SBO_OBO.obo

format-version: 1.2
remark: Systems Biology Ontology, OWL export generated by SBO Browser (http://www.ebi.ac.uk/sbo/)
ontology: http://biomodels.net/SBO/
property_value: owl:versionInfo "28:08:2021 03:13" xsd:string
name: Generated: 03:11:2021 07:00

[Term]
id: SBO:0000000
name: systems biology representation
comment: Representation of an entity used in a systems biology knowledge reconstruction, such as a model, pathway, network.

[Term]
id: SBO:0000001
name: rate law
comment: mathematical description that relates quantities of reactants to the reaction velocity.
is_a: SBO:0000064 ! mathematical expression

[Term]
id: SBO:0000002
name: quantitative systems description parameter
comment: A numerical value that defines certain characteristics of systems or system functions. It may be part of a calculation, but its value is not determined by the form of the equation itself, and may be arbitrarily assigned.
is_a: SBO:0000545 ! systems description parameter

[Term]
id: SBO:0000003
name: participant role
comment: The function of a physical or conceptual entity, that is its role, in the execution of an event or process.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000004
name: modelling framework
comment: Set of assumptions that underlay a mathematical description.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000005
name: obsolete mathematical expression
comment: The description of a system in mathematical terms.
is_a: SBO:0000064 ! mathematical expression

[Term]
id: SBO:0000006
name: obsolete parameter
comment: A numerical value that represents the amount of some entity, process or mathematical function of the system.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000007
name: obsolete participant type
comment: The 'kind' of entity involved in some process, action or reaction in the system. This may be enzyme, simple chemical, etc..
is_a: SBO:0000235 ! participant

[Term]
id: SBO:0000008
name: obsolete modelling framework
comment: Basic assumptions that underlie a mathematical model.
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000009
name: kinetic constant
comment: Synonym: reaction rate constant 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000010
name: reactant
comment: Substance consumed by a chemical reaction. Reactants react with each other to form the products of a chemical reaction. In a chemical equation the Reactants are the elements or compounds on the left hand side of the reaction equation. A reactant can be consumed and produced by the same reaction, its global quantity remaining unchanged.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000011
name: product
comment: Substance that is produced in a reaction. In a chemical\nequation the Products are the elements or compounds on the right hand side\nof the reaction equation. A product can be produced and consumed by the\nsame reaction, its global quantity remaining unchanged.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000012
name: mass action rate law
comment: The Law of Mass Action, first expressed by Waage and Guldberg in 1864 (Waage, P.; Guldberg, C. M. Forhandlinger: Videnskabs-Selskabet i Christiana 1864, 35) states that the speed of a chemical reaction is proportional to the quantity of the reacting substances. More formally, the change of a product quantity is proportional to the product of reactant activities. In the case of a reaction occurring in a gas phase, the activities are equal to the partial pressures. In the case of a well-stirred aqueous medium, the activities are equal to the concentrations. In the case of discrete kinetic description, the quantity are expressed in number of molecules and the relevant volume are implicitely embedded in the kinetic constant.
is_a: SBO:0000001 ! rate law

[Term]
id: SBO:0000013
name: catalyst
comment: Substance that accelerates the velocity of a chemical reaction without itself being consumed or transformed. This effect is achieved by lowering the free energy of the transition state.
is_a: SBO:0000459 ! stimulator

[Term]
id: SBO:0000014
name: enzyme
comment: A protein that catalyzes a chemical reaction. The word comes from en ("at" or "in") and simo ("leaven" or "yeast").
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000015
name: substrate
comment: Molecule which is acted upon by an enzyme. The substrate binds with the enzyme's active site, and the enzyme catalyzes a chemical reaction involving the substrate.
is_a: SBO:0000010 ! reactant

[Term]
id: SBO:0000016
name: unimolecular rate constant
comment: Numerical parameter that quantifies the velocity of a chemical reaction involving only one reactant.\n
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000017
name: bimolecular rate constant
comment: Numerical parameter that quantifies the velocity of a chemical reaction involving two reactants.
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000018
name: trimolecular rate constant
comment: Numerical parameter that quantifies the velocity of a chemical reaction involving three reactants.\n
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000019
name: modifier
comment: Substance that changes the velocity of a process without\nitself being consumed or transformed by the reaction.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000020
name: inhibitor
comment: Substance that decreases the probability of a chemical reaction without itself being consumed or transformed by the reaction.
is_a: SBO:0000019 ! modifier

[Term]
id: SBO:0000021
name: potentiator
comment: Synonym: activator 
is_a: SBO:0000459 ! stimulator

[Term]
id: SBO:0000022
name: forward unimolecular rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical\nreaction involving only one reactant. This parameter encompasses all the contributions to the velocity except the quantity of the reactant.
is_a: SBO:0000016 ! unimolecular rate constant
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000023
name: forward bimolecular rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving two reactants.  This parameter encompasses all the contributions to the velocity except the quantity of the reactants. 
is_a: SBO:0000017 ! bimolecular rate constant
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000024
name: forward trimolecular rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical\nreaction involving three reactants. This parameter encompasses all the contributions to the velocity except the quantity of the reactants.  
is_a: SBO:0000018 ! trimolecular rate constant
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000025
name: catalytic rate constant
comment: Synonym: turnover number 
is_a: SBO:0000035 ! forward unimolecular rate constant, continuous case

[Term]
id: SBO:0000026
name: new term name
comment: none
is_a: SBO:0000006 ! obsolete parameter

[Term]
id: SBO:0000027
name: Michaelis constant
comment: Synonym: Michaelis-Menten constant 
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000028
name: enzymatic rate law for irreversible non-modulated non-interacting unireactant enzymes
comment: Kinetics of enzymes that react only with one substance, their substrate. The enzymes do not catalyse the reactions in both directions.
is_a: SBO:0000150 ! enzymatic rate law for irreversible non-modulated non-interacting reactant enzymes
is_a: SBO:0000326 ! enzymatic rate law for non-modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Ks</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000029
name: Henri-Michaelis-Menten rate law
comment: First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois Générales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333-369.
is_a: SBO:0000028 ! enzymatic rate law for irreversible non-modulated non-interacting unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000373\">Ks</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Ks</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000030
name: Van Slyke-Cullen rate law
comment: Rate-law presented in "Donald D. Van Slyke and Glenn E. Cullen. The mode of action of urease and of enzymes in general. J. Biol. Chem., Oct 1914; 19: 141-180". It assumes that the enzymatic reaction occurs as two irreversible steps.E+S -> ES -> E+P. Although of the same form than the Henri-Michaelis-Menten equation, it is semantically different since K now represents the ratio between the production rate and the association rate of the enzyme and the substrate.
is_a: SBO:0000028 ! enzymatic rate law for irreversible non-modulated non-interacting unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000372\">Ks</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Ks</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000031
name: Briggs-Haldane rate law
comment: The Briggs-Haldane rate law is a general rate equation that does not require the restriction of equilibrium of Henri-Michaelis-Menten or irreversible reactions of Van Slyke, but instead make the hypothesis that the complex enzyme-substrate is in quasi-steady-state. Although of the same form than the Henri-Michaelis-Menten equation, it is semantically different since Km now represents a pseudo-equilibrium constant, and is equal to the ratio between the rate of consumption of the complex (sum of dissociation of substrate and generation of product) and the association rate of the enzyme and the substrate.
is_a: SBO:0000028 ! enzymatic rate law for irreversible non-modulated non-interacting unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000371\">Km</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Km</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000032
name: reverse unimolecular rate constant
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving only one product. This parameter encompasses all the contributions to the velocity except the quantity of the product.
is_a: SBO:0000016 ! unimolecular rate constant
is_a: SBO:0000156 ! reverse rate constant

[Term]
id: SBO:0000033
name: reverse bimolecular rate constant
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving only one product. This parameter encompasses all the contributions to the velocity except the quantity of the product.
is_a: SBO:0000017 ! bimolecular rate constant
is_a: SBO:0000156 ! reverse rate constant

[Term]
id: SBO:0000034
name: reverse trimolecular rate constant
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving three products. This parameter encompasses all the contributions to the velocity except the quantity of the products.
is_a: SBO:0000018 ! trimolecular rate constant
is_a: SBO:0000156 ! reverse rate constant

[Term]
id: SBO:0000035
name: forward unimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving only one reactant. This parameter encompasses all the contributions to the velocity except the quantity of the reactant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000022 ! forward unimolecular rate constant
is_a: SBO:0000154 ! forward rate constant, continuous case

[Term]
id: SBO:0000036
name: forward bimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving two reactants.  This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000023 ! forward bimolecular rate constant
is_a: SBO:0000154 ! forward rate constant, continuous case

[Term]
id: SBO:0000037
name: forward trimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving three reactants. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000024 ! forward trimolecular rate constant
is_a: SBO:0000154 ! forward rate constant, continuous case

[Term]
id: SBO:0000038
name: reverse unimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving only one product. This parameter encompasses all the contributions to the velocity except the quantity of the product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000032 ! reverse unimolecular rate constant

[Term]
id: SBO:0000039
name: reverse bimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving only one product. This parameter encompasses all the contributions to the velocity except the quantity of the product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000033 ! reverse bimolecular rate constant

[Term]
id: SBO:0000040
name: reverse trimolecular rate constant, continuous case
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction involving three products. This parameter encompasses all the contributions to the velocity except the quantity of the products. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000034 ! reverse trimolecular rate constant

[Term]
id: SBO:0000041
name: mass action rate law for irreversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products.
is_a: SBO:0000012 ! mass action rate law

[Term]
id: SBO:0000042
name: mass action rate law for reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products.
is_a: SBO:0000012 ! mass action rate law

[Term]
id: SBO:0000043
name: mass action rate law for zeroth order irreversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is constant.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions

[Term]
id: SBO:0000044
name: mass action rate law for first order irreversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions

[Term]
id: SBO:0000045
name: mass action rate law for second order irreversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to two reactant quantity.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions

[Term]
id: SBO:0000046
name: zeroth order rate constant
comment: Numerical parameter that quantifies the velocity of a chemical reaction independant of the reactant quantities. This parameter encompasses all the contributions to the velocity.
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000047
name: mass action rate law for zeroth order irreversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is constant.  It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000043 ! mass action rate law for zeroth order irreversible reactions
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">k</ci></bvar>\n     <apply>\n         <ci>k</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000048
name: forward zeroth order rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction independant of the reactant quantities. This parameter encompasses all the contributions to the velocity. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000154 ! forward rate constant, continuous case
is_a: SBO:0000162 ! forward zeroth order rate constant

[Term]
id: SBO:0000049
name: mass action rate law for first order irreversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000044 ! mass action rate law for first order irreversible reactions
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000050
name: mass action rate law for second order irreversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the square of one reactant quantity.
is_a: SBO:0000045 ! mass action rate law for second order irreversible reactions

[Term]
id: SBO:0000051
name: new term name
is_a: SBO:0000005 ! obsolete mathematical expression

[Term]
id: SBO:0000052
name: mass action rate law for second order irreversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the square of one reactant quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000050 ! mass action rate law for second order irreversible reactions, one reactant
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R</ci>\n         <ci>R</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000053
name: mass action rate law for second order irreversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of two reactants. 
is_a: SBO:0000045 ! mass action rate law for second order irreversible reactions

[Term]
id: SBO:0000054
name: mass action rate law for second order irreversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the product of two reactant quantities. It is to be used in a reaction modelled using a continuous framework.  
is_a: SBO:0000053 ! mass action rate law for second order irreversible reactions, two reactants
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R1</ci>\n         <ci>R2</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000055
name: mass action rate law for third order irreversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to three reactant quantities.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions

[Term]
id: SBO:0000056
name: mass action rate law for third order irreversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity.
is_a: SBO:0000055 ! mass action rate law for third order irreversible reactions

[Term]
id: SBO:0000057
name: mass action rate law for third order irreversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000056 ! mass action rate law for third order irreversible reactions, one reactant
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R</ci>\n         <ci>R</ci>\n         <ci>R</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000058
name: mass action rate law for third order irreversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant.
is_a: SBO:0000055 ! mass action rate law for third order irreversible reactions

[Term]
id: SBO:0000059
name: mass action rate law for third order irreversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000058 ! mass action rate law for third order irreversible reactions, two reactants
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R1</ci>\n         <ci>R1</ci>\n         <ci>R2</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000060
name: mass action rate law for third order irreversible reactions, three reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of three reactants.
is_a: SBO:0000055 ! mass action rate law for third order irreversible reactions

[Term]
id: SBO:0000061
name: mass action rate law for third order irreversible reactions, three reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the product of three reactant quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000060 ! mass action rate law for third order irreversible reactions, three reactants
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R1</ci>\n         <ci>R2</ci>\n         <ci>R3</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000062
name: continuous framework
comment: Modelling approach where the quantities of participants are considered continuous, and represented by real values. The associated simulation methods make use of differential equations.
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000063
name: discrete framework
comment: Modelling approach where the quantities of participants are considered discrete, and represented by integer values. The associated simulation methods can be deterministic or stochastic. 
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000064
name: mathematical expression
comment: Formal representation of a calculus linking parameters and variables of a model.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000065
name: forward zeroth order rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction independant of the reactant quantities. This parameter encompasses all the contributions to the velocity. It is to be used in a reaction modelled using a discrete framework.  
is_a: SBO:0000155 ! forward rate constant, discrete case
is_a: SBO:0000162 ! forward zeroth order rate constant

[Term]
id: SBO:0000066
name: forward unimolecular rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving only one reactant. This parameter encompasses all the contributions to the velocity except the quantity of the reactant. It is to be used in a reaction modelled using a discrete framework. \n
is_a: SBO:0000022 ! forward unimolecular rate constant
is_a: SBO:0000155 ! forward rate constant, discrete case

[Term]
id: SBO:0000067
name: forward bimolecular rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving two reactants.  This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a discrete framework. 
is_a: SBO:0000023 ! forward bimolecular rate constant
is_a: SBO:0000155 ! forward rate constant, discrete case

[Term]
id: SBO:0000068
name: forward trimolecular rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction involving three reactants. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a discrete framework. 
is_a: SBO:0000024 ! forward trimolecular rate constant
is_a: SBO:0000155 ! forward rate constant, discrete case

[Term]
id: SBO:0000069
name: mass action rate law for zeroth order reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant.
is_a: SBO:0000042 ! mass action rate law for reversible reactions

[Term]
id: SBO:0000070
name: mass action rate law for zeroth order forward, first order reverse, reversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000069 ! mass action rate law for zeroth order reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000071
name: mass action rate law for zeroth order forward, second order reverse, reversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional totwo product quantities.
is_a: SBO:0000069 ! mass action rate law for zeroth order reversible reactions

[Term]
id: SBO:0000072
name: mass action rate law for zeroth order forward, second order reverse, reversible reactions, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the square of one product quantity. It is to be used in a reaction modelled using a continuous framework.\n\n
is_a: SBO:0000071 ! mass action rate law for zeroth order forward, second order reverse, reversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000073
name: mass action rate law for zeroth order forward, second order reverse, reversible reactions, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the product of two product quantities. It is to be used in a reaction modelled using a continuous framework.\n
is_a: SBO:0000071 ! mass action rate law for zeroth order forward, second order reverse, reversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000074
name: mass action rate law for zeroth order forward, third order reverse, reversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to three product quantities.
is_a: SBO:0000069 ! mass action rate law for zeroth order reversible reactions

[Term]
id: SBO:0000075
name: mass action rate law for zeroth order forward, third order reverse, reversible reactions, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000074 ! mass action rate law for zeroth order forward, third order reverse, reversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000076
name: mass action rate law for zeroth order forward, third order reverse, reversible reactions, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000074 ! mass action rate law for zeroth order forward, third order reverse, reversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000077
name: mass action rate law for zeroth order forward, third order reverse, reversible reactions, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is constant. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000074 ! mass action rate law for zeroth order forward, third order reverse, reversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <ci>kf</ci>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000078
name: mass action rate law for first order reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant.
is_a: SBO:0000042 ! mass action rate law for reversible reactions

[Term]
id: SBO:0000079
name: mass action rate law for first order forward, zeroth order reverse, reversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000078 ! mass action rate law for first order reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000080
name: mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000078 ! mass action rate law for first order reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000081
name: mass action rate law for first order forward, second order reverse, reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to two product quantities.
is_a: SBO:0000078 ! mass action rate law for first order reversible reactions

[Term]
id: SBO:0000082
name: mass action rate law for first order forward, second order reverse, reversible reactions, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000081 ! mass action rate law for first order forward, second order reverse, reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000083
name: mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000081 ! mass action rate law for first order forward, second order reverse, reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000084
name: mass action rate law for first order forward, third order reverse, reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to three product quantities.
is_a: SBO:0000078 ! mass action rate law for first order reversible reactions

[Term]
id: SBO:0000085
name: mass action rate law for first order forward, third order reverse, reversible reactions, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000084 ! mass action rate law for first order forward, third order reverse, reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000086
name: mass action rate law for first order forward, third order reverse, reversible reactions, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000084 ! mass action rate law for first order forward, third order reverse, reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000087
name: mass action rate law for first order forward, third order reverse, reversible reactions, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000084 ! mass action rate law for first order forward, third order reverse, reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000088
name: mass action rate law for second order reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to two reactant quantities.
is_a: SBO:0000042 ! mass action rate law for reversible reactions

[Term]
id: SBO:0000089
name: mass action rate law for second order forward, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity.
is_a: SBO:0000088 ! mass action rate law for second order reversible reactions

[Term]
id: SBO:0000090
name: mass action rate law for second order forward, zeroth order reverse, reversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000089 ! mass action rate law for second order forward, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000091
name: mass action rate law for second order forward, first order reverse, reversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000089 ! mass action rate law for second order forward, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000092
name: mass action rate law for second order forward, second order reverse, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the quantity of two products.
is_a: SBO:0000089 ! mass action rate law for second order forward, reversible reactions, one reactant

[Term]
id: SBO:0000093
name: mass action rate law for second order forward, second order reverse, reversible reactions, one reactant, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000092 ! mass action rate law for second order forward, second order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000094
name: mass action rate law for second order forward, second order reverse, reversible reactions, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000092 ! mass action rate law for second order forward, second order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000095
name: mass action rate law for second order forward, third order reverse, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the quantity of three products.
is_a: SBO:0000089 ! mass action rate law for second order forward, reversible reactions, one reactant

[Term]
id: SBO:0000096
name: mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000095 ! mass action rate law for second order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000097
name: mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000095 ! mass action rate law for second order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000098
name: mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the square of one reactant quantity. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000095 ! mass action rate law for second order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000099
name: mass action rate law for second order forward, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities.
is_a: SBO:0000088 ! mass action rate law for second order reversible reactions

[Term]
id: SBO:0000100
name: mass action rate law for second order forward, zeroth order reverse, reversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000099 ! mass action rate law for second order forward, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000101
name: mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000099 ! mass action rate law for second order forward, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000102
name: mass action rate law for second order forward, second order reverse, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the quantity of two products.
is_a: SBO:0000099 ! mass action rate law for second order forward, reversible reactions, two reactants

[Term]
id: SBO:0000103
name: mass action rate law for second order forward, second order reverse, reversible reactions, two reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000102 ! mass action rate law for second order forward, second order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000104
name: mass action rate law for second order forward, second order reverse, reversible reactions, two reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000102 ! mass action rate law for second order forward, second order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000105
name: mass action rate law for second order forward, third order reverse, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the quantity of three products.
is_a: SBO:0000099 ! mass action rate law for second order forward, reversible reactions, two reactants

[Term]
id: SBO:0000106
name: mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000105 ! mass action rate law for second order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000107
name: mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000105 ! mass action rate law for second order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000108
name: mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of two reactant quantities. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000105 ! mass action rate law for second order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000109
name: mass action rate law for third order reversible reactions
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of a reactant quantity.
is_a: SBO:0000042 ! mass action rate law for reversible reactions

[Term]
id: SBO:0000110
name: mass action rate law for third order forward, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant.
is_a: SBO:0000109 ! mass action rate law for third order reversible reactions

[Term]
id: SBO:0000111
name: mass action rate law for third order forward, zeroth order reverse, reversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000110 ! mass action rate law for third order forward, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000112
name: mass action rate law for third order forward, first order reverse, reversible reactions, two reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000110 ! mass action rate law for third order forward, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000113
name: mass action rate law for third order forward, second order reverse, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the quantity of two products.
is_a: SBO:0000110 ! mass action rate law for third order forward, reversible reactions, two reactants

[Term]
id: SBO:0000114
name: mass action rate law for third order forward, second order reverse, reversible reactions, two reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000113 ! mass action rate law for third order forward, second order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000115
name: mass action rate law for third order forward, second order reverse, reversible reactions, two reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000113 ! mass action rate law for third order forward, second order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000116
name: mass action rate law for third order forward, third order reverse, reversible reactions, two reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the quantity of three products.
is_a: SBO:0000110 ! mass action rate law for third order forward, reversible reactions, two reactants

