATIONS CANONICAL_SMILES ACTIVITY_ID STANDARD_TYPE RELATION STANDARD_VALUE STANDARD_UNITS PCHEMBL_VALUE ACTIVITY_COMMENT DATA_VALIDITY_COMMENT POTENTIAL_DUPLICATE BAO_ENDPOINT UO_UNITS QUDT_UNITS ASSAY_ID ASSAY_CHEMBLID ASSAY_TYPE DESCRIPTION ASSAY_SRC_ID ASSAY_SRC_DESCRIPTION ASSAY_ORGANISM ASSAY_STRAIN ASSAY_TAX_ID CURATED_BY BAO_FORMAT TID TARGET_CHEMBLID TARGET_TYPE PROTEIN_ACCESSION PREF_NAME ORGANISM CONFIDENCE_SCORE TARGET_MAPPING APD_NAME APD_CONFIDENCE DOC_ID DOC_CHEMBLID PUBMED_ID JOURNAL YEAR VOLUME ISSUE FIRST_PAGE CELL_ID CELL_CHEMBL_ID CELL_NAME
CHEMBL3219907 1726302 CHEMBL3219907 1726302 27 586.52 8.14 94.13 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6cccc(Cl)c6)n2 14545671 IC50 = .00211 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219930 1726325 CHEMBL3219930 1726325 50 546.07 5.78 94.57 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCOCC6 14545694 IC50 = .00216 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219932 1726327 CHEMBL3219932 1726327 52 576.09 5.01 112.59 3 Clc1ccc2c(Nc3ccc(Nc4nc(NCCCN5CCOCC5)nc(n4)N6CCOCC6)cc3)ccnc2c1 14545696 IC50 = .00276 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219917 1726312 CHEMBL3219917 1726312 37 612.12 6.69 121.38 3 COc1ccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)cc1 14545681 IC50 = .00381 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219923 1726318 CHEMBL3219923 1726318 43 608.14 7.38 103.36 2 Clc1ccc2c(Nc3ccc(Nc4nc(NCCN5CCOCC5)nc(n4)N6CCCc7ccccc67)cc3)ccnc2c1 14545687 IC50 = .0174 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219897 1726291 CHEMBL3219897 1726291 16 556.04 7.33 94.13 2 CN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6cccc(F)c6)n2 14545660 IC50 = .0228 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL58510 90635 CHEMBL76 6579 CHLOROQUINE DIPHOSPHATE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.OP(=O)(O)O.OP(=O)(O)O 15183780 IC50 = .034 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ ART 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 15183781 IC50 = .045 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3219927 1726322 CHEMBL3219927 1726322 47 608.14 6.92 103.36 2 Clc1ccc2c(Nc3ccc(Nc4nc(NCCN5CCOCC5)nc(n4)N6CCc7ccccc7C6)cc3)ccnc2c1 14545691 IC50 = .0452 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL2088548 1366222 CHEMBL2088548 1366222 13 877.07 5.13 184.64 3 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)NCCCCCCCCNC(=O)CCC(=O)O[C@@H]3O[C@@H]4O[C@@]5(C)CC[C@H]6[C@H](C)CC[C@@H]([C@H]3C)[C@@]46OO5)O[C@@H]7O[C@@]8(C)CC[C@@H]1[C@@]27OO8 13952424 IC50 = .3 nM 9.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296215 CHEMBL3132228 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77210 CHEMBL3124935 24561670 Eur. J. Med. Chem. 2014 75 403
CHEMBL3219636 1726028 CHEMBL3219636 1726028 10b 391.34 5.47 64.63 1 CCOC(=O)C1=CNc2cc(Cc3ccc(OC(F)(F)F)cc3)ccc2C1=O 14545600 IC50 = .46 nM 9.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3218235 1724613 CHEMBL3218235 1724613 11 379.49 1.81 58.18 0 C1CC(CCO1)NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530893 IC50 = .7 nM 9.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3218246 1724624 CHEMBL3218246 1724624 22 478.62 3.25 78.49 0 CC(C)(C)OC(=O)NC1CCN(CC1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530904 IC50 = 1 nM 9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3218242 1724620 CHEMBL3218242 1724620 18 378.51 1.65 66.18 0 NC1CCN(CC1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530900 IC50 = 1.2 nM 8.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL2263540 1481391 CHEMBL2263540 1481391 4 303.35 4.56 31.23 0 COc1ccc(\C=C\C(=O)c2ccc(cc2)n3cccc3)cc1 12460158 IC50 = 1.61 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL3397103 1828820 CHEMBL3397103 1828820 7 522.59 5.08 93.43 2 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)c3ccc(\C=C\C(=O)c4oc(C)cc4)cc3)O[C@@H]5O[C@]6(C)CC[C@@H]1[C@@]25OO6 15155311 IC50 = 1.98 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3397107 1828824 CHEMBL3397107 1828824 11 578.65 5.5 98.75 2 COc1ccc(C(=O)\C=C\c2ccc(cc2)C(=O)OC3O[C@@H]4O[C@]5(C)CC[C@H]6[C@H](C)CC[C@@H]([C@H]3C)[C@@]46OO5)c(OC)c1 15155307 IC50 = 3.02 nM 8.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL1738786 1117833 CHEMBL1738786 1117833 5, DSM267 357.28 4.04 55.11 0 Cc1cc(Nc2ccc(cc2)C(F)(F)F)n3nc(nc3n1)C(C)(F)F 14734083 IC50 = 3.6 nM 8.44 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL2387268 1564043 CHEMBL2387268 1564043 82, RKA 182 503.67 2.35 63.71 1 CN1CCN(CC1)C2CCN(CC2)C(=O)CC3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6 14536107 IC50 = 4.9 nM 8.31 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327901 CHEMBL3224707 F Antimalarial activity against Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81869 CHEMBL3217710 MedChemComm 2012 3 3 281
CHEMBL2237988 1473523 CHEMBL2237988 1473523 4 326.73 3.85 63.6 0 OC1=C(C(=O)\C=C\c2ccc(Cl)cc2)C(=O)Oc3ccccc13 12393231 IC50 = 5.1 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3400178 1833200 CHEMBL3400178 1833200 14 452.54 4.83 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCC(Cc5ccccc5)CC4 15183769 IC50 = 5.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3397105 1828822 CHEMBL3397105 1828822 9 593.62 5.41 135.33 2 COc1ccc(cc1[N+](=O)[O-])C(=O)\C=C\c2ccc(cc2)C(=O)OC3O[C@@H]4O[C@]5(C)CC[C@H]6[C@H](C)CC[C@@H]([C@H]3C)[C@@]46OO5 15155309 IC50 = 5.87 nM 8.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3264799 1749791 CHEMBL3264799 1749791 3 642.87 6.45 94.14 2 CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC(C)(C)c3cccc(OC)c3)N4CCCCC4 14656158 IC50 = 6 nM 8.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15128138 IC50 = 6.8 nM 8.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3222265 1728683 CHEMBL3222265 1728683 10 418.76 5.45 36.95 1 CC(C)(C)NCc1cc(Br)cc(Nc2ccnc3cc(Cl)ccc23)c1 14536778 IC50 = 7 nM 8.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3335118 1791249 CHEMBL3335118 1791249 29 385.43 4.28 70.97 0 N\C(=N/N=C/c1ccc(F)cc1)\CC(O)c2cc3ccccc3c4ccccc24 15128108 IC50 = 8.3 nM 8.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL2237984 1473519 CHEMBL2237984 1473519 13 382.36 3.14 91.29 0 COc1ccc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)c(OC)c1OC 12393168 IC50 = 8.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ ART 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 15011103 IC50 = 9 nM 8.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3358143 1822298 CHEMBL3558756 1940602 22 692.89 4.65 152.93 1 COC1=CC(=O)N([C@H]1Cc2c[nH]c3ccccc23)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121664 IC50 = 9.7 nM 8.01 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3397104 1828821 CHEMBL3397104 1828821 8 518.6 5.54 80.29 2 C[C@@H]1CC[C@H]2[C@@H](C)C(OC(=O)c3ccc(\C=C\C(=O)c4ccccc4)cc3)O[C@@H]5O[C@]6(C)CC[C@@H]1[C@@]25OO6 15155310 IC50 = 9.73 nM 8.01 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3397108 1828825 CHEMBL3397108 1828825 12 621.93 7.53 80.29 2 C[C@@H]1CC[C@H]2[C@@H](C)[C@@H](OC(=O)c3ccc(\C=C\C(=O)c4ccc(Cl)c(Cl)c4Cl)cc3)O[C@@H]5O[C@]6(C)CC[C@@H]1[C@@]25OO6 15155306 IC50 = 10.67 nM 7.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL422330 252768 CHEMBL422330 252768 LUMEFANTRINE Lumefantrine 528.94 9.2 23.47 2 CCCCN(CCCC)CC(O)c1cc(Cl)cc2\C(=C\c3ccc(Cl)cc3)\c4cc(Cl)ccc4c12 15087877 IC50 = 12 nM 7.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL7568 2355 CHEMBL7568 2355 QUINACRINE MEP 399.96 5.67 37.39 1 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 12450937 IC50 = 13 nM 7.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3397101 1828818 CHEMBL3397101 1828818 5 312.32 3.3 72.83 0 COc1ccc(C(=O)\C=C\c2ccc(cc2)C(=O)O)c(OC)c1 15155313 IC50 = 14.83 nM 7.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3093727 1608111 CHEMBL3093727 1608111 6 700.86 3.97 132.04 1 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)NCCNC(=O)CC6CCC7(CC6)OOC8(OO7)C9CC%10CC(CC8C%10)C9 13855015 IC50 = 16.9 nM 7.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3343958 1796117 CHEMBL3343958 1796117 S-13f 291.82 3.65 28.16 0 C[C@@H](CCCN(C)C)Nc1ccnc2cc(Cl)ccc12 15139446 IC50 = 17.13 nM 7.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3093736 1608120 CHEMBL3093736 1608120 15 610.74 2.72 132.04 1 O=C(CC1CCC2(CC1)OOC3(CCCCC3)OO2)NCCCNC(=O)CC4CCC5(CC4)OOC6(CCCCC6)OO5 13855006 IC50 = 21.3 nM 7.67 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3309597 1778688 CHEMBL3309597 1778688 20b 388.93 3.64 48.47 0 CC[C@H](C)[C@@H](CC(=O)N1CCN(C)CC1)Nc2ccnc3cc(Cl)ccc23 15031378 IC50 = 33.03 nM 7.48 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL170 255947 CHEMBL170 255947 QUININE QN 324.42 2.73 45.59 0 COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 12450928 IC50 = 34 nM 7.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3309582 1778673 CHEMBL3309582 1778673 6f 348.87 2.87 57.26 0 CCN(CC)CCNC(=O)[C@H](C)Nc1ccnc2cc(Cl)ccc12 15031379 IC50 = 35.37 nM 7.45 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ 1, ART 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 14724802 IC50 = 36.2 nM 7.44 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3093734 1608118 CHEMBL3093734 1608118 13 672.81 4.17 132.04 1 O=C(CC1CCC2(CC1)OOC3(CCCCC3)OO2)NCc4cccc(CNC(=O)CC5CCC6(CC5)OOC7(CCCCC7)OO6)c4 13855008 IC50 = 38.6 nM 7.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3410336 1837113 CHEMBL3410336 1837113 4bD 625.55 4.91 163.01 2 CC(C)OC(=O)OCOP(=O)(OCOC(=O)OC(C)C)C(CCC(=O)N(C)OC(=O)C(C)(C)C)c1ccc(F)c(F)c1 15192778 IC50 = 43 nM 7.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3112879 1615832 CHEMBL3140256 1629587 33 577.2 10.13 14.24 2 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(C[n+]4ccc(cc4)N(C)c5ccc(Cl)cc5)cc3)cc2)cc1 15026482 IC50 = 45 nM 7.35 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3402978 1833194 CHEMBL3402978 1833194 8 314.38 2.37 57.69 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183760 IC50 = 46 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235670 1734195 CHEMBL3235670 1734195 12{2,2,1} 640.56 8.09 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575176 IC50 = 48.86 nM 7.31 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3343957 1796116 CHEMBL3343957 1796116 R-13e 331.88 4.57 28.16 0 C[C@H](CCCN1CCCCC1)Nc2ccnc3cc(Cl)ccc23 15139447 IC50 = 52.85 nM 7.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3309585 1778676 CHEMBL3309585 1778676 9a 392.95 2.52 73.77 0 CSCC[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031385 IC50 = 58.4 nM 7.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3335099 1791230 CHEMBL3335099 1791230 10 335.37 3.38 70.97 0 N\C(=N/N=C/c1ccc(F)cc1)\CC(O)c2cccc3ccccc23 15128127 IC50 = 60 nM 7.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3235667 1734192 CHEMBL3235667 1734192 12{2,1,1} 606.11 7.42 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575282 IC50 = 70.35 nM 7.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3286859 1757380 CHEMBL3286859 1757380 4c 602.52 4.86 118.83 1 Brc1cnc(nc1N(CC2CCCC2)NC(=O)C3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6)C#N 14724796 IC50 = 70.7 nM 7.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3235663 1734188 CHEMBL3235663 1734188 5{2,2,2,3} 600.54 7.94 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575287 IC50 = 75.68 nM 7.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235653 1734178 CHEMBL3235653 1734178 5{1,2,2,2} 625.38 8.71 70.57 2 Clc1cccc(c1)\N=C(/NCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccc(Oc5cc(Cl)ccc5Cl)cc4 14575288 IC50 = 76.24 nM 7.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235668 1734193 CHEMBL3235668 1734193 12{2,1,2} 620.14 7.48 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575292 IC50 = 78.18 nM 7.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3286860 1757381 CHEMBL3286860 1757381 4d 602.52 4.98 118.83 1 Brc1cnc(nc1N(NC(=O)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5)C7CCCCC7)C#N 14724797 IC50 = 78.5 nM 7.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3103569 1611642 CHEMBL3103569 1611642 14 473.95 5.14 84.23 1 CC(CNc1ccnc2cc(Cl)ccc12)NC(=O)c3ccc(\C=C\C(=O)c4oc(C)cc4)cc3 13886183 IC50 = 80 nM 7.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3410466 1837244 CHEMBL3410466 1837244 4cB 641.55 4.77 172.24 2 CCOC(=O)ON(C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192780 IC50 = 83 nM 7.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3235669 1734194 CHEMBL3235669 1734194 12{2,1,3} 634.17 8.06 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575307 IC50 = 94.42 nM 7.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL2312168 1511212 CHEMBL2312168 1511212 1a, LMK235 294.35 2.2 87.66 0 Cc1cc(C)cc(c1)C(=O)NOCCCCCC(=O)NO 14718484 IC50 = 100 nM 7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3222267 1728685 CHEMBL3222267 1728685 14 477.9 2.37 132.86 0 CC(C)(C)N(Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4C#N)N=O 14536780 IC50 = 113 nM 6.95 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3309595 1778686 CHEMBL3309595 1778686 14j 473.01 1.64 72.02 0 CN1CCN(CC1)C(=O)CC[C@H](Nc2ccnc3cc(Cl)ccc23)C(=O)N4CCN(C)CC4 15031394 IC50 = 113.3 nM 6.95 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3309588 1778679 CHEMBL3309588 1778679 14c 348.83 1.31 68.7 0 CN1CCN(CC1)C(=O)[C@H](CO)Nc2ccnc3cc(Cl)ccc23 15031395 IC50 = 116.2 nM 6.93 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3289160 1759705 CHEMBL3289160 1759705 1j 324.37 1.94 96.89 0 CC(C)Oc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14718488 IC50 = 150 nM 6.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3235637 1734162 CHEMBL3235637 1734162 12{1,1,2} 620.14 7.48 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575338 IC50 = 174.5 nM 6.76 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3401321 1831521 CHEMBL3401321 1831521 12b 528.52 6.01 45.56 2 CCN(CC)CCCNc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN5CCOCC5)c3cc12 15164949 IC50 = 199 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3410468 1837246 CHEMBL3410468 1837246 4cD 653.6 5.32 163.01 3 CN(OC(=O)C(C)(C)C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192782 IC50 = 200 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3289163 1759708 CHEMBL3289163 1759708 1m 324.37 2.09 96.89 0 CCCOc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720524 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3309590 1778681 CHEMBL3309590 1778681 14e 447.96 4.05 64.26 0 CN1CCN(CC1)C(=O)[C@H](Cc2c[nH]c3ccccc23)Nc4ccnc5cc(Cl)ccc45 15031405 IC50 = 223.1 nM 6.65 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3401314 1831514 CHEMBL3401314 1831514 11a 498.49 6.72 36.33 1 CCN(CC)CCNc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN5CCCC5)c3cc12 15164942 IC50 = 245 nM 6.61 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3401313 1831513 CHEMBL3401313 1831513 10f 506.13 7.07 36.33 2 CCN(CC)CCCC(C)Nc1cc(Cl)cc2nc3c4ccccc4n(CCN5CCCC5)c3cc12 15164941 IC50 = 245 nM 6.61 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3102865 1611600 CHEMBL3102865 1611600 17 548.03 4.5 102.69 1 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)NCCOCCOCCNc3ccnc4cc(Cl)ccc34 13886175 IC50 = 260 nM 6.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3311426 1780536 CHEMBL3311426 1780536 7c 477 3.83 57.7 0 CN(CCCNc1ccnc2cc(Cl)ccc12)CC3=CC(=O)C(=CN3C)OCc4ccccc4 15011085 IC50 = 300 nM 6.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3235651 1734176 CHEMBL3235651 1734176 5{1,2,1,3} 604.96 8.62 70.57 2 Clc1ccc(Cl)c(Oc2ccc(N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)c1 14578307 IC50 = 307.4 nM 6.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3416970 1840175 CHEMBL3416970 1840175 20 333.84 4.18 81.73 0 CC(C)(C)NC1=Nc2cc(sc2C(=O)N1)c3ccc(Cl)cc3 15211670 IC50 = 344 nM 6.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL470514 460157 CHEMBL470514 460157 1 267.35 4.09 66.05 0 Cc1ccc(Nc2nc(cs2)c3ccccn3)cc1 15005142 IC50 = 350 nM 6.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451703 CHEMBL3366896 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3401318 1831518 CHEMBL3401318 1831518 11e 526.5 5.77 45.56 2 Clc1ccc2c(c1)c3nc4cc(Cl)cc(NCCCN5CCOCC5)c4cc3n2CCN6CCCC6 15164946 IC50 = 407 nM 6.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3219285 1725673 CHEMBL3219285 1725673 5 521.67 5.34 53.09 2 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCN(CCC56CC7CC(CC(C7)C5)C6)CC4)c(F)cc3C1=O 14542724 IC50 = 410 nM 6.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3359697 1823868 CHEMBL3359697 1823868 13h 354.34 2.06 96.25 0 ONC(=O)C(NC(=O)c1cccc(F)c1)c2ccc(cc2)n3cccn3 15106767 IC50 = 429 nM 6.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3109555 1614756 CHEMBL3109555 1614756 10e 421.53 4.89 74.65 0 CCOc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccc(OCC)cc4 13891343 IC50 = 466 nM 6.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3309579 1778670 CHEMBL3309579 1778670 6c 394.9 3.87 48.47 0 C[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(CC3)c4ccccc4 15031443 IC50 > 500 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3109536 1614737 CHEMBL3109536 1614737 8i 429.51 4.69 74.65 0 COc1ccc(cc1)C2(NC(=N)N(CCCc3ccccc3)C2=O)c4ccc(OC)cc4 13891363 IC50 = 512 nM 6.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3109557 1614758 CHEMBL3109557 1614758 10g 361.48 5.2 56.19 1 Cc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(C)c4 13891341 IC50 = 533 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3415880 1839074 CHEMBL3415880 1839074 1p 379.17 5.54 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4cc(ccc14)C(F)(F)F 15217337 IC50 = 579.3 nM 6.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3222268 1728686 CHEMBL3222268 1728686 15 448.9 2.07 112.22 0 CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4C#N 14536788 IC50 = 630 nM 6.2 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3087891 1605373 CHEMBL3087891 1605373 3c 390.43 3.26 78.87 0 Oc1ccc(NC(=O)C2=C(C=C(OC2=O)c3ccccc3)N4CCCCC4)cc1 13836547 IC50 = 765 nM 6.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3353308 1817415 CHEMBL3353308 1817415 6q 305.3 3.86 40.54 0 ON1C(=O)C(=Cc2cc(F)ccc12)c3cccc4ccccc34 14971660 IC50 = 1100 nM 5.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3261931 1746894 CHEMBL3261931 1746894 1 612.8 3.93 50.26 1 C\C=C/1\CN2CC[C@@]34[C@@H]2C[C@@H]1[C@H]5[C@H](O)[C@H]6[C@@H]([C@H]7[C@H]8C[C@@H]9N(CC[C@]9%10[C@H]7N(C6=O)c%11ccccc%10%11)C/C/8=C/C)N([C@H]35)c%12ccccc4%12 14653937 IC50 = 1100 nM 5.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353368 CHEMBL3268229 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83054 CHEMBL3259529 24593048 J. Nat. Prod. 2014 77 4 1078
CHEMBL3109531 1614732 CHEMBL3109531 1614732 8d 353.41 3.21 74.65 0 CCCN1C(=N)NC(C1=O)(c2ccc(OC)cc2)c3ccc(OC)cc3 13891660 IC50 = 1140 nM 5.94 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3109519 1614720 CHEMBL3109519 1614720 (+/-)-10j 439.55 5.73 65.42 1 COc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(c4)c5ccccc5 13891338 IC50 = 1490 nM 5.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3087892 1605374 CHEMBL3087892 1605374 3d 435.47 2.29 91.34 0 COc1ccc(cc1)C2=CC(=C(C(=O)Nc3ccc(O)cc3)C(=O)O2)N4CCN(C)CC4 13836546 IC50 = 1568 nM 5.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3109523 1614724 CHEMBL3109523 1614724 (+/-)-10n 440.54 5 78.31 1 COc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(c4)c5ccccn5 13891334 IC50 = 1810 nM 5.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3329580 1788567 CHEMBL3329580 1788567 7f 626.67 3.87 187.64 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=S)Nc3ccccc3)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127424 IC50 = 1830 nM 5.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3353307 1817414 CHEMBL3353307 1817414 6p 331.32 3.42 59 0 ON1C(=O)C(=Cc2c3OCOc3ccc12)c4cccc5ccccc45 14971659 IC50 = 1900 nM 5.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3415882 1839076 CHEMBL3415882 1839076 1r 363.61 5.47 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4cc(F)cc(Cl)c14 15217339 IC50 > 2000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3310175 1779272 CHEMBL3310175 1779272 2 314.42 .83 98.66 0 CCCCCNC(=O)CCNC(=O)[C@H](O)[C@](C)(CO)CC=C 15055008 IC50 = 2400 nM 5.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1449458 CHEMBL3373874 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage parasite assessed as reduction in parasite proliferation after 96 hrs in presence of 1 uM pantothenate by SYBR Safe DNA gel staining based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90402 CHEMBL3352628 24986662 Bioorg. Med. Chem. Lett. 2014 24 15 3274
CHEMBL3260206 1745152 CHEMBL3260206 1745152 1a 234.3 3.99 17.3 0 C\C=C\C=C\c1nc2ccccc2n3cccc13 14668019 IC50 = 2400 nM 5.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3338922 1793427 CHEMBL3338922 1793427 6f 604.75 6.14 73.2 2 [O-][S+]1C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6c1ccc7ccccc67 15119916 IC50 = 2550 nM 5.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3335104 1791235 CHEMBL3335104 1791235 15 318.37 2.02 83.86 0 N\C(=N/N=C/c1cccnc1)\CC(O)c2cccc3ccccc23 15128122 IC50 = 2700 nM 5.57 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3329589 1788576 CHEMBL3329589 1788576 8d 533.55 2.23 218.42 2 COc1cc(ccc1NC(=S)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)[N+](=O)[O-] 15127433 IC50 = 3350 nM 5.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3329583 1788570 CHEMBL3329583 1788570 7i 626.67 3.87 187.65 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127427 IC50 = 3730 nM 5.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3353304 1817411 CHEMBL3353304 1817411 6m 331.32 3.42 59 0 ON1C(=O)C(=Cc2cc3OCOc3cc12)c4cccc5ccccc45 14971656 IC50 = 4200 nM 5.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3261890 1746853 CHEMBL3261890 1746853 13 333.55 5.28 21.26 1 CC(=CCC\C(=C\CNCCO[C@@H]1C[C@@H]2CC[C@@]1(C)C2(C)C)\C)C 14651663 IC50 = 6000 nM 5.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3329582 1788569 CHEMBL3329582 1788569 7h 610.61 2.03 172.63 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127426 IC50 = 6650 nM 5.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL2011974 1333029 CHEMBL2011974 1333029 (+/-)-11 342.39 2.73 69.08 0 CN1C(=N)NC(C1=O)(c2ccccc2)c3cccc(c3)c4cccnc4 13891329 IC50 = 6880 nM 5.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3409896 1836668 CHEMBL3409896 1836668 63 747.9 3.53 168.45 1 CC(C)C[C@H](NC(=O)CN1CCC(O)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCN=C4COc5ccc(F)cc5 15199122 IC50 = 10000 nM 5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3260216 1745162 CHEMBL3260216 1745162 1k 306.4 5.34 26.53 1 CCCC\C=C\C=C\c1nc2ccc(OC)cc2n3cccc13 14668029 IC50 = 10400 nM 4.98 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3400178 1833200 CHEMBL3400178 1833200 14 452.54 4.83 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCC(Cc5ccccc5)CC4 15183820 IC50 = 12160 nM 4.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL8 241 CHEMBL8 241 CIPROFLOXACIN 1, CIPRO 331.34 -1.27 72.88 0 OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O 14542725 IC50 = 12800 nM 4.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3261887 1746850 CHEMBL3261887 1746850 10 253.42 3.88 21.26 0 CC(=CCC\C(=C\CNCCOC(C)(C)C)\C)C 14651660 IC50 = 13000 nM 4.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3409897 1836669 CHEMBL3409897 1836669 64 775.95 4.5 168.45 1 CC(C)C[C@H](NC(=O)CN1CCC(CCO)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCN=C4COc5ccc(F)cc5 15199121 IC50 = 18800 nM 4.73 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL470981 482937 CHEMBL470981 482937 EGONOL 3, Egonol 326.34 3.87 61.06 0 COc1cc(CCCO)cc2cc(oc12)c3ccc4OCOc4c3 13952427 IC50 = 25436 nM 4.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296215 CHEMBL3132228 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77210 CHEMBL3124935 24561670 Eur. J. Med. Chem. 2014 75 403
CHEMBL1766465 1141498 CHEMBL1766465 1141498 1 314.42 .83 98.66 0 CCCCCNC(=O)CCNC(=O)[C@H](O)[C@@](C)(CO)CC=C 15055007 IC50 = 31000 nM 4.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1449458 CHEMBL3373874 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage parasite assessed as reduction in parasite proliferation after 96 hrs in presence of 1 uM pantothenate by SYBR Safe DNA gel staining based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90402 CHEMBL3352628 24986662 Bioorg. Med. Chem. Lett. 2014 24 15 3274
