scnXa.fa

>SCN11A
-MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEKKK------SKDQTGEVPQPRPQLDLKASRKLPKLYGDIPREL
IGKPLEDLDPFYRNHK-TFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSL---FSMFIIGTVIINCVFMATG
PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRA
LKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRD----------------------
-------------------------CKNISNPEA---Y---DHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPD
YNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEA
KEKMFQEAQQLLKEEKEALVAMGIDRSS--------------------LTSLETSYFTPKKRKLFGNKKRKS--------
---------------------------------------------------------------FFLRESGKDQPPGSDSD
------------------------------------------------------------EDCQKKPQLLE---------
---------------------------QTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTIT-MKEQEKSQEPCLPCGE
NLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI
IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVL
VIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSC--LRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSL
CVIVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHK---WCRKQNL
P--------QQKEVAGGCAAQ--------SKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLA---------P
LAEEEDDVEFSGED------NAQRITQPEPEQQAYELHQENK---------------KPTSQRVQSVEIDMFSEDEPHLT
IQDPRKKSDVTSILSECSTIDL---QDGFGWLPEMVPKK--QPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKTCYQI
VKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIV
SVTTLI-------NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKFG
KCINGTDSVI---NYTIITNKSQCESGNFS------WINQKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQP
EFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQ
GLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVV
VLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGM
NWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKES-CNSSSEN--------CHLPGIATSYFVSY
IIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQF
LVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKY
MMKVT-----------------KGDQGDQNDLE-----------NGPHSP---LQTLCNGDLSSFGVAKGKV--------
----HCD----------------------

>SCN7A
-------MLASPEPKGLVPFTKESFELIKQHIAKT-----------HNED-HEEEDLKPTPDLEVGKKLPFIYGNLSQGM
VSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPF---FQLFILISVLIDCVFMSLT
NLPKWRPV----LENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLD-FIPTLQTARTLRI
LKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQ--------------------E
NENETLHNR----------------TGNPY-------YIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPD
QGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKK
IEPKFQQTGKELQ-----------------------------------------------------------------EG
NETDE---------------------------------------------------------------------------
--------------------------------------------------------------------------------
------------------AKTIQIEMKKRSPISTDTSLDVLE---DATLRHK-------------EELEKSKKICPLYWY
KFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKI
IAMHPYGYFQVGWNIFDSMIVFHGLIEL--CLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLL
FTFIFFSAAFGMKLFGKNYEEF----VCHIDKD---CQ-LPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEV--AGQSW
CIPFYLMVILIGNLLVLYLFLA-LVSSFSSCKDVTA-EENNEAKNLQLAVARIKKGINYVLLKI---------LCKTQNV
PKDTMDHVNEVYVKED--ISD------HTLSELSNTQDFLKDKEKSSGTEKNAT--------ENESQSLIPSPSVSETVP
IASGESDIENLDNK------EIQSKSGDGGSK---EKIK-QS--------------------------------------
------------SSSECSTVDIAISEE---EEMFYGGERSKH----LKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKI
VENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIV
FCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFY
ECIDPTSGER-F-PSSEVMNKSRCESLLFNES--MLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQP
HFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQ
GFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMV
VIFSITGLCLPMTVG--SYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGM
YNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSY
ILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQL
IALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNY
RLRRNDKNTSDIHMIDGDRD----VHATKEGAYFDKA-------KE---------------------------KSPIQSQ
I----------------------------

>SCN10A
----MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREK--HREQKDQEEKPRPQLDLKACNQLPKFYGELPAEL
IGEPLEDLDPFYSTHR-TFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSYPLWFSLFITVTILVNCVCMTRT
DLPE---K----IEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLR-GISGLRTFRVLRA
LKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVK------------------------
--NDMAVNE----------------TTNYSSHRKPDIYINKR-------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPD
FNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEA
KEKKFQEALEMLRKEQEVLAALGIDTTS--------------------LHSHNGSPLTSKNASERRHRIKPR----VSEG
STED--NKSPRSDPYNQRR--------------------------MSFLGLASGKRRASHGSVFHFR--SPGRDISLPEG
VTDDGVFP-GDHESHRGSLLLGGGAGQ------------QGPLPRSPLPQPSNPDSRHG-------------EDEHQPPP
TSELAPG-------------AVDVSAFDAGQKKTFLSAEYLD---EPFRAQRAMSVVSIITSV-LEELEESEQKCPPCLT
SLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKI
IAFDPYYYFQKKWNIFDCIIVTVSLLEL--GVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIIL
AIIVFVFALVGKQLLGENYRNN----RKNISAP---HEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEV--GQKSI
CLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAP-EDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAE
P-ELVVKLPLSSSKAENHIAA-------------------NTARGSSGGLQAPRGPRD------EHSDFIANPTVWVSVP
IAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCG------DHLTPRSPGTGTSSEDLAPSLGETWKDESVPQ
VPAEGVDDT---SSSEGSTVDCLDPEEILRKIPELADDLE-EPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRI
VEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNI
SLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFW
RCINYTDGEFSLVPLSIVNNKSDCKIQNSTGS--FFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQP
KWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQ
GFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIV
VVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM
SSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGT-RGDCGSPAVGIIFFTTY
IIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNIL
IQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSY
VLHRSMALSNTPCVPRAEEE--AASLPD-EGFVAFTA-------NENCVL---PDKSETASATSFPPSYESV-TRGLSDR
VNMRTSSSIQNEDEA----TSMELIAPGP