[Term]
id: SBO:0000117
name: mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000116 ! mass action rate law for third order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000118
name: mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000116 ! mass action rate law for third order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000119
name: mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the  quantity of one reactant and the square of quantity of the other reactant. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000116 ! mass action rate law for third order forward, third order reverse, reversible reactions, two reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000120
name: mass action rate law for third order forward, reversible reactions, three reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities.
is_a: SBO:0000109 ! mass action rate law for third order reversible reactions

[Term]
id: SBO:0000121
name: mass action rate law for third order forward, zeroth order reverse, reversible reactions, three reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000120 ! mass action rate law for third order forward, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000122
name: mass action rate law for third order forward, first order reverse, reversible reactions, three reactants, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000120 ! mass action rate law for third order forward, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000123
name: mass action rate law for third order forward, second order reverse, reversible reactions, three reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the quantity of two products.
is_a: SBO:0000120 ! mass action rate law for third order forward, reversible reactions, three reactants

[Term]
id: SBO:0000124
name: mass action rate law for third order forward, second order reverse, reversible reactions, three reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000123 ! mass action rate law for third order forward, second order reverse, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000125
name: mass action rate law for third order forward, second order reverse, reversible reactions, three reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000123 ! mass action rate law for third order forward, second order reverse, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000126
name: mass action rate law for third order forward, third order reverse, reversible reactions, three reactants
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the quantity of three products.
is_a: SBO:0000120 ! mass action rate law for third order forward, reversible reactions, three reactants

[Term]
id: SBO:0000127
name: mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000126 ! mass action rate law for third order forward, third order reverse, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000128
name: mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000126 ! mass action rate law for third order forward, third order reverse, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000129
name: mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the product of three reactant quantities. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000126 ! mass action rate law for third order forward, third order reverse, reversible reactions, three reactants
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R1</ci>\n             <ci>R2</ci>\n             <ci>R3</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000130
name: mass action rate law for third order forward, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity.
is_a: SBO:0000109 ! mass action rate law for third order reversible reactions

[Term]
id: SBO:0000131
name: mass action rate law for third order forward, zeroth order reverse, reversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is constant. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000130 ! mass action rate law for third order forward, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000048\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <ci>kr</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000132
name: mass action rate law for third order forward, first order reverse, reversible reactions, one reactant, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the quantity of one product. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000130 ! mass action rate law for third order forward, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000038\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000133
name: mass action rate law for third order forward, second order reverse, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the quantity of two products.
is_a: SBO:0000130 ! mass action rate law for third order forward, reversible reactions, one reactant

[Term]
id: SBO:0000134
name: mass action rate law for third order forward, second order reverse, reversible reactions, one reactant, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the square of one product quantity.  It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000133 ! mass action rate law for third order forward, second order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000135
name: mass action rate law for third order forward, second order reverse, reversible reactions, one reactant, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the product of two product quantities.  It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000133 ! mass action rate law for third order forward, second order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000136
name: mass action rate law for third order forward, third order reverse, reversible reactions, one reactant
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the quantity of three products.
is_a: SBO:0000130 ! mass action rate law for third order forward, reversible reactions, one reactant

[Term]
id: SBO:0000137
name: mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, one product, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the cube of one product quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000136 ! mass action rate law for third order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n             <ci>P</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000138
name: mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, two products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the quantity of one product and the square of the quantity of the other product. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000136 ! mass action rate law for third order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000139
name: mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, three products, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does include a reverse process that creates the reactants from the products. The rate of the forward process is proportional to the cube of one reactant quantity. The rate of the reverse process is proportional to the product of three product quantities. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000136 ! mass action rate law for third order forward, third order reverse, reversible reactions, one reactant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">kf</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000040\">kr</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P3</ci></bvar>\n     <apply>\n         <minus></minus>\n         <apply>\n             <times></times>\n             <ci>kf</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n             <ci>R</ci>\n         </apply>\n         <apply>\n             <times></times>\n             <ci>kr</ci>\n             <ci>P1</ci>\n             <ci>P2</ci>\n             <ci>P3</ci>\n         </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000140
name: mass action rate law for zeroth order irreversible reactions, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is constant. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000043 ! mass action rate law for zeroth order irreversible reactions
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000065\">c</ci></bvar>\n     <apply>\n         <ci>c</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000141
name: mass action rate law for first order irreversible reactions, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities.  The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000044 ! mass action rate law for first order irreversible reactions
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000066\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>c</ci>\n         <ci>R</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000142
name: mass action rate law for second order irreversible reactions, one reactant, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the square of one reactant quantity. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000050 ! mass action rate law for second order irreversible reactions, one reactant
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000067\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R</ci></bvar>\n     <apply>\n        <times></times>\n         <ci>c</ci>\n         <apply>\n             <divide></divide>\n             <apply>\n                 <times></times>\n                 <ci>R</ci>\n                 <apply>\n                     <minus></minus>\n                     <ci>R</ci>\n                     <cn type=\"integer\">1</cn>\n                 </apply>\n             </apply>\n             <cn type=\"integer\">2</cn>\n          </apply>\n      </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000143
name: mass action rate law for second order irreversible reactions, two reactants, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of two reactants. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000053 ! mass action rate law for second order irreversible reactions, two reactants
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000067\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R2</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>c</ci>\n         <ci>R1</ci>\n         <ci>R2</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000144
name: mass action rate law for third order irreversible reactions, one reactant, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000056 ! mass action rate law for third order irreversible reactions, one reactant
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n    <lambda>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000068\">c</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R</ci></bvar>\n      <apply>\n        <times></times>\n        <ci>c</ci>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci>R</ci>\n            <apply>\n              <minus></minus>\n              <ci>R</ci>\n              <cn type=\"integer\">1</cn>\n            </apply>\n            <apply>\n              <minus></minus>\n              <ci>R</ci>\n              <cn type=\"integer\">2</cn>\n            </apply>\n          </apply>\n          <cn type=\"integer\">6</cn>\n        </apply>\n      </apply>\n    </lambda>\n  </semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000145
name: mass action rate law for third order irreversible reactions, two reactants, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000058 ! mass action rate law for third order irreversible reactions, two reactants
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000068\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R2</ci></bvar>\n     <apply>\n        <times></times>\n         <ci>c</ci>\n         <ci>R1</ci>\n         <apply>\n             <divide></divide>\n             <apply>\n                 <times></times>\n                 <ci>R2</ci>\n                 <apply>\n                     <minus></minus>\n                     <ci>R2</ci>\n                     <cn type=\"integer\">1</cn>\n                 </apply>\n             </apply>\n             <cn type=\"integer\">2</cn>\n          </apply>\n      </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000146
name: mass action rate law for third order irreversible reactions, three reactants, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of three reactants. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000060 ! mass action rate law for third order irreversible reactions, three reactants
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000068\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R3</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>c</ci>\n         <ci>R1</ci>\n         <ci>R2</ci>\n         <ci>R3</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000147
name: thermodynamic temperature
comment: Temperature is the physical property of a system which underlies the common notions of "hot" and "cold"; the material with the higher temperature is said to be hotter. Temperature is a quantity related to the average kinetic energy of the particles in a substance. The 10th Conference Generale des Poids et Mesures decided to define the thermodynamic temperature scale by choosing the triple point of water as the fundamental fixed point, and assigning to it the temperature 273,16 degrees Kelvin, exactly (0.01 degree Celsius).
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000148
name: temperature difference
comment: Quantity resulting from the difference between two thermodynamic temperatures. A difference or interval of temperature may be expressed in Kelvins or in degrees Celsius.\n
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000149
name: number of substrates
comment: Number of molecules which are acted upon by an enzyme.
is_a: SBO:0000157 ! number of reactants

[Term]
id: SBO:0000150
name: enzymatic rate law for irreversible non-modulated non-interacting reactant enzymes
comment: Kinetics of enzymes that react with one or several substances, their substrates, that bind independently. The enzymes do not catalyse the reactions in both directions.  
is_a: SBO:0000268 ! enzymatic rate law
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kp</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000149\">n</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Et</ci>\n         <ci>kp</ci>\n         <apply>\n           <product></product>\n           <bvar><ci> i </ci></bvar>\n           <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n           <uplimit><ci> n </ci></uplimit>\n           <apply>\n             <divide></divide>\n             <apply>\n               <selector></selector>\n               <ci type=\"vector\">S</ci>\n               <ci> i </ci>\n             </apply>\n             <apply>\n               <selector></selector>\n               <ci type=\"vector\">K</ci>\n               <ci> i </ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n       <apply>\n         <product></product>\n         <bvar><ci> i </ci></bvar>\n         <lowlimit>\n          <cn type=\"integer\"> 1 </cn>\n         </lowlimit>\n         <uplimit>\n           <ci> n </ci>\n         </uplimit>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <apply>\n               <selector></selector>\n               <ci type=\"vector\">S</ci>\n               <ci> i </ci>\n             </apply>\n             <apply>\n               <selector></selector>\n               <ci type=\"vector\">K</ci>\n               <ci> i </ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000151
name: enzymatic rate law for irreversible non-modulated non-interacting bireactant enzymes
comment: Kinetics of enzymes that react with two substances, their substrates, that bind independently. The enzymes do not catalyse the reactions in both directions.  
is_a: SBO:0000150 ! enzymatic rate law for irreversible non-modulated non-interacting reactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kp</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K2</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Et</ci>\n         <ci>kp</ci>\n         <apply>\n           <times></times>\n           <apply>\n             <divide></divide>\n             <ci> S1 </ci>\n             <ci> K1 </ci>\n           </apply>\n           <apply>\n             <divide></divide>\n             <ci> S2 </ci>\n             <ci> K2 </ci>\n           </apply>\n         </apply>\n       </apply>\n       <apply>\n         <times></times>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <ci> S1 </ci>\n             <ci> K1 </ci>\n           </apply>\n         </apply>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <ci> S2 </ci>\n             <ci> K2 </ci>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000152
name: enzymatic rate law for irreversible non-modulated non-interacting trireactant enzymes
comment: Kinetics of enzymes that react with three substances, their substrates, that bind independently. The enzymes do not catalyse the reactions in both directions.
is_a: SBO:0000150 ! enzymatic rate law for irreversible non-modulated non-interacting reactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kp</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S3</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">K3</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Et</ci>\n         <ci>kp</ci>\n         <apply>\n           <times></times>\n           <apply>\n             <divide></divide>\n             <ci> S1 </ci>\n             <ci> K1 </ci>\n           </apply>\n           <apply>\n             <divide></divide>\n             <ci> S2 </ci>\n             <ci> K2 </ci>\n           </apply>\n           <apply>\n             <divide></divide>\n             <ci> S3 </ci>\n             <ci> K3 </ci>\n           </apply>\n         </apply>\n       </apply>\n       <apply>\n         <times></times>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <ci> S1 </ci>\n             <ci> K1 </ci>\n           </apply>\n         </apply>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <ci> S2 </ci>\n             <ci> K2 </ci>\n           </apply>\n         </apply>\n         <apply>\n           <plus></plus>\n           <cn type=\"integer\">1</cn>\n           <apply>\n             <divide></divide>\n             <ci> S3 </ci>\n             <ci> K3 </ci>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000153
name: forward rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants.
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000154
name: forward rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000155
name: forward rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000156
name: reverse rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. 
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000157
name: number of reactants
comment: Number of different substances consumed by a chemical reaction.
is_a: SBO:0000188 ! number of biochemical items

[Term]
id: SBO:0000158
name: order of a reaction with respect to a reactant
comment: The order of a reaction with respect to a certain reactant is defined as the power to which its concentration term in the rate equation is raised.
is_a: SBO:0000382 ! biochemical exponential coefficient

[Term]
id: SBO:0000159
name: non-integral order rate constant
comment: Numerical parameter that quantifies the velocity of a chemical reaction where reactants have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the reactants.
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000160
name: forward non-integral order rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction where reactants have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the reactants.
is_a: SBO:0000153 ! forward rate constant
is_a: SBO:0000159 ! non-integral order rate constant

[Term]
id: SBO:0000161
name: reverse non-integral order rate constant
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction where products have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the products.
is_a: SBO:0000156 ! reverse rate constant
is_a: SBO:0000159 ! non-integral order rate constant

[Term]
id: SBO:0000162
name: forward zeroth order rate constant
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction independant of the reactant quantities. This parameter encompasses all the contributions to the velocity.
is_a: SBO:0000046 ! zeroth order rate constant
is_a: SBO:0000153 ! forward rate constant

[Term]
id: SBO:0000163
name: mass action rate law for irreversible reactions, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000154\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">n</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000158\">mu</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n       <times></times>\n       <ci>k</ci>\n       <apply>\n         <product></product>\n         <bvar><ci> i </ci></bvar>\n         <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit>\n         <uplimit><ci> n </ci></uplimit>\n         <apply>\n           <power></power>\n           <apply>\n             <selector></selector>\n             <ci type=\"vector\">R</ci>\n             <ci> i </ci>\n           </apply>\n           <apply>\n             <selector></selector>\n             <ci type=\"vector\">mu</ci>\n             <ci> i </ci>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000164
name: second order irreversible mass action kinetics, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to two reactant quantity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000005 ! obsolete mathematical expression
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000010\">R</ci></bvar>\n     <apply>\n       <times></times>\n       <ci>k</ci>\n       <apply>\n         <product></product>\n         <bvar><ci> i </ci></bvar>\n         <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n         <uplimit><ci> 2 </ci></uplimit>\n         <apply>\n           <selector></selector>\n           <ci type=\"vector\">R</ci>\n           <ci> i </ci>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000165
name: third order irreversible mass action kinetics, continuous scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to three reactant quantities. It is to be used in a reaction modelled using a continuous framework.  
is_a: SBO:0000005 ! obsolete mathematical expression
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000037\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000010\">R</ci></bvar>\n     <apply>\n       <times></times>\n       <ci>k</ci>\n       <apply>\n         <product></product>\n         <bvar><ci> i </ci></bvar>\n         <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n         <uplimit><ci> 3 </ci></uplimit>\n         <apply>\n           <selector></selector>\n           <ci type=\"vector\">R</ci>\n           <ci> i </ci>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000166
name: mass action rate law for irreversible reactions, discrete scheme
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000041 ! mass action rate law for irreversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000155\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">n</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000158\">mu</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R</ci></bvar>\n     <apply>\n       <times></times>\n       <ci>c</ci>\n       <apply>\n         <product></product>\n         <bvar><ci> i </ci></bvar>\n         <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit>\n         <uplimit><ci> n </ci></uplimit>\n         <apply>\n           <divide></divide>\n           <apply>\n             <factorial></factorial>\n             <apply>\n               <selector></selector>\n               <ci type=\"vector\">R</ci>\n               <ci> i </ci>\n             </apply>\n           </apply>\n           <apply>\n             <times></times>\n             <apply>\n               <factorial></factorial>\n               <apply>\n                 <minus></minus>              \n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">R</ci>\n                   <ci> i </ci>\n                 </apply>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">mu</ci>\n                   <ci> i </ci>\n                 </apply>\n               </apply>\n            </apply>\n             <apply>\n               <factorial></factorial>\n               <apply>\n                 <selector></selector>\n                 <ci type=\"vector\">mu</ci>\n                 <ci> i </ci>\n               </apply>\n            </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000167
name: biochemical or transport reaction
comment: An event involving one or more physical entities that modifies the structure, location or free energy of at least one of the participants.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000168
name: control
comment: Synonym: regulation 
is_a: SBO:0000374 ! relationship

[Term]
id: SBO:0000169
name: inhibition
comment: Negative modulation of the execution of a process.
is_a: SBO:0000168 ! control

[Term]
id: SBO:0000170
name: stimulation
comment: Positive modulation of the execution of a process.
is_a: SBO:0000168 ! control

[Term]
id: SBO:0000171
name: necessary stimulation
comment: Synonym: trigger 
is_a: SBO:0000170 ! stimulation

[Term]
id: SBO:0000172
name: catalysis
comment: Modification of the velocity of a reaction by lowering the energy of the transition state.
is_a: SBO:0000170 ! stimulation

[Term]
id: SBO:0000173
name: and
comment: All the preceding events or participating entities are necessary to perform the control.
is_a: SBO:0000237 ! logical combination

[Term]
id: SBO:0000174
name: or
comment: Any of the preceding events or participating entities are necessary to perform the control.
is_a: SBO:0000237 ! logical combination

[Term]
id: SBO:0000175
name: xor
comment: Synonym: exclusive or 
is_a: SBO:0000237 ! logical combination

[Term]
id: SBO:0000176
name: biochemical reaction
comment: An event involving one or more chemical entities that modifies the electrochemical structure of at least one of the participants.\n
is_a: SBO:0000167 ! biochemical or transport reaction

[Term]
id: SBO:0000177
name: non-covalent binding
comment: Synonym: association 
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000178
name: cleavage
comment: Rupture of a covalent bond resulting in the conversion of one physical entity into several physical entities or into a physical entity of a different topological class.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000179
name: degradation
comment: Complete disappearance of a physical entity.
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000180
name: dissociation
comment: Transformation of a non-covalent complex that results in the formation of several independent biochemical entities
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000181
name: conformational transition
comment: Biochemical reaction that does not result in the modification of covalent bonds of reactants, but rather modifies the conformation of some reactants, that is the relative position of their atoms in space.
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000182
name: conversion
comment: Biochemical reaction that results in the modification of some covalent bonds.
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000183
name: transcription
comment: Process through which a DNA sequence is copied to produce a complementary RNA.
is_a: SBO:0000205 ! composite biochemical process

[Term]
id: SBO:0000184
name: translation
comment: Process in which a polypeptide chain is produced from a messenger RNA.
is_a: SBO:0000205 ! composite biochemical process

[Term]
id: SBO:0000185
name: translocation reaction
comment: Movement of a physical entity without modification of the structure of the entity.
is_a: SBO:0000167 ! biochemical or transport reaction

[Term]
id: SBO:0000186
name: maximal velocity
comment: Synonym: Vmax 
is_a: SBO:0000046 ! zeroth order rate constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <apply>\n       <times></times>\n         <ci>Et</ci>\n         <ci>kcat</ci>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000187
name: Henri-Michaelis-Menten equation, Vmax form
comment: Version of Henri-Michaelis-Menten equation where kp*[E]t is replaced by the maximal velocity, Vmax, reached when all the enzyme is active. 
is_a: SBO:0000005 ! obsolete mathematical expression
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\">Vmax</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000015\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Vmax</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Ks</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000188
name: number of biochemical items
comment: A number of objects of the same type, identical or different, involved in a biochemical event.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000189
name: number of binding sites
comment: Number of regions on a reactant to which specific other reactants, in this context collectively called ligands, form a chemical bond.
is_a: SBO:0000188 ! number of biochemical items

[Term]
id: SBO:0000190
name: Hill coefficient
comment: Empirical parameter created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: iv-vii).
is_a: SBO:0000382 ! biochemical exponential coefficient

[Term]
id: SBO:0000191
name: Hill constant
comment: Empirical constant created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: iv-vii). Different from a microscopic dissociation constant, it has the dimension of concentration to the power of the Hill coefficient.
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000192
name: Hill-type rate law, generalised form
comment: Empirical equation created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: iv-vii).
is_a: SBO:0000001 ! rate law
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\">Vmax</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000191\">K</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\">h</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000256\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Vmax</ci>\n         <apply>\n           <power></power>\n           <ci>R</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <power></power>\n           <ci>K</ci>\n           <ci>n</ci>\n         </apply>\n         <apply>\n           <power></power>\n           <ci>R</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000193
name: equilibrium or steady-state constant
comment: Constant with the dimension of a powered concentration. It is determined at half-saturation, half-activity etc. 
is_a: SBO:0000308 ! equilibrium or steady-state characteristic

[Term]
id: SBO:0000194
name: pseudo-dissociation constant
comment: Dissociation constant equivalent to an intrinsic microscopic dissociation constant, but obtained from an averaging process, for instance by extracting the root of a Hill constant. 
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000195
name: Hill-type rate law, microscopic form
comment: Hill equation rewritten by creating a pseudo-microscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient.
is_a: SBO:0000192 ! Hill-type rate law, generalised form
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\">Vmax</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000194\">K</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\">h</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Vmax</ci>\n         <apply>\n           <power></power>\n           <ci>R</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <power></power>\n           <ci>K</ci>\n           <ci>h</ci>\n         </apply>\n         <apply>\n           <power></power>\n           <ci>R</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000196
name: concentration of an entity pool
comment: Synonym: [X] 
is_a: SBO:0000226 ! density of an entity pool

[Term]
id: SBO:0000197
name: specific concentration of an entity
comment: Concentration of an object divided by the value of another parameter having the dimension of a concentration.
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000198
name: Hill-type rate law, reduced form
comment: Hill equation rewritten by replacing the concentration of reactant with its reduced form, that is the concentration divide by a pseudo-microscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient.
is_a: SBO:0000192 ! Hill-type rate law, generalised form
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\">Vmax</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R*</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\">h</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>Vmax</ci>\n         <apply>\n           <power></power>\n           <ci>R*</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n       <apply>\n         <plus></plus>\n         <cn>1</cn>\n         <apply>\n           <power></power>\n           <ci>R*</ci>\n           <ci>h</ci>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000199
name: normalised enzymatic rate law for unireactant enzymes
comment: Kinetics of enzymes that react only with one substance, their substrate. The total enzyme concentration is considered to be equal to 1, therefore the maximal velocity equals the catalytic constant.
is_a: SBO:0000028 ! enzymatic rate law for irreversible non-modulated non-interacting unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>Ks</ci>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000200
name: redox reaction
comment: Chemical process in which atoms have their oxidation number (oxidation state) changed.
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000201
name: oxidation
comment: Chemical process during which a molecular entity loses electrons.
is_a: SBO:0000200 ! redox reaction