CHEMBL8 241 CHEMBL8 241 CIPROFLOXACIN 1, CIPRO 331.34 -1.27 72.88 0 OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O 14542717 IC50 = 47000 nM 4.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3342264 1794406 CHEMBL3342264 1794406 4 287.25 1.13 107.88 0 CN(O)C(=O)CCCC(c1ccccc1)P(=O)(O)O 15101115 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3402990 1833207 CHEMBL3402990 1833207 22 640.68 3.97 115.38 1 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCN(CC4)C(=O)[C@H](Cc5ccccc5)N6C(=O)c7ccccc7C6=O 15183828 IC50 = 52700 nM 4.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3236245 1734776 CHEMBL3236245 1734776 22 339.3 .58 89.46 0 O=C(NC1=CN=C2C=CC=CN2C1=O)OCc3ccc4OCOc4c3 14580098 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236229 1734760 CHEMBL3236229 1734760 2 362.31 1.11 73.8 0 FC(F)(F)c1ccccc1CNC(=O)NC2=CN=C3C=CC=CN3C2=O 14580083 IC50 = 100000 nM 4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236235 1734766 CHEMBL3236235 1734766 11 334.78 .27 102.04 0 ClC1=CN2C(=NC=C(NC(=O)NCc3cccs3)C2=O)C=C1 14580088 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236242 1734773 CHEMBL3236242 1734773 19 407.85 -.05 94.55 0 CC(C)(C)OC(=O)N1CCN(CC1)C(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl 14580095 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236243 1734774 CHEMBL3236243 1734774 20 401.8 -.57 98.46 0 ClC1=CN2C(=O)C(=CN=C2C=C1)NC(=O)N3CCN(CC3)C(=O)c4occc4 14580096 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338911 1793416 CHEMBL3338911 1793416 5a 554.7 5.23 73.2 2 [O-][S+]1C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6ccccc16 15119927 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338904 1793409 CHEMBL3338904 1793409 3b 552.72 6.83 62.22 2 Cc1ccc2SC[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119934 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236260 1734791 CHEMBL3236260 1734791 39 302.33 -1.25 74.24 0 O=C(NCCN1CCOCC1)C2=CN=C3C=CC=CN3C2=O 14580113 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338929 1793434 CHEMBL3338929 1793434 7g 482.54 1.89 130.65 0 CC(=O)OC[C@H]1O[C@H]2[C@H](CS(=O)(=O)c3ccc(cc23)C(C)(C)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15119909 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338908 1793413 CHEMBL3338908 1793413 3f 588.76 7.25 62.22 2 C(OCc1ccccc1)[C@H]2O[C@H]3[C@H](CSc4ccc5ccccc5c34)[C@@H](OCc6ccccc6)[C@@H]2OCc7ccccc7 15119930 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3261889 1746852 CHEMBL3261889 1746852 12 323.47 5.62 21.26 1 CC(=CCC\C(=C\CNCCOc1cccc2ccccc12)\C)C 14651662 IC50 = 309000 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL1951748 1280738 CHEMBL1963129 1284840 9 360.44 2.7 76.74 0 [Br-].CN(C)c1cc[n+](Cc2ccc(Cn3cnc(N)c4ncnc34)cc2)cc1 15026506 IC50 > 22700000 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3410086 1836860 CHEMBL3410086 1836860 92 635.73 3.92 126.24 1 CC(C)C[C@H](NC(=O)N1CCOCC1)c2occ(n2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199161 IC50 Not Active 0 BAO_0000190 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3099602 1610382 CHEMBL3099602 1610382 4f 393.87 2.75 91.41 0 Clc1ccc2c(NCCCNC(c3ccccc3)c4nnn[nH]4)ccnc2c1 13862659 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3353294 1817401 CHEMBL3353294 1817401 6c 303.31 3.11 60.77 0 ON1C(=O)C(=C(O)c2ccccc12)c3ccc4ccccc4c3 14971646 IC50 Not Active 0 BAO_0000190 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL973 96107 CHEMBL973 96107 TERIFLUNOMIDE 1, A771726 270.21 2.09 73.12 0 C\C(=C(/C#N)\C(=O)Nc1ccc(cc1)C(F)(F)F)\O 14734169 IC50 Not Determined 0 BAO_0000190 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL3353295 1817402 CHEMBL3353295 1817402 6d 321.25 3.15 60.77 0 ON1C(=O)C(=C(O)c2ccccc12)c3ccccc3C(F)(F)F 14971647 IC50 Not Active 0 BAO_0000190 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3219929 1726324 CHEMBL3219929 1726324 49 532.04 5.43 94.57 2 CN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCOCC6 14545693 IC50 = .00322 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219931 1726326 CHEMBL3219931 1726326 51 562.07 4.94 112.59 2 Clc1ccc2c(Nc3ccc(Nc4nc(NCCN5CCOCC5)nc(n4)N6CCOCC6)cc3)ccnc2c1 14545695 IC50 = .00587 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3218238 1724616 CHEMBL3218238 1724616 14 363.49 3.43 40.16 0 C1CCN(CC1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530896 IC50 = .6 nM 9.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL2387268 1564043 CHEMBL2387268 1564043 RKA182 503.67 2.35 63.71 1 CN1CCN(CC1)C2CCN(CC2)C(=O)CC3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6 14530909 IC50 = .819 nM 9.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3422770 1842217 CHEMBL3422770 1842217 1i 298.73 2.34 66.91 0 Clc1ccc2c(NNC(=O)c3cccnc3)ccnc2c1 15239352 IC50 = 1.76 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL2263536 1481387 CHEMBL2263536 1481387 10 351.44 4.75 38.76 0 COc1ccc(\C=C\C(=O)c2ccc(cc2)N3CCCCC3)cc1OC 12460152 IC50 = 3.13 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL3423371 1842824 CHEMBL3423371 1842824 1b 410.88 4.11 92.36 0 Clc1ccc2c(Nc3ccc(cc3)S(=O)(=O)Nc4ccccn4)ccnc2c1 15239345 IC50 = 3.64 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3309531 1778622 CHEMBL3309531 1778622 8i 412.91 2.56 77.48 0 OC1=CN(C2CC2)C(=CC1=O)CNCCCCNc3ccnc4cc(Cl)ccc34 15011101 IC50 = 4 nM 8.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE Artesunate 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 15217344 IC50 = 4.2 nM 8.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL2263539 1481390 CHEMBL2263539 1481390 3 305.33 3.23 57.01 0 COc1ccc(\C=C\C(=O)c2ccc(cc2)n3cncn3)cc1 12460159 IC50 = 4.56 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15139438 IC50 = 4.75 nM 8.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3112878 1615831 CHEMBL3140200 1629531 32 549.15 9.22 14.24 2 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(CCc3ccc(C[n+]4ccc(cc4)N(C)c5ccc(Cl)cc5)cc3)cc2)cc1 15026483 IC50 = 5 nM 8.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL316098 150513 CHEMBL316098 150513 N-TERT-BUTYL-AMODIAQUINE NTBAQ 355.86 4.46 57.18 0 CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 12450939 IC50 = 5.5 nM 8.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3112877 1615830 CHEMBL3140160 1629491 31 521.09 8.31 14.24 2 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(cc2)c3ccc(C[n+]4ccc(cc4)N(C)c5ccc(Cl)cc5)cc3)cc1 15026484 IC50 = 7 nM 8.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3402991 1833208 CHEMBL3402991 1833208 23 544.6 2.55 115.38 1 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H](C(C)C)N4C(=O)c5ccccc5C4=O 15183778 IC50 = 9.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL33284 46337 CHEMBL33284 46337 4 312.32 3.3 72.83 0 COc1ccc(cc1OC)C(=O)\C=C\c2ccc(cc2)C(=O)O 15155314 IC50 = 10.8 nM 7.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3286862 1757383 CHEMBL3286862 1757383 4f 497.59 3.57 118.83 0 CC(C)CN(NC(=O)C1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)c6ccnc(n6)C#N 14724799 IC50 = 13.1 nM 7.88 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL36 2080 CHEMBL36 2080 PYRIMETHAMINE PY 248.71 2.75 77.81 0 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 14542721 IC50 = 13.3 nM 7.88 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3343954 1796113 CHEMBL3343954 1796113 S-13d 346.9 3.61 31.4 0 C[C@@H](CCCN1CCN(C)CC1)Nc2ccnc3cc(Cl)ccc23 15139450 IC50 = 14.21 nM 7.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL2263537 1481388 CHEMBL2263537 1481388 11 378.85 4.61 42.43 0 Clc1nc2ccccc2cc1\C=C\C(=O)c3ccc(cc3)N4CCOCC4 12460151 IC50 = 17.03 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15121667 IC50 = 17.3 nM 7.76 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14542718 IC50 = 18 nM 7.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3402983 1833199 CHEMBL3402983 1833199 13 418.53 4.5 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183768 IC50 = 18.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3219629 1726021 CHEMBL3219629 1726021 6b 309.32 2.94 64.63 0 CCOC(=O)C1=CNc2cc(Oc3ccccc3)ccc2C1=O 14545592 IC50 = 19.3 nM 7.71 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3402984 1833201 CHEMBL3402984 1833201 15 404.5 4.11 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183770 IC50 = 19.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL588619 530450 CHEMBL588619 530450 CINCHONINE CIN 294.39 2.75 36.36 0 O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 12450944 IC50 = 21 nM 7.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL172 303542 CHEMBL172 303542 (S,R)-MEFLOQUINE MQ 378.31 4.3 45.15 0 O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 12450933 IC50 = 23 nM 7.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3235657 1734182 CHEMBL3235657 1734182 5{1,2,3,3} 639.4 9.29 70.57 2 Clc1ccc(cc1)\N=C(/NCCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccc(Oc5cc(Cl)ccc5Cl)cc4 14575155 IC50 = 29.02 nM 7.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3309532 1778623 CHEMBL3309532 1778623 8j 440.97 3.47 77.49 0 OC1=CN(C2CC2)C(=CC1=O)CNCCCCCCNc3ccnc4cc(Cl)ccc34 15011102 IC50 = 30 nM 7.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3416991 1840196 CHEMBL3416951 1840156 1a 313.42 4.01 81.73 0 Cl.Cc1ccc(cc1)c2cc3N=C(NC(C)(C)C)NC(=O)c3s2 15211669 IC50 = 35 nM 7.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3235270 1733791 CHEMBL3235270 1733791 5{1,1,1,1} 576.9 7.98 70.57 2 Clc1ccc(Cl)c(Oc2ccccc2N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)c1 14575168 IC50 = 42.47 nM 7.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3309596 1778687 CHEMBL3309596 1778687 20a 374.91 3.18 48.47 0 CC(C)[C@H](CC(=O)N1CCN(C)CC1)Nc2ccnc3cc(Cl)ccc23 15031381 IC50 = 44.12 nM 7.36 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3093735 1608119 CHEMBL3093735 1608119 14 736.94 2.88 138.52 2 O=C(CC1CCC2(CC1)OOC3(CCCCC3)OO2)NCCCN4CCN(CCCNC(=O)CC5CCC6(CC5)OOC7(CCCCC7)OO6)CC4 13855007 IC50 = 47.1 nM 7.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL2234257 1469754 CHEMBL2234257 1469754 14 382.36 3.14 91.29 0 COc1cc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)cc(OC)c1OC 12393161 IC50 > 50 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3093729 1608113 CHEMBL3093729 1608113 8 748.9 5.48 132.04 2 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)Nc6ccc(NC(=O)CC7CCC8(CC7)OOC9(OO8)C%10CC%11CC(CC9C%11)C%10)cc6 13855013 IC50 = 58.4 nM 7.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3402989 1833206 CHEMBL3402989 1833206 21 572.65 3.33 115.38 1 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H](CC(C)C)N4C(=O)c5ccccc5C4=O 15183776 IC50 = 61 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402987 1833204 CHEMBL3402987 1833204 19 316.35 1.14 66.92 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183774 IC50 = 65 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3222265 1728683 CHEMBL3222265 1728683 10 418.76 5.45 36.95 1 CC(C)(C)NCc1cc(Br)cc(Nc2ccnc3cc(Cl)ccc23)c1 14536785 IC50 = 65 nM 7.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3112876 1615829 CHEMBL3139875 1629206 30 445 6.79 14.24 1 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(C[n+]3ccc(cc3)N(C)c4ccc(Cl)cc4)cc2)cc1 15026485 IC50 = 66 nM 7.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3235671 1734196 CHEMBL3235671 1734196 12{2,2,2} 654.58 8.15 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575293 IC50 = 78.18 nM 7.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14668033 IC50 = 82 nM 7.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3335100 1791231 CHEMBL3335100 1791231 11 396.28 3.92 70.97 0 N\C(=N/N=C/c1cccc(Br)c1)\CC(O)c2cccc3ccccc23 15128126 IC50 = 91 nM 7.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3341763 1794400 CHEMBL3341763 1794400 2c 303.25 .65 117.11 0 COc1ccc(cc1)C(CCC(=O)N(C)O)P(=O)(O)O 15101109 IC50 = 100 nM 7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3335092 1791223 CHEMBL3335092 1791223 3 317.38 3.17 70.97 0 N\C(=N/N=C/c1ccccc1)\CC(O)c2cccc3ccccc23 15128134 IC50 = 100 nM 7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3235633 1734158 CHEMBL3235633 1734158 5{2,1,3,1} 572.48 7.3 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCNc4ccnc5cc(Cl)ccc45)cc1 14575313 IC50 = 103.24 nM 6.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL170 255947 CHEMBL170 255947 QUININE QN 324.42 2.73 45.59 0 COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 14542728 IC50 = 112 nM 6.95 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3219635 1726027 CHEMBL3219635 1726027 10a 391.34 5.47 64.63 1 CCOC(=O)C1=CNc2ccc(Cc3ccc(OC(F)(F)F)cc3)cc2C1=O 14545599 IC50 = 141.5 nM 6.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3415869 1839063 CHEMBL3415869 1839063 1d 284.72 4.72 17.82 0 Cn1cc2c3cc(F)ccc3nc2c4cc(Cl)ccc14 15217325 IC50 = 165.8 nM 6.78 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3416993 1840198 CHEMBL3416970 1840175 20a 333.84 4.18 81.73 0 CC(C)(C)NC1=Nc2cc(sc2C(=O)N1)c3ccc(Cl)cc3.OC(=O)\C=C\C(=O)O 15211667 IC50 = 168 nM 6.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3415877 1839071 CHEMBL3415877 1839071 1m 329.17 4.81 17.82 0 Cn1cc2c3cc(Br)ccc3nc2c4cccc(F)c14 15217334 IC50 = 178 nM 6.75 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL1951743 1280733 CHEMBL1963128 1284839 4 462.57 4.68 76.73 0 [Br-].Nc1ncnc2c1ncn2Cc3ccc(cc3)c4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4 15026511 IC50 = 191 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL591637 589617 CHEMBL591637 589617 2 327.42 3.38 108.42 0 CSc1ccccc1C(=O)Nc2nc(cs2)c3ccccn3 15005143 IC50 = 200 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451703 CHEMBL3366896 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3235665 1734190 CHEMBL3235665 1734190 5{2,2,3,2} 586.51 7.36 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575346 IC50 = 204.1 nM 6.69 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL2164256 1427681 CHEMBL2164256 1427681 2a 287.25 1.16 107.88 0 CN(O)C(=O)CCC(c1ccc(C)cc1)P(=O)(O)O 15101107 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL2312165 1511209 CHEMBL2312165 1511209 1e 280.32 1.72 87.66 0 Cc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720526 IC50 = 220 nM 6.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3415868 1839062 CHEMBL3415868 1839062 1c 266.72 4.52 17.82 0 Cn1cc2c3ccccc3nc2c4cc(Cl)ccc14 15217324 IC50 = 221.3 nM 6.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3309524 1778615 CHEMBL3309524 1778615 8b 372.85 1.49 77.48 0 CN1C=C(O)C(=O)C=C1CNCCCNc2ccnc3cc(Cl)ccc23 15011094 IC50 = 230 nM 6.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3235638 1734163 CHEMBL3235638 1734163 12{1,1,3} 634.17 8.06 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14578305 IC50 = 287 nM 6.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3109549 1614750 CHEMBL3109549 1614750 9f 407.51 4.52 74.65 0 COc1ccc(cc1)C2(NC(=N)N(CC3CCCCC3)C2=O)c4ccc(OC)cc4 13891349 IC50 = 383 nM 6.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3335107 1791238 CHEMBL3335107 1791238 18 349.4 3.36 70.97 0 C\C(=N/N=C(\N)/CC(O)c1cccc2ccccc12)\c3ccc(F)cc3 15128119 IC50 = 400 nM 6.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3109526 1614727 CHEMBL3109526 1614727 (+/-)-10q 425.52 5.78 65.42 1 N=C1NC(C(=O)N1C2CCCCC2)(c3ccccc3)c4cccc(Oc5ccccc5)c4 13891331 IC50 = 424 nM 6.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3401319 1831519 CHEMBL3401319 1831519 11f 540.57 7.74 36.33 2 CCN(CC)CCCC(C)Nc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN5CCCC5)c3cc12 15164947 IC50 = 456 nM 6.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL506 10389 CHEMBL506 10389 PRIMAQUINE PQ 259.35 2 60.17 0 COc1cc(NC(C)CCCN)c2ncccc2c1 15156330 IC50 = 460 nM 6.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462721 CHEMBL3399490 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90966 CHEMBL3396969 25461328 Eur. J. Med. Chem. 2015 90 280
CHEMBL3401322 1831522 CHEMBL3401322 1831522 12c 514.49 5.94 45.56 2 CCN(CC)CCNc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN5CCOCC5)c3cc12 15164950 IC50 = 513 nM 6.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3329578 1788565 CHEMBL3329578 1788565 7d 701.7 3.75 242.7 2 COc1cc(ccc1NC(=S)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](COC(=O)C)[C@@H](OC(=O)C)[C@H](OC(=O)C)[C@H]3OC(=O)C)c2)[N+](=O)[O-] 15127422 IC50 = 550 nM 6.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3087894 1605376 CHEMBL3087894 1605376 3f 386.2 3.03 75.63 0 OC1=C(C(=O)Nc2ccc(Br)cc2)C(=O)OC(=C1)c3ccccc3 13836544 IC50 = 750 nM 6.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3109551 1614752 CHEMBL3109551 1614752 10a 393.48 4.19 74.65 0 COc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(OC)c4 13891347 IC50 = 768 nM 6.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3087889 1605371 CHEMBL3087889 1605371 3a 388.46 3.99 58.64 0 Cc1ccc(NC(=O)C2=C(C=C(OC2=O)c3ccccc3)N4CCCCC4)cc1 13836549 IC50 = 859 nM 6.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3409907 1836679 CHEMBL3409907 1836679 74 667.81 4.13 129.31 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1)C(=O)N[C@H](C(=O)N2CCC[C@H]2COc3ccc(F)cc3)c4ccccc4 15199152 IC50 = 900 nM 6.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3093740 1608124 CHEMBL3093740 1608124 22 544.63 1.32 132.04 1 CC1(CCC(=O)NCCCCNC(=O)CCC2(C)OOC3(CCCCC3)OO2)OOC4(CCCCC4)OO1 13854147 IC50 = 908.2 nM 6.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3109559 1614760 CHEMBL3109559 1614760 10i 402.32 5.55 56.19 1 Clc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(Cl)c4 13891339 IC50 = 1060 nM 5.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3235645 1734170 CHEMBL3235645 1734170 12{1,2,5} 475.97 6.27 71.95 1 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NC4CC4)cc1)\C 14578325 IC50 > 1200 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235639 1734164 CHEMBL3235639 1734164 12{1,1,4} 491.58 6.7 71.95 1 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCc4ccccc4)cc1)\C 14578323 IC50 > 1200 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3299078 1763422 CHEMBL3299078 1763422 9 355.41 2.71 101.58 0 COC(OC)c1ccc(cc1)C(=O)Nc2nc(cs2)c3ccccn3 15005170 IC50 = 1475 nM 5.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183796 IC50 = 1920 nM 5.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465118 CHEMBL3405450 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 42 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis in presence of 12.5 ng/ml 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3335112 1791243 CHEMBL3335112 1791243 23 335.37 3.38 70.97 0 N\C(=N/N=C/c1ccc(F)cc1)\CC(O)c2ccc3ccccc3c2 15128114 IC50 = 2000 nM 5.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3344517 1796681 CHEMBL3344517 1796681 2 391.89 5.18 45.23 1 Clc1ccc2c3c4ccccc4C(=O)c3c(NCCN5CCCCC5)nc2c1 15083312 IC50 = 2339 nM 5.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3261881 1746844 CHEMBL3261881 1746844 4 331.54 5.2 21.26 1 CC(=CCC\C(=C\COCCNC1C2CC3CC(CC1C3)C2)\C)C 14651654 IC50 = 2800 nM 5.55 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3329586 1788573 CHEMBL3329586 1788573 8a 442.46 .51 148.35 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@H](O)[C@@H](O)[C@@H]1O 15127430 IC50 = 3770 nM 5.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3099818 1610601 CHEMBL3099818 1610601 3b 465.98 3.81 89.78 0 COc1ccc(cc1)C(NCCNc2ccnc3cc(Cl)ccc23)c4nnnn4C(C)(C)C 13862670 IC50 = 3821 nM 5.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3353311 1817418 CHEMBL3353311 1817418 6t 295.29 3 59 0 Cc1ccccc1C2=Cc3cc4OCOc4cc3N(O)C2=O 14971663 IC50 = 4600 nM 5.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3400178 1833200 CHEMBL3400178 1833200 14 452.54 4.83 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCC(Cc5ccccc5)CC4 15183782 IC50 = 5000 nM 5.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465108 CHEMBL3405440 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 60 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3409900 1836672 CHEMBL3409900 1836672 67 664.81 4.6 132.44 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCC1)C(=O)N[C@H](C(=O)N2CCN=C2COc3ccc(F)cc3)c4ccccc4 15199118 IC50 = 5200 nM 5.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3358136 1822291 CHEMBL3558734 1940580 13 628.85 3.5 148.74 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)NCc1ccccc1.[O-]C(=O)C(F)(F)F 15121657 IC50 = 5400 nM 5.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3409895 1836667 CHEMBL3409895 1836667 62 717.87 5.21 148.22 2 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCC1)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCN=C4COc5ccc(F)cc5 15199123 IC50 = 5500 nM 5.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3114087 1617052 CHEMBL3139389 1628720 12, VAM2-12 360.45 3.3 81.39 0 Br.[O-][N+](=O)c1ccc2N(CCCCCN3CCCCCC3)CC(=O)Nc2c1 13910786 IC50 = 5720 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183830 IC50 = 5970 nM 5.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3338921 1793426 CHEMBL3338921 1793426 6e 568.72 5.72 73.2 2 Cc1cccc2[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3C[S+]([O-])c12 15119917 IC50 = 6290 nM 5.2 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3358137 1822292 CHEMBL3558738 1940584 14 612.8 2.77 148.73 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCC[NH+]1C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)NCc2ccccc2.[O-]C(=O)C(F)(F)F 15121658 IC50 = 6600 nM 5.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3344518 1796682 CHEMBL3344518 1796682 3 393.87 3.95 54.46 0 Clc1ccc2c3c4ccccc4C(=O)c3c(NCCN5CCOCC5)nc2c1 15083313 IC50 = 6775 nM 5.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3329590 1788577 CHEMBL3329590 1788577 8e 442.46 .51 148.35 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=O)Nc3ccccc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O 15127434 IC50 = 7510 nM 5.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3329598 1788585 CHEMBL3329598 1788585 11b 310.35 3.19 67.43 0 CCOC(=O)\C=C\c1cccc(NC(=O)Nc2ccccc2)c1 15127442 IC50 = 8800 nM 5.06 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3238454 1737008 CHEMBL3238454 1737008 5c 477.55 6.42 72.39 1 CCCCN1C=C(C(=O)OCC)C(=O)c2c1ccc3nc(c4ccccc4)c(nc23)c5ccccc5 14599592 IC50 = 9170 nM 5.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3260217 1745163 CHEMBL3260217 1745163 1l 306.4 5.34 26.53 1 CCCC\C=C\C=C\c1nc2cccc(OC)c2n3cccc13 14668030 IC50 = 9800 nM 5.01 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL2046934 1350351 CHEMBL2078706 1362936 11, VAM2-11 346.42 2.85 81.4 0 Br.[O-][N+](=O)c1ccc2N(CCCCCN3CCCCC3)CC(=O)Nc2c1 13910787 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3103530 1611603 CHEMBL3103530 1611603 20 255.27 2.24 73.3 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)N 13886133 IC50 = 10000 nM 5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3353298 1817405 CHEMBL3353298 1817405 6g 237.25 2.74 40.54 0 ON1C(=O)C(=Cc2ccccc12)c3ccccc3 14971650 IC50 = 14000 nM 4.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3109545 1614746 CHEMBL3109545 1614746 9b 409.48 2.95 94.88 0 COc1ccc(cc1)C2(NC(=N)N(C3CCC(O)CC3)C2=O)c4ccc(OC)cc4 13891353 IC50 = 14800 nM 4.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL336467 229007 CHEMBL336467 229007 FUROXAN 6 187.15 -.8 75.28 0 [O-][n+]1onc(c2ccccc2)c1C#N 14536784 IC50 > 15000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3238452 1737006 CHEMBL3238452 1737006 5a 449.5 5.44 72.39 1 CCOC(=O)C1=CN(CC)c2ccc3nc(c4ccccc4)c(nc3c2C1=O)c5ccccc5 14599590 IC50 = 15400 nM 4.81 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3402991 1833208 CHEMBL3402991 1833208 23 544.6 2.55 115.38 1 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H](C(C)C)N4C(=O)c5ccccc5C4=O 15183829 IC50 = 16890 nM 4.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3290612 1761171 CHEMBL3290612 1761171 10 291.3 3.95 74.5 0 Cc1c2ccncc2c(C)c3c4cccc(c4[nH]c13)[N+](=O)[O-] 14746082 IC50 = 17000 nM 4.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL275260 5406 CHEMBL275260 5406 14 228.31 4.37 56.15 0 S=C(Nc1ccccc1)Nc2ccccc2 15127446 IC50 > 20000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3290637 1761196 CHEMBL3290637 1761196 3 792.92 .1 253.02 2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)O)[C@@H](C)CC 14710395 IC50 = 25000 nM 4.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1362075 CHEMBL3294628 F Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83803 CHEMBL3286375 24813731 Bioorg. Med. Chem. Lett. 2014 24 12 2645
CHEMBL3409915 1836687 CHEMBL3409915 1836687 82 575.7 4.68 141.57 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)c1occc1)C(=O)N[C@@H](Cc2ccccc2)C(=O)NNc3ccccc3 15199160 IC50 = 27900 nM 4.55 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3409913 1836685 CHEMBL3409913 1836685 80 691.9 5.46 129.31 2 COc1ccc(OC[C@@H]2CCCN2C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)N4CCCCC4)cc1 15199158 IC50 = 35700 nM 4.45 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3342266 1794408 CHEMBL3342266 1794408 5b 302.22 -.35 145.76 0 ONC(=O)CCC(NC(=O)c1ccccc1)P(=O)(O)O 15101117 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3233233 1731734 CHEMBL3233233 1731734 6l 587.5 7.45 83.39 2 OC(=O)C1=CN(Cc2ccc(cc2)C(F)(F)F)c3ccc4nc(c5ccc(F)cc5)c(nc4c3C1=O)c6ccc(F)cc6 14599613 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3236257 1734788 CHEMBL3236257 1734788 36 347.29 1.46 61.77 0 FC(F)(F)c1cccc(CNC(=O)C2=CN=C3C=CC=CN3C2=O)c1 14580110 IC50 = 65000 nM 4.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338912 1793417 CHEMBL3338912 1793417 5b 568.72 5.72 73.2 2 Cc1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119926 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3125843 1622452 CHEMBL3125843 1622452 Cis-D1, (-)-cis-D1 367.4 1.66 107.47 0 COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c4c(O)c(C)ncc4CO 13953877 IC50 = 108000 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296432 CHEMBL3130133 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77215 CHEMBL3124773 24565970 Bioorg. Med. Chem. 2014 22 6 1832