>SCN5A
----MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQE-SREGLPEEEAPRPQLDLQASKKLPDLYGNPPQEL
IGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLSPFHPIRRAAVKILVHSL---FNMLIMCTILTNCVFMAQH
DPPPWTKY----VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLG-NVSALRTFRVLRA
LKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---------------------NFT
ALNGTNGSV----------------EADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPD
HGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEE
KEKRFQEAMEMLKKEHEALTIRGVDTVS--------------------RSSLEMSPLAPVNSHERRSKRRKR----MSSG
TEECGEDRLPKSDSEDGPR-------------------AMNHLSLTRGLSRTSMKPRSSRGSIFTFR----RRDLGSEAD
FADDENSTAGESESHHTSLLVPWPLRR--------TSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEATSP
GSHLLRPVMLEHPPDT--TTPSEEPGGPQMLTSQAPCVDGFE---EPGARQRALSAVSVLTSA-LEELEESRHKCPPCWN
RLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKI
IALDPYYYFQQGWNIFDSIIVILSLMEL--GLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKNYSE------LRDSDS---GL-LPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEV--SGQSL
CLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAP-DEDREMNNLQLALARIQRGLRFVKRTTWDFCCGL--LRQRPQK
P-AALAAQGQL----PSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEP------------------VCVP
IAVAESDTDDQEED------EENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAE
PQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVK-DPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHI
VEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDV
SLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFG
RCINQTEGDLPL-NYTIVNNKSQCESLNLTGE--LYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP
QWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ
GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVV
VILSIVGTVLSDIIQ--KYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM
ANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGS-RGDCGSPAVGILFFTTY
IIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISL
INMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVIQRAFRRH
LLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVM-------SENFSRPLGPPSSSSISSTSFPPSYDSV-TRATSDN
LQVRGSDYSHSEDLADFPPSPDRDRESIV

>SCN4A
MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRN----KQME-IEEPERKPRSDLEAGKNLPMIYGDPPPEV
IGIPLEDLDPYYSNKK-TFIVLNKGKAIFRFSATPALYLLSPFSVVRRGAIKVLIHAL---FSMFIMITILTNCVFMTMS
DPPPWSKN----VEYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLG-NISALRTFRVLRA
LKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTW
YGNEMWYGNDSWYANDTWNSHASWATNDTFDWDA---YISDEGNFYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPN
YGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKE
KEEEFQQMLEKFKKHQEELEKAKAAQAL-------------------------------------------------EGG
EADGD---------------------------------------------------------------------------
---------------------------------------------------PAHGK-----DCNGSLDTSQ-G-------
---------------------------------------------EKGAPRQSSSGDSGISDA-MEELEEAHQKCPPWWY
KCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKL
IAMDPYEYFQQGWNIFDSIIVTLSLVEL--GLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKEC----VCKIALD---CN-LPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEV--AGQAM
CLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAAS-DEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGK--ILSPKDI
M-LSLGEADGAGEAGEAGETA------PEDEKKEPPEEDLKKDNHILNHMGLADGPPSSL--ELDHLNFINNPYLTIQVP
IASEESDLEMPTEE------ETDTFSEPEDSKKPPQPLY-DG--------------------------------------
------------NSSVCSTADYKPPEEDPEEQAEENPEGE-QPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKI
VEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDV
SIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY
YCINTTTSER-F-DISEVNNKSECESLMHTGQ--VRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQP
QYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQ
GMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTVGWNIFDFVV
VILSIVGLALSDLIQ--KYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM
SNFAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSY
IIISFLIVVNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAKPNKIKL
ITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSKVSYEPITTTLKRKHEEVCAIKIQRAYRRH
LLQRSMKQASYMYRHSHDGS--GDDAPEKEGLLANTMSKMYGHENGNSSS---PSPEEKGEAGDAGPTMGLMPISPSDTA
W---PPAPPPGQTVR------PGVKESLV