[Term]
id: SBO:0000202
name: reduction
comment: Chemical process in which a molecular entity gain electrons.
is_a: SBO:0000200 ! redox reaction

[Term]
id: SBO:0000203
name: duplication
comment: Reaction in which a reactant gives birth to two products identical to itself.
is_a: SBO:0000232 ! obsolete event

[Term]
id: SBO:0000204
name: DNA replication
comment: Process in which a DNA duplex is transformed into two identical DNA duplexes.
is_a: SBO:0000205 ! composite biochemical process

[Term]
id: SBO:0000205
name: composite biochemical process
comment: Process that involves the participation of chemical or biological entities and is composed of several elementary steps or reactions. 
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000206
name: competitive inhibitor
comment: Substance that decreases the probability of a chemical reaction, without itself being consumed or transformed by the reaction, by stericaly hindering the interaction between reactants.
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000207
name: non-competitive inhibitor
comment: Substance that decreases the probability of a chemical reaction, without itself being consumed or transformed by the reaction, and without sterically hindering the interaction between reactants.  
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000208
name: acid-base reaction
comment: Chemical reaction where a proton is given by a compound, the acid, to another one, the base (Brønsted-Lowry definition). An alternative, more general, definition is a reaction where a compound, the base, gives a pair of electrons to another, the acid (Lewis definition).
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000209
name: ionisation
comment: Ionization is the physical process of converting an atom or molecule into an ion by changing the difference between the number of protons and electrons. 
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000210
name: addition of a chemical group
comment: Covalent reaction that results in the addition of a chemical group on a molecule.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000211
name: removal of a chemical group
comment: Covalent reaction that results in the removal of a chemical group from a molecule.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000212
name: protonation
comment: Addition of a proton (H+) to a chemical entity.
is_a: SBO:0000208 ! acid-base reaction
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000213
name: deprotonation
comment: Removal of a proton (hydrogen ion H+) from a chemical entity.
is_a: SBO:0000208 ! acid-base reaction
is_a: SBO:0000211 ! removal of a chemical group

[Term]
id: SBO:0000214
name: methylation
comment: Addition of a methyl group (-CH3) to a chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000215
name: acetylation
comment: Addition of an acetyl group (-COCH3) to a chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000216
name: phosphorylation
comment: Addition of a phosphate group (-H2PO4) to a  chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000217
name: glycosylation
comment: Addition of a saccharide group to a chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000218
name: palmitoylation
comment: Addition of a palmitoyl group (CH3-[CH2]14-CO-) to a chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000219
name: myristoylation
comment: Addition of a myristoyl (CH3-[CH2]12-CO-) to a chemical entity.
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000220
name: sulfation
comment: Synonym: sulphation 
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000221
name: prenylation
comment: Synonym: isoprenylation 
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000222
name: farnesylation
comment: Addition of a farnesyl group (CH2-CH=C(CH3)-CH2-CH2-CH=C(CH3)-CH2-CH2-CH=C(CH3)2) to a chemical entity.
is_a: SBO:0000221 ! prenylation

[Term]
id: SBO:0000223
name: geranylgeranylation
comment: Addition of a geranylgeranyl group (CH2-CH=C(CH3)-CH2-CH2-CH=C(CH3)-CH2-CH2-CH=C(CH3)-CH2-CH2-CH=C(CH3)2) to a chemical entity.
is_a: SBO:0000221 ! prenylation

[Term]
id: SBO:0000224
name: ubiquitination
comment: Covalent linkage to the protein ubiquitin. 
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000225
name: delay
comment: Time during which some action is awaited.
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000226
name: density of an entity pool
comment: A quantitative measure of an amount or property of an entity expressed in terms of another dimension, such as unit length, area or volume.
is_a: SBO:0000360 ! quantity of an entity pool

[Term]
id: SBO:0000227
name: mass density of an entity
comment: The mass of an entity expressed with reference to another dimension, such as unit length, area or volume.
is_a: SBO:0000226 ! density of an entity pool

[Term]
id: SBO:0000228
name: volume density of an entity
comment: Mass of an entity per unit volume.
is_a: SBO:0000227 ! mass density of an entity

[Term]
id: SBO:0000229
name: area density of an entity
comment: The mass of an entity per unit of surface area.
is_a: SBO:0000227 ! mass density of an entity

[Term]
id: SBO:0000230
name: linear density of an entity
comment: Mass of an entity per unit length.
is_a: SBO:0000227 ! mass density of an entity

[Term]
id: SBO:0000231
name: occurring entity representation
comment: Representation of an entity that manifests, unfolds or develops through time, such as a discrete event, or a mutual or reciprocal action or influence that happens between participating physical entities, and/or other occurring entities. 
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000232
name: obsolete event
comment: A phenomenon that takes place and which may be observable, or may be determined to have occurred as the result of an action or process.
is_a: SBO:0000231 ! occurring entity representation

[Term]
id: SBO:0000233
name: hydroxylation
comment: Addition of an hydroxyl group (-OH) to a chemical entity. 
is_a: SBO:0000210 ! addition of a chemical group

[Term]
id: SBO:0000234
name: logical framework
comment: Modelling approach, pioneered by Rene Thomas and Stuart Kaufman, where the evolution of a system is described by the transitions between discrete activity states of "genes" that control each other.
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000235
name: participant
comment: Entity that affects or is affected by an event.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000236
name: physical entity representation
comment: Synonym: new synonym 
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000237
name: logical combination
comment: Combining the influence of several entities or events in a unique influence.
is_a: SBO:0000374 ! relationship

[Term]
id: SBO:0000238
name: not
comment: The preceding event or participating entity cannot participate to the control. 
is_a: SBO:0000237 ! logical combination

[Term]
id: SBO:0000239
name: allosteric control
comment: Regulation of the influence of a reaction participant by binding an effector to a binding site of the participant different of the site of the participant conveying the influence.
is_a: SBO:0000168 ! control

[Term]
id: SBO:0000240
name: material entity
comment: A real thing that is defined by its physico-chemical structure.\n
is_a: SBO:0000236 ! physical entity representation

[Term]
id: SBO:0000241
name: functional entity
comment: A real thing, defined by its properties or the actions it performs, rather than it physico-chemical structure.
is_a: SBO:0000236 ! physical entity representation

[Term]
id: SBO:0000242
name: channel
comment: A component that allows another component to pass through itself, possibly connecting different compartments.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000243
name: gene
comment: A locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions.\n\nSequence Ontology SO:0000704
is_a: SBO:0000240 ! material entity
is_a: SBO:0000404 ! unit of genetic information

[Term]
id: SBO:0000244
name: receptor
comment: Participating entity that binds to a specific physical entity and initiates the response to that physical entity.The original concept of the receptor was introduced independently at the end of the 19th century by John Newport Langley (1852-1925) and Paul Ehrlich (1854-1915).\n\nLangley JN.On the reaction of cells and of nerve-endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari. J Physiol. 1905 Dec 30;33(4-5):374-413.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000245
name: macromolecule
comment: Molecular entity mainly built-up by the repetition of pseudo-identical units.\n\nCHEBI:33839
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000246
name: information macromolecule
comment: Macromolecule whose sequence is encoded in the genome of living organisms.
is_a: SBO:0000245 ! macromolecule

[Term]
id: SBO:0000247
name: simple chemical
comment: Simple, non-repetitive chemical entity.
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000248
name: chemical macromolecule
comment: Macromolecule whose sequence is not directly encoded in the genome.
is_a: SBO:0000245 ! macromolecule

[Term]
id: SBO:0000249
name: polysaccharide
comment: Macromolecule consisting of a large number of monosaccharide residues linked by glycosidic bonds.\n\nCHEBI:18154
is_a: SBO:0000248 ! chemical macromolecule

[Term]
id: SBO:0000250
name: ribonucleic acid
comment: Synonym: RNA 
is_a: SBO:0000246 ! information macromolecule

[Term]
id: SBO:0000251
name: deoxyribonucleic acid
comment: Synonym: DNA 
is_a: SBO:0000246 ! information macromolecule

[Term]
id: SBO:0000252
name: polypeptide chain
comment: Naturally occurring macromolecule formed by the repetition of amino-acid residues linked by peptidic bonds. A polypeptide chain is synthesized by the ribosome.\n\nCHEBI:16541
is_a: SBO:0000246 ! information macromolecule

[Term]
id: SBO:0000253
name: non-covalent complex
comment: Entity composed of several independant components that are not linked by covalent bonds.
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000254
name: electrical resistance
comment: Measure of the degree to which an object opposes the passage of an electric current. The SI unit of electrical resistance is the ohm.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000255
name: physical characteristic
comment: Parameter characterising a physical system or the environment, and independent of life's influence.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000256
name: biochemical parameter
comment: Parameter that depends on the biochemical properties of a system.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000257
name: conductance
comment: Measure of how easily electricity flows along a certain path through an electrical element. The SI derived unit of conductance is the Siemens.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000258
name: capacitance
comment: Measure of the amount of electric charge stored (or separated) for a given electric potential. The unit of capacitance id the Farad.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000259
name: voltage
comment: Synonym: electrical potential difference 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000260
name: enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by one inhibitor
comment: Synonym: simple intersecting linear competitive inhibition of unireactant enzymes 
is_a: SBO:0000267 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by one inhibitor
is_a: SBO:0000270 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <ci>Ki</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000261
name: inhibitory constant
comment: Synonym: Ki 
is_a: SBO:0000282 ! dissociation constant

[Term]
id: SBO:0000262
name: enzymatic rate law for simple uncompetitive inhibition of irreversible unireactant enzymes
comment: Synonym: simple linear uncompetitive inhibition 
is_a: SBO:0000458 ! enzymatic rate law for simple uncompetitive inhibition of reversible unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <ci>Ki</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>Ks</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000263
name: relative equilibrium constant
comment: Ratio of an equilibrium constant in a given condition by the same equilibrium constant is not fullfilled.
is_a: SBO:0000308 ! equilibrium or steady-state characteristic

[Term]
id: SBO:0000264
name: relative inhibition constant
comment: Ratio of the dissociation constant of an inhibitor from the complex enzyme-substrate on the dissociation constant of an inhibitor from the free enzyme.
is_a: SBO:0000263 ! relative equilibrium constant

[Term]
id: SBO:0000265
name: enzymatic rate law for simple mixed-type inhibition of irreversible unireactant enzymes
comment: Synonym: simple intersecting linear mixed-type competitive inhibition 
is_a: SBO:0000275 ! enzymatic rate law for mixed-type inhibition of irreversible enzymes by mutually exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000385\">a</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <apply>\n                 <times></times>\n                 <ci>a</ci>\n                 <ci>Ki</ci>\n               </apply></apply>\n           </apply>\n         </apply>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <ci>Ki</ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000266
name: enzymatic rate law for simple irreversible non-competitive inhibition of unireactant enzymes
comment: Inhibition of a unireactant enzyme by one inhibitor that can bind to the complex enzyme-substrate and the free enzyme with the same equilibrium constant, and totally prevent the catalysis.
is_a: SBO:0000442 ! enzymatic rate law for simple reversible non-competitive inhibition of unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <ci>Ki</ci>\n             </apply>\n           </apply>\n         </apply>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I</ci>\n               <ci>Ki</ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000267
name: enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by one inhibitor
comment: Synonym: multiple competitive inhibition by one inhibitor of unireactant enzymes 
is_a: SBO:0000273 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by non-exclusive non-cooperative inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000189\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <ci>S</ci>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <power></power>\n             <apply>\n               <plus></plus>\n               <cn type=\"integer\">1</cn>\n               <apply>\n                 <divide></divide>\n                 <ci>I</ci>\n                 <ci>Ki</ci>\n               </apply>\n             </apply>\n             <ci>n</ci>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000268
name: enzymatic rate law
comment: Enzyme kinetics is the study of the rates of chemical reactions that are catalysed by enzymes, how this rate is controlled, and how drugs and poisons can inhibit its activity. 
is_a: SBO:0000001 ! rate law

[Term]
id: SBO:0000269
name: enzymatic rate law for unireactant enzymes
comment: Kinetics of enzymes that catalyse the transformation of only one substrate. 
is_a: SBO:0000268 ! enzymatic rate law

[Term]
id: SBO:0000270
name: enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors
comment: Inhibition of a unireactant enzyme by inhibitors that bind to the free enzyme on the same binding site than the substrate. The enzymes do not catalyse the reactions in both directions. 
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <sum></sum>\n               <bvar><ci> i </ci></bvar>\n               <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n               <uplimit><ci> n </ci></uplimit>\n               <apply>\n                 <divide></divide>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">I</ci>\n                   <ci> i </ci>\n                 </apply>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">Ki</ci>\n                   <ci> i </ci>\n                 </apply>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000271
name: enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by two exclusive inhibitors
comment: Inhibition of a unireactant enzyme by two inhibitors that bind to the free enzyme on the same binding site than the substrate.  The enzymes do not catalyse the reactions in both directions. 
is_a: SBO:0000270 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki2</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I1</ci>\n               <ci>Ki1</ci>\n             </apply>\n             <apply>\n               <divide></divide>\n               <ci>I2</ci>\n               <ci>Ki2</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000272
name: number of inhibitors
comment: Number of entities that inhibit a reaction. 
is_a: SBO:0000188 ! number of biochemical items

[Term]
id: SBO:0000273
name: enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by non-exclusive non-cooperative inhibitors
comment: Inhibition of a unireactant enzyme by inhibitors that bind independently to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions.
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000189\">m</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <product></product>\n             <bvar><ci> i </ci></bvar>\n             <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n             <uplimit><ci> n </ci></uplimit>\n             <apply>\n               <power></power>\n               <apply>\n                 <plus></plus>\n                 <cn type=\"integer\">1</cn>\n                 <apply>\n                   <divide></divide>\n                   <apply>\n                     <selector></selector>\n                     <ci type=\"vector\">I</ci>\n                     <ci> i </ci>\n                   </apply>\n                   <apply>\n                     <selector></selector>\n                     <ci type=\"vector\">Ki</ci>\n                     <ci> i </ci>\n                   </apply>\n                 </apply>\n               </apply>\n               <apply>\n                 <selector></selector>\n                 <ci type=\"vector\">m</ci>\n                 <ci> i </ci>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000274
name: enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive, non-cooperative inhibitors
comment: Inhibition of a unireactant enzyme by two inhibitors that can bind independently once to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions.
is_a: SBO:0000273 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by non-exclusive non-cooperative inhibitors
is_a: SBO:0000379 ! enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n    <lambda>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I1</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I2</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki1</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki2</ci></bvar>\n      <apply>\n    <divide></divide>\n    <apply>\n      <times></times>\n      <ci>kcat</ci>\n      <ci>Et</ci>\n      <ci>S</ci>\n    </apply>\n    <apply>\n      <plus></plus>\n      <apply>\n        <times></times>\n        <ci>Ks</ci>\n        <apply>\n          <plus></plus>\n          <cn type=\"integer\">1</cn>\n          <apply>\n        <divide></divide>\n        <ci>I1</ci>\n        <ci>Ki1</ci>\n          </apply>\n          <apply>\n        <divide></divide>\n        <ci>I2</ci>\n        <ci>Ki2</ci>\n          </apply>\n          <apply>\n        <divide></divide>\n        <apply>\n          <times></times>\n          <ci>I1</ci>\n           <ci>I2</ci>\n        </apply>\n        <apply>\n          <times></times>\n          <ci>Ki1</ci>\n          <ci>Ki2</ci>\n        </apply>\n          </apply>\n        </apply>\n      </apply>\n      <ci>S</ci>\n    </apply>\n      </apply>\n    </lambda>\n </semantics>\n </mathml:math> " http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000275
name: enzymatic rate law for mixed-type inhibition of irreversible enzymes by mutually exclusive inhibitors
comment: Inhibition of a unireactant enzyme by inhibitors that can bind to the complex enzyme-substrate and the free enzyme, possibly with different equilibrium constants, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions. 
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000385\">a</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <sum></sum>\n               <bvar><ci> i </ci></bvar>\n               <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n               <uplimit><ci> n </ci></uplimit>\n               <apply>\n                 <divide></divide>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">I</ci>\n                   <ci> i </ci>\n                 </apply>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">Ki</ci>\n                   <ci> i </ci>\n                 </apply>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <sum></sum>\n               <bvar><ci> i </ci></bvar>\n               <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n               <uplimit><ci> n </ci></uplimit>\n               <apply>\n                 <divide></divide>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">I</ci>\n                   <ci> i </ci>\n                 </apply>\n                 <apply>\n                   <times></times>\n                   <apply>\n                     <selector></selector>\n                     <ci type=\"vector\">a</ci>\n                     <ci> i </ci>\n                   </apply>\n                   <apply>\n                     <selector></selector>\n                     <ci type=\"vector\">Ki</ci>\n                     <ci> i </ci>\n                   </apply>\n                 </apply>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000276
name: enzymatic rate law for mixed-type inhibition of irreversible unireactant enzymes by two inhibitors
comment: Inhibition of unireactant enzymes by two inhibitors that can bind to the complex enzyme-substrate and the free enzyme, possibly with different equilibrium constant, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions.  
is_a: SBO:0000275 ! enzymatic rate law for mixed-type inhibition of irreversible enzymes by mutually exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000385\">a</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000385\">b</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I1</ci>\n               <apply>\n                 <times></times>\n                 <ci>a</ci>\n                 <ci>Ki1</ci>\n               </apply>\n             </apply>\n             <apply>\n               <divide></divide>\n               <ci>I2</ci>\n               <apply>\n                 <times></times>\n                 <ci>b</ci>\n                 <ci>Ki2</ci>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I1</ci>\n               <ci>Ki1</ci>\n             </apply>\n             <apply>\n               <divide></divide>\n               <ci>I2</ci>\n               <ci>Ki2</ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000277
name: enzymatic rate law for non-competitive inhibition of irreversible unireactant enzymes by two exclusively binding inhibitors
comment: Inhibition of unireactant enzymes by two inhibitors that can bind to the complex enzyme-substrate and the free enzyme with the same equilibrium constant and totally prevent the catalysis.  
is_a: SBO:0000276 ! enzymatic rate law for mixed-type inhibition of irreversible unireactant enzymes by two inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I2</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki1</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki2</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>S</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I1</ci>\n               <ci>Ki1</ci>\n             </apply>\n             <apply>\n               <divide></divide>\n               <ci>I2</ci>\n               <ci>Ki2</ci>\n             </apply>\n           </apply>\n         </apply>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <divide></divide>\n               <ci>I1</ci>\n               <ci>Ki1</ci>\n             </apply>\n             <apply>\n               <divide></divide>\n               <ci>I2</ci>\n               <ci>Ki2</ci>\n             </apply>\n           </apply>\n         </apply>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000278
name: messenger RNA
comment: Synonym: mRNA 
is_a: SBO:0000404 ! unit of genetic information

[Term]
id: SBO:0000279
name: pressure
comment: Pressure (symbol: p) is the force per unit area applied on a surface in a direction perpendicular to that surface. The unit of pressure is the Pascal (Pa), that is equal to 1 Newton per square meter.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000280
name: ligand
comment: In biochemistry, a ligand is an effector, a physical entity that binds to a site on a receptor's surface by intermolecular forces.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000281
name: equilibrium constant
comment: Synonym: Keq 
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000282
name: dissociation constant
comment: Synonym: Kd 
is_a: SBO:0000281 ! equilibrium constant
is_a: SBO:0000309 ! dissociation characteristic
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000338\">koff</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000341\">Kon</ci></bvar>\n     <apply>\n       <divide></divide>\n         <ci>koff</ci>\n         <ci>Kon</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000283
name: acid dissociation constant
comment: Synonym: Ka 
is_a: SBO:0000282 ! dissociation constant
is_a: SBO:0000310 ! acid dissociation characteristic

[Term]
id: SBO:0000284
name: transporter
comment: Participating entity that facilitates the movement of another physical entity from a defined subset of the physical environment (for instance a cellular compartment) to another. 
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000285
name: material entity of unspecified nature
comment: Material entity whose nature is unknown or irrelevant.
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000286
name: multimer
comment: Non-covalent association of identical, or pseudo-identical, entities. By pseudo-identical entities, we mean biochemical elements that differ chemically, although remaining globally identical in structure and/or function. Examples are homologous subunits in an hetero-oligomeric receptor.
is_a: SBO:0000253 ! non-covalent complex

[Term]
id: SBO:0000287
name: EC50
comment: Concentration of an active compound at which 50% of its maximal effect is observed. The EC50 is not a pure characteristic of the compound but depends on the conditions or the measurement.
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000288
name: IC50
comment: Also called half maximal inhibitory concentration, it represents the concentration of an inhibitor substance that is required to suppress 50% of an effect. 
is_a: SBO:0000193 ! equilibrium or steady-state constant