CHEMBL3402986 1833203 CHEMBL3402986 1833203 17 330.38 1.53 66.92 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183823 IC50 = 139300 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402979 1833195 CHEMBL3402979 1833195 9 328.41 2.76 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183815 IC50 = 217870 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3219632 1726024 CHEMBL3219632 1726024 8b 323.34 2.94 64.63 0 CCOC(=O)C1=CNc2cc(OCc3ccccc3)ccc2C1=O 14545596 IC50 ND(Insoluble) 0 BAO_0000190 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3238457 1737011 CHEMBL3238457 1737011 5f 579.57 7.61 72.39 2 CCOC(=O)C1=CN(Cc2ccc(cc2)C(F)(F)F)c3ccc4nc(c5ccccc5)c(nc4c3C1=O)c6ccccc6 14599595 IC50 ND(Insoluble) 0 BAO_0000190 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL2028053 1340310 CHEMBL2028053 1340310 4 476.9 5.66 84.59 1 Cc1ccc(cc1)c2cc3c(SCC(=O)Nc4cc(ccc4Cl)C(F)(F)F)nccn3n2 15005166 IC50 Not Determined 0 BAO_0000190 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE ART 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 15239355 IC50 Not Determined 0 BAO_0000190 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3219906 1726301 CHEMBL3219906 1726301 26 572.49 7.79 94.13 2 CN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6cccc(Cl)c6)n2 14545670 IC50 = .00241 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219911 1726306 CHEMBL3219911 1726306 31 586.52 8.14 94.13 2 CCN1CCN(CC1)c2nc(Nc3ccc(Cl)cc3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2 14545675 IC50 = .00414 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 12393147 IC50 = .0223 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3218236 1724614 CHEMBL3218236 1724614 12 392.53 2.08 52.19 0 CN1CCC(CC1)NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530894 IC50 = .4 nM 9.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3218239 1724617 CHEMBL3218239 1724617 15 399.47 3.33 40.16 0 FC1(F)CCN(CC1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530897 IC50 = .6 nM 9.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3423370 1842823 CHEMBL3423370 1842823 1a 333.79 2.94 93.46 0 NS(=O)(=O)c1ccc(Nc2ccnc3cc(Cl)ccc23)cc1 15239344 IC50 = 2.18 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3218240 1724618 CHEMBL3218240 1724618 16 446.62 3.54 43.4 0 C1CCN(CC1)C2CCN(CC2)C3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6 14530898 IC50 = 2.4 nM 8.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3112869 1615822 CHEMBL3140161 1629492 23 450.62 6.51 14.24 1 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(cc2)c3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc1 15026492 IC50 = 3 nM 8.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15005171 IC50 = 3 nM 8.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3397106 1828823 CHEMBL3397106 1828823 10 578.65 5.5 98.75 2 COc1ccc(cc1OC)C(=O)\C=C\c2ccc(cc2)C(=O)OC3O[C@@H]4O[C@]5(C)CC[C@H]6[C@H](C)CC[C@@H]([C@H]3C)[C@@]46OO5 15155308 IC50 = 3.36 nM 8.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3218237 1724615 CHEMBL3218237 1724615 13 429.53 1.12 96.51 0 [O-][N+]1(CCS(=O)(=O)CC1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530895 IC50 = 3.7 nM 8.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3289670 1760220 CHEMBL3289670 1760220 10, DSM330 375.27 4.25 55.11 0 Cc1cc(Nc2ccc(c(F)c2)C(F)(F)F)n3nc(nc3n1)C(C)(F)F 14734084 IC50 = 3.9 nM 8.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL3093732 1608116 CHEMBL3093732 1608116 11 714.89 4.03 132.04 1 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)NCCCNC(=O)CC6CCC7(CC6)OOC8(OO7)C9CC%10CC(CC8C%10)C9 13855010 IC50 = 4.7 nM 8.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3219638 1726030 CHEMBL3219638 1726030 11b 407.34 5.06 73.86 1 CCOC(=O)C1=CNc2cc(OCc3ccc(OC(F)(F)F)cc3)ccc2C1=O 14545602 IC50 = 5 nM 8.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3098147 1610600 CHEMBL3098147 1610600 3a 435.95 3.83 80.55 0 CC(C)(C)n1nnnc1C(NCCNc2ccnc3cc(Cl)ccc23)c4ccccc4 13862671 IC50 = 5 nM 8.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL35228 51003 CHEMBL35228 51003 PYRONARIDINE PYR 518.05 6.2 73.75 2 COc1ccc2nc3cc(Cl)ccc3c(Nc4cc(CN5CCCC5)c(O)c(CN6CCCC6)c4)c2n1 12450929 IC50 = 5.7 nM 8.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL229030 384939 CHEMBL229030 384939 1d 416.9 3.72 120.6 0 Clc1ccc2c(Nc3ccc(cc3)S(=O)(=O)Nc4nccs4)ccnc2c1 15239347 IC50 = 5.97 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL1630 476314 CHEMBL682 29097 AMODIAQUINE HYDROCHLORIDE AQ 355.86 4.76 48.39 0 Cl.CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 12450946 IC50 = 7.8 nM 8.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL2263289 1481138 CHEMBL2263289 1481138 1 323.39 3.54 38.76 0 COc1ccc(\C=C\C(=O)c2ccc(cc2)N3CCOCC3)cc1 12460161 IC50 = 7.9 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL343770 230066 CHEMBL343770 230066 TEBAQUINE TBQ 466.4 6.94 48.39 1 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1O)c4ccc(Cl)cc4 12450931 IC50 = 9.5 nM 8.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL252715 421011 CHEMBL252715 421011 (R)-CHLOROQUINE R-13a, (R)-chloroquine 319.87 4.35 28.16 0 CCN(CC)CCC[C@@H](C)Nc1ccnc2cc(Cl)ccc12 15139455 IC50 = 9.54 nM 8.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL250447 421000 CHEMBL250447 421000 S-13a, (S)-chloroquine 319.87 4.35 28.16 0 CCN(CC)CCC[C@H](C)Nc1ccnc2cc(Cl)ccc12 15139456 IC50 = 10.94 nM 7.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3093733 1608117 CHEMBL3093733 1608117 12 728.91 4.61 132.04 1 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)NCCCCNC(=O)CC6CCC7(CC6)OOC8(OO7)C9CC%10CC(CC8C%10)C9 13855009 IC50 = 11.2 nM 7.95 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3410332 1837109 CHEMBL3410332 1837109 5c 571.46 3.42 166.17 2 CN(O)C(=O)COC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192774 IC50 = 13 nM 7.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3343950 1796109 CHEMBL3343950 1796109 S-13b 333.86 3.34 37.39 0 C[C@@H](CCCN1CCOCC1)Nc2ccnc3cc(Cl)ccc23 15139454 IC50 = 14.02 nM 7.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3343956 1796115 CHEMBL3343956 1796115 S-13e 331.88 4.57 28.16 0 C[C@@H](CCCN1CCCCC1)Nc2ccnc3cc(Cl)ccc23 15139448 IC50 = 14.95 nM 7.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14542726 IC50 = 18 nM 7.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15217341 IC50 = 18 nM 7.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL1236 230562 CHEMBL1236 230562 DESETHYLCHLOROQUINE DESCQ 291.82 3.46 36.95 0 CCNCCCC(C)Nc1ccnc2cc(Cl)ccc12 12450934 IC50 = 19 nM 7.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3309598 1778689 CHEMBL3309598 1778689 20c 422.95 3.89 48.47 0 CN1CCN(CC1)C(=O)C[C@H](Cc2ccccc2)Nc3ccnc4cc(Cl)ccc34 15031377 IC50 = 19.24 nM 7.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3235642 1734167 CHEMBL3235642 1734167 12{1,2,2} 654.58 8.15 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575072 IC50 = 20.34 nM 7.69 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL21578 27150 CHEMBL21578 27150 QUINIDINE QND 324.42 2.73 45.59 0 COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1 12450943 IC50 = 21 nM 7.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL2234263 1469760 CHEMBL2234263 1469760 1 292.29 3.18 63.6 0 OC1=C(C(=O)\C=C\c2ccccc2)C(=O)Oc3ccccc13 12393252 IC50 = 22.1 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3402985 1833202 CHEMBL3402985 1833202 16 418.53 4.57 57.69 0 CC[C@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183771 IC50 = 22.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3423373 1842826 CHEMBL3423373 1842826 1e 414.87 3.86 105.5 0 Cc1onc(NS(=O)(=O)c2ccc(Nc3ccnc4cc(Cl)ccc34)cc2)c1 15239348 IC50 = 23.85 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3093737 1608121 CHEMBL3093737 1608121 16 624.76 3.3 132.04 1 O=C(CC1CCC2(CC1)OOC3(CCCCC3)OO2)NCCCCNC(=O)CC4CCC5(CC4)OOC6(CCCCC6)OO5 13855005 IC50 = 28.9 nM 7.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE 1, CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15156343 IC50 = 30 nM 7.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462721 CHEMBL3399490 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90966 CHEMBL3396969 25461328 Eur. J. Med. Chem. 2015 90 280
CHEMBL3410331 1837108 CHEMBL3410331 1837108 5b 543.41 3.01 166.17 2 CC(C)OC(=O)OCOP(=O)(OCOC(=O)OC(C)C)C(OCC(=O)N(C)O)c1ccc(F)c(F)c1 15192773 IC50 = 35 nM 7.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL172 303542 CHEMBL172 303542 (S,R)-MEFLOQUINE Mefloquine 378.31 4.3 45.15 0 O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 14668034 IC50 = 39 nM 7.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13910779 IC50 = 40 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3093744 1608128 CHEMBL3093744 1608128 26 656.81 .9 138.52 2 CC1(CCC(=O)NCCCN2CCN(CCCNC(=O)CCC3(C)OOC4(CCCCC4)OO3)CC2)OOC5(CCCCC5)OO1 13854143 IC50 = 47.5 nM 7.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3103526 1611598 CHEMBL3103526 1611598 15 516.03 6.31 84.23 2 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)NCCCCCCNc3ccnc4cc(Cl)ccc34 13886187 IC50 = 50 nM 7.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3415881 1839075 CHEMBL3415881 1839075 1q 395.17 6.72 27.05 1 Cn1cc2c3cc(Br)ccc3nc2c4cc(OC(F)(F)F)ccc14 15217338 IC50 = 57.7 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL336467 229007 CHEMBL336467 229007 FUROXAN 6 187.15 -.8 75.28 0 [O-][n+]1onc(c2ccccc2)c1C#N 14536777 IC50 = 59 nM 7.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3352874 1822300 CHEMBL3558765 1940611 24 681.9 5.23 137.14 2 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C(C)C)C(=CC1=O)OCc2ccccc2.[O-]C(=O)C(F)(F)F 15121666 IC50 = 62 nM 7.21 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3286861 1757382 CHEMBL3286861 1757382 4e 532.03 4.23 118.83 1 CC(C)CN(NC(=O)C1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)c6nc(ncc6Cl)C#N 14724798 IC50 = 80.9 nM 7.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3335097 1791228 CHEMBL3335097 1791228 8 347.41 3.15 80.2 0 COc1ccc(\C=N\N=C(/N)\CC(O)c2cccc3ccccc23)cc1 15128129 IC50 = 83 nM 7.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3235661 1734186 CHEMBL3235661 1734186 5{2,2,2,1} 572.48 7.3 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575302 IC50 = 88.73 nM 7.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL1830118 1176821 CHEMBL1830118 1176821 4 309.2 1.08 107.88 0 CN(O)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(O)O 15192766 IC50 = 120 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3114828 1617801 CHEMBL3139464 1628795 3b 307.33 -1.54 119.64 0 Cl.Cn1cc(CCN)c2C(=O)C3=C(NC=CS3(=O)=O)C(=O)c12 13924103 IC50 = 128 nM 6.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3309580 1778671 CHEMBL3309580 1778671 6d 334.84 2.23 57.26 0 C[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)NCCCN(C)C 15031398 IC50 = 142.22 nM 6.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3309583 1778674 CHEMBL3309583 1778674 7a 318.8 1.71 48.47 0 CN1CCN(CC1)C(=O)CNc2ccnc3cc(Cl)ccc23 15031401 IC50 = 149.37 nM 6.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL170 255947 CHEMBL170 255947 QUININE QN 324.42 2.73 45.59 0 COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 14542720 IC50 = 178 nM 6.75 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL1951744 1280734 CHEMBL1962949 1284660 5 464.58 5.13 76.73 1 [Br-].CN(C)c1cc[n+](Cc2ccc(CCc3ccc(Cn4cnc5c(N)ncnc45)cc3)cc2)cc1 15026510 IC50 = 191 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3309526 1778617 CHEMBL3309526 1778617 8d 386.88 2.07 77.49 0 CN1C=C(O)C(=O)C=C1CNCCCCNc2ccnc3cc(Cl)ccc23 15011096 IC50 = 200 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3311434 1780544 CHEMBL3311434 1780544 8a 358.82 1.42 77.49 0 CN1C=C(O)C(=O)C=C1CNCCNc2ccnc3cc(Cl)ccc23 15011093 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3359700 1823871 CHEMBL3359700 1823871 13m 351.36 1.1 122.27 0 Nc1ccc(cc1)C(=O)NC(C(=O)NO)c2ccc(cc2)n3cccn3 15106770 IC50 = 228 nM 6.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3335098 1791229 CHEMBL3335098 1791229 9 377.44 3.26 100.43 0 CCOc1cc(\C=N\N=C(/N)\CC(O)c2cccc3ccccc23)ccc1O 15128128 IC50 = 250 nM 6.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL2311803 1510843 CHEMBL2311803 1510843 1f 334.29 2.17 87.66 0 ONC(=O)CCCCCONC(=O)c1ccc(cc1)C(F)(F)F 14720530 IC50 = 260 nM 6.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3415879 1839073 CHEMBL3415879 1839073 1o 347.16 5.01 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4ccc(F)c(F)c14 15217336 IC50 = 290.2 nM 6.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3338914 1793419 CHEMBL3338914 1793419 5d 610.8 6.63 73.2 2 CC(C)(C)c1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119924 IC50 = 300 nM 6.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3109524 1614725 CHEMBL3109524 1614725 (+/-)-10o 440.54 4.58 78.31 0 COc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(c4)c5ccncc5 13891333 IC50 = 318 nM 6.5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3358134 1822289 CHEMBL3558733 1940579 11 628.85 3.5 148.74 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)NCc1ccccc1.[O-]C(=O)C(F)(F)F 15121655 IC50 = 320 nM 6.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3289169 1759714 CHEMBL3289169 1759714 1s 366.45 3.46 96.89 0 CCCCCCOc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720532 IC50 = 350 nM 6.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3235631 1734156 CHEMBL3235631 1734156 5{2,1,2,2} 586.51 7.36 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1 14578311 IC50 = 369.18 nM 6.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3401315 1831515 CHEMBL3401315 1831515 11b 496.47 6.48 36.33 1 Clc1ccc2c(c1)c3nc4cc(Cl)cc(NCCN5CCCC5)c4cc3n2CCN6CCCC6 15164943 IC50 = 375 nM 6.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3326561 1787379 CHEMBL3558256 1940102 15 493.65 6.03 76.02 1 [Br-].C(Sc1ncnc2c1ncn2Cc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)c6ccccc6 15026500 IC50 = 411 nM 6.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3109543 1614744 CHEMBL3109543 1614744 8q 407.51 4.65 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C3CCCCCC3)C2=O)c4ccc(OC)cc4 13891355 IC50 = 427 nM 6.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3401312 1831512 CHEMBL3401312 1831512 10e 492.06 5.11 45.56 1 Clc1cc(NCCCN2CCOCC2)c3cc4c(nc3c1)c5ccccc5n4CCN6CCCC6 15164940 IC50 = 469 nM 6.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3344524 1796688 CHEMBL3344524 1796688 10 406.91 5.24 60.75 1 O\N=C\1/c2ccccc2c3c1c(NCCN4CCCCC4)nc5cc(Cl)ccc35 15083316 IC50 = 530 nM 6.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3335108 1791239 CHEMBL3335108 1791239 19 331.41 3.66 70.97 0 Cc1ccc(\C=N\N=C(/N)\CC(O)c2ccc3ccccc3c2)cc1 15128118 IC50 = 540 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3311424 1780534 CHEMBL3311424 1780534 7a 448.94 3.23 66.49 0 CN1C=C(OCc2ccccc2)C(=O)C=C1CNCCNc3ccnc4cc(Cl)ccc34 15011083 IC50 = 540 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3109527 1614728 CHEMBL3109527 1614728 (+/-)-10r 439.55 5.79 65.42 1 N=C1NC(C(=O)N1C2CCCCC2)(c3ccccc3)c4cccc(OCc5ccccc5)c4 13891330 IC50 = 641 nM 6.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3401317 1831517 CHEMBL3401317 1831517 11d 524.53 7 36.33 2 Clc1ccc2c(c1)c3nc4cc(Cl)cc(NCCCN5CCCCC5)c4cc3n2CCN6CCCC6 15164945 IC50 = 660 nM 6.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3109522 1614723 CHEMBL3109522 1614723 (+/-)-10m 410.51 4.59 69.08 0 N=C1NC(C(=O)N1C2CCCCC2)(c3ccccc3)c4cccc(c4)c5cccnc5 13891335 IC50 = 750 nM 6.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3087895 1605377 CHEMBL3087895 1605377 3g 325.29 2.48 75.63 0 OC1=C(C(=O)Nc2ccc(F)cc2)C(=O)OC(=C1)c3ccccc3 13836543 IC50 = 900 nM 6.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3344519 1796683 CHEMBL3344519 1796683 4 406.91 4.22 48.47 0 CN1CCN(CCNc2nc3ccc(Cl)cc3c4c5ccccc5C(=O)c24)CC1 15083314 IC50 = 1031 nM 5.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3260213 1745159 CHEMBL3260213 1745159 1h 292.37 4.89 26.53 0 CCC\C=C\C=C\c1nc2cccc(OC)c2n3cccc13 14668026 IC50 = 1600 nM 5.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3415874 1839068 CHEMBL3415874 1839068 1j 266.72 4.52 17.82 0 Cn1cc2c3ccccc3nc2c4cccc(Cl)c14 15217331 IC50 > 2000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3329581 1788568 CHEMBL3329581 1788568 7g 660.67 2.94 172.63 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=O)Nc3ccc4ccccc4c3)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127425 IC50 = 2180 nM 5.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183797 IC50 = 2440 nM 5.61 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465119 CHEMBL3405451 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 42 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis in presence of 6.25 ng/ml 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3353310 1817417 CHEMBL3353310 1817417 6s 303.31 3.41 60.77 0 ON1C(=O)C(=Cc2cc(O)ccc12)c3cccc4ccccc34 14971662 IC50 = 2500 nM 5.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3338918 1793423 CHEMBL3338918 1793423 6b 568.72 5.72 73.2 2 Cc1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119920 IC50 = 2570 nM 5.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3353299 1817406 CHEMBL3353299 1817406 6h 287.31 3.65 40.54 0 ON1C(=O)C(=Cc2ccccc12)c3cccc4ccccc34 14971651 IC50 = 2600 nM 5.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3260209 1745155 CHEMBL3260209 1745155 1d 264.32 3.97 26.53 0 COc1cccc2nc(\C=C\C=C\C)c3cccn3c12 14668022 IC50 = 3200 nM 5.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3260212 1745158 CHEMBL3260212 1745158 1g 292.37 4.89 26.53 0 CCC\C=C\C=C\c1nc2ccc(OC)cc2n3cccc13 14668025 IC50 = 3300 nM 5.48 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3338916 1793421 CHEMBL3338916 1793421 5f 604.75 6.14 73.2 2 [O-][S+]1C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6c1ccc7ccccc67 15119922 IC50 = 3550 nM 5.45 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3353314 1817421 CHEMBL3353314 1817421 6w 295.29 3 59 0 Cc1ccccc1C2=Cc3c4OCOc4ccc3N(O)C2=O 14971666 IC50 = 3600 nM 5.44 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3238459 1737013 CHEMBL3238459 1737013 5h 539.45 6.51 72.39 2 CCOC(=O)C1=CN(CC(F)(F)F)c2ccc3nc(c4ccc(F)cc4)c(nc3c2C1=O)c5ccc(F)cc5 14599597 IC50 = 3920 nM 5.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3358130 1822285 CHEMBL3558725 1940571 3 579.77 2.69 137.14 1 COC1=CC(=O)N([C@H]1C)C(=O)CC[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121651 IC50 = 4375 nM 5.36 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL1951742 1280732 CHEMBL1962409 1284120 3 436.53 4.22 76.73 0 [Br-].CN(C)c1cc[n+](Cc2ccc(cc2)c3ccc(Cn4cnc5c(N)ncnc45)cc3)cc1 15026512 IC50 = 4840 nM 5.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3353306 1817413 CHEMBL3353306 1817413 6o 347.36 3.62 59 0 COc1cc2C=C(C(=O)N(O)c2cc1OC)c3cccc4ccccc34 14971658 IC50 = 5000 nM 5.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3353301 1817408 CHEMBL3353301 1817408 6j 305.25 3.69 40.54 0 ON1C(=O)C(=Cc2ccccc12)c3ccccc3C(F)(F)F 14971653 IC50 = 5900 nM 5.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3114092 1617057 CHEMBL3139636 1628967 18, VAM2-18 408.49 3.79 72.61 0 Br.CN1C(=O)CN(CCCCCN2CCc3ccccc3C2)c4ccc(cc14)[N+](=O)[O-] 13910780 IC50 = 6470 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3329596 1788583 CHEMBL3329596 1788583 8k 428.5 2.86 143.14 0 O[C@@H]1CO[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@H](O)[C@H]1O 15127440 IC50 = 6890 nM 5.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3329591 1788578 CHEMBL3329591 1788578 8f 458.53 2.35 163.37 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=S)Nc3ccccc3)cc2)[C@H](O)[C@@H](O)[C@@H]1O 15127435 IC50 = 11850 nM 4.93 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3233984 1732492 CHEMBL3233984 1732492 13 288.38 3.59 54.12 0 CCCCCC(=O)NCCc1c[nH]c2ccc(OC)cc12 14579774 IC50 = 19100 nM 4.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338673 CHEMBL3242011 F Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82320 CHEMBL3232831 24699367 Eur. J. Med. Chem. 2014 78 375
CHEMBL3238458 1737012 CHEMBL3238458 1737012 5g 485.48 5.85 72.39 1 CCOC(=O)C1=CN(CC)c2ccc3nc(c4ccc(F)cc4)c(nc3c2C1=O)c5ccc(F)cc5 14599596 IC50 = 32200 nM 4.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL1729464 1110195 CHEMBL1729464 1110195 18 364.39 1.86 66.92 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCOCC4 15183824 IC50 = 49430 nM 4.31 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3358131 1822286 CHEMBL3558730 1940576 4 581.79 2.46 137.14 1 CO[C@H]1CC(=O)N([C@H]1C)C(=O)CC[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121652 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3233228 1731729 CHEMBL3233228 1731729 6g 457.43 5.27 83.39 1 CCN1C=C(C(=O)O)C(=O)c2c1ccc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5 14599608 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3342268 1794410 CHEMBL3342268 1794410 7 330.21 1.24 134.68 0 OP(=O)(O)CCC(c1cccc2ccccc12)P(=O)(O)O 15101119 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3342263 1794405 CHEMBL3342263 1794405 3b 291.19 -.08 135.13 0 COc1ccc(cc1)C(OCC(=O)NO)P(=O)(O)O 15101114 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3233229 1731730 CHEMBL3233229 1731730 6h 511.4 5.93 83.39 2 OC(=O)C1=CN(CC(F)(F)F)c2ccc3nc(c4ccc(F)cc4)c(nc3c2C1=O)c5ccc(F)cc5 14599609 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3261888 1746851 CHEMBL3261888 1746851 11 273.41 4.71 21.26 0 CC(=CCC\C(=C\CNCCOc1ccccc1)\C)C 14651661 IC50 = 51000 nM 4.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3236230 1734761 CHEMBL3236230 1734761 3 362.31 1.11 73.8 0 FC(F)(F)c1ccc(CNC(=O)NC2=CN=C3C=CC=CN3C2=O)cc1 14580082 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338905 1793410 CHEMBL3338905 1793410 3c 568.72 6.33 71.45 2 COc1ccc2SC[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119933 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236265 1734796 CHEMBL3236265 1734796 45 362.42 .62 65.01 0 O=C(NC1CCN(Cc2ccccc2)CC1)C3=CN=C4C=CC=CN4C3=O 14580118 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3233045 1734800 CHEMBL3233045 1734800 55 453.41 2.92 71 0 COc1ccc(cc1)C2=CN3C(=NC=C(C(=O)NCc4ccc(cc4)C(F)(F)F)C3=O)C=C2 14580122 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236256 1734787 CHEMBL3236256 1734787 35 347.29 1.46 61.77 0 FC(F)(F)c1ccccc1CNC(=O)C2=CN=C3C=CC=CN3C2=O 14580109 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236248 1734779 CHEMBL3236248 1734779 25 347.73 1.39 71 0 Fc1cccc(COC(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl)c1 14580101 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236268 1734799 CHEMBL3236268 1734799 53 403.41 2.18 71 0 COc1ccc(cc1)C2=CN3C(=NC=C(C(=O)NCc4cccc(F)c4)C3=O)C=C2 14580121 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236237 1734768 CHEMBL3236237 1734768 13 396.75 1.48 73.8 0 FC(F)(F)c1ccc(CNC(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl)cc1 14580090 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236261 1734792 CHEMBL3236261 1734792 40 352.39 1.66 83.89 0 CCCCCOc1cccnc1NC(=O)C2=CN=C3C=CC=CN3C2=O 14580114 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3402989 1833206 CHEMBL3402989 1833206 21 572.65 3.33 115.38 1 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H](CC(C)C)N4C(=O)c5ccccc5C4=O 15183827 IC50 = 203000 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3121247 1620566 CHEMBL3121247 1620566 6 578.52 -.53 214.05 3 COc1cc(O[C@@H]2O[C@H](CO[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)[C@H](O)[C@H]2O)c4C(=O)C=C(Oc4c1)c5ccc(O)cc5 13928646 IC50 > 250000 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3353293 1817399 CHEMBL3353293 1817399 6a 253.25 2.21 60.77 0 ON1C(=O)C(=C(O)c2ccccc12)c3ccccc3 14971644 IC50 Not Active 0 BAO_0000190 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3219913 1726308 CHEMBL3219913 1726308 33 568.07 7.11 103.36 2 COc1cccc(Nc2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCN(C)CC6)c1 14545677 IC50 = .00426 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219914 1726309 CHEMBL3219914 1726309 34 582.1 7.46 103.36 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6cccc(OC)c6)n2 14545678 IC50 = .0089 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219904 1726298 CHEMBL3219904 1726298 23 586.06 6.85 112.15 2 Fc1ccc(Nc2nc(NCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)cc1 14545667 IC50 = .00981 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219928 1726323 CHEMBL3219928 1726323 48 622.16 6.98 103.36 2 Clc1ccc2c(Nc3ccc(Nc4nc(NCCCN5CCOCC5)nc(n4)N6CCc7ccccc7C6)cc3)ccnc2c1 14545692 IC50 = .0203 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219908 1726303 CHEMBL3219908 1726303 28 602.52 7.31 112.15 2 Clc1cccc(Nc2nc(NCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)c1 14545672 IC50 = .0306 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3218234 1724612 CHEMBL3218234 1724612 10 413.5 3.08 48.95 0 FC1(F)CCC(CC1)NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530892 IC50 = .4 nM 9.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3423375 1842828 CHEMBL3423375 1842828 1g 269.73 4.25 36.95 0 Clc1ccc2c(NNc3ccccc3)ccnc2c1 15239350 IC50 = .46 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE 2 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 13952428 IC50 = .82 nM 9.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296215 CHEMBL3132228 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77210 CHEMBL3124935 24561670 Eur. J. Med. Chem. 2014 75 403
CHEMBL3099819 1610602 CHEMBL3099819 1610602 3c 449.98 4.32 80.55 0 Cc1ccc(cc1)C(NCCNc2ccnc3cc(Cl)ccc23)c4nnnn4C(C)(C)C 13862669 IC50 = 1 nM 9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL252518 420212 CHEMBL252518 420212 ARTENIMOL DHA 284.35 1.62 57.15 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@@H](O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 15155304 IC50 = 1.45 nM 8.84 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE ASN 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 13854141 IC50 = 1.6 nM 8.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL567979 577678 CHEMBL567979 577678 2 296.32 2.34 58.29 0 COc1ccc2c(c1)C(=O)C(=[N+]2[O-])c3ccc(cc3)N(C)C 15048717 IC50 = 1.7 nM 8.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1447345 CHEMBL3379769 F Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90150 CHEMBL3352368 24594524 Eur. J. Med. Chem. 2014 76 369
CHEMBL1450 378315 CHEMBL1450 378315 ATOVAQUONE ATV 366.84 5.32 54.37 1 OC1=C([C@@H]2CC[C@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 14542727 IC50 = 1.9 nM 8.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL587764 530157 CHEMBL587764 530157 1SR 692.91 4.95 136.66 1 CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC(C)(C)c3cccc(OC)c3)N4CCCCS4(=O)=O 14656156 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL2263541 1481392 CHEMBL2263541 1481392 6 363.41 4.53 49.69 0 COc1cc(\C=C\C(=O)c2ccc(cc2)n3cccc3)cc(OC)c1OC 12460156 IC50 = 2.03 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL36 2080 CHEMBL36 2080 PYRIMETHAMINE PY 248.71 2.75 77.81 0 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 14542729 IC50 = 2.1 nM 8.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3125599 1622206 CHEMBL3125599 1622206 11 692.75 6.3 130.35 3 COc1cc(CCCOC(=O)CCC(=O)O[C@@H]2O[C@@H]3O[C@@]4(C)CC[C@H]5[C@H](C)CC[C@@H]([C@H]2C)[C@@]35OO4)cc6cc(oc16)c7ccc8OCOc8c7 13952426 IC50 = 2.3 nM 8.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296215 CHEMBL3132228 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77210 CHEMBL3124935 24561670 Eur. J. Med. Chem. 2014 75 403
