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Example_Analysis_Workflow

-
-
-

Example_Analysis_Workflow

- - - Source: vignettes/Example_Analysis_Workflow.Rmd -
Example_Analysis_Workflow.Rmd
+ Source: vignettes/Example_Analysis_Workflow.qmd +
- - -
+
+
+
+
+
+    

+
-
For a particular endpoint, analysis should follow the recommended
-flowchart in OECD 54 or in specific test guidelines. Deviations from a
-standard procedure should be justified.

-

-
Example Routine Analysis Flowcharts
+

+
For a particular endpoint, analysis should follow the recommended flowchart in OECD 54 or in specific test guidelines. Deviations from a standard procedure should be justified.

+
Example Routine Analysis Flowcharts
 

-
Typical flowcharts for derving NOECs and ECx are shown in @fig-NOEC-Monotonic , @fig-NOEC-nonMonotonic and @fig-ECx-Monotonic . For dose response with
-hormesis effects or highly erratic, it should be consulted with at
-statistician.

-

-NOEC Monotonic
NOEC Monotonic

+
Typical flowcharts for derving NOECs and ECx are shown in Figure 1 , Figure 2 and Figure 3 . For dose response with hormesis effects or highly erratic, it should be consulted with at statistician.

+

+

+
 

-

-NOEC non-Monotonic
NOEC non-Monotonic

+

+Figure 1: NOEC Monotonic
+

 

-

-ECx Monotonic
ECx Monotonic

+

+

+
 

-
In this vignette, we are going to use dataset oecd201 as an
-example.

+

+Figure 2: NOEC non-Monotonic
+

 

-

-
Data overview
-

+

+

+
+

+

+Figure 3: ECx Monotonic
+

 

-

-
Assumptions check
+
In this vignette, we are going to use dataset oecd201 as an example.

+
Data overview
 

-
Pretests or checks could be conducted before testing, however,
-assumptions could also be checked after modelling, using a more holistic
-approach. Here we follow the routine procedure.

+
Assumptions check
+

+
Pretests or checks could be conducted before testing, however, assumptions could also be checked after modelling, using a more holistic approach. Here we follow the routine procedure.

 

-
To allow the choice of the appropriate statistical tests, the
-normality and homoscedasticity (variance homogeneity) of a certain
-endpoint (e.g., shoot dry weight) data were checked.

+
To allow the choice of the appropriate statistical tests, the normality and homoscedasticity (variance homogeneity) of a certain endpoint (e.g., shoot dry weight) data were checked.

 

-

-
Check for normality
+
Check for normality
 

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-

-

-
NOER determination
+
NOER determination
 

-

-

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ER and ER determination
+
ER and ER determination
 

-

-

-
An overview of the endpoints
+
An overview of the endpoints
 

-
The NOER, LOER, ER25 and ER50 for survival, plant height and shoot
-dry weight expressed as g a.s./ha are summarized for each of the plant
-species for the final assessment (21 days after application) and can be
-found in the following tables.

-

-
-