[Term]
id: SBO:0000289
name: functional compartment
comment: Logical or physical subset of the event space that contains pools, that is sets of participants considered identical when it comes to the event they are involved into. A compartment can have any number of dimensions, including 0, and be of any size including null.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000290
name: physical compartment
comment: Specific location of space, that can be bounded or not. A physical compartment can have 1, 2 or 3  dimensions.
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000291
name: empty set
comment: Entity defined by the absence of any actual object. An empty set is often used to represent the source of a creation process or the result of a degradation process. 
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000292
name: spatial continuous framework
comment: Modelling approach where the quantities of participants are considered continuous, and represented by real values. The associated simulation methods make use of differential equations. The models take into account the distribution of the entities and describe the spatial fluxes. 
is_a: SBO:0000062 ! continuous framework

[Term]
id: SBO:0000293
name: non-spatial continuous framework
comment: Modelling approach where the quantities of participants are considered continuous, and represented by real values. The associated simulation methods make use of differential equations. The models do not take into account the distribution of the entities and describe only the temporal fluxes.  
is_a: SBO:0000062 ! continuous framework

[Term]
id: SBO:0000294
name: spatial discrete framework
comment: Modelling approach where the quantities of participants are considered discrete, and represented by integer values. The associated simulation methods can be deterministic or stochastic. The models take into account the distribution of the entities and describe the spatial fluxes.  
is_a: SBO:0000063 ! discrete framework

[Term]
id: SBO:0000295
name: non-spatial discrete framework
comment: Modelling approach where the quantities of participants are considered discrete, and represented by integer values. The associated simulation methods can be deterministic or stochastic.The models do not take into account the distribution of the entities and describe only the temporal fluxes.   \n
is_a: SBO:0000063 ! discrete framework

[Term]
id: SBO:0000296
name: macromolecular complex
comment: Non-covalent complex of one or more macromolecules and zero or more simple chemicals.
is_a: SBO:0000253 ! non-covalent complex

[Term]
id: SBO:0000297
name: protein complex
comment: Macromolecular complex containing one or more polypeptide chains possibly associated with simple chemicals.\n\nCHEBI:36080
is_a: SBO:0000296 ! macromolecular complex

[Term]
id: SBO:0000298
name: synthetic chemical compound
comment: Chemical entity that is engineered by a human-designed process ex-vivo rather than a produced by a living entity.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000299
name: metabolite
comment: Substance produced by metabolism or by a metabolic process.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000300
name: total concentration of enzyme
comment: Synonym: Et 
is_a: SBO:0000006 ! obsolete parameter

[Term]
id: SBO:0000301
name: total catalytic efficiency
comment: Constant representing the actual efficiency of an enzyme at a given concentration, taking into account its microscopic catalytic activity and the rates of substrate binding and dissociation.\n\nNB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281-291).
is_a: SBO:0000035 ! forward unimolecular rate constant, continuous case
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\">Vmax</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Km</ci></bvar>\n     <apply>\n       <divide></divide>\n         <ci>Vmax</ci>\n         <ci>Km</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000302
name: catalytic efficiency
comment: Constant representing the actual efficiency of an enzyme, taking into account its microscopic catalytic activity and the rates of substrate binding and dissociation.
is_a: SBO:0000036 ! forward bimolecular rate constant, continuous case
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Km</ci></bvar>\n     <apply>\n       <divide></divide>\n         <ci>kcat</ci>\n         <ci>Km</ci>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000303
name: biochemical potential
comment: Synonym: chemical potential 
is_a: SBO:0000308 ! equilibrium or steady-state characteristic

[Term]
id: SBO:0000304
name: pH
comment: Synonym: potential of hydrogen 
is_a: SBO:0000303 ! biochemical potential

[Term]
id: SBO:0000305
name: pOH
comment: Negative logarithm (base 10) of the activity of hydroxyde in a solution. In a diluted solution, this activity is equal to the concentration of ions HO-.
is_a: SBO:0000303 ! biochemical potential

[Term]
id: SBO:0000306
name: pK
comment: Synonym: dissociation potential 
is_a: SBO:0000303 ! biochemical potential
is_a: SBO:0000309 ! dissociation characteristic
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\">K</ci></bvar>\n     <apply>\n       <minus></minus>\n       <apply>\n         <log></log>\n         <ci>K</ci>\n       </apply>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000307
name: pKa
comment: Synonym: potential of acid 
is_a: SBO:0000306 ! pK
is_a: SBO:0000310 ! acid dissociation characteristic
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000283\">Ka</ci></bvar>\n     <apply>\n       <minus></minus>\n       <apply>\n         <log></log>\n         <ci>Ka</ci>\n       </apply>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000308
name: equilibrium or steady-state characteristic
comment: Quantitative parameter that characterises a biochemical equilibrium. 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000309
name: dissociation characteristic
comment: Quantitative parameter that characterises a dissociation.  
is_a: SBO:0000308 ! equilibrium or steady-state characteristic

[Term]
id: SBO:0000310
name: acid dissociation characteristic
comment: Quantitative parameter that characterises an acid-base reaction.
is_a: SBO:0000309 ! dissociation characteristic

[Term]
id: SBO:0000311
name: heterogeneous nuclear RNA
comment: Synonym: Precursor mRNA 
is_a: SBO:0000278 ! messenger RNA

[Term]
id: SBO:0000312
name: mature messenger RNA
comment: Completely processed single strand of messenger ribonucleic acid (mRNA), synthesized from a DNA template in the nucleus of a cell by transcription and containing copies of only the exons of a gene.
is_a: SBO:0000278 ! messenger RNA

[Term]
id: SBO:0000313
name: transfer RNA
comment: Synonym: tRNA 
is_a: SBO:0000334 ! non-coding RNA

[Term]
id: SBO:0000314
name: ribosomal RNA
comment: Synonym: rRNA 
is_a: SBO:0000334 ! non-coding RNA

[Term]
id: SBO:0000315
name: ribozyme
comment: Synonym: ribonucleic acid enzyme 
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000316
name: microRNA
comment: Synonym: miRNA 
is_a: SBO:0000334 ! non-coding RNA

[Term]
id: SBO:0000317
name: small interfering RNA
comment: Synonym: siRNA 
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000318
name: small nuclear RNA
comment: Synonym: snRNA 
is_a: SBO:0000334 ! non-coding RNA

[Term]
id: SBO:0000319
name: small nucleolar RNA
comment: Synonym: snoRNA 
is_a: SBO:0000334 ! non-coding RNA

[Term]
id: SBO:0000320
name: product catalytic rate constant
comment: Synonym: kcatp 
is_a: SBO:0000025 ! catalytic rate constant

[Term]
id: SBO:0000321
name: substrate catalytic rate constant
comment: Synonym: reverse catalytic rate constant 
is_a: SBO:0000025 ! catalytic rate constant

[Term]
id: SBO:0000322
name: Michaelis constant for substrate
comment: Synonym: Kms 
is_a: SBO:0000027 ! Michaelis constant

[Term]
id: SBO:0000323
name: Michaelis constant for product
comment: Synonym: Kmp 
is_a: SBO:0000027 ! Michaelis constant

[Term]
id: SBO:0000324
name: forward maximal velocity
comment: Synonym: Vmaxf 
is_a: SBO:0000186 ! maximal velocity
is_a: SBO:0000350 ! forward reaction velocity
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000320\">kcatp</ci></bvar>\n     <apply>\n       <times></times>\n         <ci>Et</ci>\n         <ci>kcatp</ci>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000325
name: reverse maximal velocity
comment: Synonym: Vmaxr 
is_a: SBO:0000186 ! maximal velocity
is_a: SBO:0000353 ! reverse reaction velocity
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000321\">kcats</ci></bvar>\n     <apply>\n       <times></times>\n         <ci>Et</ci>\n         <ci>kcats</ci>\n     </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000326
name: enzymatic rate law for non-modulated unireactant enzymes
comment: Kinetics of enzymes that react only with one substance, their substrate, and are not modulated by other compounds.
is_a: SBO:0000269 ! enzymatic rate law for unireactant enzymes

[Term]
id: SBO:0000327
name: non-macromolecular ion
comment: Chemical entity having a net electric charge.
is_a: SBO:0000247 ! simple chemical

[Term]
id: SBO:0000328
name: non-macromolecular radical
comment: chemical entity possessing an unpaired electron.
is_a: SBO:0000247 ! simple chemical

[Term]
id: SBO:0000329
name: transcription start site
comment: Synonym: TSS 
is_a: SBO:0000404 ! unit of genetic information

[Term]
id: SBO:0000330
name: dephosphorylation
comment: Removal of a phosphate group (-H2PO4) from a chemical entity. 
is_a: SBO:0000211 ! removal of a chemical group

[Term]
id: SBO:0000331
name: half-life
comment: Time interval over which a quantified entity is reduced to half its original value.
is_a: SBO:0000009 ! kinetic constant
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000332
name: half-life of an exponential decay
comment: Time taken by a quantity decreasing according to a mono-exponential decay to be divided by two. Sometimes called t1/2.
is_a: SBO:0000331 ! half-life
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000356\">l</ci></bvar>\n     <apply>\n       <divide></divide>\n         <apply>\n           <ln></ln>           \n           <cn type=\"integer\">2</cn>\n         </apply>\n         <ci>l</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000333
name: monoexponential decay rate law
comment: Monotonic decrease of a quantity proportionally to its value.
is_a: SBO:0000049 ! mass action rate law for first order irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000332\">l</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <apply>\n         <divide></divide>\n         <ci>R</ci>\n         <ci>l</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000334
name: non-coding RNA
comment: RNA molecule that is not translated into a protein. \n\nSequence Ontology SO:0000655
is_a: SBO:0000404 ! unit of genetic information

[Term]
id: SBO:0000335
name: gene coding region
comment: Portion of DNA or RNA that is transcribed into another RNA, such as a messenger RNA or a non-coding RNA (for instance a transfert RNA or a ribosomal RNA).
is_a: SBO:0000354 ! informational molecule segment

[Term]
id: SBO:0000336
name: interactor
comment: Entity participating in a physical or functional interaction.
is_a: SBO:0000010 ! reactant

[Term]
id: SBO:0000337
name: association constant
comment: Synonym: Ka 
is_a: SBO:0000281 ! equilibrium constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000338\">koff</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000341\">Kon</ci></bvar>\n     <apply>\n       <divide></divide>\n         <ci>kon</ci>\n         <ci>Koff</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000338
name: dissociation rate constant
comment: Synonym: kd 
is_a: SBO:0000035 ! forward unimolecular rate constant, continuous case
is_a: SBO:0000038 ! reverse unimolecular rate constant, continuous case

[Term]
id: SBO:0000339
name: bimolecular association rate constant
comment: Rate with which two components associate into a complex.
is_a: SBO:0000036 ! forward bimolecular rate constant, continuous case
is_a: SBO:0000341 ! association rate constant

[Term]
id: SBO:0000340
name: trimolecular association rate constant
comment: Rate with which three components associate into a complex.
is_a: SBO:0000037 ! forward trimolecular rate constant, continuous case
is_a: SBO:0000341 ! association rate constant

[Term]
id: SBO:0000341
name: association rate constant
comment: Rate with which components associate into a complex.
is_a: SBO:0000154 ! forward rate constant, continuous case

[Term]
id: SBO:0000342
name: molecular or genetic interaction
comment: Mutual or reciprocal action or influence between molecular entities.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000343
name: genetic interaction
comment: A phenomenon whereby an observed phenotype, qualitative or quantative, is not explainable by the simple additive effects of the individual gene pertubations alone. Genetic interaction between perturbed genes is usually expected to generate a 'defective' phenotype. The level of defectiveness is often used to sub-classify this phenomenon.\n
is_a: SBO:0000342 ! molecular or genetic interaction

[Term]
id: SBO:0000344
name: molecular interaction
comment: Relationship between molecular entities, based on contacts, direct or indirect. 
is_a: SBO:0000342 ! molecular or genetic interaction

[Term]
id: SBO:0000345
name: time
comment: Fundmental quantity of the measuring system used to sequence events, to compare the durations of events and the intervals between them, and to quantify the motions or the transformation of entities. The SI base unit for time is the SI second. The second is the duration of\n9,192,631,770 periods of the radiation corresponding to the transition\nbetween the two hyperfine levels of the ground state of the caesium 133\natom.
is_a: SBO:0000255 ! physical characteristic

[Term]
id: SBO:0000346
name: temporal measure
comment: Fundamental quantity of the measuring system used to sequence events, to compare the durations of events and the intervals between them, and to quantify the motions or the transformation of entities. The SI base unit for time is the SI second. The second is the duration of 9,192,631,770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000347
name: duration
comment: Amount of time during which an event persists.
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000348
name: exponential time constant
comment: Synonym: mean lifetime 
is_a: SBO:0000009 ! kinetic constant
is_a: SBO:0000346 ! temporal measure
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000356\">l</ci></bvar>\n     <apply>\n       <divide></divide>\n       <cn type=\"integer\">1</cn>\n       <ci>l</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000349
name: inactivation rate constant
comment: Synonym: kinact 
is_a: SBO:0000035 ! forward unimolecular rate constant, continuous case

[Term]
id: SBO:0000350
name: forward reaction velocity
comment: The speed of an enzymatic reaction at a defined concentration of substrate(s) and enzyme.
is_a: SBO:0000048 ! forward zeroth order rate constant, continuous case

[Term]
id: SBO:0000352
name: reverse zeroth order rate constant
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction independant of the reactant quantities. This parameter encompasses all the contributions to the velocity. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000046 ! zeroth order rate constant
is_a: SBO:0000156 ! reverse rate constant

[Term]
id: SBO:0000353
name: reverse reaction velocity
comment: The speed of an enzymatic reaction at a defined concentration of substrate(s) and enzyme. 
is_a: SBO:0000352 ! reverse zeroth order rate constant

[Term]
id: SBO:0000354
name: informational molecule segment
comment: Fragment of a macromolecule that carries genetic information.
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000355
name: conservation law
comment: Mathematical expression stating that a quantity is conserved in a system, whatever happens within the boundaries of that system. 
is_a: SBO:0000064 ! mathematical expression

[Term]
id: SBO:0000356
name: decay constant
comment: Kinetic constant characterising a mono-exponential decay. It is the inverse of the mean lifetime of the continuant being decayed. Its unit is "per time". 
is_a: SBO:0000035 ! forward unimolecular rate constant, continuous case
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000348\">t</ci></bvar>\n     <apply>\n       <divide></divide>\n       <cn type=\"integer\">1</cn>\n       <ci>t</ci>\n     </apply>\n   </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000357
name: biological effect of a perturbation
comment: Biochemical networks can be affected by external influences. Those influences can be well-defined physical perturbations, such as a light pulse, or a change in temperature but also more complex of not well defined phenomena, for instance a biological process, an experimental setup, or a mutation.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000358
name: phenotype
comment: A biochemical network can generate phenotypes or affects biological processes. Such processes can take place at different levels and are independent of the biochemical network itself.\n
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000359
name: mass conservation law
comment: A chemical moiety that exists under different forms but is not created nor destroyed in a biochemical system. In any given system such a conserved moiety is characterized by a finite number of particles that exist in the system and is invariant.\n
is_a: SBO:0000355 ! conservation law
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000002\">a</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">n</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000360\">S</ci></bvar>\n    <apply>\n      <sum></sum>\n      <bvar><ci> i </ci></bvar>\n      <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit>\n      <uplimit><ci> n </ci></uplimit>\n      <apply>\n        <times></times>\n        <apply>\n          <selector></selector>\n          <ci type=\"vector\">a</ci>\n          <ci> i </ci>\n        </apply>\n        <apply>\n          <selector></selector>\n          <ci type=\"vector\">S</ci>\n          <ci> i </ci>\n        </apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000360
name: quantity of an entity pool
comment: The enumeration of co-localised, identical biochemical entities of a specific state, which constitute a pool. The form of enumeration may be purely numerical, or may be given in relation to another dimension such as length or volume.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000361
name: amount of an entity pool
comment: A numerical measure of the quantity, or of some property, of the entities that constitute the entity pool.  \n
is_a: SBO:0000360 ! quantity of an entity pool

[Term]
id: SBO:0000362
name: concentration conservation law
comment: If all forms of a moiety exist in a single compartment and the size of that compartment is fixed then the Mass Conservation is also a Concentration Conservation.\n\n
is_a: SBO:0000359 ! mass conservation law
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000002\">a</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">n</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">S</ci></bvar>\n    <apply>\n      <sum></sum>\n      <bvar><ci> i </ci></bvar>\n      <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit>\n      <uplimit><ci> n </ci></uplimit>\n      <apply>\n        <times></times>\n        <apply>\n          <selector></selector>\n          <ci type=\"vector\">a</ci>\n          <ci> i </ci>\n        </apply>\n        <apply>\n          <selector></selector>\n          <ci type=\"vector\">S</ci>\n          <ci> i </ci>\n        </apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000363
name: activation constant
comment: Synonym: Kx 
is_a: SBO:0000282 ! dissociation constant

[Term]
id: SBO:0000364
name: multimer cardinality
comment: Number of monomers composing a multimeric entity.
is_a: SBO:0000188 ! number of biochemical items

[Term]
id: SBO:0000365
name: forward non-integral order rate constant, continuous case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction where reactants have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the reactants.It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000154 ! forward rate constant, continuous case
is_a: SBO:0000160 ! forward non-integral order rate constant

[Term]
id: SBO:0000366
name: forward non-integral order rate constant, discrete case
comment: Numerical parameter that quantifies the forward velocity of a chemical reaction where reactants have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the reactants. It is to be used in a reaction modelled using a discrete framework. 
is_a: SBO:0000155 ! forward rate constant, discrete case
is_a: SBO:0000160 ! forward non-integral order rate constant

[Term]
id: SBO:0000367
name: reverse non-integral order rate constant, discrete case
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction where products have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the products. It is to be used in a reaction modelled using a discrete framework.\n
is_a: SBO:0000161 ! reverse non-integral order rate constant

[Term]
id: SBO:0000368
name: reverse non-integral order rate constant, continuous case
comment: Numerical parameter that quantifies the reverse velocity of a chemical reaction where products have non-integral orders. This parameter encompasses all the contributions to the velocity except the quantity of the products. It is to be used in a reaction modelled using a continuous framework. 
is_a: SBO:0000161 ! reverse non-integral order rate constant

[Term]
id: SBO:0000369
name: gene regulatory region
comment: Region of a gene that is involved in the modulation of the expression of the gene. 
is_a: SBO:0000354 ! informational molecule segment

[Term]
id: SBO:0000370
name: Michaelis constant in non-equilibrium situation
comment: Michaelis constant derived or experimentally measured under non-equilibrium conditions.
is_a: SBO:0000027 ! Michaelis constant

[Term]
id: SBO:0000371
name: Michaelis constant in quasi-steady state situation
comment: Michaelis constant derived using a steady-state assumption for enzyme-substrate and enzyme-product intermediates. For example see Briggs-Haldane equation (SBO:0000031).
is_a: SBO:0000370 ! Michaelis constant in non-equilibrium situation

[Term]
id: SBO:0000372
name: Michaelis constant in irreversible situation
comment: Michaelis constant derived assuming enzyme-substrate and enzyme-product intermediates are formed in consecutive irreversible reactions. The constant K is the ratio of the forward rate constants. For example see Van Slyke-Cullen equation (SBO:0000030).
is_a: SBO:0000370 ! Michaelis constant in non-equilibrium situation

[Term]
id: SBO:0000373
name: Michaelis constant in fast equilibrium situation
comment: Michaelis constant as determined in a reaction where the formation of the enzyme-substrate complex occurs at a much faster rate than subsequent steps, and so are assumed to be in a quasi-equilibrium situation. K is equivalent to an equilibrium constant. For example see Henri-Michaelis-Menten equation (SBO:0000029).
is_a: SBO:0000027 ! Michaelis constant

[Term]
id: SBO:0000374
name: relationship
comment: connectedness between entities and/or interactions representing their relatedness or influence.
is_a: SBO:0000231 ! occurring entity representation

[Term]
id: SBO:0000375
name: process
comment: A sequential series of actions, motions, or occurrences, such as chemical reactions, that affect one or more entities in a phenomenologically characteristic manner.
is_a: SBO:0000231 ! occurring entity representation

[Term]
id: SBO:0000376
name: hydrolysis
comment: Decomposition of a compound by reaction with water, where the hydroxyl and H groups are incorporated into different products
is_a: SBO:0000178 ! cleavage