>SCN8A
---MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHRED-DEDSKPKPNSDLEAGKSLPFIYGDIPQGL
VAVPLEDFDPYYLTQK-TFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSV---FSMIIMCTILTNCVFMTFS
NPPDWSKN----VEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLG-NVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP---------------------I
NFNESYLEN----------------GTKGFDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPN
YGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQ
KEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGS-PRSSSEISKLSSKSAKERRNRRKKRKQKELSEG
EEKGDPEKVFKSESEDGMRRKAFRLP--DNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENE
FADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG-GPGSHIG-
-GRLLPE------------ATTEVEIKKKGPGSLLVSMDQLA---SYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWY
KFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL
IAMDPYYYFQEGWNIFDGFIVSLSLMEL--SLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKEC----VCKINQD---CE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEV--AGQAM
CLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAAT-DDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAH--F--KQRE
A-DEVKPLDELYEKKANCIAN------HTGADIHRNGDFQKNGNGTTSGI--GSSVEKYIIDE-DHMSFINNPNLTVRVP
IAVGESDFENLNTE------DVSSESDPEGSK---DKLD-DT--------------------------------------
------------SSSEGSTIDIKPEVE---EVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLI
VEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAV
SLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYH
YCFNETSEIR-F-EIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQP
KYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQ
GIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV
VILSIVGMFLADIIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM
SNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSY
IIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIEL
IAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGH
LARR--------------------GFICKKTTSNKLE-------NGGTHR---EKKESTPSTAS-LPSYDSV-TKPEKEK
QQRAEEGRRERAKRQ------KEVRESKC

>SCN9A
-----MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKE----EKKD-DDEEAPKPSSDLEAGKQLPFIYGDIPPGM
VSEPLEDLDPYYADKK-TFIVLNKGKTIFRFNATPALYMLSPFSPLRRISIKILVHSL---FSMLIMCTILTNCIFMTMN
NPPDWTKN----VEYTFTGIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLG-NVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKC---------------------FRNSL
ENNETLESI----------------MNTLESEED---F---RKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPD
YGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ
KELEFQQMLDRLKKEQEEAEAIAAAAAE----YTSIRRSRIMGL---SESSSETSKLSSKSAKERRNRRKKKNQKKLSSG
EEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFK--GRGRDIGSETE
FADDEHSIFGDNESRRGSLFVPHRPQERRS-----SNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVD-GRSALMLP
NGQLLPEVIIDKATSDDSGTTNQIH-KKRRCSSYLLSEDMLN---DPNLRQRAMSRASILTNT-VEELEESRQKCPPWWY
RFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKL
IAMDPYEYFQVGWNIFDSLIVTLSLVEL--FLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKEC----VCKINDD---CT-LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEV--AGQAM
CLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAI-EEDPDANNLQIAVTRIKKGINYVKQTLREFILKA--FSKKPKI
S-REIRQAEDLNTKKENYISN------HTLAEMSKGHNFLKEKD-KISGF--GSSVDKHLMEDSDGQSFIHNPSLTVTVP
IAPGESDLENMNAE------ELSSDSDSEYSK---VRLN-RS--------------------------------------
------------SSSECSTVDNPLPGE--GEEAEAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKI
VEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDV
SLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY
ECINTTDGSR-F-PASQVPNRSECFALMNVSQN-VRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP
KYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ
GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVV
VIISIVGMFLADLIE--TYFVSPTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
SNFAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSY
IIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL
IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRY
RLRQNVKNISSIYIKDGDRD---DDLLNKKDMAFDNV-------NENSSP---EKTDATSSTTS-PPSYDSV-TKPDKEK
Y---EQDRTEKEDKG------KDSKESKK