CHEMBL3093731 1608115 CHEMBL3093731 1608115 10 841.08 4.19 138.52 2 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)NCCCN6CCN(CCCNC(=O)CC7CCC8(CC7)OOC9(OO8)C%10CC%11CC(CC9C%11)C%10)CC6 13855011 IC50 = 3.5 nM 8.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL1213257 685098 CHEMBL1213257 685098 AMOPYROQUINE AMOPYR 353.85 4.52 48.39 0 Oc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1CN4CCCC4 12450940 IC50 = 5.3 nM 8.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL2263538 1481389 CHEMBL2263538 1481389 2 307.39 4.31 29.54 0 COc1ccc(\C=C\C(=O)c2ccc(cc2)N3CCCC3)cc1 12460160 IC50 = 6.3 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL2234265 1469762 CHEMBL2234265 1469762 10 322.31 3.17 72.83 0 COc1ccc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)cc1 12393189 IC50 = 7.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL237586 399320 CHEMBL237586 399320 5 382.45 3.24 60.03 0 COc1cc(\C=C\C(=O)c2ccc(cc2)N3CCNCC3)cc(OC)c1OC 12460157 IC50 = 9 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ 3 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 14536775 IC50 = 11 nM 7.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3309599 1778690 CHEMBL3309599 1778690 30 436.98 4.22 48.47 0 CN1CCN(CC1)C(=O)CC[C@H](Cc2ccccc2)Nc3ccnc4cc(Cl)ccc34 15031375 IC50 = 11.51 nM 7.94 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3289671 1760221 CHEMBL3289671 1760221 11, DSM331 393.26 4.45 55.11 0 Cc1cc(Nc2cc(F)c(c(F)c2)C(F)(F)F)n3nc(nc3n1)C(C)(F)F 14734089 IC50 = 12 nM 7.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL2263534 1481385 CHEMBL2263534 1481385 8 367.44 4.28 48 0 COc1cc(\C=C\C(=O)c2ccc(cc2)N3CCCC3)cc(OC)c1OC 12460154 IC50 = 13 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL3410328 1837105 CHEMBL3410328 1837105 5a 571.46 4.22 166.17 2 CCCCOC(=O)OCOP(=O)(OCOC(=O)OCCCC)C(OCC(=O)N(C)O)c1ccc(F)c(F)c1 15192770 IC50 = 14 nM 7.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13924046 IC50 = 15 nM 7.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3335117 1791248 CHEMBL3335117 1791248 28 367.44 4.08 70.97 0 N\C(=N/N=C/c1ccccc1)\CC(O)c2cc3ccccc3c4ccccc24 15128109 IC50 = 16 nM 7.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15011104 IC50 = 16 nM 7.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL2234259 1469756 CHEMBL2234259 1469756 8 335.35 3.35 66.84 0 CN(C)c1ccc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)cc1 12393203 IC50 = 17.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL1729464 1110195 CHEMBL1729464 1110195 18 364.39 1.86 66.92 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCOCC4 15183773 IC50 = 18 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3286858 1757379 CHEMBL3286858 1757379 4b 590.51 4.56 118.83 1 CC(C)CN(NC(=O)CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)c6nc(ncc6Br)C#N 14724795 IC50 = 18.9 nM 7.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3222266 1728684 CHEMBL3222266 1728684 13 495.92 2.32 141.66 0 CC(C)(C)N(Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4\C=N\O)N=O 14536779 IC50 = 24 nM 7.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3343960 1796119 CHEMBL3343960 1796119 S-13g 319.87 4.04 36.95 0 C[C@@H](CCCNC(C)(C)C)Nc1ccnc2cc(Cl)ccc12 15139444 IC50 = 32.95 nM 7.48 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3309592 1778683 CHEMBL3309592 1778683 14g 332.83 1.96 48.47 0 CN1CCN(CC1)C(=O)CCNc2ccnc3cc(Cl)ccc23 15031380 IC50 = 35.89 nM 7.45 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ Artemisinin 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 13928641 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3397100 1828817 CHEMBL3397100 1828817 3 327.29 3.21 109.42 0 COc1ccc(cc1[N+](=O)[O-])C(=O)\C=C\c2ccc(cc2)C(=O)O 15155315 IC50 = 40.66 nM 7.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3235627 1734152 CHEMBL3235627 1734152 5{2,1,1,1} 538.04 6.64 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)cc1 14575167 IC50 = 42 nM 7.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL510457 495348 CHEMBL510457 495348 DEHYDROXY TEBAQUINE DOHTBQ 450.4 7.18 28.16 1 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4ccc(Cl)cc4 12450932 IC50 = 42 nM 7.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3235655 1734180 CHEMBL3235655 1734180 5{1,2,3,1} 611.35 8.64 70.57 2 Clc1ccc(cc1)\N=C(/NCCNc2ccnc3cc(Cl)ccc23)\Nc4ccc(Oc5cc(Cl)ccc5Cl)cc4 14575172 IC50 = 43.97 nM 7.36 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL2237985 1473520 CHEMBL2237985 1473520 15 282.25 2.58 76.74 0 OC1=C(C(=O)\C=C\c2occc2)C(=O)Oc3ccccc13 12393154 IC50 > 50 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL2237989 1473524 CHEMBL2237989 1473524 5 361.18 4.51 63.6 0 OC1=C(C(=O)\C=C\c2ccc(Cl)cc2Cl)C(=O)Oc3ccccc13 12393224 IC50 > 50 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3233039 1734200 CHEMBL3233039 1734200 12{2,3,3} 668.61 8.73 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575272 IC50 = 56.37 nM 7.25 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3093728 1608112 CHEMBL3093728 1608112 7 748.9 5.48 132.04 2 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)Nc6cccc(NC(=O)CC7CCC8(CC7)OOC9(OO8)C%10CC%11CC(CC9C%11)C%10)c6 13855014 IC50 = 57.2 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3235652 1734177 CHEMBL3235652 1734177 5{1,2,2,1} 611.35 8.64 70.57 2 Clc1cccc(c1)\N=C(/NCCNc2ccnc3cc(Cl)ccc23)\Nc4ccc(Oc5cc(Cl)ccc5Cl)cc4 14575275 IC50 = 62.75 nM 7.2 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3309593 1778684 CHEMBL3309593 1778684 14h 346.85 2.28 48.47 0 CN1CCN(CC1)C(=O)CCCNc2ccnc3cc(Cl)ccc23 15031388 IC50 = 65.06 nM 7.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3103567 1611640 CHEMBL3103567 1611640 12 473.95 4.82 84.23 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)NCCCNc3ccnc4cc(Cl)ccc34 13886185 IC50 = 70 nM 7.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3402975 1833191 CHEMBL3402975 1833191 5 314.38 2.31 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183763 IC50 = 74.2 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235647 1734172 CHEMBL3235647 1734172 12{1,3,2} 654.58 8.15 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575285 IC50 = 74.48 nM 7.13 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235660 1734185 CHEMBL3235660 1734185 5{2,2,1,3} 566.09 7.28 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575298 IC50 = 86.01 nM 7.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235277 1733798 CHEMBL3235277 1733798 5{1,1,3,2} 625.38 8.71 70.57 2 Clc1ccc(cc1)\N=C(/NCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccccc4Oc5cc(Cl)ccc5Cl 14575299 IC50 = 87.2 nM 7.06 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235648 1734173 CHEMBL3235648 1734173 12{1,3,3} 668.61 8.73 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575309 IC50 = 96.79 nM 7.01 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3093745 1608129 CHEMBL3093745 1608129 27 336.38 1.26 92.04 0 CC1(CCC(=O)Nc2cccc(N)c2)OOC3(CCCCC3)OO1 13854142 IC50 = 101.9 nM 6.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3103566 1611639 CHEMBL3103566 1611639 11 459.92 4.76 84.23 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)NCCNc3ccnc4cc(Cl)ccc34 13886180 IC50 = 110 nM 6.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3235635 1734160 CHEMBL3235635 1734160 5{2,1,3,3} 600.54 7.94 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1 14575323 IC50 = 123.88 nM 6.91 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL98 11305 CHEMBL98 11305 VORINOSTAT SAHA, Vorinostat 264.32 2.01 78.43 0 ONC(=O)CCCCCCC(=O)Nc1ccccc1 14718487 IC50 = 130 nM 6.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3114829 1617802 CHEMBL3139405 1628736 3c 321.35 -1.11 105.65 0 Cl.CNCCc1cn(C)c2C(=O)C3=C(C(=O)c12)S(=O)(=O)C=CN3 13924102 IC50 = 137 nM 6.86 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ ART 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 15183832 IC50 = 159 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3309529 1778620 CHEMBL3309529 1778620 8g 398.89 1.98 77.48 0 OC1=CN(C2CC2)C(=CC1=O)CNCCCNc3ccnc4cc(Cl)ccc34 15011099 IC50 = 160 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3335101 1791232 CHEMBL3335101 1791232 12 353.37 3.58 70.97 0 N\C(=N/N=C/c1ccc(F)cc1F)\CC(O)c2cccc3ccccc23 15128125 IC50 = 190 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3335106 1791237 CHEMBL3335106 1791237 17 359.46 4.27 70.97 0 CCC\C(=N/N=C(\N)/CC(O)c1cccc2ccccc12)\c3ccccc3 15128120 IC50 = 240 nM 6.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3235634 1734159 CHEMBL3235634 1734159 5{2,1,3,2} 586.51 7.36 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1 14578303 IC50 = 240.82 nM 6.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3342260 1794402 CHEMBL3342260 1794402 2e 333.27 .64 126.34 0 COc1ccc(cc1OC)C(CCC(=O)N(C)O)P(=O)(O)O 15101111 IC50 = 290 nM 6.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3219284 1725672 CHEMBL3219284 1725672 4 449.52 4.13 53.09 0 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCN(Cc5ccccc5)CC4)c(F)cc3C1=O 14542723 IC50 = 320 nM 6.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3401316 1831516 CHEMBL3401316 1831516 11c 512.52 6.78 36.33 2 CCN(CC)CCCNc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN5CCCC5)c3cc12 15164944 IC50 = 392 nM 6.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3335105 1791236 CHEMBL3335105 1791236 16 307.35 2.57 84.11 0 N\C(=N/N=C/c1occc1)\CC(O)c2cccc3ccccc23 15128121 IC50 = 510 nM 6.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3109552 1614753 CHEMBL3109552 1614753 (+/-)-10b 363.45 4.21 65.42 0 COc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccccc4 13891346 IC50 = 533 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3358132 1822287 CHEMBL3558728 1940574 9 642.87 3.96 148.74 1 CC[C@H](C)[C@H]([NH+](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)NCc1ccccc1.[O-]C(=O)C(F)(F)F 15121653 IC50 = 540 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3311425 1780535 CHEMBL3311425 1780535 7b 462.97 3.29 66.49 0 CN1C=C(OCc2ccccc2)C(=O)C=C1CNCCCNc3ccnc4cc(Cl)ccc34 15011084 IC50 = 580 nM 6.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3219637 1726029 CHEMBL3219637 1726029 11a 407.34 5.06 73.86 1 CCOC(=O)C1=CNc2ccc(OCc3ccc(OC(F)(F)F)cc3)cc2C1=O 14545601 IC50 = 674.8 nM 6.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3109521 1614722 CHEMBL3109521 1614722 (+/-)-10l 440.54 4.58 78.31 0 COc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(c4)c5cccnc5 13891336 IC50 = 787 nM 6.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3235644 1734169 CHEMBL3235644 1734169 12{1,2,4} 526.03 7.36 71.95 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCc4ccccc4)cc1)\C 14578546 IC50 > 800 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235656 1734181 CHEMBL3235656 1734181 5{1,2,3,2} 625.38 8.71 70.57 2 Clc1ccc(cc1)\N=C(/NCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccc(Oc5cc(Cl)ccc5Cl)cc4 14578547 IC50 > 800 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL203125 343725 CHEMBL203125 343725 FOSMIDOMYCIN 1 183.1 -1.4 107.88 0 ON(CCCP(=O)(O)O)C=O 15192761 IC50 = 880 nM 6.06 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL575569 571475 CHEMBL575569 571475 CIPROFLOXACIN ETHYL ESTER 2 359.39 2.01 61.88 0 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O 14542722 IC50 = 890 nM 6.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330107 CHEMBL3223444 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3109553 1614754 CHEMBL3109553 1614754 (+/-)-10c 363.45 4.21 65.42 0 COc1cccc(c1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccccc4 13891345 IC50 = 917 nM 6.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3335111 1791242 CHEMBL3335111 1791242 22 377.44 3.26 100.43 0 CCOc1cc(\C=N\N=C(/N)\CC(O)c2ccc3ccccc3c2)ccc1O 15128115 IC50 = 1100 nM 5.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3358135 1822290 CHEMBL3558739 1940585 12 621.83 2.49 189.87 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)Nc1nccs1.[O-]C(=O)C(F)(F)F 15121656 IC50 = 1100 nM 5.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3329569 1788556 CHEMBL3329569 1788556 5a 645.67 2.31 186.05 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NS(=O)(=O)c3ccc(C)cc3)c2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127413 IC50 = 1140 nM 5.94 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3219645 1726037 CHEMBL3219645 1726037 15a 363.41 4.45 64.63 0 O=C(OC1CCCCC1)C2=CNc3ccc(Oc4ccccc4)cc3C2=O 14545609 IC50 = 1820.4 nM 5.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3335114 1791245 CHEMBL3335114 1791245 25 386.27 4.5 70.97 0 N\C(=N/N=C/c1ccc(Cl)c(Cl)c1)\CC(O)c2ccc3ccccc3c2 15128112 IC50 = 1900 nM 5.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3342258 1794399 CHEMBL3342258 1794399 2b 273.22 .95 116.67 0 Cc1ccc(cc1)C(CCC(=O)NO)P(=O)(O)O 15101108 IC50 = 2600 nM 5.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL588662 542963 CHEMBL588662 542963 4, TCMDC-136879 383.49 5.05 58.69 1 CCC(CN1C(=NC(C1=O)(c2ccccc2)c3ccccc3)N)c4ccccc4 13891664 IC50 = 2760 nM 5.56 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3233985 1732493 CHEMBL3233985 1732493 14 294.35 3.22 54.12 0 COc1ccc2[nH]cc(CCNC(=O)c3ccccc3)c2c1 14579775 IC50 = 2930 nM 5.53 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338673 CHEMBL3242011 F Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82320 CHEMBL3232831 24699367 Eur. J. Med. Chem. 2014 78 375
CHEMBL3329573 1788560 CHEMBL3329573 1788560 6b 477.53 .79 161.77 0 Cc1ccc(cc1)S(=O)(=O)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)c2 15127417 IC50 = 3890 nM 5.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3329570 1788557 CHEMBL3329570 1788557 5b 645.67 2.31 186.05 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NS(=O)(=O)c3ccc(C)cc3)c2)[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127414 IC50 = 3960 nM 5.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3335113 1791244 CHEMBL3335113 1791244 24 353.37 3.58 70.97 0 N\C(=N/N=C/c1ccc(F)cc1F)\CC(O)c2ccc3ccccc3c2 15128113 IC50 = 4000 nM 5.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3290639 1761198 CHEMBL3290639 1761198 5 811.97 2.77 223.92 2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c2cccc(CNC(=O)[C@H](Cc3ccccc3)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC1=O)c2)[C@@H](C)O)[C@@H](C)CC 14710397 IC50 = 4000 nM 5.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1362075 CHEMBL3294628 F Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83803 CHEMBL3286375 24813731 Bioorg. Med. Chem. Lett. 2014 24 12 2645
CHEMBL3353316 1817423 CHEMBL3353316 1817423 6y 269.27 3.44 40.54 0 Cc1ccccc1C2=Cc3c(F)cccc3N(O)C2=O 14971668 IC50 = 5000 nM 5.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3353313 1817420 CHEMBL3353313 1817420 6v 311.33 3.2 59 0 COc1cc2C=C(C(=O)N(O)c2cc1OC)c3ccccc3C 14971665 IC50 = 5500 nM 5.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3342261 1794403 CHEMBL3342261 1794403 2f 319.25 .43 135.13 0 COc1ccc(cc1OC)C(CCC(=O)NO)P(=O)(O)O 15101112 IC50 = 6800 nM 5.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3335273 1791406 CHEMBL3335273 1791406 1, MDN-0104 527.73 3.27 112.96 1 CCCCCCCCCCC\C=C(/C)\C(=O)C(C)(C)C(=O)OC[C@@H](O)COCC[C@@H](C(=O)[O-])[N+](C)(C)C 15123943 IC50 = 7000 nM 5.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1442150 CHEMBL3374670 F Antiplasmodial activity against Plasmodium falciparum 3D7 late ring stages and early trophozoites forms infected in human erythrocytes assessed as parasite growth inhibition by LDH release assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89329 CHEMBL3352318 25215605 J. Nat. Prod. 2014 77 9 2118
CHEMBL3325778 1786588 CHEMBL3325778 1786588 2 498.65 3.67 78.9 0 CC[C@]12CC[C@](C)(O1)[C@H]3CC[C@@]4(C)C5=C(C(=O)C[C@]34CO2)[C@@](C)(CCC(=O)OC)[C@@H](CC5=O)C(=C)C 15018482 IC50 = 7900 nM 5.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1453443 CHEMBL3361764 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90123 CHEMBL3352211 J. Nat. Prod. 2014 77 8 1847
CHEMBL3114091 1617056 CHEMBL3139385 1628716 17, VAM2-17 374.48 3.51 72.61 0 Br.CN1C(=O)CN(CCCCCN2CCCCCC2)c3ccc(cc13)[N+](=O)[O-] 13910781 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3114089 1617054 CHEMBL3139634 1628965 14, VAM2-14 320.39 2.14 72.61 0 Br.CN(C)CCCCCN1CC(=O)N(C)c2cc(ccc12)[N+](=O)[O-] 13910784 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3114086 1617051 CHEMBL3139396 1628727 10, VAM2-10 332.4 2.39 81.4 0 Br.[O-][N+](=O)c1ccc2N(CCCCCN3CCCC3)CC(=O)Nc2c1 13910788 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3261886 1746849 CHEMBL3261886 1746849 9 345.52 4.66 38.33 0 CC(=CCC\C(=C\COCC(=O)NC1C2CC3CC(CC1C3)C2)\C)C 14651659 IC50 = 11000 nM 4.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL217786 361658 CHEMBL217786 361658 CQPYRID 235.37 2.34 28.16 0 CCN(CC)CCCC(C)Nc1ccncc1 12450925 IC50 = 12000 nM 4.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3238453 1737007 CHEMBL3238453 1737007 5b 503.47 6.1 72.39 2 CCOC(=O)C1=CN(CC(F)(F)F)c2ccc3nc(c4ccccc4)c(nc3c2C1=O)c5ccccc5 14599591 IC50 = 13100 nM 4.88 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3409914 1836686 CHEMBL3409914 1836686 81 592.77 4.74 131.67 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCC1)C(=O)N[C@@H](Cc2ccccc2)C(=O)NNc3ccccc3 15199159 IC50 = 14200 nM 4.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3261882 1746845 CHEMBL3261882 1746845 5 332.52 5.47 18.46 1 CC(=CCC\C(=C\COCCOC1C2CC3CC(CC1C3)C2)\C)C 14651655 IC50 = 24000 nM 4.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3103564 1611637 CHEMBL3103564 1611637 22 325.36 2.34 59.75 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)N3CCOCC3 13886134 IC50 > 30000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3236258 1734789 CHEMBL3236258 1734789 37 347.29 1.46 61.77 0 FC(F)(F)c1ccc(CNC(=O)C2=CN=C3C=CC=CN3C2=O)cc1 14580111 IC50 = 37000 nM 4.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL402471 444728 CHEMBL402471 444728 ISOCRENATOSIDE 8 622.57 .42 234.28 3 C[C@@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](COC(=O)\C=C\c3ccc(O)c(O)c3)O[C@H]4OC[C@@H](O[C@H]24)c5ccc(O)c(O)c5)[C@H](O)[C@H](O)[C@H]1O 13928644 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3342267 1794409 CHEMBL3342267 1794409 6 335.29 1.99 116.67 0 Oc1ccccc1NC(=O)CCC(c2ccccc2)P(=O)(O)O 15101118 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3402988 1833205 CHEMBL3402988 1833205 20 330.38 1.6 66.92 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183826 IC50 = 60570 nM 4.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3236250 1734781 CHEMBL3236250 1734781 28 351.36 -.53 116.89 0 NC(=O)[C@H](Cc1ccccc1)NC(=O)NC2=CN=C3C=CC=CN3C2=O 14580103 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236266 1734797 CHEMBL3236266 1734797 46 337.35 1.41 52.98 0 Fc1ccccc1CN(C2CC2)C(=O)C3=CN=C4C=CC=CN4C3=O 14580119 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236253 1734784 CHEMBL3236253 1734784 31 299.33 .03 97.59 0 CC(C)C[C@H](NC(=O)NC1=CN=C2C=CC=CN2C1=O)C#N 14580106 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236251 1734782 CHEMBL3236251 1734782 29 317.34 -.85 116.89 0 CC(C)C[C@H](NC(=O)NC1=CN=C2C=CC=CN2C1=O)C(=O)N 14580104 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236262 1734793 CHEMBL3236262 1734793 41 372.38 1.46 83.89 0 O=C(Nc1ncccc1OCc2ccccc2)C3=CN=C4C=CC=CN4C3=O 14580115 IC50 = 100000 nM 4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3109538 1614739 CHEMBL3109538 1614739 8k 307.39 3.3 56.19 0 CC(C)(C)N1C(=N)NC(C1=O)(c2ccccc2)c3ccccc3 13891361 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3402982 1833198 CHEMBL3402982 1833198 12 328.41 2.83 57.69 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183818 IC50 = 106650 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402981 1833197 CHEMBL3402981 1833197 11 314.38 2.37 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183817 IC50 = 130500 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402987 1833204 CHEMBL3402987 1833204 19 316.35 1.14 66.92 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183825 IC50 = 205600 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL2048506 1351939 CHEMBL2048506 1351939 1 594.56 5.01 200.27 4 CCCCOC(=O)[C@@H]1[C@H](Oc2c(O)ccc(\C=C\C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(=O)O)c12)c4ccc(O)c(O)c4 13928651 IC50 Not Determined 0 BAO_0000190 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3121248 1620567 CHEMBL3121248 1620567 10 550.47 .29 210.89 3 COc1cc(cc(OC)c1O)C2=C(O[C@@H]3O[C@H](COC(=O)C)[C@@H](O)[C@H](O)[C@H]3O)C(=O)c4c(O)cc(O)cc4O2 13928642 IC50 Not Determined 0 BAO_0000190 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE Artesunate 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 14530908 IC50 Not Determined 0 BAO_0000190 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL537778 542003 CHEMBL537778 542003 6 470.16 6.97 49.84 1 Brc1ccc(Nc2nc3ccccc3nc2Nc4ccc(Br)cc4)cc1 15005168 IC50 Not Determined 0 BAO_0000190 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ, 1 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14547968 IC50 = .00245 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219918 1726313 CHEMBL3219918 1726313 38 598.1 7.1 112.59 3 COc1ccc(Nc2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCN(C)CC6)cc1OC 14545682 IC50 = .00504 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219903 1726297 CHEMBL3219903 1726297 22 570.06 7.68 94.13 2 CCN1CCN(CC1)c2nc(Nc3ccc(F)cc3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2 14545666 IC50 = .0111 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219924 1726319 CHEMBL3219924 1726319 44 622.16 7.44 103.36 2 Clc1ccc2c(Nc3ccc(Nc4nc(NCCCN5CCOCC5)nc(n4)N6CCCc7ccccc67)cc3)ccnc2c1 14545688 IC50 = .0147 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3217778 1726300 CHEMBL3217778 1726300 25 541.02 8.29 90.89 2 Fc1ccc(Nc2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCCCC6)cc1 14545669 IC50 = .0418 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3218241 1724619 CHEMBL3218241 1724619 17 377.52 3.83 48.95 0 C1CCC(CC1)NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530899 IC50 = .4 nM 9.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3289672 1760222 CHEMBL3289672 1760222 6, DSM338 397.23 5.01 55.11 1 Cc1cc(Nc2cc(F)c(c(F)c2)C(F)(F)F)n3nc(nc3n1)C(F)(F)F 14734082 IC50 = 1.8 nM 8.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL3264812 1749805 CHEMBL3264812 1749805 18 635.83 6.89 90.9 2 CCCN(CCC)C(=O)c1cc(cc(c1)c2ccccc2)C(=O)N[C@@H](Cc3ccccc3)[C@H](O)CNC(C)(C)c4cccc(OC)c4 14656161 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL1450 378315 CHEMBL1450 378315 ATOVAQUONE ATV 366.84 5.32 54.37 1 OC1=C([C@@H]2CC[C@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 14542719 IC50 = 2.3 nM 8.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3218248 1724626 CHEMBL3218242 1724620 24 378.51 1.65 66.18 0 Cc1ccc(cc1)S(=O)(=O)O.NC2CCN(CC2)C3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6 14530906 IC50 = 2.5 nM 8.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3112870 1615823 CHEMBL3140257 1629588 24 478.67 7.42 14.24 1 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(CCc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc2)cc1 15026491 IC50 = 3 nM 8.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL2234256 1469753 CHEMBL2234256 1469753 7 337.28 3.08 109.41 0 OC1=C(C(=O)\C=C\c2ccc(cc2)[N+](=O)[O-])C(=O)Oc3ccccc13 12393210 IC50 = 3.1 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3343961 1796120 CHEMBL3343961 1796120 R-13g 319.87 4.04 36.95 0 C[C@H](CCCNC(C)(C)C)Nc1ccnc2cc(Cl)ccc12 15139443 IC50 = 4.66 nM 8.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3219634 1726026 CHEMBL3219634 1726026 9b 393.31 5.06 73.86 1 CCOC(=O)C1=CNc2cc(Oc3ccc(OC(F)(F)F)cc3)ccc2C1=O 14545598 IC50 = 5.3 nM 8.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15123942 IC50 = 5.5 nM 8.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1442150 CHEMBL3374670 F Antiplasmodial activity against Plasmodium falciparum 3D7 late ring stages and early trophozoites forms infected in human erythrocytes assessed as parasite growth inhibition by LDH release assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89329 CHEMBL3352318 25215605 J. Nat. Prod. 2014 77 9 2118
CHEMBL172 303542 CHEMBL172 303542 (S,R)-MEFLOQUINE MQ 378.31 4.3 45.15 0 O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 15128137 IC50 = 6.5 nM 8.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL1235 230459 CHEMBL1235 230459 DESETHYL AMODIAQUINE DESAQ 327.81 3.88 57.18 0 CCNCc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 12450936 IC50 = 6.9 nM 8.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3410330 1837107 CHEMBL3410330 1837107 4b 541.43 3.54 156.94 2 CC(C)OC(=O)OCOP(=O)(OCOC(=O)OC(C)C)C(CCC(=O)N(C)O)c1ccc(F)c(F)c1 15192772 IC50 = 8 nM 8.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3219644 1726036 CHEMBL3219644 1726036 14b 323.34 3.32 64.63 0 CC(C)OC(=O)C1=CNc2cc(Oc3ccccc3)ccc2C1=O 14545608 IC50 = 8.45 nM 8.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14724803 IC50 = 9.25 nM 8.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13854139 IC50 = 10.2 nM 7.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL242326 391919 CHEMBL242326 391919 11 338.31 2.93 93.06 0 COc1cc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)ccc1O 12393182 IC50 = 11.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3343962 1796121 CHEMBL3343962 1796121 S-13h 305.85 4 28.16 0 CCN(C)CCC[C@H](C)Nc1ccnc2cc(Cl)ccc12 15139442 IC50 = 12.39 nM 7.91 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3343952 1796111 CHEMBL3343952 1796111 S-13c 317.86 4.11 28.16 0 C[C@@H](CCCN1CCCC1)Nc2ccnc3cc(Cl)ccc23 15139452 IC50 = 15.76 nM 7.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL168777 281323 CHEMBL168777 281323 2 252.26 3.33 54.37 0 OC(=O)c1ccc(\C=C\C(=O)c2ccccc2)cc1 15155316 IC50 = 29.55 nM 7.53 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL3219646 1726038 CHEMBL3219646 1726038 15b 363.41 4.45 64.63 0 O=C(OC1CCCCC1)C2=CNc3cc(Oc4ccccc4)ccc3C2=O 14545610 IC50 = 29.6 nM 7.53 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3410471 1837249 CHEMBL3410471 1837249 5cC 642.54 3.59 184.27 2 CCNC(=O)ON(C)C(=O)COC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192785 IC50 = 31 nM 7.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3235643 1734168 CHEMBL3235643 1734168 12{1,2,3} 668.61 8.73 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575157 IC50 = 31.23 nM 7.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3402976 1833192 CHEMBL3402976 1833192 6 348.4 2.63 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCCC4 15183762 IC50 = 31.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402982 1833198 CHEMBL3402982 1833198 12 328.41 2.83 57.69 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183767 IC50 = 35 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235674 1734199 CHEMBL3235674 1734199 12{2,3,2} 654.58 8.15 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575164 IC50 = 38.51 nM 7.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL533841 530449 CHEMBL533841 530449 CINCHONIDINE CIND 294.39 2.75 36.36 0 O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 12450941 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3222268 1728686 CHEMBL3222268 1728686 15 448.9 2.07 112.22 0 CC(C)(C)NCc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4C#N 14536781 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL381059 342892 CHEMBL381059 342892 7a 307.34 3.35 55.4 0 CCOC(=O)C1=CNc2ccc(Cc3ccccc3)cc2C1=O 14545593 IC50 = 40.4 nM 7.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3397102 1828819 CHEMBL3397102 1828819 6 355.6 5.32 54.37 1 OC(=O)c1ccc(\C=C\C(=O)c2ccc(Cl)c(Cl)c2Cl)cc1 15155312 IC50 = 40.96 nM 7.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL261371 431151 CHEMBL261371 431151 2c 425.41 1.5 138.48 0 CC(=O)N(O)CCCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C 15192764 IC50 = 41 nM 7.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3402977 1833193 CHEMBL3402977 1833193 7 300.35 1.92 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183761 IC50 = 42.5 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235673 1734198 CHEMBL3235673 1734198 12{2,3,1} 640.56 8.09 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575169 IC50 = 43.09 nM 7.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3402986 1833203 CHEMBL3402986 1833203 17 330.38 1.53 66.92 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183772 IC50 = 46 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3286864 1757385 CHEMBL3286864 1757385 13 394.27 2.56 98.97 0 CC(C)CN(NC(=O)C1CCC(=O)CC1)c2nc(ncc2Br)C#N 14724801 IC50 = 48.2 nM 7.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3114830 1617803 CHEMBL3139377 1628708 3a 293.3 -1.74 130.5 0 Cl.NCCc1c[nH]c2C(=O)C3=C(C(=O)c12)S(=O)(=O)C=CN3 13924052 IC50 = 51 nM 7.