[Term]
id: SBO:0000377
name: isomerisation
comment: A reaction in which the principal reactant and principal product are isomers of each other
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000378
name: enzymatic rate law for inhibition of irreversible unireactant enzymes by competing substrates
comment: Inhibition of a unireactant enzyme by competing substrates (Sa) that bind to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions.\n\n\n\n\n
is_a: SBO:0000270 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ksa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n               <sum></sum>\n               <bvar><ci> i </ci></bvar>\n               <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n               <uplimit><ci> n </ci></uplimit>\n               <apply>\n                 <divide></divide>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">Sa</ci>\n                   <ci> i </ci>\n                 </apply>\n                 <apply>\n                   <selector></selector>\n                   <ci type=\"vector\">Ksa</ci>\n                   <ci> i </ci>\n                 </apply>\n               </apply>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>\n\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000379
name: enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two non-exclusive inhibitors
comment: Inhibition of a unireactant enzyme by two inhibitors that can bind once to the free enzyme and preclude the binding of the substrate. Binding of one inhibitor may affect binding of the other, or not. The enzymes do not catalyse the reactions in both directions.
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n    <lambda>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I1</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">I2</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000383\">a</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki1</ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Ki2</ci></bvar>\n      <apply>\n    <divide></divide>\n    <apply>\n      <times></times>\n      <ci>kcat</ci>\n      <ci>Et</ci>\n      <ci>S</ci>\n    </apply>\n    <apply>\n      <plus></plus>\n      <apply>\n        <times></times>\n        <ci>Ks</ci>\n        <apply>\n          <plus></plus>\n          <cn type=\"integer\">1</cn>\n          <apply>\n        <divide></divide>\n        <ci>I1</ci>\n        <ci>Ki1</ci>\n          </apply>\n          <apply>\n        <divide></divide>\n        <ci>I2</ci>\n        <ci>Ki2</ci>\n          </apply>\n          <apply>\n        <divide></divide>\n        <apply>\n          <times></times>\n          <ci>I1</ci>\n           <ci>I2</ci>\n        </apply>\n        <apply>\n          <times></times>\n      <ci>a</ci>   \n          <ci>Ki1</ci>\n          <ci>Ki2</ci>\n        </apply>\n          </apply>\n        </apply>\n      </apply>\n      <ci>S</ci>\n    </apply>\n      </apply>\n    </lambda>\n </semantics>\n </mathml:math> " http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000380
name: biochemical coefficient
comment: number used as a multiplicative or exponential factor for quantities, expressions or functions
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000381
name: biochemical proportionality coefficient
comment: A multiplicative factor for quantities, expressions or functions 
is_a: SBO:0000380 ! biochemical coefficient

[Term]
id: SBO:0000382
name: biochemical exponential coefficient
comment: number used as an exponential factor for quantities, expressions or functions 
is_a: SBO:0000380 ! biochemical coefficient

[Term]
id: SBO:0000383
name: biochemical cooperative inhibition coefficient
comment: The coefficient used to quantify the effect on inhibition constants of multiple inhibitors binding non-exclusively to the enzyme.
is_a: SBO:0000381 ! biochemical proportionality coefficient

[Term]
id: SBO:0000384
name: biochemical inhibitory proportionality coefficient
comment: Coefficient that quantifies the effect on inhibition constants of either binding of multiple substrates or inhibitors.
is_a: SBO:0000381 ! biochemical proportionality coefficient

[Term]
id: SBO:0000385
name: biochemical cooperative inhibitor substrate coefficient
comment: The coefficient that describes the proportional change of Ks or Ki when inhibitor or substrate is bound, respectively, to the enzyme.
is_a: SBO:0000381 ! biochemical proportionality coefficient

[Term]
id: SBO:0000386
name: enzymatic rate law for inhibition of irreversible unireactant enzymes by single competing substrate
comment: Inhibition of a unireactant enzyme by a competing substrate (Sa) that binds to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions.
is_a: SBO:0000378 ! enzymatic rate law for inhibition of irreversible unireactant enzymes by competing substrates
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ksa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n                <divide></divide>\n                <ci>Sa</ci>\n                <ci>Ksa</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>  \n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000387
name: enzymatic rate law for competitive inhibition of irreversible unireactant enzyme by product
comment: Inhibition of a unireactant enzyme by a competing product (P) that binds to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions.\n
is_a: SBO:0000270 ! enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Kp</ci></bvar>\n          <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n                <divide></divide>\n                <ci>P</ci>\n                <ci>Kp</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>  \n\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000388
name: enzymatic rate law for inhibition of irreversible unireactant enzymes by single competing substrate with product inhibition
comment: Inhibition of a unireactant enzyme by a competing substrate (Sa) that binds to the free enzyme on the same binding site, and competitive inhibition by a product (P) and an alternative product (Pa). The enzyme does not catalyse the reactions in both directions.\n 
is_a: SBO:0000378 ! enzymatic rate law for inhibition of irreversible unireactant enzymes by competing substrates
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000025\">kcat</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\">Et</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">S</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ks</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Ksa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Kp</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Kpa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">Pa</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci></bvar>\n     <apply>\n       <divide></divide>\n       <apply>\n         <times></times>\n         <ci>kcat</ci>\n         <ci>Et</ci>\n         <ci>S</ci>\n       </apply>\n       <apply>\n         <plus></plus>\n         <apply>\n           <times></times>\n           <ci>Ks</ci>\n           <apply>\n             <plus></plus>\n             <cn type=\"integer\">1</cn>\n             <apply>\n                <divide></divide>\n                <ci>Sa</ci>\n                <ci>Ksa</ci>\n             </apply>\n             <apply>\n                <divide></divide>\n                <ci>P</ci>\n                <ci>Kpa</ci>\n             </apply>\n             <apply>\n                <divide></divide>\n                <ci>Pa</ci>\n                <ci>Kpa</ci>\n             </apply>\n           </apply>\n         </apply>\n         <ci>S</ci>\n       </apply>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>  \n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000389
name: switch value
comment: A parameter value taken by a switch, which has a discrete set of values which can be alternated or switched between.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000390
name: boolean switch
comment: Synonym: binary switch 
is_a: SBO:0000389 ! switch value

[Term]
id: SBO:0000391
name: steady state expression
comment: A mathematical expression that describes a steady state situation
is_a: SBO:0000064 ! mathematical expression

[Term]
id: SBO:0000392
name: equivalence
comment: Term to signify those material or conceptual entities that are identical in some respect within a frame of reference
is_a: SBO:0000374 ! relationship

[Term]
id: SBO:0000393
name: production
comment: Generation of a material or conceptual entity. 
is_a: SBO:0000168 ! control

[Term]
id: SBO:0000394
name: consumption
comment: Decrease in amount of a material or conceptual entity.  
is_a: SBO:0000168 ! control

[Term]
id: SBO:0000395
name: encapsulating process
comment: An aggregation of interactions and entities into a single process.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000396
name: uncertain process
comment: An equivocal or conjectural process, whose existence is assumed but not proven.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000397
name: omitted process
comment: One or more processes that are not represented in certain representations or interpretations of a model.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000398
name: logical relationship
comment: Relationship between entities (material or conceptual) and logical operators, or between logical operators themselves. 
is_a: SBO:0000374 ! relationship

[Term]
id: SBO:0000399
name: decarboxylation
comment: A process in which a carboxyl group (COOH) is removed from a molecule as carbon dioxide.
is_a: SBO:0000211 ! removal of a chemical group

[Term]
id: SBO:0000400
name: decarbonylation
comment: Removal of a carbonyl group (-C-O-) from a molecule, usually as carbon monoxide
is_a: SBO:0000211 ! removal of a chemical group

[Term]
id: SBO:0000401
name: deamination
comment: Removal of an amine group from a molecule, often under the addition of water
is_a: SBO:0000211 ! removal of a chemical group

[Term]
id: SBO:0000402
name: transfer of a chemical group
comment: Covalent reaction that results in the transfer of a chemical group from one molecule to another.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000403
name: transamination
comment: The transfer of an amino group between two molecules. Commonly in biology this is restricted to reactions between an amino acid and an alpha-keto carbonic acid, whereby the reacting amino acid is converted into an alpha-keto acid, and the alpha-keto acid reactant into an amino acid.
is_a: SBO:0000402 ! transfer of a chemical group

[Term]
id: SBO:0000404
name: unit of genetic information
comment: Functional entity associated with or derived from a unit of inheritance.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000405
name: perturbing agent
comment: A material entity that is responsible for a perturbing effect
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000406
name: observable
comment: An entity that can be measured quantitatively
is_a: SBO:0000240 ! material entity

[Term]
id: SBO:0000407
name: absolute inhibition
comment: Control that precludes the execution of a process.
is_a: SBO:0000169 ! inhibition

[Term]
id: SBO:0000408
name: biological activity
comment: Effect of a biological entity on biological structures or processes.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000409
name: interaction outcome
comment: Entity that results from the interaction between other entities.
is_a: SBO:0000236 ! physical entity representation

[Term]
id: SBO:0000410
name: implicit compartment
comment: A compartment whose existence is inferred due to the presence of known material entities which must be bounded, allowing the creation of material entity pools.
is_a: SBO:0000290 ! physical compartment

[Term]
id: SBO:0000411
name: absolute stimulation
comment: Control that always triggers the controlled process.
is_a: SBO:0000170 ! stimulation

[Term]
id: SBO:0000412
name: biological activity
comment: The potential action that a biological entity has on other entities. Example are enzymatic activity, binding activity etc.
is_a: SBO:0000231 ! occurring entity representation

[Term]
id: SBO:0000413
name: positional relationship
comment: The connectedness between entities as related by their position\n
is_a: SBO:0000374 ! relationship

[Term]
id: SBO:0000414
name: cis
comment: Positional relationship between entities on the same strand (e.g. in DNA), or on the same side.\n
is_a: SBO:0000413 ! positional relationship

[Term]
id: SBO:0000415
name: trans
comment: Positional relationship between entities on different sides, or strands
is_a: SBO:0000413 ! positional relationship

[Term]
id: SBO:0000416
name: true
comment: One of the two values possible from a boolean switch, which equates to '1', 'on' or 'input'.
is_a: SBO:0000390 ! boolean switch

[Term]
id: SBO:0000417
name: false
comment: One of the two values possible from a boolean switch, which equates to '0', 'off' or 'no input'.
is_a: SBO:0000390 ! boolean switch

[Term]
id: SBO:0000418
name: multimer of complexes
comment: Non-covalent association between several independant complexes
is_a: SBO:0000286 ! multimer

[Term]
id: SBO:0000419
name: multimer of informational molecule segment
comment: Non-covalent association between portions of macromolecules that carry genetic information
is_a: SBO:0000286 ! multimer

[Term]
id: SBO:0000420
name: multimer of macromolecules
comment: Non-covalent association between several macromolecules
is_a: SBO:0000286 ! multimer
is_a: SBO:0000296 ! macromolecular complex

[Term]
id: SBO:0000421
name: multimer of simple chemicals
comment: Non-covalent association between several simple chemicals
is_a: SBO:0000286 ! multimer

[Term]
id: SBO:0000422
name: isoinhibition constant
comment: Inhibitory constant for the binding of a given ligand with an isomeric form of an enzyme.\n
is_a: SBO:0000261 ! inhibitory constant

[Term]
id: SBO:0000423
name: pseudo-dissociation constant for product
comment: In reversible reactions this is the concentration of product that is required to achieve half activation or inhibition in Hill-type kinetics, in the absence of the substrate. 
is_a: SBO:0000194 ! pseudo-dissociation constant

[Term]
id: SBO:0000424
name: pseudo-dissociation constant for substrate
comment: In reversible reactions this is the concentration of substrate that is required to achieve half activation or inhibition in Hill-type kinetics, in the absence of the product. 
is_a: SBO:0000194 ! pseudo-dissociation constant

[Term]
id: SBO:0000425
name: reversible Hill-type enzymatic rate law
comment: Reversible Hill-type kinetics represents the situation where a single substrate and product bind cooperatively and reversibly to the enzyme. Co-operativity is seen if the Hill coefficient (h) is greater than 1, indicating that the binding of one substrate (or product) molecule facilitates the binding of the next. The opposite effect is evident with a coefficient less than 1. 
is_a: SBO:0000268 ! enzymatic rate law

[Term]
id: SBO:0000426
name: modulated reversible Hill-type rate law
comment: Reversible Hill-type kinetics in the presence of at least one modifier whose binding is affected by the presence of the substrate or product.
is_a: SBO:0000425 ! reversible Hill-type enzymatic rate law

[Term]
id: SBO:0000427
name: modulated reversible Hill-type rate law with one modifier
comment: The modifier can be either an activator or inhibitor depending on the value of alpha (activator for values larger than 1, inhibitor for values smaller than 1; no effect if exactly 1). This reflects the effect of the presence of substrate and product on the binding of the modifier. The equation, derived by Hofmeyr and Cornish-Bowden (Comput. Appl. Biosci. 13, 377 - 385 (1997)
is_a: SBO:0000426 ! modulated reversible Hill-type rate law
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000518\"> Modifier\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000424\"> Ks\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000423\"> Kp\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\"> h\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000287\"> Mhalf\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\"> alpha\n          </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Ks </ci>\n            </apply>\n            <apply>\n              <minus></minus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <ci> product </ci>\n                <apply>\n                  <times></times>\n                  <ci> substrate </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Ks </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <minus></minus>\n                <ci> h </ci>\n                <cn> 1 </cn>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <power></power>\n                  <apply>\n                    <divide></divide>\n                    <ci> Modifier </ci>\n                    <ci> Mhalf </ci>\n                  </apply>\n                  <ci> h </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <times></times>\n                  <ci> alpha </ci>\n                  <apply>\n                    <power></power>\n                    <apply>\n                      <divide></divide>\n                      <ci> Modifier </ci>\n                      <ci> Mhalf </ci>\n                    </apply>\n                    <ci> h </ci>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Ks </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kp </ci>\n                </apply>\n              </apply>\n              <ci> h </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000428
name: modulated reversible Hill-type rate law with two modifiers
comment: The modifiers can be either activators or inhibitors depending on the values of and alpha (activators for values larger than 1, inhibitors for values smaller than 1; no effect if exactly 1). The assumption is that the binding of one modifier affects the binding of the second. Modifiers are assumed to bind at different sites.  The synergetic effects of the two modifiers depend on the parameter alpha (if unity then they are independent; if zero they compete for the same binding site). and reflect the effect of the presence of substrate and product on the binding of modifier A or modifier B. alphaA and  alphaB  factors account for the effect of substrate and product binding on the binding of modifier A and modifier B respectively. alphaAB accounts for the interaction of the modifiers on each others binding.\n  (if < 1 Ma is inhibitor, if > 1 activator)\nalpha_2 	: factor accounting for the effect of S and P on the binding of Mb\n  (if < 1 Mb is inhibitor, if > 1 activator)\nalpha_3 	: factor accounting for interaction of Ma to Mb binding to the enzyme (and v. v.).
is_a: SBO:0000426 ! modulated reversible Hill-type rate law
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n    <lambda>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">substrate</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">product</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000518\">ModifierA</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000518\">ModifierB</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\">Keq</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\">Vf</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000424\">Shalve</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000423\">Phalve</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\">h</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000287\">MAhalf</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\">alphaA</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000287\">MBhalf</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\">alphaB</ci>\n      </bvar>\n      <bvar>\n        <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\">alphaAB</ci>\n      </bvar>\n      <apply>\n        <divide></divide>\n        <apply>\n          <times></times>\n          <apply>\n            <divide></divide>\n            <apply>\n              <times></times>\n              <ci>Vf</ci>\n              <ci>substrate</ci>\n            </apply>\n            <ci>Ks</ci>\n          </apply>\n          <apply>\n            <minus></minus>\n            <cn>1</cn>\n            <apply>\n              <divide></divide>\n              <ci>product</ci>\n              <apply>\n                <times></times>\n                <ci>substrate</ci>\n                <ci>Keq</ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <power></power>\n            <apply>\n              <plus></plus>\n              <apply>\n                <divide></divide>\n                <ci>substrate</ci>\n                <ci>Ks</ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <ci>product</ci>\n                <ci>Kp</ci>\n              </apply>\n            </apply>\n            <apply>\n              <minus></minus>\n              <ci>h</ci>\n              <cn>1</cn>\n            </apply>\n          </apply>\n        </apply>\n        <apply>\n          <plus></plus>\n          <apply>\n            <divide></divide>\n            <apply>\n              <plus></plus>\n              <cn>1</cn>\n              <apply>\n                <power></power>\n                <apply>\n                  <divide></divide>\n                  <ci>ModifierA</ci>\n                  <ci>MAhalf</ci>\n                </apply>\n                <ci>h</ci>\n              </apply>\n              <apply>\n                <power></power>\n                <apply>\n                  <divide></divide>\n                  <ci>ModifierB</ci>\n                  <ci>MBhalf</ci>\n                </apply>\n                <ci>h</ci>\n              </apply>\n            </apply>\n            <apply>\n              <plus></plus>\n              <cn>1</cn>\n              <apply>\n                <times></times>\n                <ci>alphaA</ci>\n                <apply>\n                  <power></power>\n                  <apply>\n                    <divide></divide>\n                    <ci>ModifierA</ci>\n                    <ci>MAhalf</ci>\n                  </apply>\n                  <ci>h</ci>\n                </apply>\n              </apply>\n              <apply>\n                <times></times>\n                <ci>alphaB</ci>\n                <apply>\n                  <power></power>\n                  <apply>\n                    <divide></divide>\n                    <ci>ModifierB</ci>\n                    <ci>MBhalf</ci>\n                  </apply>\n                  <ci>h</ci>\n                </apply>\n              </apply>\n              <apply>\n                <times></times>\n                <ci>alphaA</ci>\n                <ci>alphaB</ci>\n                <ci>alphaAB</ci>\n                <apply>\n                  <power></power>\n                  <apply>\n                    <divide></divide>\n                    <ci>ModifierA</ci>\n                    <ci>MAhalf</ci>\n                  </apply>\n                  <ci>h</ci>\n                </apply>\n                <apply>\n                  <power></power>\n                  <apply>\n                    <divide></divide>\n                    <ci>ModifierB</ci>\n                    <ci>MBhalf</ci>\n                  </apply>\n                  <ci>h</ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <power></power>\n            <apply>\n              <plus></plus>\n              <apply>\n                <divide></divide>\n                <ci>substrate</ci>\n                <ci>Ks</ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <ci>product</ci>\n                <ci>Kp</ci>\n              </apply>\n            </apply>\n            <ci>h</ci>\n          </apply>\n        </apply>\n      </apply>\n    </lambda>\n  </semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000429
name: enzymatic rate law for multireactant enzymes
comment: Kinetics of enzyme-catalysed reactions with 2 or more substrates or products\n
is_a: SBO:0000268 ! enzymatic rate law

[Term]
id: SBO:0000430
name: enzymatic rate law for modulated unireactant enzymes
comment: Kinetics of enzymes that react with one substance, and whose activity may be positively or negatively modulated.
is_a: SBO:0000269 ! enzymatic rate law for unireactant enzymes