>SCN3A
---MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDN-DDENKPKPNSDLEAGKNLPFIYGDIPPEM
VSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILTPLNPVRKIAIKILVHSL---FSMLIMCTILTNCVFMTLS
NPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLG-NVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----SDSAFETNTTSYFNGTM
DSNGTFVNV----------------TMSTFNWKD---YIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPN
YGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQ
KEAEFQQMLEQLKKQQEEAQAVAAASAA------SRDFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEG
NNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFR--GRAKDVGSEND
FADDEHSTFEDSESRRDSLFVPHRHGERRN-----SNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVG-GPSALTSP
TGQLPPE-----------GTTTETEVRKRRLSSYQISMEMLE---DSSGRQRAVSIASILTNT-MEELEESRQKCPPCWY
RFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKI
IAMDPYYYFQEGWNIFDGIIVSLSLMEL--GLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKEC----VCKINDD---CT-LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEV--AGQTM
CLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKA--FFRKPKV
I--EIHE----GNKIDSCMSN------NTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVP
IAVGESDFENLNTE------EFSSESELEESK---EKLN-AT--------------------------------------
------------SSSEGSTVDVVLPRE--GEQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSI
VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDV
SLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY
HCVNMTTGNM-F-DISDVNNLSDCQAL---GKQ-ARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQP
VYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQ
GMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVV
VILSIVGMFLAEMIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
SNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSY
IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL
IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNFRCY
LLKQRLKNISSNYNKEAIKG--RIDLPIKQDMIIDKL-------NGNSTP---EKTDGSSSTTS-PPSYDSV-TKPDKEK
F---EKDKPEKESKG------KEVRENQK

>SCN1A
---MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKP----DKKD-DDENGPKPNSDLEAGKNLPFIYGDIPPEM
VSEPLEDLDPYYINKK-TFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSL---FSMLIMCTILTNCVFMTMS
NPPDWTKN----VEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPP----TNASLEEHSIE-KNITV
NYNGTLINE----------------TVFEFDWKS---YIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPN
YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ
KEAEFQQMIEQLKKQQEAAQQAATATAS----EHSREPSAAGRL---SDSSSEASKLSSKSAKERRNRRKKRKQKEQSGG
EEKDE-DEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFR--GRAKDVGSEND
FADDEHSTFEDNESRRDSLFVPRRHGERRN-----SNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVG-GPSVPTSP
VGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLE---DPSQRQRAMSIASILTNT-VEELEESRQKCPPCWY
KFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKI
IAMDPYYYFQEGWNIFDGFIVTLSLVEL--GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKDC----VCKIASD---CQ-LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEV--AGQAM
CLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAAT-DDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQS--FIRKQKI
L-DEIKPLDDLNNKKDSCMSN------HTA-EIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVP
IAVGESDFENLNTE------DFSSESDLEESK---EKLNESS--------------------------------------
------------SSSEGSTVDIGAPVE---EQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRI
VEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDV
SLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY
HCINTTTGDR-F-DIEDVNNHTDCLKLIERNET-ARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQP
KYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQ
GMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVV
VILSIVGMFLAELIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSY
IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQL
IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRH
LLKRTVKQASFTYNKNKIKG--GANLLIKEDMIIDRI-------NENSIT---EKTDLTMSTAACPPSYDRV-TKPIVEK
H----------EQEG------KDEKAKGK

>SCN2A
---MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ----ERKDEDDENGPKPNSDLEAGKSLPFIYGDIPPEM
VSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILTPFNPIRKLAIKILVHSL---FNMLIMCTILTNCVFMTMS
NPPDWTKN----VEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG-NVSALRTFRVLRA
LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPP----DNSSFEINITSFFNNSL
DGNGTTFNR----------------TVSIFNWDE---YIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPN
YGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQ
KEAEFQQMLEQLKKQQEEAQAAAAAASA----E-SRDFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGE
EEKN--DRVRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFR--GRAKDIGSEND
FADDEHSTFEDNDSRRDSLFVPHRHGERRH-----SNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVG-GPSTLTS-
AGQLLPE-----------GTTTETEIRKRRSSSYHVSMDLLE---DPTSRQRAMSIASILTNT-MEELEESRQKCPPCWY
KFANMCLIWDCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKI
IAMDPYYYFQEGWNIFDGFIVSLSLMEL--GLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL
AIIVFIFAVVGMQLFGKSYKEC----VCKISND---CE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEV--AGQTM
CLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAAT-DDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKA--FVRKQKA
L-DEIKPLEDLNNKKDSCISN------HTTIEIGKDLNYLKDGNGTTSGI--GSSVEKYVVDESDYMSFINNPSLTVTVP
IAVGESDFENLNTE------EFSSESDMEESK---EKLN-AT--------------------------------------
------------SSSEGSTVDIGAPAE--GEQPEVEPEESLEPEACFTEDCVRKFKCCQISIEEGKGKLWWNLRKTCYKI
VEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDV
SLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFY
HCINYTTGEM-F-DVSVVNNYSECKALIESNQT-ARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQP
KYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQ
GMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV
VILSIVGMFLAELIE--KYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGM
SNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSY
IIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQL
IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIIIQRAYRRY
LLKQKVKKVSSIYKKDKGKE--CDGTPIKEDTLIDKL-------NENSTP---EKTDMTPSTTS-PPSYDSV-TKPEKEK
F---EKDKSEKEDKG------KDIRESKK