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289792 CHEMBL3119266 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3235276 1733797 CHEMBL3235276 1733797 5{1,1,3,1} 611.35 8.64 70.57 2 Clc1ccc(cc1)\N=C(/NCCNc2ccnc3cc(Cl)ccc23)\Nc4ccccc4Oc5cc(Cl)ccc5Cl 14575273 IC50 = 58.08 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3309577 1778668 CHEMBL3309577 1778668 6a 332.83 2.2 48.47 0 C[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031390 IC50 = 73.79 nM 7.13 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL1830114 1176817 CHEMBL1830114 1176817 3 295.18 .88 116.67 0 ONC(=O)CCC(c1ccc(F)c(F)c1)P(=O)(O)O 15192765 IC50 = 75 nM 7.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3093739 1608123 CHEMBL3093739 1608123 21 530.61 .74 132.04 1 CC1(CCC(=O)NCCCNC(=O)CCC2(C)OOC3(CCCCC3)OO2)OOC4(CCCCC4)OO1 13855003 IC50 = 76.5 nM 7.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13836542 IC50 = 78 nM 7.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL1951752 1280742 CHEMBL1962950 1284661 13 518.68 6.5 76.73 2 [Br-].Nc1ncn(Cc2ccc(CCCCc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc2)c6ncnc16 15026502 IC50 = 84 nM 7.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3235274 1733795 CHEMBL3235274 1733795 5{1,1,2,2} 625.38 8.71 70.57 2 Clc1cccc(c1)\N=C(/NCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccccc4Oc5cc(Cl)ccc5Cl 14575300 IC50 = 87.68 nM 7.06 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3326564 1787382 CHEMBL3558258 1940104 18 571.76 8 76.02 2 [Br-].CN(C)c1cc[n+](Cc2ccc(CCc3ccc(Cn4cnc5c(SCc6ccccc6)ncnc45)cc3)cc2)cc1 15026497 IC50 = 92 nM 7.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3415871 1839065 CHEMBL3415871 1839065 1g 359.65 5.75 17.82 1 Cc1cc(Br)cc2c3cn(C)c4ccc(Cl)cc4c3nc12 15217328 IC50 = 95 nM 7.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3358144 1822299 CHEMBL3558763 1940609 23 639.83 4.01 137.14 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1CC(=CC1=O)OCc2ccccc2.[O-]C(=O)C(F)(F)F 15121665 IC50 = 96 nM 7.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3235629 1734154 CHEMBL3235629 1734154 5{2,1,1,3} 566.09 7.28 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1 14575316 IC50 = 109 nM 6.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3335096 1791227 CHEMBL3335096 1791227 7 385.38 4.11 70.97 0 N\C(=N/N=C/c1ccc(cc1)C(F)(F)F)\CC(O)c2cccc3ccccc23 15128130 IC50 = 110 nM 6.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3410337 1837114 CHEMBL3410337 1837114 4cA 611.52 3.78 163.01 2 CN(OC(=O)C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192779 IC50 = 114 nM 6.94 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3235654 1734179 CHEMBL3235654 1734179 5{1,2,2,3} 639.4 9.29 70.57 2 Clc1ccc(Cl)c(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)c1 14575324 IC50 = 126 nM 6.9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3415873 1839067 CHEMBL3415873 1839067 1i 316.78 5.43 17.82 1 Cn1cc2c3ccc4ccccc4c3nc2c5cc(Cl)ccc15 15217330 IC50 = 136.3 nM 6.87 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3235275 1733796 CHEMBL3235275 1733796 5{1,1,2,3} 639.4 9.29 70.57 2 Clc1ccc(Cl)c(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)c1 14575329 IC50 = 148.87 nM 6.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3112612 1617800 CHEMBL3139298 1628629 3d 307.33 -1.31 116.51 0 Cl.CNCCc1c[nH]c2C(=O)C3=C(C(=O)c12)S(=O)(=O)C=CN3 13924101 IC50 = 160 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3309530 1778621 CHEMBL3309530 1778621 8h 412.91 2.51 68.7 0 CN(CCCNc1ccnc2cc(Cl)ccc12)CC3=CC(=O)C(=CN3C4CC4)O 15011100 IC50 = 170 nM 6.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL2312164 1511208 CHEMBL2312164 1511208 1d 280.32 1.72 87.66 0 Cc1cccc(c1)C(=O)NOCCCCCC(=O)NO 14718491 IC50 = 190 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3289165 1759710 CHEMBL3289165 1759710 1o 310.35 1.56 96.89 0 CCOc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720527 IC50 = 230 nM 6.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3359699 1823870 CHEMBL3359699 1823870 13l 351.36 1.1 122.27 0 Nc1cccc(c1)C(=O)NC(C(=O)NO)c2ccc(cc2)n3cccn3 15106769 IC50 = 233 nM 6.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3093741 1608125 CHEMBL3093741 1608125 23 564.62 2.18 132.04 1 CC1(CCC(=O)Nc2cccc(NC(=O)CCC3(C)OOC4(CCCCC4)OO3)c2)OOC5(CCCCC5)OO1 13854146 IC50 = 305.2 nM 6.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3342262 1794404 CHEMBL3342262 1794404 3a 305.22 .13 126.34 0 COc1ccc(cc1)C(OCC(=O)N(C)O)P(=O)(O)O 15101113 IC50 = 310 nM 6.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3087890 1605372 CHEMBL3087890 1605372 3b 453.33 4.25 58.64 0 Brc1ccc(NC(=O)C2=C(C=C(OC2=O)c3ccccc3)N4CCCCC4)cc1 13836548 IC50 = 337 nM 6.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3335110 1791241 CHEMBL3335110 1791241 21 347.41 3.15 80.2 0 COc1ccc(\C=N\N=C(/N)\CC(O)c2ccc3ccccc3c2)cc1 15128116 IC50 = 380 nM 6.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3109544 1614745 CHEMBL3109544 1614745 9a 395.45 2.17 83.88 0 COc1ccc(cc1)C2(NC(=N)N(C3CCOCC3)C2=O)c4ccc(OC)cc4 13891354 IC50 = 459 nM 6.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3329588 1788575 CHEMBL3329588 1788575 8c 517.49 .39 203.39 2 COc1ccc(NC(=O)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)c(c1)[N+](=O)[O-] 15127432 IC50 = 560 nM 6.25 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL596333 595615 CHEMBL596333 595615 ISOCRYPTOLEPINE 1a 232.28 3.85 17.82 0 Cn1cc2c3ccccc3nc2c4ccccc14 15217322 IC50 = 585 nM 6.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3261932 1746895 CHEMBL3261932 1746895 2 867.13 7.58 36.51 2 C\C=C/1\CN2CC[C@@]34[C@@H]2C[C@@H]1[C@@H]5C=C([C@H]6C[C@@]78[C@@H]9C[C@@H](\C(=C/C)\CN69)C%10=C%11N%12[C@H]%13C(=C%11N([C@H]7%10)c%14ccccc8%14)[C@H]%15C[C@@H]%16N(CC[C@]%13%16c%17ccccc%12%17)C/C/%15=C/C)C(=O)N([C@H]35)c%18ccccc4%18 14653938 IC50 = 600 nM 6.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353368 CHEMBL3268229 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83054 CHEMBL3259529 24593048 J. Nat. Prod. 2014 77 4 1078
CHEMBL3109547 1614748 CHEMBL3109547 1614748 9d 408.49 2.44 77.89 0 COc1ccc(cc1)C2(NC(=N)N(C3CCN(C)CC3)C2=O)c4ccc(OC)cc4 13891351 IC50 = 697 nM 6.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3359698 1823869 CHEMBL3359698 1823869 13i 354.34 2.06 96.25 0 ONC(=O)C(NC(=O)c1ccc(F)cc1)c2ccc(cc2)n3cccn3 15106768 IC50 = 703 nM 6.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3289171 1759716 CHEMBL3289171 1759716 1u 284.28 1.44 87.66 0 ONC(=O)CCCCCONC(=O)c1ccccc1F 14720535 IC50 = 730 nM 6.14 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3235636 1734161 CHEMBL3235636 1734161 12{1,1,1} 606.11 7.42 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14578545 IC50 > 800 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3344526 1796690 CHEMBL3344526 1796690 12 421.92 4.28 63.99 0 CN1CCN(CCNc2nc3ccc(Cl)cc3c4c5ccccc5\C(=N/O)\c24)CC1 15083318 IC50 = 818 nM 6.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3344523 1796687 CHEMBL3344523 1796687 9 406.91 5.24 60.75 1 O\N=C\1/c2ccccc2c3c1c(NCCN4CCCCC4)nc5ccc(Cl)cc35 15083315 IC50 = 843 nM 6.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL2312166 1511210 CHEMBL2312166 1511210 1h 280.32 1.72 87.66 0 Cc1ccccc1C(=O)NOCCCCCC(=O)NO 14720536 IC50 = 1120 nM 5.95 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3260208 1745154 CHEMBL3260208 1745154 1c 264.32 3.97 26.53 0 COc1ccc2nc(\C=C\C=C\C)c3cccn3c2c1 14668021 IC50 = 1500 nM 5.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3415876 1839070 CHEMBL3415876 1839070 1l 246.31 4.34 17.82 0 Cc1cccc2c3nc4ccccc4c3cn(C)c12 15217333 IC50 = 1569.4 nM 5.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3326236 1787051 CHEMBL3326236 1787051 3 558.7 2.87 97.36 1 CC[C@]12CC[C@](C)(O1)[C@]3(CC[C@]4(C)[C@@]35CO[C@]46[C@H](C[C@@H](C(=C)C)[C@](C)(CCC(=O)OC)[C@H]6C(=O)C5)OC(=O)C)O2 15018483 IC50 = 1700 nM 5.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1453443 CHEMBL3361764 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90123 CHEMBL3352211 J. Nat. Prod. 2014 77 8 1847
CHEMBL3338925 1793430 CHEMBL3338925 1793430 7c 600.72 5.31 88.67 2 COc1ccc2c(c1)[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119913 IC50 = 1800 nM 5.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338928 1793433 CHEMBL3338928 1793433 7f 620.75 6.23 79.44 2 O=S1(=O)C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6c1ccc7ccccc67 15119910 IC50 = 2090 nM 5.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3109554 1614755 CHEMBL3109554 1614755 10d 501.42 8.46 74.65 2 FC(F)(F)Oc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccc(OC(F)(F)F)cc4 13891344 IC50 = 2200 nM 5.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3338919 1793424 CHEMBL3338919 1793424 6c 584.72 5.21 82.43 2 COc1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119919 IC50 = 2210 nM 5.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338913 1793418 CHEMBL3338913 1793418 5c 584.72 5.21 82.43 2 COc1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119925 IC50 = 2750 nM 5.56 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338935 1793440 CHEMBL3338935 1793440 9e 584.72 5.81 79.44 2 Cc1cccc2[C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS(=O)(=O)c12 15119903 IC50 = 3400 nM 5.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3353317 1817424 CHEMBL3353317 1817424 6z 267.28 2.99 60.77 0 Cc1ccccc1C2=Cc3cc(O)ccc3N(O)C2=O 14971669 IC50 = 3500 nM 5.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3400178 1833200 CHEMBL3400178 1833200 14 452.54 4.83 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCC(Cc5ccccc5)CC4 15183784 IC50 = 3800 nM 5.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465109 CHEMBL3405441 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 90 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3109539 1614740 CHEMBL3109539 1614740 8l 351.4 2.82 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C3CC3)C2=O)c4ccc(OC)cc4 13891360 IC50 = 4110 nM 5.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL1951741 1280731 CHEMBL1963089 1284800 2 386.47 3.16 76.73 0 [Br-].Nc1ncnc2c1ncn2Cc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3 15026513 IC50 = 6432 nM 5.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3409904 1836676 CHEMBL3409904 1836676 71 776.98 5.26 156.1 2 CC(C)C[C@H](NC(=O)CN1CCC(CCO)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199149 IC50 = 6700 nM 5.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3219642 1726034 CHEMBL3219642 1726034 13b 237.25 2.77 38.33 0 O=C1C=CNc2cc(Oc3ccccc3)ccc12 14545606 IC50 = 6725 nM 5.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3238456 1737010 CHEMBL3238456 1737010 5e 529.56 6.88 72.39 2 CCOC(=O)C1=CN(Cc2ccc(F)cc2)c3ccc4nc(c5ccccc5)c(nc4c3C1=O)c6ccccc6 14599594 IC50 = 6940 nM 5.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3260219 1745165 CHEMBL3260219 1745165 1n 278.35 4.32 26.53 0 CCOc1ccn2c3ccccc3nc(\C=C\C=C\C)c12 14668032 IC50 = 7700 nM 5.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3335109 1791240 CHEMBL3335109 1791240 20 385.38 4.11 70.97 0 N\C(=N/N=C/c1ccc(cc1)C(F)(F)F)\CC(O)c2ccc3ccccc3c2 15128117 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL1965543 1286834 CHEMBL1965543 1286834 11 264.36 4.44 19.03 0 CN1CCc2c(C)c3[nH]c4ccccc4c3c(C)c2C1 14746083 IC50 = 13000 nM 4.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL3222267 1728685 CHEMBL3222267 1728685 14 477.9 2.37 132.86 0 CC(C)(C)N(Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4C#N)N=O 14536787 IC50 > 15000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3238448 1737002 CHEMBL3238448 1737002 3a 467.52 5.37 90.41 1 CCOC(=O)C(=CNc1ccc2nc(c3ccccc3)c(nc2c1)c4ccccc4)C(=O)OCC 14599586 IC50 = 16000 nM 4.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3329600 1788587 CHEMBL3329600 1788587 15 287.27 2.4 96.18 0 COc1ccc(NC(=O)Nc2ccccc2)c(c1)[N+](=O)[O-] 15127447 IC50 > 20000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL182659 304848 CHEMBL182659 304848 12 247.31 2.8 54.55 0 Cc1ccc(cc1)S(=O)(=O)Nc2ccccc2 15127444 IC50 > 20000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3329593 1788580 CHEMBL3329593 1788580 8h 442.46 .51 148.35 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@@H](O)[C@@H](O)[C@@H]1O 15127437 IC50 = 20000 nM 4.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3125842 1622451 CHEMBL3125842 1622451 trans-L1, (+)-trans-L1 367.4 1.66 107.47 0 COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c4c(O)c(C)ncc4CO 13953878 IC50 = 22000 nM 4.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296432 CHEMBL3130133 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77215 CHEMBL3124773 24565970 Bioorg. Med. Chem. 2014 22 6 1832
CHEMBL3121245 1620564 CHEMBL3121245 1620564 3 542.49 4.86 166.14 2 Oc1ccc(cc1)[C@@H]2CCc3c(O)cc4O[C@@]5(Oc6cc(O)cc(O)c6C(=O)[C@@]5(O)c4c3O2)c7ccc(O)cc7 13928649 IC50 = 60580 nM 4.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3236267 1734798 CHEMBL3236267 1734798 47 361.32 1.9 61.77 0 CC1=CC2=NC=C(C(=O)NCc3ccc(cc3)C(F)(F)F)C(=O)N2C=C1 14580120 IC50 = 70000 nM 4.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338930 1793435 CHEMBL3338930 1793435 8 356.43 .75 112.44 0 CC(C)(C)c1ccc2c(c1)[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3CS2(=O)=O 15119908 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236247 1734778 CHEMBL3236247 1734778 24 330.73 .03 83.89 0 ClC1=CN2C(=NC=C(NC(=O)OCc3cccnc3)C2=O)C=C1 14580100 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236269 1734801 CHEMBL3236269 1734801 56 379.41 .75 80.23 0 COc1ccc(cc1)C2=CN3C(=O)C(=CN=C3C=C2)C(=O)NCC4CCCO4 14580123 IC50 = 100000 nM 4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236263 1734794 CHEMBL3236263 1734794 43 284.27 -.61 87.8 0 Cc1onc(C)c1NC(=O)C2=CN=C3C=CC=CN3C2=O 14580116 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338934 1793439 CHEMBL3338934 1793439 9d 626.8 6.73 79.44 2 CC(C)(C)c1ccc2c(c1)[C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119904 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3409905 1836677 CHEMBL3409905 1836677 72 747.94 4.82 139.11 1 CC(C)C[C@H](NC(=O)CN1CCN(C)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199150 IC50 Not Active 0 BAO_0000190 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3099601 1610381 CHEMBL3099601 1610381 4e 414.29 3.36 91.41 0 Clc1ccc(cc1)C(NCCNc2ccnc3cc(Cl)ccc23)c4nnn[nH]4 13862660 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL597262 584621 CHEMBL597262 584621 5 260.34 1.12 83.24 0 CN(C)c1ccc(cc1)N2C(=NC(=NC2(C)C)N)N 15005167 IC50 Not Determined 0 BAO_0000190 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3219631 1726023 CHEMBL3219631 1726023 8a 323.34 2.94 64.63 0 CCOC(=O)C1=CNc2ccc(OCc3ccccc3)cc2C1=O 14545595 IC50 ND(Insoluble) 0 BAO_0000190 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3219900 1726294 CHEMBL3219900 1726294 19 600.09 6.91 112.15 2 Fc1cccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)c1 14545663 IC50 = .00136 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219898 1726292 CHEMBL3219898 1726292 17 570.06 7.68 94.13 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6cccc(F)c6)n2 14545661 IC50 = .00247 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219919 1726314 CHEMBL3219919 1726314 39 612.12 7.45 112.59 3 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6ccc(OC)c(OC)c6)n2 14545683 IC50 = .00258 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219920 1726315 CHEMBL3219920 1726315 40 642.15 6.67 130.61 3 COc1ccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)cc1OC 14545684 IC50 = .00458 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219912 1726307 CHEMBL3219912 1726307 32 616.54 7.37 112.15 2 Clc1ccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)cc1 14545676 IC50 = .00463 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219910 1726305 CHEMBL3219910 1726305 30 572.49 7.79 94.13 2 CN1CCN(CC1)c2nc(Nc3ccc(Cl)cc3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2 14545674 IC50 = .0078 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219902 1726296 CHEMBL3219902 1726296 21 556.04 7.33 94.13 2 CN1CCN(CC1)c2nc(Nc3ccc(F)cc3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2 14545665 IC50 = .00897 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219921 1726316 CHEMBL3219921 1726316 41 578.11 7.87 85.33 2 CN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCCc7ccccc67 14545685 IC50 = .0126 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219905 1726299 CHEMBL3219905 1726299 24 600.09 6.91 112.15 2 Fc1ccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)cc1 14545668 IC50 = .0158 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219922 1726317 CHEMBL3219922 1726317 42 592.14 8.21 85.33 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCCc7ccccc67 14545686 IC50 = .0208 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219899 1726293 CHEMBL3219899 1726293 18 586.06 6.85 112.15 2 Fc1cccc(Nc2nc(NCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)c1 14545662 IC50 = .04 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219901 1726295 CHEMBL3219901 1726295 20 541.02 8.29 90.89 2 Fc1cccc(Nc2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCCCC6)c1 14545664 IC50 = .129 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3218232 1724610 CHEMBL3218232 1724610 8 365.46 2.2 49.39 0 C1CN(CCO1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530890 IC50 = .4 nM 9.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3422771 1842218 CHEMBL3422771 1842218 1j 297.74 3.49 54.02 0 Clc1ccc2c(NNC(=O)c3ccccc3)ccnc2c1 15239353 IC50 = .89 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3218247 1724625 CHEMBL3218235 1724613 23 379.49 1.81 58.18 0 Cl.C1CC(CCO1)NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530905 IC50 = 1 nM 9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3099821 1610604 CHEMBL3099821 1610604 3f 449.98 3.89 80.55 0 CC(C)(C)n1nnnc1C(NCCCNc2ccnc3cc(Cl)ccc23)c4ccccc4 13862666 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3099822 1610605 CHEMBL3099822 1610605 3g 464.01 4.47 80.55 0 CC(C)(C)n1nnnc1C(NCCCCNc2ccnc3cc(Cl)ccc23)c4ccccc4 13862665 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3218245 1724623 CHEMBL3218245 1724623 21 378.46 1.39 69.26 0 O=C1CN(CCN1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530903 IC50 = 3.5 nM 8.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE AS 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 15155303 IC50 = 4 nM 8.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE 1, CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15031352 IC50 = 5.4 nM 8.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL1107 152728 CHEMBL1107 152728 HALOFANTRINE HF 500.42 8.2 23.47 2 CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F 12450924 IC50 = 5.8 nM 8.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL2234266 1469763 CHEMBL2234266 1469763 9 306.31 3.67 63.6 0 Cc1ccc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)cc1 12393196 IC50 = 6.1 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL1082723 630274 CHEMBL1082723 630274 N ITD609 390.24 4.43 56.92 0 C[C@H]1Cc2c([nH]c3cc(Cl)c(F)cc23)[C@@]4(N1)C(=O)Nc5ccc(Cl)cc45 14579776 IC50 = 10 nM 8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338673 CHEMBL3242011 F Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82320 CHEMBL3232831 24699367 Eur. J. Med. Chem. 2014 78 375
CHEMBL3343953 1796112 CHEMBL3343953 1796112 R-13c 317.86 4.11 28.16 0 C[C@H](CCCN1CCCC1)Nc2ccnc3cc(Cl)ccc23 15139451 IC50 = 10.19 nM 7.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15083319 IC50 = 12 nM 7.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14530907 IC50 = 12.52 nM 7.9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3410327 1837104 CHEMBL3410327 1837104 4a 569.49 4.75 156.94 2 CCCCOC(=O)OCOP(=O)(OCOC(=O)OCCCC)C(CCC(=O)N(C)O)c1ccc(F)c(F)c1 15192769 IC50 = 13 nM 7.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15119901 IC50 = 16 nM 7.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3423372 1842825 CHEMBL3423372 1842825 1c 411.86 3.46 105.25 0 Clc1ccc2c(Nc3ccc(cc3)S(=O)(=O)Nc4ncccn4)ccnc2c1 15239346 IC50 = 16.3 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3103565 1611638 CHEMBL3103565 1611638 1 256.25 2.87 67.5 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)O 15155317 IC50 = 18.32 nM 7.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL416956 51162 CHEMBL416956 51162 MEFLOQUINE Mefloquine 378.31 4.3 45.15 0 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 15217342 IC50 = 20 nM 7.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3358142 1822297 CHEMBL3558742 1940588 21 669.85 4.11 157.37 1 COC1=CC(=O)N([C@H]1Cc2ccc(O)cc2)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121663 IC50 = 20 nM 7.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3235650 1734175 CHEMBL3235650 1734175 5{1,2,1,2} 590.93 8.04 70.57 2 Clc1ccc(Cl)c(Oc2ccc(N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)c1 14575074 IC50 = 23.12 nM 7.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235632 1734157 CHEMBL3235632 1734157 5{2,1,2,3} 600.54 7.94 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc1 14575163 IC50 = 37.56 nM 7.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3415878 1839072 CHEMBL3415878 1839072 1n 329.17 4.81 17.82 0 Cn1cc2c3cc(Br)ccc3nc2c4ccc(F)cc14 15217335 IC50 = 37.9 nM 7.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3235649 1734174 CHEMBL3235649 1734174 5{1,2,1,1} 576.9 7.98 70.57 2 Clc1ccc(Cl)c(Oc2ccc(N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)c1 14575165 IC50 = 39.45 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15211671 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3311432 1780542 CHEMBL3311432 1780542 7i 503.04 4.36 66.48 1 Clc1ccc2c(NCCCCNCC3=CC(=O)C(=CN3C4CC4)OCc5ccccc5)ccnc2c1 15011091 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3410467 1837245 CHEMBL3410467 1837245 4cC 640.56 4.12 175.04 2 CCNC(=O)ON(C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192781 IC50 = 45 nM 7.35 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3309594 1778685 CHEMBL3309594 1778685 14i 458.98 1.32 72.02 0 CN1CCN(CC1)C(=O)C[C@H](Nc2ccnc3cc(Cl)ccc23)C(=O)N4CCN(C)CC4 15031383 IC50 = 47.94 nM 7.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3103568 1611641 CHEMBL3103568 1611641 13 487.98 5.4 84.23 1 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)NCCCCNc3ccnc4cc(Cl)ccc34 13886188 IC50 = 50 nM 7.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3235672 1734197 CHEMBL3235672 1734197 12{2,2,3} 668.61 8.73 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1)\C 14575268 IC50 = 51.93 nM 7.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL1656 495274 CHEMBL1656 495274 BIDESETHYL CHLOROQUINE BIDESCQ 263.77 2.68 50.94 0 CC(CCCN)Nc1ccnc2cc(Cl)ccc12 12450930 IC50 = 55 nM 7.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3286857 1757378 CHEMBL3286857 1757378 4a 576.48 4.32 118.83 1 CC(C)CN(NC(=O)C1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)c6nc(ncc6Br)C#N 14724794 IC50 = 58.1 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3235664 1734189 CHEMBL3235664 1734189 5{2,2,3,1} 572.48 7.3 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575279 IC50 = 69.03 nM 7.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235273 1733794 CHEMBL3235273 1733794 5{1,1,2,1} 611.35 8.64 70.57 2 Clc1cccc(c1)\N=C(/NCCNc2ccnc3cc(Cl)ccc23)\Nc4ccccc4Oc5cc(Cl)ccc5Cl 14575281 IC50 = 69.56 nM 7.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3112868 1615821 CHEMBL3140235 1629566 22 374.52 4.99 14.24 0 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(C[n+]3ccc(cc3)N4CCCC4)cc2)cc1 15026493 IC50 = 94 nM 7.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3114830 1617803 CHEMBL3139377 1628708 3a 293.3 -1.74 130.5 0 Cl.NCCc1c[nH]c2C(=O)C3=C(C(=O)c12)S(=O)(=O)C=CN3 13924104 IC50 = 104 nM 6.98 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3326565 1787383 CHEMBL3558262 1940108 19 597.79 8.46 76.02 2 [Br-].C(Cc1ccc(Cn2cnc3c(SCc4ccccc4)ncnc23)cc1)c5ccc(C[n+]6ccc(cc6)N7CCCC7)cc5 15026496 IC50 = 149 nM 6.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3261884 1746847 CHEMBL3306874 1768845 7 360.6 4.38 9.23 0 [I-].CC(=CCC\C(=C\C[N+](C)(C)CCOC1C2CC3CC(CC1C3)C2)\C)C 14651657 IC50 = 160 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3219628 1726020 CHEMBL3219628 1726020 6a 309.32 2.94 64.63 0 CCOC(=O)C1=CNc2ccc(Oc3ccccc3)cc2C1=O 14545591 IC50 = 164 nM 6.79 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3289162 1759707 CHEMBL3289162 1759707 1l 338.4 2.54 96.89 0 CCCCOc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14718490 IC50 = 170 nM 6.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3416992 1840197 CHEMBL3416958 1840163 8a 299.39 3.8 81.73 0 CC(C)NC1=Nc2cc(sc2C(=O)N1)c3ccc(C)cc3.OC(=O)\C=C\C(=O)O 15211668 IC50 = 182 nM 6.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3335095 1791226 CHEMBL3335095 1791226 6 331.41 3.66 70.97 0 Cc1ccc(\C=N\N=C(/N)\CC(O)c2cccc3ccccc23)cc1 15128131 IC50 = 190 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3358129 1822284 CHEMBL3558774 1940620 2 579.77 2.58 137.14 1 CO[C@H]1CC(=O)N([C@H]1C)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121650 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3359693 1823864 CHEMBL3359693 1823864 13d 316.35 1.73 96.25 0 CC(C)(C)C(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106764 IC50 = 227 nM 6.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3401320 1831520 CHEMBL3401320 1831520 12a 494.07 5.34 45.56 1 CCN(CC)CCCNc1cc(Cl)cc2nc3c4ccccc4n(CCN5CCOCC5)c3cc12 15164948 IC50 = 320 nM 6.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3311428 1780538 CHEMBL3311428 1780538 7e 505.05 4.79 66.49 1 CN1C=C(OCc2ccccc2)C(=O)C=C1CNCCCCCCNc3ccnc4cc(Cl)ccc34 15011087 IC50 = 390 nM 6.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3359691 1823862 CHEMBL3359691 1823862 13b 288.3 .85 96.25 0 CCC(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106763 IC50 = 455 nM 6.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3109542 1614743 CHEMBL3109542 1614743 8p, CWHM-117 393.48 4.19 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccc(OC)cc4 13891356 IC50 = 463 nM 6.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3410325 1837102 CHEMBL3410325 1837102 1c 411.38 1.42 138.48 0 CC(C)(C)C(=O)OCOP(=O)(CCCN(O)C=O)OCOC(=O)C(C)(C)C 15192763 IC50 = 480 nM 6.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3359692 1823863 CHEMBL3359692 1823863 13c 302.33 1.32 96.25 0 CC(C)C(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106762 IC50 = 532 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3401311 1831511 CHEMBL3401311 1831511 10d 490.08 6.34 36.33 1 Clc1cc(NCCCN2CCCCC2)c3cc4c(nc3c1)c5ccccc5n4CCN6CCCC6 15164939 IC50 = 535 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3359694 1823865 CHEMBL3359694 1823865 13e 331.37 1.11 108.28 0 CC(C)(C)NC(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106765 IC50 = 597 nM 6.