[Term]
id: SBO:0000431
name: unmodulated reversible Hill-type rate law
comment: Reversible equivalent of Hill kinetics, where substrate and product bind co-operatively to the enzyme. A Hill coefficient (h) of greater than 1 indicates positive co-operativity between substrate and product, while h values below 1 indicate negative co-operativity. \n
is_a: SBO:0000425 ! reversible Hill-type enzymatic rate law
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000424\"> Ks\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000423\"> Kp\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\"> h\n          </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Ks</ci>\n            </apply>\n            <apply>\n              <minus></minus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <ci> product </ci>\n                <apply>\n                  <times></times>\n                  <ci> substrate </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Ks</ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <minus></minus>\n                <ci> h </ci>\n                <cn> 1 </cn>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Ks</ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kp </ci>\n                </apply>\n              </apply>\n              <ci> h </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000432
name: irreversible Michaelis Menten rate law for two substrates
comment: Enzymatic rate law for an irreversible reaction involving two substrates and one product.
is_a: SBO:0000429 ! enzymatic rate law for multireactant enzymes
property_value: seeAlso "        <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n	<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n          <lambda>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> A </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> B </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> KmA </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> KmB </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> KiA </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\"> Et </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000320\"> kcat </ci>\n            </bvar>\n	    <apply>\n	      <divide></divide>\n	      <apply>\n		<times></times>\n		<ci> Et </ci>\n		<ci> kcat </ci>\n		<ci> A </ci>\n		<ci> B </ci>\n	      </apply>\n	      <apply>\n		<plus></plus>\n		<apply>\n		  <times></times>\n		  <ci> KiA </ci>\n		  <ci> KmB </ci>\n		</apply>\n		<apply>\n		  <times></times>\n		  <ci> KmB </ci>\n		  <ci> A </ci>\n		</apply>\n		<apply>\n		  <times></times>\n		  <ci> KmA </ci>\n		  <ci> B </ci>\n		</apply>\n		<apply>\n		  <times></times>\n		  <ci> A </ci>\n		  <ci> B </ci>\n		</apply>\n	      </apply>\n	    </apply>\n          </lambda>\n	</semantics>\n        </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000433
name: Ordered Bi-Bi mechanism rate law
comment: Enzymatic rate law for a reaction involving two substrates and two products. The products P and then Q are released strictly in order, while the substrates are bound strictly in the order A and then B.
is_a: SBO:0000429 ! enzymatic rate law for multireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sb</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">Pp</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">Pq</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kma </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kmb </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kia </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kib </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kip </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> Vf </ci>\n            <apply>\n              <minus></minus>\n              <apply>\n                <times></times>\n                <ci>Sa</ci>\n                <ci>Sb</ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci>Pp</ci>\n                  <ci>Pq</ci>\n                </apply>\n                <ci> Keq </ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci>Sa</ci>\n              <ci>Sb</ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci>Pp</ci>\n                  <ci> Kip </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kma </ci>\n              <ci>Sb</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kmb </ci>\n              <apply>\n                <plus></plus>\n                <ci>Sa</ci>\n                <ci> Kia </ci>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <divide></divide>\n                <ci> Vf </ci>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <times></times>\n                  <ci> Kmq </ci>\n                  <ci>Pp</ci>\n                  <apply>\n                    <plus></plus>\n                    <cn> 1 </cn>\n                    <apply>\n                      <divide></divide>\n                      <ci>Sa</ci>\n                      <ci> Kia </ci>\n                    </apply>\n                  </apply>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci>Pq</ci>\n                  <apply>\n                    <plus></plus>\n                    <apply>\n                      <times></times>\n                      <ci> Kmp </ci>\n                      <apply>\n                        <plus></plus>\n                        <cn> 1 </cn>\n                        <apply>\n                          <divide></divide>\n                          <apply>\n                            <times></times>\n                            <ci> Kma </ci>\n                            <ci>Sb</ci>\n                          </apply>\n                          <apply>\n                            <times></times>\n                            <ci> Kia </ci>\n                            <ci> Kmb </ci>\n                          </apply>\n                        </apply>\n                      </apply>\n                    </apply>\n                    <apply>\n                      <times></times>\n                      <ci>Pp</ci>\n                      <apply>\n                        <plus></plus>\n                        <cn> 1 </cn>\n                        <apply>\n                          <divide></divide>\n                          <ci>Sb</ci>\n                          <ci> Kib </ci>\n                        </apply>\n                      </apply>\n                    </apply>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000434
name: Ordered Bi-Uni mechanism rate law
comment: Enzymatic rate for a reaction involving two substrates and one product. The substrates A and then B are bound strictly in order.
is_a: SBO:0000429 ! enzymatic rate law for multireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">	\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sb</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kma </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kmb </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kia </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> Vf </ci>\n            <apply>\n              <minus></minus>\n              <apply>\n                <times></times>\n                <ci>Sa</ci>\n                <ci>Sb</ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <ci>P</ci>\n                <ci> Keq </ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci>Sa</ci>\n              <ci>Sb</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kma </ci>\n              <ci>Sb</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kmb </ci>\n              <ci>Sa</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <divide></divide>\n                <ci> Vf </ci>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <ci> Kmp </ci>\n                <apply>\n                  <times></times>\n                  <ci>P</ci>\n                  <apply>\n                    <plus></plus>\n                    <cn> 1 </cn>\n                    <apply>\n                      <divide></divide>\n                      <ci>Sa</ci>\n                      <ci> Kia </ci>\n                    </apply>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000435
name: Ordered Uni-Bi mechanism rate law
comment: Enzymatic rate law for a reaction with one substrate and two products. The products P and then Q are released in the strict order P and then Q.
is_a: SBO:0000429 ! enzymatic rate law for multireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> productp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> productq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kip </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> Vf </ci>\n            <apply>\n              <minus></minus>\n              <ci> substrate </ci>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> productp </ci>\n                  <ci> productq </ci>\n                </apply>\n                <ci> Keq </ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <ci> Kms </ci>\n            <apply>\n              <times></times>\n              <ci> substrate </ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> productp </ci>\n                  <ci> Kip </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <divide></divide>\n                <ci> Vf </ci>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <times></times>\n                  <ci> Kmq </ci>\n                  <ci> productp </ci>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci> Kmp </ci>\n                  <ci> productq </ci>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci> productp </ci>\n                  <ci> productq </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n     </semantics>\n    </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000436
name: Ping Pong Bi-Bi mechanism rate law
comment: Enzymatic rate law for a reaction involving two substrates and two products. The first product (P) is released after the first substrate (A) has been bound. The second product (Q) is released after the second substrate (B) has been bound. 
is_a: SBO:0000429 ! enzymatic rate law for multireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sa</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">Sb</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">Pp</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">Pq</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kma </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kmb </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kmq </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kia </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Kiq </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> Vf </ci>\n            <apply>\n              <minus></minus>\n              <apply>\n                <times></times>\n                <ci>Sa</ci>\n                <ci>Sb</ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci>Pp</ci>\n                  <ci>Pq</ci>\n                </apply>\n                <ci> Keq </ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci>Sa</ci>\n              <ci>Sb</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kmb </ci>\n              <ci>Sa</ci>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kma </ci>\n              <ci>Sb</ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci>Pq</ci>\n                  <ci> Kiq </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <divide></divide>\n                <ci> Vf </ci>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> Keq </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <times></times>\n                  <ci> Kmq </ci>\n                  <ci>Pp</ci>\n                  <apply>\n                    <plus></plus>\n                    <cn> 1 </cn>\n                    <apply>\n                      <divide></divide>\n                      <ci>Sa</ci>\n                      <ci> Kia </ci>\n                    </apply>\n                  </apply>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci>Pq</ci>\n                  <apply>\n                    <plus></plus>\n                    <ci> Kmp </ci>\n                    <ci>Pp</ci>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000437
name: reversible Iso Uni-Uni
comment: Enzyme catalysed reaction involving one substrate and one product. Unlike the reversible uni-uni mechanism (SBO:0000326), the mechanism assumes an enzyme intermediate. Therefore, the free enzyme generated after the release of product from enzyme-product complex is not the same form as that which bind the substrate to form enzyme-substrate complex. Some permeases are thought to follow this mechanism, such that isomerization in the membrane may be accomplished through re-orientation in the membrane.
is_a: SBO:0000326 ! enzymatic rate law for non-modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000422\"> Kii\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf\n          </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq\n          </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> Vf </ci>\n            <apply>\n              <minus></minus>\n              <ci> substrate </ci>\n              <apply>\n                <divide></divide>\n                <ci> product </ci>\n                <ci> Keq </ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci> substrate </ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kii </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> Kms </ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000438
name: reversible Uni-Uni
comment: Synonym: Uni-Uni Reversible Simple Michaelis-Menten 
is_a: SBO:0000326 ! enzymatic rate law for non-modulated unireactant enzymes
property_value: seeAlso "        <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n          <lambda>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000505\"> Et </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000320\"> kcatp </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000321\"> kcats </ci>\n            </bvar>\n            <apply>\n              <divide></divide>\n                 <apply>\n                    <times></times>\n                  <ci> Et </ci>\n              <apply>\n                <minus></minus>\n                <apply>\n                  <divide></divide>\n                  <apply>\n                    <times></times>\n                    <ci> kcatp </ci>\n                    <ci> substrate </ci>\n                  </apply>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <apply>\n                    <times></times>\n                    <ci> kcats </ci>\n                    <ci> product </ci>\n                  </apply>\n                  <ci> Kmp </ci>\n                </apply>\n                </apply>\n             </apply>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n            </apply>\n          </lambda>\n</semantics>\n        </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000439
name: Uni-Uni Reversible using Haldane relationship
comment: Synonym: Uni-Uni 
is_a: SBO:0000326 ! enzymatic rate law for non-modulated unireactant enzymes
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n	<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n          <lambda>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n            </bvar>\n            <bvar>\n              <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> Keq </ci>\n            </bvar>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <apply>\n                  <minus></minus>\n                  <ci> substrate </ci>\n                  <apply>\n                    <divide></divide>\n                    <ci> product </ci>\n                    <ci> Keq </ci>\n                  </apply>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <ci> substrate </ci>\n                <apply>\n                  <times></times>\n                  <ci> Kms </ci>\n                  <apply>\n                    <plus></plus>\n                    <cn> 1 </cn>\n                    <apply>\n                      <divide></divide>\n                      <ci> product </ci>\n                      <ci> Kmp </ci>\n                    </apply>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </lambda>\n	  </semantics>\n        </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000440
name: enzymatic rate law for irreversible allosteric inhibition
comment: Enzymatic rate law which follows from the allosteric concerted model (symmetry model or MWC model).This states that enzyme subunits can assume one of two conformational states (relaxed or tense), and that the state of one subunit is shared or enforced on the others. The binding of a ligand to a site other than that bound by the substrate (active site) can shift the conformation from one state to the other. L represents the equilibrium constant between active and inactive states of the enzyme, and n represents the number of binding sites for the substrate and inhibitor.
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\"> Ks </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000189\"> n </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000281\"> L </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <ci> Ks </ci>\n                <ci> substrate </ci>\n              </apply>\n              <apply>\n                <minus></minus>\n                <ci> n </ci>\n                <cn> 1 </cn>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci> L </ci>\n              <apply>\n                <power></power>\n                <apply>\n                  <times></times>\n                  <ci> Ks </ci>\n                  <apply>\n                    <plus></plus>\n                    <cn> 1 </cn>\n                    <apply>\n                      <divide></divide>\n                      <ci> Inhibitor </ci>\n                      <ci> Ki </ci>\n                    </apply>\n                  </apply>\n                </apply>\n                <ci> n </ci>\n              </apply>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <plus></plus>\n                <ci> Ks </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> n </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000441
name: enzymatic rate law for mixed-type inhibition of reversible enzymes by mutually exclusive inhibitors
comment: Reversible inhibition of a unireactant enzyme by inhibitors that can bind to the enzyme-substrate complex and to the free enzyme with the same equilibrium constant. The inhibitor is noncompetitive with the substrate.
is_a: SBO:0000275 ! enzymatic rate law for mixed-type inhibition of irreversible enzymes by mutually exclusive inhibitors
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">product</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\">Inhibitor</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\">Kms</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\">Kmp</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\">Vf</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\">Vr</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Kis</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\">Kic</ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> Inhibitor </ci>\n              <ci> Kis </ci>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> Inhibitor </ci>\n                  <ci> Kic </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000442
name: enzymatic rate law for simple reversible non-competitive inhibition of unireactant enzymes
comment: Reversible inhibition of a unireactant enzyme by one inhibitor that can bind to the enzyme-substrate complex and to the free enzyme with the same equilibrium constant. The inhibitor is noncompetitive with the substrate.\n
is_a: SBO:0000265 ! enzymatic rate law for simple mixed-type inhibition of irreversible unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <times></times>\n            <apply>\n              <plus></plus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <ci> substrate </ci>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <ci> product </ci>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <apply>\n              <plus></plus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <ci> Inhibitor </ci>\n                <ci> Ki </ci>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000443
name: enzymatic rate law for reversible essential activation
comment: Synonym: specific activation 
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes

[Term]
id: SBO:0000444
name: enzymatic rate law for reversible mixed activation
comment: Enzymatic rate law where the activator enhances the rate of reaction through specific and catalytic effects, which increase the apparent limiting rate and decrease apparent Michaelis constant. The activator can bind reversibly both the free enzyme and enzyme-substrate complex, while the substrate can bind only to enzyme-activator complex. Catalytic activity is seen only when enzyme, substrate and activator are complexed.
is_a: SBO:0000443 ! enzymatic rate law for reversible essential activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\"> Activator </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Kas </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Kac </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <minus></minus>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vf </ci>\n                  <ci> substrate </ci>\n                </apply>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> product </ci>\n                </apply>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <plus></plus>\n            <ci> Kas </ci>\n            <ci> Activator </ci>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <ci> Kac </ci>\n                <ci> Activator </ci>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000445
name: enzymatic rate law for irreversible substrate activation
comment: This enzymatic rate law is available only for irreversible reactions, with one substrate and one product. There is a second binding site for the enzyme which, when occupied, activates the enzyme. Substrate binding at either site can occur at random.\n
is_a: SBO:0000444 ! enzymatic rate law for reversible mixed activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\"> Ksc </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\"> Ksa </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <apply>\n              <power></power>\n              <apply>\n                <divide></divide>\n                <ci> substrate </ci>\n                <ci> Ksa </ci>\n              </apply>\n              <cn> 2 </cn>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Ksc </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Ksa </ci>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <divide></divide>\n                <ci> substrate </ci>\n                <ci> Ksa </ci>\n              </apply>\n              <cn> 2 </cn>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000446
name: enzymatic rate law for irrreversible mixed activation
comment: Enzymatic rate law where the activator enhances the rate of reaction through specific and catalytic effects, which increase the apparent limiting rate and decrease apparent Michaelis constant. The activator can bind irreversibly both free enzyme and enzyme-substrate complex, while the substrate can bind only to enzyme-activator complex. Catalytic activity is seen only when enzyme, substrate and activator are complexed.
is_a: SBO:0000444 ! enzymatic rate law for reversible mixed activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\"> Activator </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Kas </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Kac </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci> Kms </ci>\n              <apply>\n                <plus></plus>\n                <ci> Kas </ci>\n                <ci> Activator </ci>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> substrate </ci>\n              <apply>\n                <plus></plus>\n                <ci> Kac </ci>\n                <ci> Activator </ci>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000447
name: enzymatic rate law for reversible catalytic activation with one activator
comment: Enzymatic rate law where an activator enhances the rate of reaction by increasing the apparent limiting rate; The reversible binding of the activator to the enzyme-substrate complex is required for enzyme catalytic activity (to generate the product). \n
is_a: SBO:0000444 ! enzymatic rate law for reversible mixed activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\"> Activator </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Ka </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <minus></minus>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vf </ci>\n                  <ci> substrate </ci>\n                </apply>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> product </ci>\n                </apply>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <times></times>\n            <apply>\n              <plus></plus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <ci> substrate </ci>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <ci> product </ci>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <apply>\n              <plus></plus>\n              <ci> Ka </ci>\n              <ci> Activator </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000448
name: enzymatic rate law for reversible specific activation
comment: Enzymatic rate law for one substrate, one product and one modifier which acts as an activator. The activator enhances the rate of reaction by decreasing the apparent Michaelis constant. The activator reversibly binds to the enzyme before the enzyme can bind the substrate.
is_a: SBO:0000444 ! enzymatic rate law for reversible mixed activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\"> Activator </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Ka </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <minus></minus>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vf </ci>\n                  <ci> substrate </ci>\n                </apply>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> product </ci>\n                </apply>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <plus></plus>\n            <ci> Ka </ci>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n              <ci> Activator </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000449
name: enzymatic rate law for irreversible catalytic activation with one activator
comment: Enzymatic rate law where an activator enhances the rate of reaction by increasing the apparent limiting rate; The activator binding to the enzyme-substrate complex (irreversibly) is required for enzyme catalytic activity (to generate the product). 
is_a: SBO:0000447 ! enzymatic rate law for reversible catalytic activation with one activator
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\"> Activator </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\"> Ka </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <times></times>\n            <apply>\n              <plus></plus>\n              <ci> Kms </ci>\n              <ci> substrate </ci>\n            </apply>\n            <apply>\n              <plus></plus>\n              <ci> Ka </ci>\n              <ci> Activator </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000450
name: enzymatic rate law for irreversible specific activation
comment: Enzymatic rate law for one substrate, one product and one modifier which acts as an activator. The activator enhances the rate of reaction by decreasing the apparent Michaelis constant. The activator must bind to the enzyme before the enzyme can bind the substrate. 
is_a: SBO:0000448 ! enzymatic rate law for reversible specific activation
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\">substrate</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\">Activator</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\">Kms</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\">V</ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000363\">Ka</ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n            <ci> Activator </ci>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci> Kms </ci>\n              <ci> Ka </ci>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <ci> Kms </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Activator </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000451
name: enzymatic rate law for reversible reactions with competitive inhibition
comment: This enzymatic rate law involves one substrate, one product and one or more modifiers. The modifiers act as competitive inhibitors of the substrate at the enzyme binding site; The modifiers (inhibitors) reversibly bound to the enzyme block access to the substrate. The inhibitors have the effect of increasing the apparent Km, and bind exclusively to the enzymes.
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000272\">n</ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> product </ci>\n              <ci> Kmp </ci>\n            </apply>\n            <apply>\n              <sum></sum>\n              <bvar>\n                <ci> i </ci>\n              </bvar>\n              <lowlimit>\n                <cn type=\"integer\"> 1 </cn>\n              </lowlimit>\n              <uplimit>\n                <ci> n </ci>\n              </uplimit>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <selector></selector>\n                  <ci type=\"vector\">I</ci>\n                  <ci> i </ci>\n                </apply>\n                <apply>\n                  <selector></selector>\n                  <ci type=\"vector\">Ki</ci>\n                  <ci> i </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000452
name: enzymatic rate law for reversible competitive inhibition by one inhibitor
comment: This enzymatic rate law involves one substrate, one product and one modifier. The modifier acts as a competitive inhibitor with the substrate at the enzyme binding site; The modifier (inhibitor) reversibly bound to the enzyme blocks access to the substrate. The inhibitor has the effect of increasing the apparent Km. 
is_a: SBO:0000451 ! enzymatic rate law for reversible reactions with competitive inhibition
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> product </ci>\n              <ci> Kmp </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> Inhibitor </ci>\n              <ci> Ki </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000453
name: enzymatic rate law for reversible empirical allosteric inhibition by one inhibitor
comment: Enzymatic rate law where the reversible binding of one ligand decreases the affinity for substrate at other active sites. The ligand does not bind the same site as the substrate on the enzyme. This is an empirical equation, where n represents the Hill coefficient.
is_a: SBO:0000451 ! enzymatic rate law for reversible reactions with competitive inhibition
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000190\"> n </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> product </ci>\n              <ci> Kmp </ci>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <divide></divide>\n                <ci> Inhibitor </ci>\n                <ci> Ki </ci>\n              </apply>\n              <ci> n </ci>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000454
name: enzymatic rate law for reversible substrate inhibition
comment: Enzymatic rate law where the substrate for an enzyme also acts as a reversible  inhibitor. This may entail a second (non-active) binding site for the enzyme. The inhibition constant is then the dissociation constant for the substrate from this second site.
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> substrate </ci>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <ci> product </ci>\n              <ci> Kmp </ci>\n            </apply>\n            <apply>\n              <power></power>\n              <apply>\n                <divide></divide>\n                <ci> substrate </ci>\n                <ci> Ki </ci>\n              </apply>\n              <cn> 2 </cn>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000455
name: enzymatic rate law for irreversible substrate inhibition
comment: Enzymatic rate law where the substrate for an enzyme also acts as an irreversible inhibitor. This may entail a second (non-active) binding site for the enzyme. The inhibition constant is then the dissociation constant for the substrate from this second site.\n
is_a: SBO:0000454 ! enzymatic rate law for reversible substrate inhibition
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\"> Km </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n          </apply>\n          <apply>\n            <plus></plus>\n            <ci> Km </ci>\n            <ci> substrate </ci>\n            <apply>\n              <times></times>\n              <ci> Km </ci>\n              <apply>\n                <power></power>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Ki </ci>\n                </apply>\n                <cn> 2 </cn>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000456
name: enzymatic rate law for reversible unireactant enzyme with a single hyperbolic modulator
comment: Enzymatic rate law where the modifier can act as an activator or inhibitor, depending upon the values of the kinetic constants. The modifier can bind reversibly to all forms of the enzyme and all enzyme-substrate complexes are reactive. \n'a' represents the ratio of dissociation constant of the elementary step Enzyme-Substrate complex + Modifier = Enzyme-Substrate-Modifier complex over that of Enzyme + Modifier = Enzyme-Modifier complex.\n'b' represents ratio of the rate constant of elementary step Enzyme-Substrate-Modifier complex -> Enzyme-Modifier complex + Product over that of Enzyme-Substrate complex -> Enzyme + Product.\n 
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000518\"> Modifier </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\"> Kd </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\"> a </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\"> b </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <apply>\n              <minus></minus>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vf </ci>\n                  <ci> substrate </ci>\n                </apply>\n                <ci> Kms </ci>\n              </apply>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> Vr </ci>\n                  <ci> product </ci>\n                </apply>\n                <ci> Kmp </ci>\n              </apply>\n            </apply>\n            <apply>\n              <plus></plus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> b </ci>\n                  <ci> Modifier </ci>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci> a </ci>\n                  <ci> Kd </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <divide></divide>\n              <ci> Modifier </ci>\n              <ci> Kd </ci>\n            </apply>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> Modifier </ci>\n                  <apply>\n                    <times></times>\n                    <ci> a </ci>\n                    <ci> Kd </ci>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000457
name: enzymatic rate law for irreversible unireactant enzyme with a single hyperbolic modulator
comment: Enzymatic rate law where the modifier can act as an activator or inhibitor, depending upon the values of the kinetic constants. The modifier can bind irreversibly to all forms of the enzyme and all enzyme-substrate complexes are reactive. \n'a' represents the ratio of dissociation constant of the elementary step Enzyme-Substrate complex + Modifier = Enzyme-Substrate-Modifier complex) over that of Enzyme + Modifier = Enzyme-Modifier complex.\n'b' represents ratio of the rate constant of elementary step Enzyme-Substrate-Modifier complex -> Enzyme-Modifier complex + Product over that of Enzyme-Substrate complex -> Enzyme + Product.\n 
is_a: SBO:0000456 ! enzymatic rate law for reversible unireactant enzyme with a single hyperbolic modulator
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000518\"> Modifier </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\"> Km </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> V </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000282\"> Kd </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\"> a </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000381\"> b </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <times></times>\n            <ci> V </ci>\n            <ci> substrate </ci>\n            <apply>\n              <plus></plus>\n              <cn> 1 </cn>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <times></times>\n                  <ci> b </ci>\n                  <ci> Modifier </ci>\n                </apply>\n                <apply>\n                  <times></times>\n                  <ci> a </ci>\n                  <ci> Kd </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <apply>\n              <times></times>\n              <ci> Km </ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> Modifier </ci>\n                  <ci> Kd </ci>\n                </apply>\n              </apply>\n            </apply>\n            <apply>\n              <times></times>\n              <ci> substrate </ci>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> Modifier </ci>\n                  <apply>\n                    <times></times>\n                    <ci> a </ci>\n                    <ci> Kd </ci>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000458
name: enzymatic rate law for simple uncompetitive inhibition of reversible unireactant enzymes
comment: Reversible inhibition of a unireactant enzyme by one inhibitor, which binds to the enzyme-substrate complex. The inhibitor is uncompetitive with the substrate.\n
is_a: SBO:0000430 ! enzymatic rate law for modulated unireactant enzymes
property_value: seeAlso "  <mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n    <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n      <lambda>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000515\"> substrate </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\"> product </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000521\"> Inhibitor </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\"> Kms </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000323\"> Kmp </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000324\"> Vf </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000325\"> Vr </ci>\n        </bvar>\n        <bvar>\n          <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000261\"> Ki </ci>\n        </bvar>\n        <apply>\n          <divide></divide>\n          <apply>\n            <minus></minus>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vf </ci>\n                <ci> substrate </ci>\n              </apply>\n              <ci> Kms </ci>\n            </apply>\n            <apply>\n              <divide></divide>\n              <apply>\n                <times></times>\n                <ci> Vr </ci>\n                <ci> product </ci>\n              </apply>\n              <ci> Kmp </ci>\n            </apply>\n          </apply>\n          <apply>\n            <plus></plus>\n            <cn> 1 </cn>\n            <apply>\n              <times></times>\n              <apply>\n                <plus></plus>\n                <apply>\n                  <divide></divide>\n                  <ci> substrate </ci>\n                  <ci> Kms </ci>\n                </apply>\n                <apply>\n                  <divide></divide>\n                  <ci> product </ci>\n                  <ci> Kmp </ci>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <cn> 1 </cn>\n                <apply>\n                  <divide></divide>\n                  <ci> Inhibitor </ci>\n                  <ci> Ki </ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </lambda>\n    </semantics>\n  </mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000459
name: stimulator
comment: Synonym: activator 
is_a: SBO:0000019 ! modifier

[Term]
id: SBO:0000460
name: enzymatic catalyst
comment: A substance that accelerates the velocity of a chemical reaction without itself being consumed or transformed, by lowering the free energy of the transition state. The substance acting as a catalyst is an enzyme.
is_a: SBO:0000013 ! catalyst

[Term]
id: SBO:0000461
name: essential activator
comment: Synonym: necessary stimulator 
is_a: SBO:0000459 ! stimulator

[Term]
id: SBO:0000462
name: non-essential activator
comment: An activator which is not necessary for an enzymatic reaction, but whose presence will further increase enzymatic activity. 
is_a: SBO:0000459 ! stimulator

[Term]
id: SBO:0000463
name: standard biochemical potential
comment: Synonym: standard chemical potential 
is_a: SBO:0000303 ! biochemical potential

[Term]
id: SBO:0000464
name: state variable assignment
comment: Assignment of a state or a value to a state variable, characteristic or property, of a biological entity.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000465
name: spatial measure
comment: The measurable dimensions of an object which are minimally required to define the space that an object occupies.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000466
name: length
comment: The length of an object is the longest measurable distance between its extremities. 
is_a: SBO:0000465 ! spatial measure

[Term]
id: SBO:0000467
name: area
comment: The area of an object is a quantity expressing its two-dimensional size, usually part or all of its surface. 
is_a: SBO:0000465 ! spatial measure

[Term]
id: SBO:0000468
name: volume
comment: A quantity representing the three-dimensional space occupied by all or part of an object.
is_a: SBO:0000465 ! spatial measure

[Term]
id: SBO:0000469
name: containment
comment: Synonym: inclusion 
is_a: SBO:0000413 ! positional relationship

[Term]
id: SBO:0000470
name: mass fraction
comment: For a given substance, A, its mass fraction (x A) is defined as the ratio of its mass (m A) to the total mass (m total) in which it is present, where the sum of all mass fractions is equal to 1. This provides a means to express concentration in a dimensionless size. 
is_a: SBO:0000540 ! fraction of an entity pool

[Term]
id: SBO:0000471
name: molal concentration of an entity
comment: Molality denotes the number of moles of solute per kilogram of solvent (not solution). The term molal solution is used as a shorthand for a "one molal solution", i.e. a solution which contains one mole of the solute per kilogram of the solvent. The SI unit for molality is mol/kg.
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000472
name: molar concentration of an entity
comment: Molarity, or molar concentration, denotes the number of moles of a given substance per litre of solution. The unit of measure of molarity is mol/L, molar, or the capital letter M as an abbreviated form.
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000473
name: denotement
comment: Term to signify where a material or conceptual entity is represented or denoted by a symbol or by some other abbreviated form. 
is_a: SBO:0000552 ! reference annotation

[Term]
id: SBO:0000474
name: convenience function
comment: Mathematical function commonly used in biological modeling,  which enable simplification of more complex expressions
is_a: SBO:0000064 ! mathematical expression

[Term]
id: SBO:0000475
name: periodic forcing function
comment: Synonym: input signal step function 
is_a: SBO:0000474 ! convenience function
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n    <lambda>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000586\"> time </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000584\"> Theta0 </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000492\"> Theta1 </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000477\"> Phi </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000347\"> Tp </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000476\"> Tc </ci></bvar>\n      <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000347\"> Tw </ci></bvar>\n      <apply>\n        <plus></plus>\n        <ci> Theta0 </ci>\n        <apply>\n          <times></times>\n          <cn> 0.5 </cn>\n          <ci> Theta1 </ci>\n          <apply>\n            <plus></plus>\n            <apply>\n              <minus></minus>\n              <apply>\n                <plus></plus>\n                <cn type=\"integer\"> 1 </cn>\n                <apply>\n                  <tanh></tanh>\n                  <apply>\n                    <divide></divide>\n                    <apply>\n                      <minus></minus>\n                      <apply>\n                        <plus></plus>\n                        <ci> time </ci>\n                        <ci> Phi </ci>\n                      </apply>\n                      <apply>\n                        <times></times>\n                        <ci> Tc </ci>\n                        <apply>\n                          <floor></floor>\n                          <apply>\n                            <divide></divide>\n                            <apply>\n                              <plus></plus>\n                              <ci> time </ci>\n                              <ci> Phi </ci>\n                            </apply>\n                            <ci> Tc </ci>\n                          </apply>\n                        </apply>\n                      </apply>\n                    </apply>\n                    <ci> Tw </ci>\n                  </apply>\n                </apply>\n              </apply>\n              <apply>\n                <plus></plus>\n                <cn type=\"integer\"> 1 </cn>\n                <apply>\n                  <tanh></tanh>\n                  <apply>\n                    <divide></divide>\n                    <apply>\n                      <minus></minus>\n                      <apply>\n                        <minus></minus>\n                        <apply>\n                          <plus></plus>\n                          <ci> time </ci>\n                          <ci> Phi </ci>\n                        </apply>\n                        <apply>\n                          <times></times>\n                          <ci> Tc </ci>\n                          <apply>\n                            <floor></floor>\n                            <apply>\n                              <divide></divide>\n                              <apply>\n                                <plus></plus>\n                                <ci> time </ci>\n                                <ci> Phi </ci>\n                              </apply>\n                              <ci> Tc </ci>\n                            </apply>\n                          </apply>\n                        </apply>\n                      </apply>\n                      <ci> Tp </ci>\n                    </apply>\n                    <ci> Tw </ci>\n                  </apply>\n                </apply>\n              </apply>\n            </apply>\n            <cn type=\"integer\"> 1 </cn>\n            <apply>\n              <tanh></tanh>\n              <apply>\n                <divide></divide>\n                <apply>\n                  <minus></minus>\n                  <apply>\n                    <minus></minus>\n                    <apply>\n                      <plus></plus>\n                      <ci> time </ci>\n                      <ci> Phi </ci>\n                    </apply>\n                    <apply>\n                      <times></times>\n                      <ci> Tc </ci>\n                      <apply>\n                        <floor></floor>\n                        <apply>\n                          <divide></divide>\n                          <apply>\n                            <plus></plus>\n                            <ci> time </ci>\n                            <ci> Phi </ci>\n                          </apply>\n                          <ci> Tc </ci>\n                        </apply>\n                      </apply>\n                    </apply>\n                  </apply>\n                  <ci> Tc </ci>\n                </apply>\n                <ci> Tw </ci>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </apply>\n    </lambda>\n  </semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000476
name: period
comment: The period is the duration of one cycle in a repeating event. [wikipedia]
is_a: SBO:0000347 ! duration

[Term]
id: SBO:0000477
name: phase shift
comment: Synonym: temporal offset 
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000478
name: powered product of Michaelis constant
comment: The product of the Michaelis constants, to the power of their respective stoichiometric coefficients, for either substrates or products.
is_a: SBO:0000193 ! equilibrium or steady-state constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Km</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">x</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000481\">n</ci></bvar>\n    <apply>\n      <product></product>\n      <bvar><ci> i </ci></bvar>\n      <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n      <uplimit><ci> x </ci></uplimit>\n      <apply>\n	<power></power>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">Km</ci>\n	  <ci> i </ci>\n	</apply>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">n</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000479
name: powered product of substrate Michaelis constants
comment: The product of the substrate Michaelis constants, to the power of their respective stoichiometric coefficients.
is_a: SBO:0000478 ! powered product of Michaelis constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000322\">Kms</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000149\">x</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000481\">n</ci></bvar>\n    <apply>\n      <product></product>\n      <bvar><ci> i </ci></bvar>\n      <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n      <uplimit><ci> x </ci></uplimit>\n      <apply>\n	<power></power>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">Kms</ci>\n	  <ci> i </ci>\n	</apply>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">n</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>\n" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000480
name: powered product of product Michaelis constants
comment: The product of the product Michaelis constants, to the power of their respective stoichiometric coefficients.
is_a: SBO:0000478 ! powered product of Michaelis constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000027\">Km</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000490\">x</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000481\">n</ci></bvar>\n    <apply>\n      <product></product>\n      <bvar><ci> i </ci></bvar>\n      <lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n      <uplimit><ci> x </ci></uplimit>\n      <apply>\n	<power></power>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">Km</ci>\n	  <ci> i </ci>\n	</apply>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">n</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000481
name: stoichiometric coefficient
comment: The stoichiometric coefficient represents the degree to which a chemical species participates in a reaction. It corresponds to the number of molecules of a reactant that are consumed or produced with each occurrence of a reaction event.
is_a: SBO:0000380 ! biochemical coefficient

[Term]
id: SBO:0000482
name: geometric mean rate constant
comment: The geometric mean turnover rate of an enzyme in either forward or backward direction for a reaction, measured per second.
is_a: SBO:0000009 ! kinetic constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000009\">k</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000188\">n</ci></bvar>\n    <apply>\n      <root></root>\n      <degree> <ci> n </ci> \n      </degree>\n      <apply>\n	<product></product>\n	<bvar><ci> i </ci></bvar>\n	<lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n	<uplimit><ci> n </ci></uplimit>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">k</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000483
name: forward geometric mean rate constant
comment: The geometric mean turnover rate of an enzyme in the forward direction for a reaction, measured per second.
is_a: SBO:0000482 ! geometric mean rate constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000153\">kf</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000188\">n</ci></bvar>\n    <apply>\n      <root></root>\n      <degree> <ci> n </ci> \n      </degree>\n      <apply>\n	<product></product>\n	<bvar><ci> i </ci></bvar>\n	<lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n	<uplimit><ci> n </ci></uplimit>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">kf</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000484
name: reverse geometric mean rate constant
comment: The geometric mean turnover rate of an enzyme in the reverse direction for a reaction, measured per second.
is_a: SBO:0000482 ! geometric mean rate constant
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000156\">kr</ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000188\">n</ci></bvar>\n    <apply>\n      <root></root>\n      <degree> <ci> n </ci> \n      </degree>\n      <apply>\n	<product></product>\n	<bvar><ci> i </ci></bvar>\n	<lowlimit><cn type=\"integer\"> 1 </cn></lowlimit>\n	<uplimit><ci> n </ci></uplimit>\n	<apply>\n	  <selector></selector>\n	  <ci type=\"vector\">kr</ci>\n	  <ci> i </ci>\n	</apply>\n      </apply>\n    </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000485
name: basal rate constant
comment: The minimal velocity observed under defined conditions, which may or may not include the presence of an effector. For example in an inhibitory system, this would be the residual velocity observed under full inhibition. In non-essential activation, this would be the velocity in the absence of any activator.
is_a: SBO:0000046 ! zeroth order rate constant

[Term]
id: SBO:0000486
name: relative basal rate constant
comment: The ratio of the basal activity to the maximal velocity of a reaction. The values range between 0 and 1.
is_a: SBO:0000381 ! biochemical proportionality coefficient
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000485\"> b </ci></bvar>\n    <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000186\"> vmax</ci></bvar>\n    <apply>\n      <divide></divide>\n      <ci> b </ci>\n      <ci> vmax </ci>\n    </apply>\n  </lambda>\n</mathml:math> " http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000487
name: relative activity function
comment: Function which ranges from 0 to 1, to describe the relative activation or inhibition of a reaction or process, actual or conceptual.  
is_a: SBO:0000474 ! convenience function

[Term]
id: SBO:0000488
name: relative activation function
comment: Function which ranges from 0 to 1, to describe the relative activation of a reaction or process, actual or conceptual.  
is_a: SBO:0000487 ! relative activity function

[Term]
id: SBO:0000489
name: relative inhibition function
comment: Function which ranges from 0 to 1, to describe the relative inhibition of a reaction or process, actual or conceptual.  
is_a: SBO:0000487 ! relative activity function

[Term]
id: SBO:0000490
name: number of products
comment: Number of molecules which are generated by an enzyme.
is_a: SBO:0000188 ! number of biochemical items

[Term]
id: SBO:0000491
name: diffusion coefficient
comment: Synonym: diffusivity 
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000492
name: amplitude
comment: Amplitude is the magnitude of change in the oscillating variable, with each oscillation, within an oscillating system. 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000493
name: functional domain
comment: A spatial region of an entity that confers a function
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000494
name: binding site
comment: A specific domain of a spatio-temporal entity to which another spatio-temporal entity is able to bind, forming chemical bonds.  
is_a: SBO:0000493 ! functional domain

[Term]
id: SBO:0000495
name: catalytic site
comment: A catalytic site is the region which confers specificity of a substrate for the binding entity, and where specific reactions take place in the conversion of the substrate to the product. 
is_a: SBO:0000493 ! functional domain

[Term]
id: SBO:0000496
name: transmembrane domain
comment: A transmembrane domain is any three-dimensional protein structure which is thermodynamically stable in a membrane. This may be a single alpha helix, a stable complex of several transmembrane alpha helices, a transmembrane beta barrel, a beta-helix of gramicidin A, or any other structure.\n\n
is_a: SBO:0000493 ! functional domain

[Term]
id: SBO:0000497
name: ternary switch
comment: A parameter that has three discrete values which may be alternated between. 
is_a: SBO:0000389 ! switch value

[Term]
id: SBO:0000498
name: relative activity
comment: Value which ranges from 0 to 1, to describe the relative activity of a process or reaction. 
is_a: SBO:0000381 ! biochemical proportionality coefficient

[Term]
id: SBO:0000499
name: genetic interaction
comment: A phenomenon whereby an observed phenotype, qualitative or quantative,  is not explainable by the simple additive effects of the individual gene pertubations alone. Genetic interaction between perturbed genes is usually expected to generate a 'defective' phenotype. The level of defectiveness is often used to sub-classify this phenomenon.\n
is_a: SBO:0000231 ! occurring entity representation

[Term]
id: SBO:0000500
name: genetic suppression
comment: Genetic suppression is said to have occurred when the phenotypic effect of an initial mutation in a gene is less severe, or entirely negated, by a subsequent mutation. \n
is_a: SBO:0000343 ! genetic interaction

[Term]
id: SBO:0000501
name: genetic enhancement
comment: Genetic enhancement is said to have occurred when the phenotypic effect of an initial mutation in a gene is made increasingly severe by a subsequent mutation.
is_a: SBO:0000343 ! genetic interaction

[Term]
id: SBO:0000502
name: synthetic lethality
comment: Synthetic lethality is said to have occurred where gene mutations, each of which map to a separate locus, fail to complement in an offspring to correct a phenotype, as would be expected.\n\n
is_a: SBO:0000343 ! genetic interaction

[Term]
id: SBO:0000503
name: number of entity pool constituents
comment: The numerical quantification of an entity pool. This may be expressed as, for example, the number of molecules or the number of moles of identical entities of which an specific entity pool is comprised.
is_a: SBO:0000361 ! amount of an entity pool

[Term]
id: SBO:0000504
name: mass of an entity pool
comment: The mass that comprises an entity pool.
is_a: SBO:0000361 ! amount of an entity pool

[Term]
id: SBO:0000505
name: concentration of enzyme
comment: Amount of enzyme present per unit of volume. The participant role 'enzymatic catalyst' is defined in SBO:0000460.
is_a: SBO:0000518 ! concentration of modifier

[Term]
id: SBO:0000506
name: mass of enzyme
comment: Amount, expressed as a mass, of an enzyme. The participant role 'enzymatic catalyst' is defined in SBO:0000460.
is_a: SBO:0000504 ! mass of an entity pool

[Term]
id: SBO:0000507
name: number of an enzyme
comment: Amount, expressed as a number, of a specific enzyme comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'enzymatic catalyst' is defined in SBO:0000460.
is_a: SBO:0000517 ! number of a modifier

[Term]
id: SBO:0000508
name: number of a reactant
comment: The amount, expressed as a number, of a specific reactant comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'reactant' is defined in SBO:0000010. 
is_a: SBO:0000503 ! number of entity pool constituents

[Term]
id: SBO:0000509
name: concentration of reactant
comment: The amount of a specific entity pool reactant present per unit of volume. The participant role 'reactant' is defined in SBO:0000010.\n
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000510
name: mass of reactant
comment: The amount, expressed as a mass, of a specific reactant entity pool. The participant role 'reactant' is defined in SBO:0000010.
is_a: SBO:0000504 ! mass of an entity pool

[Term]
id: SBO:0000511
name: number of a product
comment: The amount, expressed as a number, of a specific product comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'product' is defined in SBO:0000011.
is_a: SBO:0000503 ! number of entity pool constituents

[Term]
id: SBO:0000512
name: concentration of product
comment: The amount of a specific entity pool product present per unit of volume. The participant role 'product' is defined in SBO:0000011.
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000513
name: mass of product
comment: The amount, expressed as a mass, of a specific product entity pool. The participant role 'product' is defined in SBO:0000011.
is_a: SBO:0000504 ! mass of an entity pool

[Term]
id: SBO:0000514
name: number of a substrate
comment: The amount, expressed as a number, of a specific substrate comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'substrate' is defined in SBO:0000015.
is_a: SBO:0000508 ! number of a reactant

[Term]
id: SBO:0000515
name: concentration of substrate
comment: The amount of a specific entity pool substrate present per unit of volume. The participant role 'substrate' is defined in SBO:0000015.
is_a: SBO:0000509 ! concentration of reactant

[Term]
id: SBO:0000516
name: mass of substrate
comment: The amount, expressed as a mass, of a specific substrate entity pool. The participant role 'substrate' is defined in SBO:0000015.
is_a: SBO:0000510 ! mass of reactant

[Term]
id: SBO:0000517
name: number of a modifier
comment: The amount, expressed as a number, of a specific modifier comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'modifier' is defined in SBO:0000019.
is_a: SBO:0000503 ! number of entity pool constituents

[Term]
id: SBO:0000518
name: concentration of modifier
comment: The amount of a specific modifier entity pool present per unit of volume. The participant role 'modifier' is defined in SBO:0000019.
is_a: SBO:0000196 ! concentration of an entity pool

[Term]
id: SBO:0000519
name: mass of modifier
comment: The amount, expressed as a mass, of a specific modifier entity pool. The participant role 'modifier' is defined in SBO:0000019.
is_a: SBO:0000504 ! mass of an entity pool

[Term]
id: SBO:0000520
name: number of an inhibitor
comment: The amount, expressed as a number, of a specific inhibitor comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'inhibitor' is defined in SBO:0000020.
is_a: SBO:0000517 ! number of a modifier

[Term]
id: SBO:0000521
name: concentration of inhibitor
comment: The amount of a specific inhibitor entity pool present per unit of volume. The participant role 'inhibitor' is defined in SBO:0000020.\n
is_a: SBO:0000518 ! concentration of modifier