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3311431 1780541 CHEMBL3311431 1780541 7h 503.04 4.32 57.7 1 CN(CCCNc1ccnc2cc(Cl)ccc12)CC3=CC(=O)C(=CN3C4CC4)OCc5ccccc5 15011090 IC50 = 670 nM 6.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3415883 1839077 CHEMBL3415883 1839077 1s 363.61 5.47 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4cc(Cl)cc(F)c14 15217340 IC50 = 757.8 nM 6.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL453011 442987 CHEMBL453011 442987 Cordypyridone B 277.36 2.33 60.77 0 C[C@@H]1C[C@H](C)[C@@H](C2=C(O)C=CN(O)C2=O)[C@@](C)(C1)C=C 14971671 IC50 = 800 nM 6.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL1951751 1280741 CHEMBL1963090 1284801 12 492.64 6.04 76.73 1 [Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(Cn4cnc(N)c5ncnc45)cc3)cc2)cc1 15026503 IC50 = 930 nM 6.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3093738 1608122 CHEMBL3093738 1608122 20 516.58 .68 132.04 1 CC1(CCC(=O)NCCNC(=O)CCC2(C)OOC3(CCCCC3)OO2)OOC4(CCCCC4)OO1 13855004 IC50 = 937.7 nM 6.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3338920 1793425 CHEMBL3338920 1793425 6d 610.8 6.63 73.2 2 CC(C)(C)c1ccc2[S+]([O-])C[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119918 IC50 = 1330 nM 5.88 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL591362 589520 CHEMBL591362 589520 3 360.23 3.59 83.12 0 Brc1ccccc1C(=O)Nc2nc(cs2)c3ccccn3 15005144 IC50 = 1360 nM 5.87 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451703 CHEMBL3366896 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL375673 384940 CHEMBL375673 384940 DESCAQ 270.71 3.99 45.15 0 Oc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1 12450945 IC50 = 1400 nM 5.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL470514 460157 CHEMBL470514 460157 1 267.35 4.09 66.05 0 Cc1ccc(Nc2nc(cs2)c3ccccn3)cc1 15005163 IC50 = 1470 nM 5.83 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3329576 1788563 CHEMBL3329576 1788563 7b 626.67 3.87 187.65 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127420 IC50 = 1910 nM 5.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3415875 1839069 CHEMBL3415875 1839069 1k 345.62 5.27 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4cccc(Cl)c14 15217332 IC50 > 2000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3329572 1788559 CHEMBL3329572 1788559 6a 477.53 .79 161.77 0 Cc1ccc(cc1)S(=O)(=O)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2 15127416 IC50 = 2200 nM 5.66 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3260211 1745157 CHEMBL3260211 1745157 1f 292.37 4.89 26.53 0 CCC\C=C\C=C\c1nc2cc(OC)ccc2n3cccc13 14668024 IC50 = 2300 nM 5.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3338932 1793437 CHEMBL3338932 1793437 9b 584.72 5.81 79.44 2 Cc1ccc2c(c1)[C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119906 IC50 = 2340 nM 5.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3109535 1614736 CHEMBL3109535 1614736 8h 415.48 4.24 74.65 0 COc1ccc(cc1)C2(NC(=N)N(CCc3ccccc3)C2=O)c4ccc(OC)cc4 13891656 IC50 = 2380 nM 5.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3261880 1746843 CHEMBL3261880 1746843 3 331.54 5.2 21.26 1 CC(=CCC\C(=C\CNCCOC1C2CC3CC(CC1C3)C2)\C)C 14651653 IC50 = 2400 nM 5.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3260210 1745156 CHEMBL3260210 1745156 1e 262.35 4.9 17.3 0 CCC\C=C\C=C\c1nc2ccccc2n3cccc13 14668023 IC50 = 2500 nM 5.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3329574 1788561 CHEMBL3329574 1788561 6c 447.5 1.3 141.54 0 Cc1ccc(cc1)S(=O)(=O)Nc2cccc(\C=C\C(=O)C[C@@H]3OC[C@@H](O)[C@H](O)[C@H]3O)c2 15127418 IC50 = 2930 nM 5.53 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3335093 1791224 CHEMBL3335093 1791224 4 303.36 3.03 70.97 0 N\C(=N/N=C/c1ccccc1)\C(O)c2cccc3ccccc23 15128133 IC50 = 3000 nM 5.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3329595 1788582 CHEMBL3329595 1788582 8j 412.44 1.02 128.12 0 O[C@@H]1CO[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@H](O)[C@H]1O 15127439 IC50 = 3440 nM 5.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3338915 1793420 CHEMBL3338915 1793420 5e 568.72 5.72 73.2 2 Cc1cccc2[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3C[S+]([O-])c12 15119923 IC50 = 4130 nM 5.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338931 1793436 CHEMBL3338931 1793436 9a 570.7 5.33 79.44 2 O=S1(=O)C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@H]2c6ccccc16 15119907 IC50 = 4140 nM 5.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3329585 1788572 CHEMBL3329585 1788572 7k 554.61 4 161.35 1 CC(=O)O[C@@H]1CO[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@H](OC(=O)C)[C@H]1OC(=O)C 15127429 IC50 = 4200 nM 5.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3409894 1836666 CHEMBL3409894 1836666 61 719.85 3.98 157.45 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCN=C4COc5ccc(F)cc5 15199124 IC50 > 5000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL250450 420125 CHEMBL250450 420125 ISOQUERCETIN 5 464.38 -.3 206.59 2 OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O 13928647 IC50 = 5540 nM 5.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3329592 1788579 CHEMBL3329592 1788579 8g 492.52 1.42 148.35 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=O)Nc3ccc4ccccc4c3)cc2)[C@H](O)[C@@H](O)[C@@H]1O 15127436 IC50 = 5910 nM 5.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3260214 1745160 CHEMBL3260214 1745160 1i 276.38 5.36 17.3 1 CCCC\C=C\C=C\c1nc2ccccc2n3cccc13 14668027 IC50 = 6300 nM 5.2 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3409906 1836678 CHEMBL3409906 1836678 73 790.96 5.19 162.16 2 COC(=O)C1CCN(CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5)CC1 15199151 IC50 = 6700 nM 5.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3109529 1614730 CHEMBL3109529 1614730 8b 325.36 2.33 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C)C2=O)c3ccc(OC)cc3 13891662 IC50 = 7920 nM 5.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3219640 1726032 CHEMBL3219640 1726032 12b 262.26 2.61 62.12 0 O=C1C(=CNc2cc(Oc3ccccc3)ccc12)C#N 14545604 IC50 = 8102.5 nM 5.09 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3329587 1788574 CHEMBL3329587 1788574 8b 458.53 2.35 163.37 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@H](O)[C@@H](O)[C@@H]1O 15127431 IC50 = 9430 nM 5.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3409902 1836674 CHEMBL3409902 1836674 69 718.9 5.97 135.86 2 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCC1)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199116 IC50 = 9700 nM 5.01 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3409901 1836673 CHEMBL3409901 1836673 68 720.87 4.74 145.09 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199117 IC50 = 10000 nM 5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3335115 1791246 CHEMBL3335115 1791246 26 318.37 2.02 83.86 0 N\C(=N/N=C/c1cccnc1)\CC(O)c2ccc3ccccc3c2 15128111 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3335094 1791225 CHEMBL3335094 1791225 5 303.36 3.03 70.97 0 N\C(=N/N=C/c1ccccc1)\C(O)c2ccc3ccccc3c2 15128132 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL1630 476314 CHEMBL682 29097 AMODIAQUINE HYDROCHLORIDE 5 355.86 4.76 48.39 0 Cl.CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 14536783 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL2046935 1350352 CHEMBL2079504 1363734 16, VAM2-16 360.45 3.05 72.61 0 Br.CN1C(=O)CN(CCCCCN2CCCCC2)c3ccc(cc13)[N+](=O)[O-] 13910782 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3335116 1791247 CHEMBL3335116 1791247 27 307.35 2.57 84.11 0 N\C(=N/N=C/c1occc1)\CC(O)c2ccc3ccccc3c2 15128110 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL1951740 1280730 CHEMBL1962408 1284119 1 360.44 2.7 76.73 0 [Br-].CN(C)c1cc[n+](Cc2ccc(Cn3cnc4c(N)ncnc34)cc2)cc1 15026514 IC50 = 14307 nM 4.84 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3238451 1737005 CHEMBL3238451 1737005 4b 457.43 5.75 85.2 1 CCOC(=O)c1cnc2ccc3nc(c4ccc(F)cc4)c(nc3c2c1O)c5ccc(F)cc5 14599589 IC50 = 15700 nM 4.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3329597 1788584 CHEMBL3329597 1788584 11a 345.41 3.48 80.85 0 CCOC(=O)\C=C\c1cccc(NS(=O)(=O)c2ccc(C)cc2)c1 15127441 IC50 = 16120 nM 4.79 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3409903 1836675 CHEMBL3409903 1836675 70 748.93 4.29 156.1 1 CC(C)C[C@H](NC(=O)CN1CCC(O)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCC[C@H]4COc5ccc(F)cc5 15199148 IC50 = 16700 nM 4.78 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL216579 360437 CHEMBL216579 360437 Compound B, Genz-10850 393.48 4.38 39.34 0 O=C(N1CCN(CC1)C2c3ccccc3c4ccccc24)c5ccc6[nH]ccc6c5 15087880 IC50 = 16900 nM 4.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3409898 1836670 CHEMBL3409898 1836670 65 746.91 4.06 151.47 1 CC(C)C[C@H](NC(=O)CN1CCN(C)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N4CCN=C4COc5ccc(F)cc5 15199120 IC50 = 17500 nM 4.76 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3238461 1737015 CHEMBL3238461 1737015 5j 495.48 6.69 72.39 1 CCOC(=O)C1=CN(CC#C)c2ccc3nc(c4ccc(F)cc4)c(nc3c2C1=O)c5ccc(F)cc5 14599599 IC50 = 18700 nM 4.73 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3290638 1761197 CHEMBL3290638 1761197 4 777.95 2.06 223.92 2 CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@H](Cc3ccccc3)NC1=O)[C@@H](C)O)[C@@H](C)CC 14710396 IC50 = 23000 nM 4.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1362075 CHEMBL3294628 F Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83803 CHEMBL3286375 24813731 Bioorg. Med. Chem. Lett. 2014 24 12 2645
CHEMBL8 241 CHEMBL8 241 CIPROFLOXACIN Ciprofloxacin 331.34 -1.27 72.88 0 OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O 14599614 IC50 = 23100 nM 4.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ artemisinin 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 15018484 IC50 = 30400 nM 4.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1453443 CHEMBL3361764 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90123 CHEMBL3352211 J. Nat. Prod. 2014 77 8 1847
CHEMBL3236244 1734775 CHEMBL3236244 1734775 21 313.28 1.02 71 0 Fc1cccc(COC(=O)NC2=CN=C3C=CC=CN3C2=O)c1 14580097 IC50 = 33000 nM 4.48 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3238460 1737014 CHEMBL3238460 1737014 5i 513.53 6.83 72.39 2 CCCCN1C=C(C(=O)OCC)C(=O)c2c1ccc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5 14599598 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3402985 1833202 CHEMBL3402985 1833202 16 418.53 4.57 57.69 0 CC[C@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183822 IC50 = 53790 nM 4.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL2048508 1351941 CHEMBL2048508 1351941 7 320.25 1.24 147.68 1 O[C@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3cc(O)c(O)c(O)c3 13928645 IC50 = 75540 nM 4.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3402976 1833192 CHEMBL3402976 1833192 6 348.4 2.63 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCCC4 15183812 IC50 = 87600 nM 4.06 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3236246 1734777 CHEMBL3236246 1734777 23 330.73 .25 83.89 0 ClC1=CN2C(=NC=C(NC(=O)OCc3ccccn3)C2=O)C=C1 14580099 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236240 1734771 CHEMBL3236240 1734771 16 370.83 1.47 65.01 0 CC(C)N(Cc1ccccc1)C(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl 14580093 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3402975 1833191 CHEMBL3402975 1833191 5 314.38 2.31 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183811 IC50 = 236180 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3352826 1817400 CHEMBL3352826 1817400 6b 303.31 3.11 60.77 0 ON1C(=O)C(=C(O)c2ccccc12)c3cccc4ccccc34 14971645 IC50 Not Active 0 BAO_0000190 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3409909 1836681 CHEMBL3409909 1836681 76 723.92 4.64 140.31 1 CC(C)C[C@H](NC(=O)CN1CCC(CCO)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N2CCC[C@H]2COc3ccc(F)cc3)c4ccccc4 15199154 IC50 Not Active 0 BAO_0000190 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3264810 1749803 CHEMBL3264810 1749803 16 641.88 7.56 90.9 2 CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC(C)(C)c3cccc(OC)c3)C4CCCCC4 14656159 IC50 Not Determined 0 BAO_0000190 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL540445 504633 CHEMBL540445 504633 PARTHENOLIDE PTD 248.32 2.92 38.83 0 C\C\1=C/CC[C@@]2(C)O[C@H]2[C@H]3OC(=O)C(=C)[C@@H]3CC1 13886131 IC50 Not Determined 0 BAO_0000190 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3099603 1610383 CHEMBL3099603 1610383 4g 407.9 3.33 91.41 0 Clc1ccc2c(NCCCCNC(c3ccccc3)c4nnn[nH]4)ccnc2c1 13862658 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3099823 1610606 CHEMBL3099823 1610606 4a 379.85 2.69 91.41 0 Clc1ccc2c(NCCNC(c3ccccc3)c4nnn[nH]4)ccnc2c1 13862664 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3099600 1610380 CHEMBL3099600 1610380 4d 448.74 4.02 91.41 0 Clc1ccc2c(NCCNC(c3ccc(Cl)c(Cl)c3)c4nnn[nH]4)ccnc2c1 13862661 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3219915 1726310 CHEMBL3219915 1726310 35 612.12 6.69 121.38 3 COc1cccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)c1 14545679 IC50 = .00298 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219909 1726304 CHEMBL3219909 1726304 29 616.54 7.37 112.15 2 Clc1cccc(Nc2nc(NCCCN3CCOCC3)nc(Nc4ccc(Nc5ccnc6cc(Cl)ccc56)cc4)n2)c1 14545673 IC50 = .00382 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219916 1726311 CHEMBL3219916 1726311 36 582.1 7.46 103.36 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(Nc6ccc(OC)cc6)n2 14545680 IC50 = .00426 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ artemisinine 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 14653940 IC50 = .01 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1353368 CHEMBL3268229 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83054 CHEMBL3259529 24593048 J. Nat. Prod. 2014 77 4 1078
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14653939 IC50 = .02 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1353368 CHEMBL3268229 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83054 CHEMBL3259529 24593048 J. Nat. Prod. 2014 77 4 1078
CHEMBL3423374 1842827 CHEMBL3423374 1842827 1f 193.63 1.96 50.94 0 NNc1ccnc2cc(Cl)ccc12 15239349 IC50 < .19 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL2088546 1366220 CHEMBL2088546 1366220 12 822.94 2.16 204.86 2 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)NCC(O)CNC(=O)CCC(=O)O[C@@H]3O[C@@H]4O[C@@]5(C)CC[C@H]6[C@H](C)CC[C@@H]([C@H]3C)[C@@]46OO5)O[C@@H]7O[C@@]8(C)CC[C@@H]1[C@@]27OO8 13952425 IC50 = .32 nM 9.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296215 CHEMBL3132228 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77210 CHEMBL3124935 24561670 Eur. J. Med. Chem. 2014 75 403
CHEMBL3218244 1724622 CHEMBL3218244 1724622 20 351.48 2.9 48.95 0 CC(C)(C)NC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4 14530902 IC50 = 1.3 nM 8.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL3112871 1615824 CHEMBL3140162 1629493 25 506.72 8.33 14.24 2 [Br-].[Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc2)cc1 15026490 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL2259746 1477559 CHEMBL2259746 1477559 7 364.39 3.32 62.58 0 COc1cc(\C=C\C(=O)c2ccc(cc2)n3ccnc3)cc(OC)c1OC 12460155 IC50 = 2.48 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183779 IC50 = 3.42 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3264811 1749804 CHEMBL3264811 1749804 17 628.84 6 94.14 2 CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNC(C)(C)c3cccc(OC)c3)N4CCCC4 14656160 IC50 = 4 nM 8.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL2237987 1473522 CHEMBL2237987 1473522 3 326.73 3.85 63.6 0 OC1=C(C(=O)\C=C\c2cccc(Cl)c2)C(=O)Oc3ccccc13 12393238 IC50 = 4.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3219630 1726022 CHEMBL3219630 1726022 7b 307.34 3.35 55.4 0 CCOC(=O)C1=CNc2cc(Cc3ccccc3)ccc2C1=O 14545594 IC50 = 4.57 nM 8.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14747275 IC50 = 5 nM 8.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1363024 CHEMBL3292841 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83975 CHEMBL3286377 24929343 Eur. J. Med. Chem. 2014 82 459
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE 1, CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13862657 IC50 = 5.2 nM 8.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3397305 1829024 CHEMBL3397305 1829024 37b, TDR 58846 277.79 3.21 28.16 0 CN(C)C(C)(C)CNc1ccnc2cc(Cl)ccc12 15156352 IC50 = 5.52 nM 8.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462725 CHEMBL3399494 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90966 CHEMBL3396969 25461328 Eur. J. Med. Chem. 2015 90 280
CHEMBL3397304 1829023 CHEMBL3397304 1829023 37a, TDR 58845 249.74 2.24 50.94 0 CC(C)(N)CNc1ccnc2cc(Cl)ccc12 15156351 IC50 = 5.52 nM 8.26 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462725 CHEMBL3399494 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 72 hrs by SYBR green I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90966 CHEMBL3396969 25461328 Eur. J. Med. Chem. 2015 90 280
CHEMBL2237983 1473518 CHEMBL2237983 1473518 12 352.34 3.15 82.06 0 COc1ccc(\C=C\C(=O)C2=C(O)c3ccccc3OC2=O)cc1OC 12393175 IC50 = 6.2 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15155305 IC50 = 8.6 nM 8.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462646 CHEMBL3399333 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90962 CHEMBL3396954 25461309 Eur. J. Med. Chem. 2015 90 33
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15026481 IC50 = 10 nM 8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ 3 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 14536782 IC50 = 12 nM 7.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3410333 1837110 CHEMBL3410333 1837110 4bA 583.47 3.37 163.01 2 CC(C)OC(=O)OCOP(=O)(OCOC(=O)OC(C)C)C(CCC(=O)N(C)OC(=O)C)c1ccc(F)c(F)c1 15192775 IC50 = 13 nM 7.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3410335 1837112 CHEMBL3410335 1837112 4bC 612.51 3.71 175.04 2 CCNC(=O)ON(C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C 15192777 IC50 = 14 nM 7.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL1630 476314 CHEMBL682 29097 AMODIAQUINE HYDROCHLORIDE 5 355.86 4.76 48.39 0 Cl.CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 14536776 IC50 = 15 nM 7.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328983 CHEMBL3223114 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3358141 1822296 CHEMBL3558740 1940586 20 605.81 3.64 137.14 1 COC1=CC(=O)N([C@H]1C(C)C)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121662 IC50 = 16.6 nM 7.78 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL448594 495275 CHEMBL448594 495275 Chloroquine-pyrolidinyl CQPYROL, Chloroquine-pyrolidinyl 317.86 4.11 28.16 0 CC(CCCN1CCCC1)Nc2ccnc3cc(Cl)ccc23 12450935 IC50 = 19 nM 7.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3410470 1837248 CHEMBL3410470 1837248 5cB 643.52 4.24 181.46 2 CCOC(=O)ON(C)C(=O)COC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192784 IC50 = 23 nM 7.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3410334 1837111 CHEMBL3410334 1837111 4bB 613.5 4.36 172.24 2 CCOC(=O)ON(C)C(=O)CCC(c1ccc(F)c(F)c1)P(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C 15192776 IC50 = 28 nM 7.55 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3343951 1796110 CHEMBL3343951 1796110 R-13b 333.86 3.34 37.39 0 C[C@H](CCCN1CCOCC1)Nc2ccnc3cc(Cl)ccc23 15139453 IC50 = 28.1 nM 7.55 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3402990 1833207 CHEMBL3402990 1833207 22 640.68 3.97 115.38 1 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCN(CC4)C(=O)[C@H](Cc5ccccc5)N6C(=O)c7ccccc7C6=O 15183777 IC50 = 33.8 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235659 1734184 CHEMBL3235659 1734184 5{2,2,1,2} 552.07 6.7 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575161 IC50 = 36.63 nM 7.44 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3112875 1615828 CHEMBL3140284 1629615 29 603.24 10.59 14.24 2 [Br-].[Br-].CN(c1ccc(Cl)cc1)c2cc[n+](Cc3ccc(CCCCc4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)cc3)cc2 15026486 IC50 = 37 nM 7.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3112873 1615826 CHEMBL3140234 1629565 27 547.13 8.77 14.24 2 [Br-].[Br-].CN(c1ccc(Cl)cc1)c2cc[n+](Cc3ccc(cc3)c4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)cc2 15026488 IC50 = 38 nM 7.42 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3093742 1608126 CHEMBL3093742 1608126 24 564.62 2.18 132.04 1 CC1(CCC(=O)Nc2ccc(NC(=O)CCC3(C)OOC4(CCCCC4)OO3)cc2)OOC5(CCCCC5)OO1 13854145 IC50 = 40.9 nM 7.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3402981 1833197 CHEMBL3402981 1833197 11 314.38 2.37 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183766 IC50 = 41 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235662 1734187 CHEMBL3235662 1734187 5{2,2,2,2} 586.51 7.36 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3cccc(Cl)c3)\NCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575178 IC50 = 49.6 nM 7.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL124495 204004 CHEMBL124495 204004 NICOTINIC ACID HYDRAZIDE 1h 137.14 -.81 68.01 0 NNC(=O)c1cccnc1 15239351 IC50 > 50 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL541700 558129 CHEMBL541700 558129 GALLINAMIDE A Gallinamide A 592.77 3.9 134.35 1 CC[C@H](C)[C@H](N(C)C)C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C)C(=CC1=O)OC 15121641 IC50 = 50 nM 7.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435067 CHEMBL3387713 F Antiplasmodial activity against Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 13886186 IC50 = 50 nM 7.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL2237986 1473521 CHEMBL2237986 1473521 2 326.73 3.85 63.6 0 OC1=C(C(=O)\C=C\c2ccccc2Cl)C(=O)Oc3ccccc13 12393245 IC50 > 50 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3235646 1734171 CHEMBL3235646 1734171 12{1,3,1} 640.56 8.09 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccc(Cl)cc3)\NCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575267 IC50 = 51.51 nM 7.29 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3326567 1787385 CHEMBL3558266 1940112 21 625.85 9.37 76.02 2 [Br-].C(CCc1ccc(Cn2cnc3c(SCc4ccccc4)ncnc23)cc1)Cc5ccc(C[n+]6ccc(cc6)N7CCCC7)cc5 15026494 IC50 = 54 nM 7.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3358140 1822295 CHEMBL3558746 1940592 19 563.73 2.42 137.14 1 COC1=CC(=O)N(C1)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121661 IC50 = 57.3 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL2263229 1481077 CHEMBL2263229 1481077 DEHYDROXYFLUORO TEBAQUINE FTBQ 468.39 7.39 28.16 1 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)c(F)c(c1)c4ccc(Cl)cc4 12450938 IC50 = 61 nM 7.21 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3402979 1833195 CHEMBL3402979 1833195 9 328.41 2.76 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCCC3 15183764 IC50 = 71.5 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3235271 1733792 CHEMBL3235271 1733792 5{1,1,1,2} 590.93 8.04 70.57 2 Clc1ccc(Cl)c(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)c1 14575286 IC50 = 74.73 nM 7.13 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3343965 1796124 CHEMBL3343965 1796124 R-13i 488.19 9.96 28.16 1 CCCCCCCCN(CCCCCCCC)CCC[C@@H](C)Nc1ccnc2cc(Cl)ccc12 15139439 IC50 = 78.58 nM 7.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3219153 1725540 CHEMBL3219153 1725540 34 420.93 5.14 59.07 1 COc1cc(NC(C)CCCNc2ccnc3cc(Cl)ccc23)c4ncccc4c1 15156342 IC50 = 80 nM 7.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1462721 CHEMBL3399490 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90966 CHEMBL3396969 25461328 Eur. J. Med. Chem. 2015 90 280
CHEMBL170 255947 CHEMBL170 255947 QUININE Quinine 324.42 2.73 45.59 0 COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 15217343 IC50 = 80 nM 7.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3309578 1778669 CHEMBL3309578 1778669 6b 362.9 2.93 57.26 0 CCN(CC)CCCNC(=O)[C@H](C)Nc1ccnc2cc(Cl)ccc12 15031391 IC50 = 82.64 nM 7.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3309587 1778678 CHEMBL3309587 1778678 14b 374.91 3.5 48.47 0 CC[C@H](C)[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031392 IC50 = 83.82 nM 7.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3112872 1615825 CHEMBL3140163 1629494 26 471.04 7.25 14.24 1 [Br-].[Br-].CN(c1ccc(Cl)cc1)c2cc[n+](Cc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc2 15026489 IC50 = 92 nM 7.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3343964 1796123 CHEMBL3343964 1796123 S-13i 488.19 9.96 28.16 1 CCCCCCCCN(CCCCCCCC)CCC[C@H](C)Nc1ccnc2cc(Cl)ccc12 15139440 IC50 = 94.76 nM 7.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3235628 1734153 CHEMBL3235628 1734153 5{2,1,1,2} 552.07 6.7 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCNc4ccnc5cc(Cl)ccc45)cc1 14575319 IC50 = 120.3 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3326560 1787378 CHEMBL3558253 1940099 14 467.61 5.57 76.02 1 [Br-].CN(C)c1cc[n+](Cc2ccc(Cn3cnc4c(SCc5ccccc5)ncnc34)cc2)cc1 15026501 IC50 = 122 nM 6.91 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3309589 1778680 CHEMBL3309589 1778680 14d 362.85 1.69 68.7 0 C[C@H](O)[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031399 IC50 = 142.5 nM 6.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL2096627 1369636 CHEMBL387326 371643 QUININE SULFATE Quinine sulfate 324.42 2.73 45.59 0 O.O.COc1ccc2nccc([C@@H](O)[C@@H]3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)[C@@H]7CC8CCN7C[C@@H]8C=C)c6c5.OS(=O)(=O)O 14746085 IC50 = 150 nM 6.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL205338 343917 CHEMBL205338 343917 FR-900098 2, FR900098 197.13 -1.32 107.88 0 CC(=O)N(O)CCCP(=O)(O)O 15192762 IC50 = 160 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3335102 1791233 CHEMBL3335102 1791233 13 353.37 3.58 70.97 0 N\C(=N/N=C/c1ccc(F)c(F)c1)\CC(O)c2cccc3ccccc23 15128124 IC50 = 180 nM 6.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL1962575 1284286 CHEMBL1962575 1284286 1f 345.62 5.27 17.82 1 Cn1cc2c3cc(Br)ccc3nc2c4cc(Cl)ccc14 15217327 IC50 = 181.8 nM 6.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3309525 1778616 CHEMBL3309525 1778616 8c 386.88 2.02 68.69 0 CN(CCCNc1ccnc2cc(Cl)ccc12)CC3=CC(=O)C(=CN3C)O 15011095 IC50 = 190 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3235272 1733793 CHEMBL3235272 1733793 5{1,1,1,3} 604.96 8.62 70.57 2 Clc1ccc(Cl)c(Oc2ccccc2N\C(=N\c3ccccc3)\NCCCCNc4ccnc5cc(Cl)ccc45)c1 14575343 IC50 = 194.41 nM 6.71 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL591637 589617 CHEMBL591637 589617 2 327.42 3.38 108.42 0 CSc1ccccc1C(=O)Nc2nc(cs2)c3ccccn3 15005164 IC50 = 200 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL1951750 1280740 CHEMBL1962411 1284122 11 490.62 5.59 76.73 1 [Br-].Nc1ncn(Cc2ccc(CCc3ccc(C[n+]4ccc(cc4)N5CCCC5)cc3)cc2)c6ncnc16 15026504 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3289164 1759709 CHEMBL3289164 1759709 1n 352.43 3 96.89 0 CCCCCOc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720525 IC50 = 210 nM 6.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3415872 1839066 CHEMBL3415872 1839066 1h 296.75 4.5 27.05 0 COc1ccc2nc3c(cn(C)c4ccc(Cl)cc34)c2c1 15217329 IC50 = 211.4 nM 6.67 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3219633 1726025 CHEMBL3219633 1726025 9a 393.31 5.06 73.86 1 CCOC(=O)C1=CNc2ccc(Oc3ccc(OC(F)(F)F)cc3)cc2C1=O 14545597 IC50 = 229.8 nM 6.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3289166 1759711 CHEMBL3289166 1759711 1p 324.37 2.09 96.89 0 CCCOc1ccccc1C(=O)NOCCCCCC(=O)NO 14720528 IC50 = 240 nM 6.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3311430 1780540 CHEMBL3311430 1780540 7g 489.01 3.78 66.48 0 Clc1ccc2c(NCCCNCC3=CC(=O)C(=CN3C4CC4)OCc5ccccc5)ccnc2c1 15011089 IC50 = 240 nM 6.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3309586 1778677 CHEMBL3309586 1778677 14a 360.88 3.04 48.47 0 CC(C)[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031408 IC50 = 270.8 nM 6.57 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3309528 1778619 CHEMBL3309528 1778619 8f 384.86 1.91 77.49 0 OC1=CN(C2CC2)C(=CC1=O)CNCCNc3ccnc4cc(Cl)ccc34 15011098 IC50 = 300 nM 6.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL123 22942 CHEMBL123 22942 ELLIPTECINE 1, Ellipticine 246.31 4.05 28.68 0 Cc1c2ccncc2c(C)c3c4ccccc4[nH]c13 14746079 IC50 = 350 nM 6.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL3359696 1823867 CHEMBL3359696 1823867 13g 354.34 2.06 96.25 0 ONC(=O)C(NC(=O)c1ccccc1F)c2ccc(cc2)n3cccn3 15106766 IC50 = 351 nM 6.45 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3401323 1831523 CHEMBL3401323 1831523 14 500.51 6.95 36.33 2 CCN(CC)CCNc1cc(Cl)cc2nc3c4cc(Cl)ccc4n(CCN(CC)CC)c3cc12 15164951 IC50 = 397 nM 6.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3401309 1831509 CHEMBL3401309 1831509 10b 462.03 5.82 36.33 1 Clc1cc(NCCN2CCCC2)c3cc4c(nc3c1)c5ccccc5n4CCN6CCCC6 15164937 IC50 = 468 nM 6.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3401310 1831510 CHEMBL3401310 1831510 10c 478.07 6.12 36.33 1 CCN(CC)CCCNc1cc(Cl)cc2nc3c4ccccc4n(CCN5CCCC5)c3cc12 15164938 IC50 = 480 nM 6.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3326566 1787384 CHEMBL3558265 1940111 20 599.81 8.91 76.02 2 [Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(Cn4cnc5c(SCc6ccccc6)ncnc45)cc3)cc2)cc1 15026495 IC50 = 500 nM 6.3 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3103529 1611602 CHEMBL3103529 1611602 19 485.96 5.14 66.65 1 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)N3CCN(CC3)c4ccnc5cc(Cl)ccc45 13886171 IC50 = 540 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3235658 1734183 CHEMBL3235658 1734183 5{2,2,1,1} 538.04 6.64 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccccc3)\NCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14578562 IC50 > 900 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3219285 1725673 CHEMBL3219285 1725673 5 521.67 5.34 53.09 2 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCN(CCC56CC7CC(CC(C7)C5)C6)CC4)c(F)cc3C1=O 14542716 IC50 = 1000 nM 6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3109558 1614759 CHEMBL3109558 1614759 10h 402.32 5.55 56.19 1 Clc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccc(Cl)cc4 13891340 IC50 = 1070 nM 5.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3219284 1725672 CHEMBL3219284 1725672 4 449.52 4.13 53.09 0 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCN(Cc5ccccc5)CC4)c(F)cc3C1=O 14542715 IC50 = 1080 nM 5.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3235640 1734165 CHEMBL3235640 1734165 12{1,1,5} 441.52 5.6 71.95 1 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3ccccc3)\NC4CC4)cc1)\C 14578324 IC50 > 1200 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL306472 110100 CHEMBL306472 110100 2 246.31 3.85 28.68 0 Cc1nccc2c(C)c3[nH]c4ccccc4c3cc12 14746080 IC50 = 1200 nM 5.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL3329571 1788558 CHEMBL3329571 1788558 5c 573.61 2.44 159.75 1 CC(=O)O[C@@H]1CO[C@@H](CC(=O)\C=C\c2cccc(NS(=O)(=O)c3ccc(C)cc3)c2)[C@H](OC(=O)C)[C@H]1OC(=O)C 15127415 IC50 = 1390 nM 5.86 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL591362 589520 CHEMBL591362 589520 3 360.23 3.59 83.12 0 Brc1ccccc1C(=O)Nc2nc(cs2)c3ccccn3 15005165 IC50 = 1580 nM 5.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3342259 1794401 CHEMBL3342259 1794401 2d 289.22 .45 125.9 0 COc1ccc(cc1)C(CCC(=O)NO)P(=O)(O)O 15101110 IC50 = 1700 nM 5.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183783 IC50 = 2000 nM 5.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465108 CHEMBL3405440 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 60 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL575569 571475 CHEMBL575569 571475 CIPROFLOXACIN ETHYL ESTER 2 359.39 2.01 61.88 0 CCOC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O 14542714 IC50 = 2330 nM 5.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330106 CHEMBL3223443 F Antimalarial activity against schizont stage of chloroquine-susceptible Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81776 CHEMBL3217739 MedChemComm 2011 2 5 430
CHEMBL3338933 1793438 CHEMBL3338933 1793438 9c 600.72 5.31 88.67 2 COc1ccc2c(c1)[C@@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119905 IC50 = 2500 nM 5.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3353300 1817407 CHEMBL3353300 1817407 6i 287.31 3.65 40.54 0 ON1C(=O)C(=Cc2ccccc12)c3ccc4ccccc4c3 14971652 IC50 = 2900 nM 5.54 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3353302 1817409 CHEMBL3353302 1817409 6k 251.28 3.23 40.54 0 Cc1ccccc1C2=Cc3ccccc3N(O)C2=O 14971654 IC50 = 3000 nM 5.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3329584 1788571 CHEMBL3329584 1788571 7j 538.55 2.16 146.33 1 CC(=O)O[C@@H]1CO[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@H](OC(=O)C)[C@H]1OC(=O)C 15127428 IC50 = 3170 nM 5.5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3326562 1787380 CHEMBL3558260 1940106 16 543.7 7.09 76.02 2 [Br-].CN(C)c1cc[n+](Cc2ccc(cc2)c3ccc(Cn4cnc5c(SCc6ccccc6)ncnc45)cc3)cc1 15026499 IC50 = 3223 nM 5.49 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3338903 1793408 CHEMBL3338903 1793408 3a 538.7 6.34 62.22 2 C(OCc1ccccc1)[C@H]2O[C@H]3[C@H](CSc4ccccc34)[C@@H](OCc5ccccc5)[C@@H]2OCc6ccccc6 15119935 IC50 = 3460 nM 5.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL582580 542604 CHEMBL582580 542604 8o 333.43 4.22 58.69 0 NC1=NC(C(=O)N1C2CCCCC2)(c3ccccc3)c4ccccc4 13891357 IC50 = 3850 nM 5.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3109530 1614731 CHEMBL3109530 1614731 8c 339.39 2.68 74.65 0 CCN1C(=N)NC(C1=O)(c2ccc(OC)cc2)c3ccc(OC)cc3 13891661 IC50 = 3950 nM 5.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3325777 1786587 CHEMBL3325777 1786587 1 542.7 3.95 88.13 1 CC[C@]12CC[C@](C)(O1)[C@H]3CC[C@@]4(C)C5=C(C(=O)C[C@]34CO2)[C@@](C)(CCC(=O)OC)[C@@H](C[C@@H]5OC(=O)C)C(=C)C 15018481 IC50 = 4000 nM 5.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1453443 CHEMBL3361764 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90123 CHEMBL3352211 J. Nat. Prod. 2014 77 8 1847
CHEMBL3219641 1726033 CHEMBL3219641 1726033 13a 237.25 2.77 38.33 0 O=C1C=CNc2ccc(Oc3ccccc3)cc12 14545605 IC50 = 4698 nM 5.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3125844 1622453 CHEMBL3125844 1622453 trans-D1, (-)-trans-D1 367.4 1.66 107.47 0 COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@@H](N1)c4c(O)c(C)ncc4CO 13953876 IC50 = 8000 nM 5.1 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296432 CHEMBL3130133 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77215 CHEMBL3124773 24565970 Bioorg. Med. Chem. 2014 22 6 1832
CHEMBL3109533 1614734 CHEMBL3109533 1614734 8f 341.41 3.95 56.19 0 N=C1NC(C(=O)N1Cc2ccccc2)(c3ccccc3)c4ccccc4 13891658 IC50 = 8290 nM 5.08 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL61 4775 CHEMBL61 4775 PODOFILOX PPT 414.41 2.11 92.68 0 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 15128135 IC50 = 9200 nM 5.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3113928 1616891 CHEMBL3139258 1628589 9, VAM2-9 306.36 1.93 81.39 0 Br.CN(C)CCCCCN1CC(=O)Nc2cc(ccc12)[N+](=O)[O-] 13910789 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3114090 1617055 CHEMBL3139390 1628721 15, VAM2-15 346.42 2.6 72.61 0 Br.CN1C(=O)CN(CCCCCN2CCCC2)c3ccc(cc13)[N+](=O)[O-] 13910783 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3260218 1745164 CHEMBL3260218 1745164 1m 260.33 4.46 17.3 0 C\C=C\C=C\C=C\c1nc2ccccc2n3cccc13 14668031 IC50 = 10100 nM 5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL354676 282288 CHEMBL354676 282288 DIPHENYLUREA 13 212.25 2.52 41.13 0 O=C(Nc1ccccc1)Nc2ccccc2 15127445 IC50 = 13790 nM 4.86 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3125840 1622449 CHEMBL3125840 1622449 PT3 367.4 1.66 107.47 0 COC(=O)C1Cc2c([nH]c3ccccc23)C(N1)c4c(O)c(C)ncc4CO 13953880 IC50 = 14000 nM 4.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296432 CHEMBL3130133 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77215 CHEMBL3124773 24565970 Bioorg. Med. Chem. 2014 22 6 1832
CHEMBL3261885 1746848 CHEMBL3261885 1746848 8 345.52 4.66 38.33 0 CC(=CCC\C(=C\CNC(=O)COC1C2CC3CC(CC1C3)C2)\C)C 14651658 IC50 = 18000 nM 4.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3103565 1611638 CHEMBL3103565 1611638 10 256.25 2.87 67.5 0 Cc1oc(cc1)C(=O)\C=C\c2ccc(cc2)C(=O)O 13886150 IC50 = 18400 nM 4.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL288084 45637 CHEMBL288084 45637 12 260.33 2.68 54.12 0 CCCC(=O)NCCc1c[nH]c2ccc(OC)cc12 14579773 IC50 = 19170 nM 4.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338673 CHEMBL3242011 F Antiplasmodial activity against ring stage synchronized Plasmodium falciparum 3D7 infected in erythrocytes assessed as parasitemia level after 48 hrs by flow cytometry relative to control 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82320 CHEMBL3232831 24699367 Eur. J. Med. Chem. 2014 78 375
CHEMBL3329599 1788586 CHEMBL3329599 1788586 11c 326.41 5.04 82.45 1 CCOC(=O)\C=C\c1cccc(NC(=S)Nc2ccccc2)c1 15127443 IC50 > 20000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL337309 228888 CHEMBL337309 228888 TAXIFOLIN 9, Dihydroquercetin 304.25 1.48 127.45 0 OC1C(Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3 13928643 IC50 = 48170 nM 4.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3358138 1822293 CHEMBL3558741 1940587 15 742 4.35 177.84 2 CC[C@H](C)[C@H]([NH+](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)NCc1ccccc1.[O-]C(=O)C(F)(F)F 15121659 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3233221 1731722 CHEMBL3233221 1731722 5l 615.55 8.03 72.39 2 CCOC(=O)C1=CN(Cc2ccc(cc2)C(F)(F)F)c3ccc4nc(c5ccc(F)cc5)c(nc4c3C1=O)c6ccc(F)cc6 14599601 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3233232 1731733 CHEMBL3233232 1731733 6k 537.49 6.71 83.39 2 OC(=O)C1=CN(Cc2ccc(F)cc2)c3ccc4nc(c5ccc(F)cc5)c(nc4c3C1=O)c6ccc(F)cc6 14599612 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3125841 1622450 CHEMBL3125841 1622450 Cis-L1, (+)-cis-L1 367.4 1.66 107.47 0 COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](N1)c4c(O)c(C)ncc4CO 13953879 IC50 = 91000 nM 4.04 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1296432 CHEMBL3130133 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77215 CHEMBL3124773 24565970 Bioorg. Med. Chem. 2014 22 6 1832
CHEMBL3236234 1734765 CHEMBL3236234 1734765 10 350.41 1.54 65.01 0 CC(C)N(Cc1ccccc1)C(=O)NC2=CN=C3C=C(C)C=CN3C2=O 14580087 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338917 1793422 CHEMBL3338917 1793422 6a 554.7 5.23 73.2 2 [O-][S+]1C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6ccccc16 15119921 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236236 1734767 CHEMBL3236236 1734767 12 296.71 -1.18 83.03 0 COCCNC(=O)NC1=CN=C2C=CC(=CN2C1=O)Cl 14580089 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3109532 1614733 CHEMBL3109532 1614733 8e 387.43 3.91 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C2=O)c3ccccc3)c4ccc(OC)cc4 13891659 IC50 = 100000 nM 4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3236249 1734780 CHEMBL3236249 1734780 26 380.4 .68 100.1 0 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)NC2=CN=C3C=CC=CN3C2=O 14580102 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236254 1734785 CHEMBL3236254 1734785 33 309.32 .5 71 0 COc1ccc(CNC(=O)C2=CN=C3C=CC=CN3C2=O)cc1 14580107 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338906 1793411 CHEMBL3338906 1793411 3d 594.8 7.74 62.22 2 CC(C)(C)c1ccc2SC[C@@H]3[C@@H](OCc4ccccc4)[C@H](OCc5ccccc5)[C@@H](COCc6ccccc6)O[C@@H]3c2c1 15119932 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236252 1734783 CHEMBL3236252 1734783 30 333.34 .35 97.59 0 O=C(N[C@@H](Cc1ccccc1)C#N)NC2=CN=C3C=CC=CN3C2=O 14580105 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3402977 1833193 CHEMBL3402977 1833193 7 300.35 1.92 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183813 IC50 = 141600 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402978 1833194 CHEMBL3402978 1833194 8 314.38 2.37 57.69 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCCC3 15183814 IC50 = 146430 nM Outside typical range 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3409910 1836682 CHEMBL3409910 1836682 77 694.88 4.2 123.32 1 CC(C)C[C@H](NC(=O)CN1CCN(C)CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N2CCC[C@H]2COc3ccc(F)cc3)c4ccccc4 15199155 IC50 Not Active 0 BAO_0000190 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3099824 1610607 CHEMBL3099824 1610607 4b 409.87 2.68 100.64 0 COc1ccc(cc1)C(NCCNc2ccnc3cc(Cl)ccc23)c4nnn[nH]4 13862663 IC50 Not Determined 0 BAO_0000190 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL2048505 1351938 CHEMBL2048505 1351938 DIMETHYL LITHOSPERMATE 2 566.51 3.91 189.27 2 COC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c3O[C@@H]([C@@H](C(=O)OC)c23)c4ccc(O)c(O)c4 13928650 IC50 Not Determined 0 BAO_0000190 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3238455 1737009 CHEMBL3238455 1737009 5d 459.5 6.28 72.39 1 CCOC(=O)C1=CN(CC#C)c2ccc3nc(c4ccccc4)c(nc3c2C1=O)c5ccccc5 14599593 IC50 ND(Insoluble) 0 BAO_0000190 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3299076 1763420 CHEMBL3299076 1763420 7 309.34 2.6 100.19 0 O=Cc1ccc(cc1)C(=O)Nc2nc(cs2)c3ccccn3 15005169 IC50 Not Determined 0 BAO_0000190 1451722 CHEMBL3366915 F Antiplasmodium activity against blood stage Plasmodium falciparum 3D7 assessed as reduction in parasite growth after 72 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 84057 CHEMBL3297686 24786226 J. Med. Chem. 2014 57 11 4521
CHEMBL3219926 1726321 CHEMBL3219926 1726321 46 592.14 7.75 85.33 2 CCN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCc7ccccc7C6 14545690 IC50 = .0121 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL3219925 1726320 CHEMBL3219925 1726320 45 578.11 7.4 85.33 2 CN1CCN(CC1)c2nc(Nc3ccc(Nc4ccnc5cc(Cl)ccc45)cc3)nc(n2)N6CCc7ccccc7C6 14545689 IC50 = .0281 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1330162 CHEMBL3223790 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81834 CHEMBL3217722 MedChemComm 2012 3 1 71
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15239354 IC50 < .19 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1475830 CHEMBL3425119 F Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 cultivated in human type O+ red blood cells assessed as reduction in parasite infection incubated for 48 hrs by microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91699 CHEMBL3421546 25920564 Bioorg. Med. Chem. Lett. 2015 25 11 2308
CHEMBL3099820 1610603 CHEMBL3099820 1610603 3d 504.84 5.16 80.55 2 CC(C)(C)n1nnnc1C(NCCNc2ccnc3cc(Cl)ccc23)c4ccc(Cl)c(Cl)c4 13862668 IC50 = .4 nM 9.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL3218233 1724611 CHEMBL3218233 1724611 9 349.46 2.97 40.16 0 C1CCN(C1)C2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530891 IC50 = .7 nM 9.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL2387268 1564043 CHEMBL2387268 1564043 Scheme-1, R1C2 503.67 2.35 63.71 1 CN1CCN(CC1)C2CCN(CC2)C(=O)CC3CCC4(CC3)OOC5(OO4)C6CC7CC(CC5C7)C6 13854050 IC50 = .9 nM 9.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279484 CHEMBL3097009 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3218243 1724621 CHEMBL3218243 1724621 19 335.44 2.46 48.95 0 C1CC1NC2CCC3(CC2)OOC4(OO3)C5CC6CC(CC4C6)C5 14530901 IC50 = 1.5 nM 8.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1327298 CHEMBL3225043 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81804 CHEMBL3217563 MedChemComm 2011 2 7 661
CHEMBL567979 577678 CHEMBL567979 577678 6 296.32 2.34 58.29 0 COc1ccc2c(c1)C(=O)C(=[N+]2[O-])c3ccc(cc3)N(C)C 14535872 IC50 = 1.7 nM 8.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328342 CHEMBL3223045 F Antiplasmodial activity against Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81813 CHEMBL3217635 MedChemComm 2011 2 9 860
CHEMBL361497 316347 CHEMBL361497 316347 ARTESUNATE AS 384.42 1.85 100.52 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@H](OC(=O)CCC(=O)O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 15128136 IC50 = 1.9 nM 8.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL2414256 1575489 CHEMBL2414256 1575489 3e 470.4 4.49 80.55 0 CC(C)(C)n1nnnc1C(NCCNc2ccnc3cc(Cl)ccc23)c4ccc(Cl)cc4 13862667 IC50 = 2 nM 8.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1281764 CHEMBL3100533 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76309 CHEMBL3098028 ACS Med. Chem. Lett. 2013 4 12 1198
CHEMBL252518 420212 CHEMBL252518 420212 ARTENIMOL DHA 284.35 1.62 57.15 0 C[C@@H]1CC[C@H]2[C@@H](C)[C@@H](O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 13854140 IC50 = 3.5 nM 8.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3093730 1608114 CHEMBL3093730 1608114 9 776.95 5.49 132.04 2 O=C(CC1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)NCc6cccc(CNC(=O)CC7CCC8(CC7)OOC9(OO8)C%10CC%11CC(CC9C%11)C%10)c6 13855012 IC50 = 4 nM 8.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3343959 1796118 CHEMBL3343959 1796118 R-13f 291.82 3.65 28.16 0 C[C@H](CCCN(C)C)Nc1ccnc2cc(Cl)ccc12 15139445 IC50 = 6 nM 8.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL1956290 1281810 CHEMBL1956290 1281810 7, DSM195 361.25 4.6 55.11 0 Cc1cc(Nc2ccc(cc2)C(F)(F)F)n3nc(nc3n1)C(F)(F)F 14734086 IC50 = 6.3 nM 8.2 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE Chloroquine 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14572066 IC50 = 6.57 nM 8.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3343955 1796114 CHEMBL3343955 1796114 R-13d 346.9 3.61 31.4 0 C[C@H](CCCN1CCN(C)CC1)Nc2ccnc3cc(Cl)ccc23 15139449 IC50 = 6.92 nM 8.16 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL3343963 1796122 CHEMBL3343963 1796122 R-13h 305.85 4 28.16 0 CCN(C)CCC[C@@H](C)Nc1ccnc2cc(Cl)ccc12 15139441 IC50 = 7.78 nM 8.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1433294 CHEMBL3389401 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by Malaria SYBR Green I-nucleic acid staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89540 CHEMBL3352664 25284252 Bioorg. Med. Chem. 2014 22 21 5950
CHEMBL2263535 1481386 CHEMBL2263535 1481386 9 337.41 4.29 38.77 0 COc1cc(OC)cc(\C=C\C(=O)c2ccc(cc2)N3CCCC3)c1 12460153 IC50 = 8.43 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 909864 CHEMBL3055177 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 after 48 hr by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69902 CHEMBL3046891 Med Chem Res 2009 18 6 407
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 14718482 IC50 = 10 nM 8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE 16, CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15127448 IC50 = 11 nM 7.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL567597 575613 CHEMBL567597 575613 ARTEMISININ Artemisinin 282.33 2 53.99 0 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@]4(C)CC[C@@H]1[C@@]23OO4 14710398 IC50 = 13 nM 7.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1362075 CHEMBL3294628 F Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83803 CHEMBL3286375 24813731 Bioorg. Med. Chem. Lett. 2014 24 12 2645
CHEMBL3402980 1833196 CHEMBL3402980 1833196 10 362.42 3.09 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCCCC4 15183765 IC50 = 13.05 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 12450942 IC50 = 14 nM 7.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL2237990 1473525 CHEMBL2237990 1473525 6 337.28 3.08 109.41 0 OC1=C(C(=O)\C=C\c2cccc(c2)[N+](=O)[O-])C(=O)Oc3ccccc13 12393217 IC50 = 15.6 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 900243 CHEMBL3051455 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by in vitro cell culture method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69063 CHEMBL3044612 Med Chem Res 2012 21 8 1780
CHEMBL3402988 1833205 CHEMBL3402988 1833205 20 330.38 1.6 66.92 0 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCOCC3 15183775 IC50 = 20 ug.mL-1 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL1631 476316 CHEMBL1631 476316 BIDESETHYL AMODIAQUINE BIDESAQ 299.75 3.09 71.17 0 NCc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 12450926 IC50 = 21 nM 7.68 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL76 6579 CHEMBL76 6579 CHLOROQUINE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 15164952 IC50 = 23 nM 7.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL3286863 1757384 CHEMBL3286863 1757384 4g 532.03 4.44 118.83 1 CC(C)CN(NC(=O)C1CCC2(CC1)OOC3(OO2)C4CC5CC(CC3C5)C4)c6cc(Cl)nc(n6)C#N 14724800 IC50 = 28.4 nM 7.55 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1364095 CHEMBL3292034 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by FACS analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83829 CHEMBL3286314 24824551 J. Med. Chem. 2014 57 11 4916
CHEMBL3112874 1615827 CHEMBL3140283 1629614 28 575.19 9.68 14.24 2 [Br-].[Br-].CN(c1ccc(Cl)cc1)c2cc[n+](Cc3ccc(CCc4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)cc3)cc2 15026487 IC50 = 31 nM 7.51 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3235666 1734191 CHEMBL3235666 1734191 5{2,2,3,3} 600.54 7.94 79.8 2 COc1ccc(Oc2ccc(N\C(=N\c3ccc(Cl)cc3)\NCCCCNc4ccnc5cc(Cl)ccc45)cc2)cc1 14575159 IC50 = 33.7 nM 7.47 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3235641 1734166 CHEMBL3235641 1734166 12{1,2,1} 640.56 8.09 96.87 2 COC(=O)\C(=C\c1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCNc4ccnc5cc(Cl)ccc45)cc1)\C 14575160 IC50 = 34.87 nM 7.46 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3410326 1837103 CHEMBL3410326 1837103 3a 555.46 4.54 165.73 2 CCCCOC(=O)OCOP(=O)(OCOC(=O)OCCCC)C(CCC(=O)NO)c1ccc(F)c(F)c1 15192768 IC50 = 39 nM 7.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3311429 1780539 CHEMBL3311429 1780539 7f 474.98 3.72 66.49 0 Clc1ccc2c(NCCNCC3=CC(=O)C(=CN3C4CC4)OCc5ccccc5)ccnc2c1 15011088 IC50 = 40 nM 7.4 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3235630 1734155 CHEMBL3235630 1734155 5{2,1,2,1} 572.48 7.3 79.8 2 COc1ccc(Oc2ccccc2N\C(=N\c3cccc(Cl)c3)\NCCNc4ccnc5cc(Cl)ccc45)cc1 14575170 IC50 = 43.42 nM 7.36 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3410329 1837106 CHEMBL3410329 1837106 3b 527.41 3.34 165.73 2 CC(C)OC(=O)OCOP(=O)(OCOC(=O)OC(C)C)C(CCC(=O)NO)c1ccc(F)c(F)c1 15192771 IC50 = 49 nM 7.31 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL579223 577677 CHEMBL579223 577677 1 301.68 2.63 64.28 0 [O-][N+]1=C(C(=O)c2cc3OCOc3cc12)c4ccc(Cl)cc4 15048718 IC50 = 58 nM 7.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1447345 CHEMBL3379769 F Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90150 CHEMBL3352368 24594524 Eur. J. Med. Chem. 2014 76 369
CHEMBL3309591 1778682 CHEMBL3309591 1778682 14f 374.91 3.43 48.47 0 CC(C)C[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)N3CCN(C)CC3 15031386 IC50 = 60.16 nM 7.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL3309581 1778672 CHEMBL3309581 1778672 6e 360.88 3.09 57.26 0 C[C@H](Nc1ccnc2cc(Cl)ccc12)C(=O)NCCN3CCCCC3 15031387 IC50 = 64.09 nM 7.19 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL58510 90635 CHEMBL76 6579 CHLOROQUINE DIPHOSPHATE CQ 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.OP(=O)(O)O.OP(=O)(O)O 15183831 IC50 = 66 nM 7.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3358128 1822283 CHEMBL3558771 1940617 1 577.76 2.8 137.14 1 COC1=CC(=O)N([C@H]1C)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)[NH+](C)C.[O-]C(=O)C(F)(F)F 15121649 IC50 = 89.3 nM 7.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3289159 1759704 CHEMBL3289159 1759704 1i 322.4 2.63 87.66 0 CC(C)(C)c1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14718483 IC50 = 90 nM 7.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3103528 1611601 CHEMBL3103528 1611601 18 545.07 5.02 87.47 2 CN(CCCNC(=O)c1ccc(\C=C\C(=O)c2oc(C)cc2)cc1)CCCNc3ccnc4cc(Cl)ccc34 13886182 IC50 = 90 nM 7.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL1951745 1280735 CHEMBL1962939 1284650 6 490.62 5.59 76.73 1 [Br-].Nc1ncnc2c1ncn2Cc3ccc(CCc4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)cc3 15026509 IC50 = 93 nM 7.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3309584 1778675 CHEMBL3309584 1778675 8a 408.92 3.75 48.47 0 CN1CCN(CC1)C(=O)[C@H](Cc2ccccc2)Nc3ccnc4cc(Cl)ccc34 15031393 IC50 = 108.9 nM 6.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456263 CHEMBL3362373 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by SYBR Green-1 staining-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90228 CHEMBL3352032 24906512 Bioorg. Med. Chem. 2014 22 14 3573
CHEMBL58510 90635 CHEMBL76 6579 CHLOROQUINE DIPHOSPHATE Chloroquine diphosphate 319.87 4.35 28.16 0 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.OP(=O)(O)O.OP(=O)(O)O 14746084 IC50 = 110 nM 6.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1361747 CHEMBL3292172 F Antiplasmodial activity against drug susceptible Plasmodium falciparum 3D7 NF54 isolate in human erythrocytes assessed as growth inhibition after 48 hrs by optical microscopy 1 Scientific Literature Plasmodium falciparum 3D7 NF54 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83801 CHEMBL3286184 24813729 Bioorg. Med. Chem. Lett. 2014 24 12 2631
CHEMBL3326563 1787381 CHEMBL3558264 1940110 17 569.74 7.55 76.02 2 [Br-].C(Sc1ncnc2c1ncn2Cc3ccc(cc3)c4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)c7ccccc7 15026498 IC50 = 119 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3415867 1839061 CHEMBL3415867 1839061 1b 329.17 4.81 17.82 0 Cn1cc2c3cc(Br)ccc3nc2c4cc(F)ccc14 15217323 IC50 = 119.3 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3311427 1780537 CHEMBL3311427 1780537 7d 477 3.87 66.49 0 CN1C=C(OCc2ccccc2)C(=O)C=C1CNCCCCNc3ccnc4cc(Cl)ccc34 15011086 IC50 = 120 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL2312167 1511211 CHEMBL2312167 1511211 1b 294.35 2.2 87.66 0 Cc1ccc(cc1C)C(=O)NOCCCCCC(=O)NO 14718485 IC50 = 120 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL2312163 1511207 CHEMBL2312163 1511207 1c 308.37 2.43 87.66 0 CC(C)c1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14718486 IC50 = 120 nM 6.92 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3416951 1840156 CHEMBL3416951 1840156 1 313.42 4.01 81.73 0 Cc1ccc(cc1)c2cc3N=C(NC(C)(C)C)NC(=O)c3s2 15211673 IC50 = 140 nM 6.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3309527 1778618 CHEMBL3309527 1778618 8e 414.93 2.98 77.49 0 CN1C=C(O)C(=O)C=C1CNCCCCCCNc2ccnc3cc(Cl)ccc23 15011097 IC50 = 150 nM 6.82 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3289161 1759706 CHEMBL3289161 1759706 1k 342.39 2.75 87.66 0 ONC(=O)CCCCCONC(=O)c1ccc(cc1)c2ccccc2 14718489 IC50 = 160 nM 6.8 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL1951746 1280736 CHEMBL1963071 1284782 7 492.64 6.04 76.73 1 [Br-].CN(C)c1cc[n+](Cc2ccc(CCCCc3ccc(Cn4cnc5c(N)ncnc45)cc3)cc2)cc1 15026508 IC50 = 162 nM 6.79 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3415870 1839064 CHEMBL3415870 1839064 1e 301.17 5.18 17.82 1 Cn1cc2c3cc(Cl)ccc3nc2c4cc(Cl)ccc14 15217326 IC50 = 172.2 nM 6.76 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1471795 CHEMBL3417906 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91542 CHEMBL3414562 25747499 Eur. J. Med. Chem. 2015 94 56
CHEMBL3219643 1726035 CHEMBL3219643 1726035 14a 323.34 3.32 64.63 0 CC(C)OC(=O)C1=CNc2ccc(Oc3ccccc3)cc2C1=O 14545607 IC50 = 183.9 nM 6.74 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3311433 1780543 CHEMBL3311433 1780543 7j 531.09 5.28 66.49 2 Clc1ccc2c(NCCCCCCNCC3=CC(=O)C(=CN3C4CC4)OCc5ccccc5)ccnc2c1 15011092 IC50 = 190 nM 6.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1456431 CHEMBL3368880 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90381 CHEMBL3352080 24974345 Bioorg. Med. Chem. Lett. 2014 24 15 3263
CHEMBL3264796 1749788 CHEMBL3264796 1749788 1SS 692.91 4.95 136.66 1 CCCN(CCC)C(=O)c1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@@H](O)CNC(C)(C)c3cccc(OC)c3)N4CCCCS4(=O)=O 14656157 IC50 = 200 nM 6.7 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1353682 CHEMBL3271814 F Antimalarial activity against blood-stage Plasmodium falciparum 3D7 assessed as inhibition of parasite growth after 96 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83020 CHEMBL3259525 ACS Med. Chem. Lett. 2014 5 4 373
CHEMBL3289167 1759712 CHEMBL3289167 1759712 1q 324.37 2.09 96.89 0 CCCOc1cccc(c1)C(=O)NOCCCCCC(=O)NO 14720529 IC50 = 240 nM 6.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3109528 1614729 CHEMBL3109528 1614729 8a 443.54 5.01 74.65 1 CCC(CN1C(=N)NC(C1=O)(c2ccc(OC)cc2)c3ccc(OC)cc3)c4ccccc4 13891665 IC50 = 244 nM 6.61 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3416958 1840163 CHEMBL3416958 1840163 8 299.39 3.8 81.73 0 CC(C)NC1=Nc2cc(sc2C(=O)N1)c3ccc(C)cc3 15211672 IC50 = 247 nM 6.61 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1470497 CHEMBL3419214 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91563 CHEMBL3414541 25791675 Eur. J. Med. Chem. 2015 95 16
CHEMBL3335103 1791234 CHEMBL3335103 1791234 14 386.27 4.5 70.97 0 N\C(=N/N=C/c1ccc(Cl)c(Cl)c1)\CC(O)c2cccc3ccccc23 15128123 IC50 = 250 nM 6.6 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1432089 CHEMBL3389348 F Antiplasmodial activity against Plasmodium falciparum 3D7 asexual blood stages after 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89298 CHEMBL3351566 25195945 J. Med. Chem. 2014 57 19 7971
CHEMBL3289168 1759713 CHEMBL3289168 1759713 1r 322.4 3.09 87.66 0 CCCCc1ccc(cc1)C(=O)NOCCCCCC(=O)NO 14720531 IC50 = 260 nM 6.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL492529 476772 CHEMBL492529 476772 8, DSM267 293.25 3.55 55.11 0 Cc1cc(Nc2ccc(cc2)C(F)(F)F)n3ncnc3n1 14734105 IC50 = 260 nM 6.59 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1366445 CHEMBL3296345 F Antimalarial activity against Plasmodium falciparum 3D7 infected in RBC after 72 hrs by SYBR green dye based flow cytometry 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83791 CHEMBL3286300 24801997 J. Med. Chem. 2014 57 12 5381
CHEMBL3103527 1611599 CHEMBL3103527 1611599 16 487.98 5.03 75.44 1 CN(CCCNc1ccnc2cc(Cl)ccc12)C(=O)c3ccc(\C=C\C(=O)c4oc(C)cc4)cc3 13886173 IC50 = 370 nM 6.43 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3338926 1793431 CHEMBL3338926 1793431 7d 626.8 6.73 79.44 2 CC(C)(C)c1ccc2c(c1)[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119912 IC50 = 390 nM 6.41 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3093743 1608127 CHEMBL3093743 1608127 25 592.68 2.2 132.04 1 CC1(CCC(=O)NCc2cccc(CNC(=O)CCC3(C)OOC4(CCCCC4)OO3)c2)OOC5(CCCCC5)OO1 13854144 IC50 = 415.5 nM 6.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1279485 CHEMBL3097010 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 48 hrs by SYBR green-1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76174 CHEMBL3091350 24148834 Bioorg. Med. Chem. 2013 21 23 7392
CHEMBL3114827 1617799 CHEMBL3139373 1628704 17 307.33 -1.54 119.63 0 Cl.Cn1cc(CCN)c2C(=O)C3=C(C(=O)c12)S(=O)(=O)C=CN3 13924100 IC50 = 416 nM 6.38 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1289813 CHEMBL3119287 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76783 CHEMBL3112478 ACS Med. Chem. Lett. 2014 5 2 178
CHEMBL3109548 1614749 CHEMBL3109548 1614749 9e 494.58 3.28 104.19 0 COc1ccc(cc1)C2(NC(=N)N(C3CCN(CC3)C(=O)OC(C)(C)C)C2=O)c4ccc(OC)cc4 13891350 IC50 = 436 nM 6.36 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL1951747 1280737 CHEMBL1962410 1284121 8 518.68 6.5 76.73 2 [Br-].Nc1ncnc2c1ncn2Cc3ccc(CCCCc4ccc(C[n+]5ccc(cc5)N6CCCC6)cc4)cc3 15026507 IC50 = 460 nM 6.34 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3109550 1614751 CHEMBL3109550 1614751 9g 409.48 2.75 83.88 0 COc1ccc(cc1)C2(NC(=N)N(CC3CCOCC3)C2=O)c4ccc(OC)cc4 13891348 IC50 = 463 nM 6.33 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL2164262 1427687 CHEMBL2164262 1427687 5 311.18 .55 117.11 0 CN(O)C(=O)COC(c1ccc(F)c(F)c1)P(=O)(O)O 15192767 IC50 = 540 nM 6.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL2311802 1510842 CHEMBL2311802 1510842 1g 284.28 1.44 87.66 0 ONC(=O)CCCCCONC(=O)c1ccc(F)cc1 14720533 IC50 = 580 nM 6.24 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3109520 1614721 CHEMBL3109520 1614721 (+/-)-10k 440.54 4.58 78.31 0 COc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4cccc(c4)c5cccnc5 13891337 IC50 = 595 nM 6.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3109541 1614742 CHEMBL3109541 1614742 8n 379.45 3.73 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C3CCCC3)C2=O)c4ccc(OC)cc4 13891358 IC50 = 611 nM 6.21 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3359690 1823861 CHEMBL3359690 1823861 13a 274.28 .19 96.25 0 CC(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106730 IC50 = 619 nM 6.21 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3289170 1759715 CHEMBL3289170 1759715 1t 256.26 .63 100.8 0 ONC(=O)CCCCCONC(=O)c1occc1 14720534 IC50 = 620 nM 6.21 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1365849 CHEMBL3296470 F Antimalarial activity against asexual blood stage of Plasmodium falciparum 3D7 infected in human serum assessed as [3H]hypoxanthine incorporation incubated for 48 hrs prior to 3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83947 CHEMBL3286295 24904967 Eur. J. Med. Chem. 2014 82 204
CHEMBL3235278 1733799 CHEMBL3235278 1733799 5{1,1,3,3} 639.4 9.29 70.57 2 Clc1ccc(cc1)\N=C(/NCCCCNc2ccnc3cc(Cl)ccc23)\Nc4ccccc4Oc5cc(Cl)ccc5Cl 14578317 IC50 = 653.5 nM 6.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1337264 CHEMBL3240878 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected after 72 hrs by Malaria SYBR Green I-staining based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82186 CHEMBL3232804 24630564 Bioorg. Med. Chem. Lett. 2014 24 7 1719
CHEMBL3401308 1831508 CHEMBL3401308 1831508 10a 464.05 6.05 36.33 1 CCN(CC)CCNc1cc(Cl)cc2nc3c4ccccc4n(CCN5CCCC5)c3cc12 15164936 IC50 = 656 nM 6.18 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465729 CHEMBL3405490 F Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected with human red blood cells incubated for 48 hrs by SYBR Green method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91115 CHEMBL3400065 25725608 Bioorg. Med. Chem. 2015 23 7 1530
CHEMBL468610 495781 CHEMBL468610 495781 AQPYRID 271.36 2.76 48.39 0 CCN(CC)Cc1cc(Nc2ccncc2)ccc1O 12450927 IC50 = 680 nM 6.17 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 910493 CHEMBL3055250 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 69829 CHEMBL3044897 Med Chem Res 2007 16 5 213
CHEMBL3109540 1614741 CHEMBL3109540 1614741 8m 365.43 3.28 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C3CCC3)C2=O)c4ccc(OC)cc4 13891359 IC50 = 722 nM 6.14 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3109525 1614726 CHEMBL3109525 1614726 10p 487.59 4.96 81.97 0 N=C1NC(C(=O)N1C2CCCCC2)(c3cccc(c3)c4cccnc4)c5cccc(c5)c6cccnc6 13891332 IC50 = 725 nM 6.14 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3359688 1823859 CHEMBL3359688 1823859 7 332.35 1.76 105.48 0 CC(C)(C)OC(=O)NC(C(=O)NO)c1ccc(cc1)n2cccn2 15106731 IC50 = 783 nM 6.11 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438461 CHEMBL3384273 F Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 72 hrs by DAPI staining based confocal microscopy 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89558 CHEMBL3351583 25299353 J. Med. Chem. 2014 57 21 9168
CHEMBL3109534 1614735 CHEMBL3109534 1614735 8g 401.46 3.92 74.65 0 COc1ccc(cc1)C2(NC(=N)N(Cc3ccccc3)C2=O)c4ccc(OC)cc4 13891657 IC50 = 855 nM 6.07 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3329577 1788564 CHEMBL3329577 1788564 7c 685.63 1.9 227.67 2 COc1ccc(NC(=O)Nc2cccc(\C=C\C(=O)C[C@@H]3O[C@H](COC(=O)C)[C@@H](OC(=O)C)[C@H](OC(=O)C)[C@H]3OC(=O)C)c2)c(c1)[N+](=O)[O-] 15127421 IC50 = 940 nM 6.03 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL1951749 1280739 CHEMBL1963130 1284841 10 436.53 4.22 76.73 0 [Br-].CN(C)c1cc[n+](Cc2ccc(cc2)c3ccc(Cn4cnc(N)c5ncnc45)cc3)cc1 15026505 IC50 = 949 nM 6.02 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1448863 CHEMBL3375065 F Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90672 CHEMBL3351532 25089811 Eur. J. Med. Chem. 2014 85 289
CHEMBL3222266 1728684 CHEMBL3222266 1728684 13 495.92 2.32 141.66 0 CC(C)(C)N(Cc1cc(Nc2ccnc3cc(Cl)ccc23)cc(c1)c4no[n+]([O-])c4\C=N\O)N=O 14536786 IC50 = 1070 nM 5.97 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1328984 CHEMBL3223115 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81968 CHEMBL3217651 MedChemComm 2012 3 12 1505
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183785 IC50 = 1100 nM 5.96 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465109 CHEMBL3405441 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 90 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3109556 1614757 CHEMBL3109556 1614757 10f 361.48 5.2 56.19 1 Cc1ccc(cc1)C2(NC(=N)N(C3CCCCC3)C2=O)c4ccc(C)cc4 13891342 IC50 = 1260 nM 5.9 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3353312 1817419 CHEMBL3353312 1817419 6u 281.31 3.21 49.77 0 COc1ccc2N(O)C(=O)C(=Cc2c1)c3ccccc3C 14971664 IC50 = 1300 nM 5.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3353305 1817412 CHEMBL3353305 1817412 6n 317.34 3.64 49.77 0 COc1ccc2N(O)C(=O)C(=Cc2c1)c3cccc4ccccc34 14971657 IC50 = 1300 nM 5.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3402992 1833209 CHEMBL3402992 1833209 24 572.65 3.46 115.38 1 CC[C@@H](C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCN(CC3)C(=O)[C@H]([C@H](C)CC)N4C(=O)c5ccccc5C4=O 15183795 IC50 = 1390 nM 5.86 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465117 CHEMBL3405449 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 42 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis in presence of 25 ng/ml 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3353309 1817416 CHEMBL3353309 1817416 6r 305.3 3.86 40.54 0 ON1C(=O)C(=Cc2c(F)cccc12)c3cccc4ccccc34 14971661 IC50 = 1400 nM 5.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3087893 1605375 CHEMBL3087893 1605375 3e 321.33 2.77 75.63 0 Cc1ccc(NC(=O)C2=C(O)C=C(OC2=O)c3ccccc3)cc1 13836545 IC50 = 1420 nM 5.85 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1275216 CHEMBL3091119 F Antimalarial activity against ring-stage Plasmodium falciparum 3D7 assessed as schizonticidal activity after 42 hrs 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76085 CHEMBL3085730 24211636 Eur. J. Med. Chem. 2013 70 607
CHEMBL3109537 1614738 CHEMBL3109537 1614738 8j 353.41 3.06 74.65 0 COc1ccc(cc1)C2(NC(=N)N(C(C)C)C2=O)c3ccc(OC)cc3 13891362 IC50 = 1660 nM 5.78 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3344516 1796680 CHEMBL3344516 1796680 1 391.89 5.18 45.23 1 Clc1ccc2nc(NCCN3CCCCC3)c4C(=O)c5ccccc5c4c2c1 15083311 IC50 = 1713 nM 5.77 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3358133 1822288 CHEMBL3558722 1940568 10 680.88 1.8 186.48 1 CC[C@H](C)[C@H]([NH+](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)OC.[O-]C(=O)C(F)(F)F 15121654 IC50 = 1900 nM 5.72 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3329575 1788562 CHEMBL3329575 1788562 7a 610.61 2.03 172.63 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=O)Nc3ccccc3)c2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127419 IC50 = 2290 nM 5.64 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3338924 1793429 CHEMBL3338924 1793429 7b 584.72 5.81 79.44 2 Cc1ccc2c(c1)[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS2(=O)=O 15119914 IC50 = 2320 nM 5.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338927 1793432 CHEMBL3338927 1793432 7e 584.72 5.81 79.44 2 Cc1cccc2[C@H]3O[C@H](COCc4ccccc4)[C@@H](OCc5ccccc5)[C@H](OCc6ccccc6)[C@H]3CS(=O)(=O)c12 15119911 IC50 = 2340 nM 5.63 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3261883 1746846 CHEMBL3261883 1746846 6 345.56 5.27 21.26 1 CC(=CCC\C(=C\CNCCCOC1C2CC3CC(CC1C3)C2)\C)C 14651656 IC50 = 2400 nM 5.62 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL561057 555040 CHEMBL561057 555040 1, SQ109 330.55 4.94 24.06 0 CC(=CCC\C(=C\CNCCNC1C2CC3CC(CC1C3)C2)\C)C 14651652 IC50 = 3000 nM 5.52 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1352746 CHEMBL3267780 F Antimicrobial activity against Plasmodium falciparum 3D7 by intraerythrocytic assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83048 CHEMBL3259693 24568559 J. Med. Chem. 2014 57 7 3126
CHEMBL3260207 1745153 CHEMBL3260207 1745153 1b 264.32 3.97 26.53 0 COc1ccc2c(c1)nc(\C=C\C=C\C)c3cccn23 14668020 IC50 = 3300 nM 5.48 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3353315 1817422 CHEMBL3353315 1817422 6x 269.27 3.44 40.54 0 Cc1ccccc1C2=Cc3cc(F)ccc3N(O)C2=O 14971667 IC50 = 4800 nM 5.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3109546 1614747 CHEMBL3109546 1614747 9c 394.47 1.91 86.68 0 COc1ccc(cc1)C2(NC(=N)N(C3CCNCC3)C2=O)c4ccc(OC)cc4 13891352 IC50 > 5000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1286907 CHEMBL3110821 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in RBV after 72 hrs by SYBR Green I-based fluorescence method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76635 CHEMBL3108756 ACS Med. Chem. Lett. 2014 5 1 89
CHEMBL3409899 1836671 CHEMBL3409899 1836671 66 666.78 3.37 141.66 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1)C(=O)N[C@H](C(=O)N2CCN=C2COc3ccc(F)cc3)c4ccccc4 15199119 IC50 > 5000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3329579 1788566 CHEMBL3329579 1788566 7e 610.61 2.03 172.63 2 CC(=O)OC[C@H]1O[C@@H](CC(=O)\C=C\c2ccc(NC(=O)Nc3ccccc3)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15127423 IC50 = 5270 nM 5.28 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3344525 1796689 CHEMBL3344525 1796689 11 408.88 4.01 69.98 0 O\N=C\1/c2ccccc2c3c1c(NCCN4CCOCC4)nc5cc(Cl)ccc35 15083317 IC50 = 5390 nM 5.27 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1437053 CHEMBL3390205 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human type A-positive red blood cells assessed as growth inhibition after 72 hrs by spectrophotometrically 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89596 CHEMBL3351756 25311562 Bioorg. Med. Chem. 2014 22 21 5757
CHEMBL3238462 1737016 CHEMBL3238462 1737016 5k 565.54 7.29 72.39 2 CCOC(=O)C1=CN(Cc2ccc(F)cc2)c3ccc4nc(c5ccc(F)cc5)c(nc4c3C1=O)c6ccc(F)cc6 14599600 IC50 = 7590 nM 5.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3353303 1817410 CHEMBL3353303 1817410 6l 267.28 2.73 49.77 0 COc1ccccc1C2=Cc3ccccc3N(O)C2=O 14971655 IC50 = 7600 nM 5.12 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1444305 CHEMBL3380888 F Antiplasmodial activity against Plasmodium falciparum 3D7 incubated for 36 to 42 hrs by Giemsa staining method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90074 CHEMBL3351258 25544370 Bioorg. Med. Chem. Lett. 2015 25 3 607
CHEMBL3260215 1745161 CHEMBL3260215 1745161 1j 306.4 5.34 26.53 1 CCCC\C=C\C=C\c1nc2cc(OC)ccc2n3cccc13 14668028 IC50 = 8900 nM 5.05 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1347469 CHEMBL3268261 F Antimicrobial activity against chloroquine and mefloquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR Green I assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 83300 CHEMBL3259800 24858543 Eur. J. Med. Chem. 2014 81 378
CHEMBL3410469 1837247 CHEMBL3410469 1837247 4cE 682.6 3.67 175.48 2 CN(OC(=O)N1CCOCC1)C(=O)CCC(c2ccc(F)c(F)c2)P(=O)(OCOC(=O)OC(C)(C)C)OCOC(=O)OC(C)(C)C 15192783 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1467370 CHEMBL3411607 F Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91397 CHEMBL3407342 25633870 J. Med. Chem. 2015 58 4 2025
CHEMBL3103563 1611636 CHEMBL3103563 1611636 21 311.37 3.78 59.31 0 CCCCNC(=O)c1ccc(\C=C\C(=O)c2oc(C)cc2)cc1 13886132 IC50 = 10000 nM 5 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1283898 CHEMBL3106511 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by LDH colorimetric assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76600 CHEMBL3102808 24411478 Bioorg. Med. Chem. 2014 22 3 1128
CHEMBL3219639 1726031 CHEMBL3219639 1726031 12a 262.26 2.61 62.12 0 O=C1C(=CNc2ccc(Oc3ccccc3)cc12)C#N 14545603 IC50 > 10000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1330156 CHEMBL3223784 F Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 81832 CHEMBL3217655 MedChemComm 2012 3 1 39
CHEMBL3114088 1617053 CHEMBL3139307 1628638 13, VAM2-13 394.47 3.59 81.4 0 Br.[O-][N+](=O)c1ccc2N(CCCCCN3CCc4ccccc4C3)CC(=O)Nc2c1 13910785 IC50 > 10000 ug.mL-1 Outside typical range 0 BAO_0000190 UO_0000274 http://www.openphacts.org/units/MicrogramPerMilliliter 1291179 CHEMBL3116668 F Antimalarial activity against intraerythrocytic asexual stage of Plasmodium falciparum 3D7 assessed as inhibition of [G-3H]-hypoxanthine uptake by semiautomated microdilution method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 76764 CHEMBL3112492 24513185 Bioorg. Med. Chem. 2014 22 5 1568
CHEMBL3409912 1836684 CHEMBL3409912 1836684 79 681.84 4.45 129.31 1 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)N1CCOCC1)C(=O)N[C@@H](Cc2ccccc2)C(=O)N3CCC[C@H]3COc4ccc(F)cc4 15199157 IC50 = 10200 nM 4.99 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1468094 CHEMBL3413867 F Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by SYBR green assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91458 CHEMBL3407376 25840796 Bioorg. Med. Chem. 2015 23 9 2221
CHEMBL3310175 1779272 CHEMBL3310175 1779272 2 314.42 .83 98.66 0 CCCCCNC(=O)CCNC(=O)[C@H](O)[C@](C)(CO)CC=C 15055009 IC50 = 13000 nM 4.89 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1449459 CHEMBL3373875 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage parasite assessed as reduction in parasite proliferation after 96 hrs in presence of 50 uM pantothenate by SYBR Safe DNA gel staining based assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90402 CHEMBL3352628 24986662 Bioorg. Med. Chem. Lett. 2014 24 15 3274
CHEMBL3329594 1788581 CHEMBL3329594 1788581 8i 458.53 2.35 163.36 1 OC[C@H]1O[C@@H](CC(=O)\C=C\c2cccc(NC(=S)Nc3ccccc3)c2)[C@@H](O)[C@@H](O)[C@@H]1O 15127438 IC50 = 13070 nM 4.88 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1454180 CHEMBL3363210 F Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR Green fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 90818 CHEMBL3351535 25147607 ACS Med. Chem. Lett. 2014 5 8 878
CHEMBL3238449 1737003 CHEMBL3238449 1737003 3b 503.5 5.78 90.41 2 CCOC(=O)C(=CNc1ccc2nc(c3ccc(F)cc3)c(nc2c1)c4ccc(F)cc4)C(=O)OCC 14599587 IC50 = 21300 nM 4.67 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3238450 1737004 CHEMBL3238450 1737004 4a 421.45 5.34 85.2 1 CCOC(=O)c1cnc2ccc3nc(c4ccccc4)c(nc3c2c1O)c5ccccc5 14599588 IC50 = 29800 nM 4.53 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3402980 1833196 CHEMBL3402980 1833196 10 362.42 3.09 57.69 0 O=C([C@H](Cc1ccccc1)N2C(=O)c3ccccc3C2=O)N4CCCCC4 15183816 IC50 = 36050 nM 4.44 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3233230 1731731 CHEMBL3233230 1731731 6i 485.48 6.25 83.39 1 CCCCN1C=C(C(=O)O)C(=O)c2c1ccc3nc(c4ccc(F)cc4)c(nc23)c5ccc(F)cc5 14599610 IC50 = 40400 nM 4.39 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3236255 1734786 CHEMBL3236255 1734786 34 297.28 .72 61.77 0 Fc1cccc(CNC(=O)C2=CN=C3C=CC=CN3C2=O)c1 14580108 IC50 = 43000 nM 4.37 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3402983 1833199 CHEMBL3402983 1833199 13 418.53 4.5 57.69 0 CC(C)C[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183819 IC50 = 44230 nM 4.35 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3402984 1833201 CHEMBL3402984 1833201 15 404.5 4.11 57.69 0 CC(C)[C@H](N1C(=O)c2ccccc2C1=O)C(=O)N3CCC(Cc4ccccc4)CC3 15183821 IC50 = 48240 nM 4.32 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1465107 CHEMBL3405439 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 91160 CHEMBL3400128 25766631 Bioorg. Med. Chem. 2015 23 8 1817
CHEMBL3233231 1731732 CHEMBL3233231 1731732 6j 467.42 6.12 83.39 1 OC(=O)C1=CN(CC#C)c2ccc3nc(c4ccc(F)cc4)c(nc3c2C1=O)c5ccc(F)cc5 14599611 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1338149 CHEMBL3242157 F Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 50 hrs by SYBR Green1 dye-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82233 CHEMBL3232776 24650715 Eur. J. Med. Chem. 2014 77 280
CHEMBL3342265 1794407 CHEMBL3342265 1794407 5a 316.25 -.14 136.98 0 CN(O)C(=O)CCC(NC(=O)c1ccccc1)P(=O)(O)O 15101116 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1436201 CHEMBL3386563 F Antimicrobial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2-based ELISA 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89435 CHEMBL3351943 25254502 J. Med. Chem. 2014 57 21 8827
CHEMBL3358139 1822294 CHEMBL3558743 1940589 16 780.01 2.18 215.58 2 CC[C@H](C)[C@H]([NH+](C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N[C@@H](C)C(=O)N1C[C@@H](O)C[C@H]1C(=O)OC.[O-]C(=O)C(F)(F)F 15121660 IC50 > 50000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1435074 CHEMBL3388291 F Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89734 CHEMBL3351948 25412465 J. Med. Chem. 2014 57 24 10557
CHEMBL3236259 1734790 CHEMBL3236259 1734790 38 315.27 .92 61.77 0 Fc1ccc(CNC(=O)C2=CN=C3C=CC=CN3C2=O)c(F)c1 14580112 IC50 = 59000 nM 4.23 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3121246 1620565 CHEMBL3121246 1620565 4 330.33 3.43 96.22 0 CCOC(=O)c1c(O)cc(O)c2CCC(Oc12)c3ccc(O)cc3 13928648 IC50 = 60280 nM 4.22 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1293986 CHEMBL3122353 F Antiplasmodial activity against chloroquine-sensitive blood stage Plasmodium falciparum 3D7 after 72 hrs by SYBR Green I-based fluorescence assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 77021 CHEMBL3120068 24530004 Bioorg. Med. Chem. Lett. 2014 24 5 1261
CHEMBL3236233 1734764 CHEMBL3236233 1734764 9 336.39 1.1 65.01 0 CC(C)N(Cc1ccccc1)C(=O)NC2=CN=C3C=CC=CN3C2=O 14580086 IC50 = 70000 nM 4.15 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236231 1734762 CHEMBL3236231 1734762 5 398.46 2.23 73.8 0 O=C(NCCC(c1ccccc1)c2ccccc2)NC3=CN=C4C=CC=CN4C3=O 14580084 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236238 1734769 CHEMBL3236238 1734769 14 396.75 1.48 73.8 0 FC(F)(F)c1cccc(CNC(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl)c1 14580091 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236232 1734763 CHEMBL3236232 1734763 7 387.39 1.11 95.92 0 O=C(NC1=CN=C2C=CC=CN2C1=O)Nc3ncccc3OCc4ccccc4 14580085 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338936 1793441 CHEMBL3338936 1793441 9f 620.75 6.23 79.44 2 O=S1(=O)C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@H]2c6c1ccc7ccccc67 15119902 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236239 1734770 CHEMBL3236239 1734770 15 396.75 1.48 73.8 0 FC(F)(F)c1ccccc1CNC(=O)NC2=CN=C3C=CC(=CN3C2=O)Cl 14580092 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3236264 1734795 CHEMBL3236264 1734795 44 323.35 .87 71 0 COc1ccc(cc1)C(C)NC(=O)C2=CN=C3C=CC=CN3C2=O 14580117 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338923 1793428 CHEMBL3338923 1793428 7a 570.7 5.33 79.44 2 O=S1(=O)C[C@@H]2[C@@H](OCc3ccccc3)[C@H](OCc4ccccc4)[C@@H](COCc5ccccc5)O[C@@H]2c6ccccc16 15119915 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3236241 1734772 CHEMBL3236241 1734772 18 433.46 -.5 110.24 0 O=C(NC1=CN=C2C=CC=CN2C1=O)N3CCN(CC3)c4ncccc4C(=O)NC5CC5 14580094 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1336160 CHEMBL3241120 F Antimalarial activity against erythrocytic stages of chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O-positive erythrocytes after 48 hrs by SYBR Green-I fluorescence-based method 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 82351 CHEMBL3232972 24763263 Eur. J. Med. Chem. 2014 79 422
CHEMBL3338910 1793415 CHEMBL3338910 1793415 4 324.44 1.77 95.22 0 CC(C)(C)c1ccc2SC[C@@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]3c2c1 15119928 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197
CHEMBL3338909 1793414 CHEMBL3338909 1793414 3g 464.57 2.52 113.43 0 CC(=O)COC[C@H]1O[C@H]2[C@H](CSc3ccc(cc23)C(C)(C)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 15119929 IC50 > 100000 nM 0 BAO_0000190 UO_0000065 http://www.openphacts.org/units/Nanomolar 1438359 CHEMBL3382422 F Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by parasite lactate dehydrogenase assay 1 Scientific Literature Plasmodium falciparum 3D7 36329 Autocuration BAO_0000218 107053 CHEMBL2366922 ORGANISM Plasmodium falciparum 3D7 Plasmodium falciparum 3D7 1 Non-molecular 89443 CHEMBL3352507 25255435 Eur. J. Med. Chem. 2014 87 197