[Term]
id: SBO:0000522
name: mass of inhibitor
comment: The amount, expressed as a mass, of a specific inhibitor entity pool. The participant role 'inhibitor' is defined in SBO:0000020.
is_a: SBO:0000519 ! mass of modifier

[Term]
id: SBO:0000523
name: number of an activator
comment: The amount, expressed as a number, of a specific activator comprising an entity pool. This may be expressed, for example, as the number of molecules, or the number of moles. The participant role 'activator' is defined in SBO:0000459. 
is_a: SBO:0000517 ! number of a modifier

[Term]
id: SBO:0000524
name: concentration of activator
comment: The amount of a specific activator entity pool present per unit of volume. The participant role 'activator' is defined in SBO:0000459.
is_a: SBO:0000518 ! concentration of modifier

[Term]
id: SBO:0000525
name: mass of activator
comment: The amount, expressed as a mass, of a specific activator entity pool. The participant role 'activator' is defined in SBO:0000459.
is_a: SBO:0000519 ! mass of modifier

[Term]
id: SBO:0000526
name: protein complex formation
comment: The process by which two or more proteins interact non-covalently to form a protein complex (SBO:0000297).
is_a: SBO:0000344 ! molecular interaction

[Term]
id: SBO:0000527
name: modular rate law
comment: Modular rate laws are a set of rate laws that provide a means to parameterise a system in a manner that is a compromise between mathematical abstraction and biochemical detail. They share the same common form:\n\nv = u f (T/(D + Dreg))\n\nThe individual numerator and denominator terms can substituted with alternative forms, depending on reaction details and model formulation, to generate specific modular rate laws. The terms represented are;\nv, reaction rate;\nu, enzyme amount;\nT, modular term derived from stoichiometries, metabolite concentrations and reactant constants;\nD, modular term for polynomial of scaled concentrations;\nDreg, competitive regulation binding states term;\nf, modular term for regulation factor.
is_a: SBO:0000001 ! rate law

[Term]
id: SBO:0000528
name: common modular rate law
comment: The common modular rate law is a generalised form of reversible Michaelis Menten kinetics, using a denominator where each binding state of the enzyme is represented. It is assumed that substrates and products bind independently and randomly, and that substrates and products cannot be bound at the same time.
is_a: SBO:0000527 ! modular rate law

[Term]
id: SBO:0000529
name: direct binding modular rate law
comment: The direct binding modular rate law makes the assumption that both substrates and products bind simultaneously and in a single step, hence the total binding states possible enumerate to 3; nothing bound, substrates bound, and products bound. Substrates and products cannot be bound at the same time.
is_a: SBO:0000527 ! modular rate law

[Term]
id: SBO:0000530
name: simultaneous binding modular rate law
comment: The simultaneous binding modular rate law makes the assumption that substrates and products can be bound simultaneously, and in any combination.
is_a: SBO:0000527 ! modular rate law

[Term]
id: SBO:0000531
name: power-law modular rate law
comment: For the power-law rate law, the denominator is set to be a constant, and the rate law does not saturate.
is_a: SBO:0000527 ! modular rate law

[Term]
id: SBO:0000532
name: force-dependent modular rate law
comment: Modular rate law where the D term is given by the square root of the product of\nterms (c/KM)^m where c, KM, and m denote the concentrations, Michaelis constants, and molecularities, respectively, and the product is taken over all reactants and products involved in the reaction.
is_a: SBO:0000527 ! modular rate law

[Term]
id: SBO:0000533
name: specific activator
comment: An essential activator that affects the apparent value of the specificity\nconstant. Mechanistically, the activator would need to be bound before\nreactant and product binding can take place.
is_a: SBO:0000461 ! essential activator

[Term]
id: SBO:0000534
name: catalytic activator
comment: An essential activator that affects the apparent value of the catalytic\nconstant.
is_a: SBO:0000461 ! essential activator

[Term]
id: SBO:0000535
name: binding activator
comment: An essential activator that affects the apparent value of the Michaelis\nconstant(s).
is_a: SBO:0000461 ! essential activator

[Term]
id: SBO:0000536
name: partial inhibitor
comment: Substance that, when bound, decreases enzymatic activity to a lower,\nnonzero value, without itself being consumed or transformed by the\nreaction, and without sterically hindering the interaction between\nreactants. The enzyme-inhibitor complex does retain some basal level of activity.
is_a: SBO:0000207 ! non-competitive inhibitor

[Term]
id: SBO:0000537
name: complete inhibitor
comment: Substance that, when bound, completely negates enzymatic activity, without\nitself being consumed or transformed by the reaction, and without\nsterically hindering the interaction between reactants. The inhibitor\nbinds to all enzyme species independently and with the same affinity,\ncompletely inhibiting any enzymatic activity.
is_a: SBO:0000207 ! non-competitive inhibitor

[Term]
id: SBO:0000538
name: ionic permeability
comment: Synonym: membrane permeability 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000539
name: probabilistic parameter
comment: A quantitative parameter that represents a probability value, assigned to a specific event.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000540
name: fraction of an entity pool
comment: A ratio that represents the quantity of a defined constituent entity over the total number of all constituent entities present. 
is_a: SBO:0000360 ! quantity of an entity pool

[Term]
id: SBO:0000541
name: mole fraction
comment: The number of moles of a constituent entity, divided by the total number of all constituent entities present in a system. 
is_a: SBO:0000540 ! fraction of an entity pool

[Term]
id: SBO:0000542
name: basic reproductive ratio
comment: Synonym: R0 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000543
name: protein aggregate
comment: A nonspecific coalescence of misfolded proteins which may or may not form a precipitate, depending upon particle size.
is_a: SBO:0000296 ! macromolecular complex

[Term]
id: SBO:0000544
name: metadata representation
comment: Supplementary information relating to a primary item of data, traditionally termed 'data about data'. It can describe, for example, the location or type of the data, or its relationship to other data.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000545
name: systems description parameter
comment: A value, numerical or symbolic, that defines certain characteristics of systems or system functions, or is necessary in their derivation.
is_a: SBO:0000000 ! systems biology representation

[Term]
id: SBO:0000546
name: qualitative systems description parameter
comment: A non-numerical value that defines certain characteristics of systems or system functions.
is_a: SBO:0000545 ! systems description parameter

[Term]
id: SBO:0000547
name: boolean logical framework
comment: Equationally defined algebraic framework usually interpreted as a two-valued logic using the basic Boolean operations (conjunction, disjunction and negation), together with the constants '0' and '1' denoting false and true values, respectively.
is_a: SBO:0000234 ! logical framework

[Term]
id: SBO:0000548
name: multi-valued logical framework
comment: Extension of the boolean logical framework which associates a defined number of possible integer values (states) with the variables.
is_a: SBO:0000547 ! boolean logical framework

[Term]
id: SBO:0000549
name: fuzzy logical framework
comment: Extension of the Boolean logical framework which allows intermediate or undetermined values for the logical variables.
is_a: SBO:0000547 ! boolean logical framework

[Term]
id: SBO:0000550
name: annotation
comment: Supplementary information that does not modify the semantics of the presented information.
is_a: SBO:0000544 ! metadata representation

[Term]
id: SBO:0000551
name: controlled short label
comment: The use of an abbreviated name, taken from a controlled vocabulary of terms, which is used to represent some information about the entity to which it is attached.
is_a: SBO:0000555 ! controlled annotation

[Term]
id: SBO:0000552
name: reference annotation
comment: Additional information that supplements existing data, usually in a document, by providing a link to more detailed information, which is held externally, or elsewhere.
is_a: SBO:0000550 ! annotation

[Term]
id: SBO:0000553
name: bibliographical reference
comment: An annotation which directs one to information contained within a published body of knowledge, usually a book or scientific journal.
is_a: SBO:0000552 ! reference annotation

[Term]
id: SBO:0000554
name: database cross reference
comment: Synonym: db xref 
is_a: SBO:0000552 ! reference annotation

[Term]
id: SBO:0000555
name: controlled annotation
comment: Annotation which complies with the full set of defined rules in its construction.
is_a: SBO:0000557 ! embedded annotation

[Term]
id: SBO:0000556
name: uncontrolled annotation
comment: Annotation which does not comply with, or is not restricted by, any rules in its construction. Examples would include free text annotations.
is_a: SBO:0000557 ! embedded annotation

[Term]
id: SBO:0000557
name: embedded annotation
comment: Annotation that directly incorporates information into the body of a document.
is_a: SBO:0000550 ! annotation

[Term]
id: SBO:0000558
name: specific activity
comment: A measure of enzyme activity under standard conditions, at a specific substrate concentration (usually saturation), expressed as the amount of product formed per unit time, per amount of enzyme. This is often expressed as micromol per min per mg, rather than the less practical official unit, Katal (1 mol per second).
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000559
name: enzyme activity
comment: A measure of the amount of active enzyme present, expressed under specified conditions. This is often expressed as micromol per min (also known as enzyme unit, U), rather than the less practical official SI unit, Katal (1 mol per second). Enzyme activity normally refers to the natural substrate for the enzyme, but can also be given for standardised substrates such as gelatin, where it is then referred to as GDU (Gelatin Digesting Units).
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000560
name: mass action rate law for first order irreversible reactions, single essential stimulator, continuous scheme
comment: Reaction scheme in which the reaction velocity is direct proportional to the activity or concentration of a single molecular species. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of the stimulator. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000163 ! mass action rate law for irreversible reactions, continuous scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000035\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\">A</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>A</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math> " http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000561
name: mass action rate law for first order irreversible reactions, single essential stimulator, discrete scheme
comment: Reaction scheme in which the reaction velocity is direct proportional to the activity or quantity of a single molecular species. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of the stimulator. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000166 ! mass action rate law for irreversible reactions, discrete scheme
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000066\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000523\">A</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>c</ci>\n         <ci>A</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000562
name: mass action like rate law for second order irreversible reactions, one reactant, one essential stimulator
comment: Reaction scheme where the products are created from a reactant and the change of a product quantity is proportional to the product of the reactant and the stimulator activities. The reaction scheme does not include any reverse process that creates the reactant from the products. The change of a product quantity is proportional to the quantity of the reactant and the stimulator. 
is_a: SBO:0000045 ! mass action rate law for second order irreversible reactions

[Term]
id: SBO:0000563
name: mass action like rate law for second order irreversible reactions, one reactant, one essential stimulator, continuous scheme
comment: Reaction scheme where the products are created from a reactant and the change of a product quantity is proportional to the product of the reactant and the stimulator activities. The reaction scheme does not include any reverse process that creates the reactant from the products. The change of a product quantity is proportional to the quantity of the reactant and the stimulator. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000562 ! mass action like rate law for second order irreversible reactions, one reactant, one essential stimulator
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000036\">k</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000524\">A</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>k</ci>\n         <ci>R</ci>\n         <ci>A</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math> " http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000564
name: mass action like rate law for second order irreversible reactions, one reactant, one essential stimulator, discrete scheme
comment: Reaction scheme where the products are created from a reactant and the change of a product quantity is proportional to the product of the reactant and the stimulator quantities. The reaction scheme does not include any reverse process that creates the reactant from the products. The change of a product quantity is proportional to the quantity of the reactant and the stimulator. It is to be used in a reaction modelled using a discrete framework.
is_a: SBO:0000562 ! mass action like rate law for second order irreversible reactions, one reactant, one essential stimulator
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n <semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000063\">\n   <lambda>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000067\">c</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000508\">R</ci></bvar>\n     <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000523\">A</ci></bvar>\n     <apply>\n         <times></times>\n         <ci>c</ci>\n         <ci>R</ci>\n         <ci>A</ci>\n     </apply>\n   </lambda>\n</semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000565
name: systems description constant
comment: A physical constant that is required in the calculation of a system parameter. 
is_a: SBO:0000545 ! systems description parameter

[Term]
id: SBO:0000566
name: relative permeability
comment: The permeability of an ion through a channel or membrane expressed in relation to the reference ion, which is given the value 1. For example, if a membrane is most permeable to K+, then that is assigned the reference permeability value of 1, and the value for Na+ may be 0.05.
is_a: SBO:0000538 ! ionic permeability

[Term]
id: SBO:0000567
name: universal gas constant
comment: Synonym: molar gas constant 
is_a: SBO:0000565 ! systems description constant

[Term]
id: SBO:0000568
name: Faraday constant
comment: Named after Michael Faraday, it is the magnitude of electric charge per mole of electrons. It has the value 96,485.3365 C/mol (Coulombs per Mole), and the symbol F.
is_a: SBO:0000565 ! systems description constant

[Term]
id: SBO:0000569
name: Goldman equation
comment: Synonym: Goldman-Hodgkin-Katz voltage equation 
is_a: SBO:0000391 ! steady state expression
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000567\">R</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000147\">T</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000568\">F</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000538\">P</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000566\">p</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">C</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">c</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">A</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">a</ci>\n    </bvar>\n     <apply>\n      <apply>\n        <divide></divide>\n        <apply>\n          <apply>\n            <times></times>\n            <ci>R</ci>\n            <ci>T</ci>\n          </apply>\n        </apply>\n        <ci>F</ci>\n      </apply>\n      <apply>\n        <ln></ln>\n        <apply>\n          <divide></divide>\n          <apply>\n            <plus></plus>\n            <apply>\n              <sum></sum>\n              <apply>\n                <times></times>\n                <ci>A</ci>\n                <ci>p</ci>\n              </apply>\n            </apply>\n            <apply>\n              <sum></sum>\n              <apply>\n                <times></times>\n                <ci>c</ci>\n                <ci>P</ci>\n              </apply>\n            </apply>\n          </apply>\n          <apply>\n            <apply>\n              <plus></plus>\n              <apply>\n                <sum></sum>\n                <apply>\n                  <times></times>\n                  <ci>a</ci>\n                  <ci>p</ci>\n                </apply>\n              </apply>\n              <apply>\n                <sum></sum>\n                <apply>\n                  <times></times>\n                  <ci>C</ci>\n                  <ci>P</ci>\n                </apply>\n              </apply>\n            </apply>\n          </apply>\n        </apply>\n      </apply>\n     </apply>\n  </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000570
name: Nernst potential
comment: Synonym: reversal potential 
is_a: SBO:0000569 ! Goldman equation
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n  <lambda>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000567\">R</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000147\">T</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000568\">F</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000503\">z</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">X</ci>\n    </bvar>\n    <bvar>\n      <ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000196\">x</ci>\n    </bvar>\n     <apply>\n      <apply>\n       <divide></divide>\n        <apply>\n         <times></times>\n          <ci>R</ci>\n          <ci>T</ci>\n        </apply>\n       <apply>\n        <times></times>\n         <ci>z</ci>\n         <ci>F</ci>\n       </apply>\n      </apply>\n      <apply>\n        <ln></ln>\n         <apply>\n          <divide></divide>\n          <apply>\n           <ci>X</ci>\n          </apply>\n            <ci>x</ci>\n          </apply>\n        </apply>\n      </apply>\n   </lambda>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000571
name: thermodynamic parameter
comment: Parameters used in the study of thermodynamics, a physical science that\npertains to the relationship between heat and other forms of energy such\nas 'work done' in material bodies.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000572
name: enthalpy
comment: A thermodynamic potential whose natural variables are entropy (S) and\npressure (p). The enthalpy of a system, measured in Joules (J), is defined\nas H = U + pV (where H is enthalpy, U is the internal energy, p is the\npressure at the system boundary, and V is the system volume).\nsymbol: H
is_a: SBO:0000571 ! thermodynamic parameter

[Term]
id: SBO:0000573
name: enthalpy change
comment: Change in enthalpy observed in the constituents of a thermodynamic system\nwhen undergoing a transformation or chemical reaction. This is the\npreferred way of expressing the energy changes to a system at constant\npressure, since enthalpy itself cannot be directly measured. The enthalpy\nchange is positive in endothermic reactions, negative in exothermic\nreactions, and is defined as the difference between the final and initial enthalpy of the system under study: ΔH = Hf - Hi. The standard unit of measure is J. Symbol: ΔH
is_a: SBO:0000572 ! enthalpy

[Term]
id: SBO:0000574
name: standard enthalpy of formation
comment: The enthalpy change observed in a constituent of a thermodynamic system\nwhen one mole of a compound, in its standard state, is formed from its\nelementary antecedents, in their standard state(s), under standard\nconditions (1 bar). The standard unit of measure is kJ/mol.\nSymbol: DeltaHf0, DeltafH0
is_a: SBO:0000573 ! enthalpy change

[Term]
id: SBO:0000575
name: standard enthalpy of reaction
comment: The enthalpy change observed in a constituent of a thermodynamic system\nwhen one mole of substance reacts completely, under standard conditions (1\nbar). The standard unit of measure is kJ/mol.\nSymbol: DeltaHr0, DeltarH0
is_a: SBO:0000573 ! enthalpy change

[Term]
id: SBO:0000576
name: entropy
comment: A thermodynamic property which acts as a measure of the state of disorder\nof a system. Its natural variables are the internal energy (U) and the\nvolume (V). It is defined by dS = (1/T)dU + (p/T)dV. The second law of\nthermodynamics states that in an isolated system, natural processes tend\nto increase in disorder or entropy. The standard unit of measure is Joules\nper Kelvin (J/K).\nsymbol: S
is_a: SBO:0000571 ! thermodynamic parameter

[Term]
id: SBO:0000577
name: entropy change
comment: The increase or decrease of the entropy of a system. For values greater\nthan zero, there is an implied increase in the disorder of a system, for\nexample during a reaction, and decreased disorder where the values are\nless than zero. The entropy change of a process is defined as the initial\nsystem entropy value minus the final entropy value: DeltaS = Sf - Si. The\nstandard unit of measure is J/K.\nsymbol: DeltaS
is_a: SBO:0000576 ! entropy

[Term]
id: SBO:0000578
name: standard entropy of reaction 
comment: The entropy change observed in a thermodynamic system when one mole of\nsubstance reacts completely, under standard conditions (1 bar).  The\nstandard unit of measure is kJ/(mol K). This can be calculated using the\nentropies for products and reactants: DeltaS(reaction)=sum DeltaS (products) - sum DeltaS reactants. The standard unit of measure is kJ/(mol K).\nsymbol: DeltaSro
is_a: SBO:0000577 ! entropy change

[Term]
id: SBO:0000579
name: standard entropy of formation
comment: The change in entropy associated with the formation of one mole of a\nsubstance from its elements in their standard states under standard\nconditions (1 bar). The standard unit of measure is kJ/(mol K).\nsymbol: DeltaSfo
is_a: SBO:0000577 ! entropy change

[Term]
id: SBO:0000580
name: Gibbs free energy
comment: Synonym: Gibbs function 
is_a: SBO:0000571 ! thermodynamic parameter

[Term]
id: SBO:0000581
name: Gibbs free energy change
comment: The increase or decrease of the Gibbs free energy of a system. During a\nreaction, this is equal to the change in enthalpy of the system minus the\nchange in the product of the temperature times the entropy of the system: ΔG = ΔH - T ΔS. A negative value indicates that the reaction will be favoured and will\nrelease energy. The magnitude of the value indicates how far the reaction\nis from equilibrium, where there will be no free energy change. The\nstandard unit of measure is kJ/mol. Symbol: ΔG.
is_a: SBO:0000580 ! Gibbs free energy

[Term]
id: SBO:0000582
name: standard Gibbs free energy of formation
comment: The change in Gibbs free energy associated with the formation of 1 mole of substance from elements in their standard states under standard conditions (1 bar). For aqueous solutions, each solute must be present in 1M concentration. The standard unit of measure is kJ/mol. Symbol: ΔGf°.
is_a: SBO:0000581 ! Gibbs free energy change

[Term]
id: SBO:0000583
name: standard Gibbs free energy of reaction
comment: The Gibbs free energy change observed in a thermodynamic system when one\nmole of substance reacts completely, under standard conditions (1 bar). For aqueous solutions, each solute must be present in 1M concentration. The standard unit of measure is kJ/mol. Symbol: ΔG°.
is_a: SBO:0000581 ! Gibbs free energy change

[Term]
id: SBO:0000584
name: temporal offset
comment: A duration of time after which a phase shift occurs.
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000585
name: simulation duration
comment: The total length of time over which a model is simulated, where the time scale is indicated within the model simulation. 
is_a: SBO:0000347 ! duration

[Term]
id: SBO:0000586
name: model time
comment: A conceptualisation of time which is intrinsic to a mathematical model, and which can be used to describe other variables or parameters of the model.
is_a: SBO:0000346 ! temporal measure

[Term]
id: SBO:0000587
name: transcellular membrane influx reaction
comment: A transport reaction which results in the entry of the transported entity, into the cell.
is_a: SBO:0000185 ! translocation reaction

[Term]
id: SBO:0000588
name: transcellular membrane efflux reaction
comment: A transport reaction which results in the removal of the transported entity from the cell.
is_a: SBO:0000185 ! translocation reaction

[Term]
id: SBO:0000589
name: genetic production
comment: A composite biochemical process through which a gene sequence is fully converted into mature gene products. These gene products may include RNA species as well as proteins, and the process encompasses all intermediate steps required to generate the active form of the gene product.
is_a: SBO:0000205 ! composite biochemical process

[Term]
id: SBO:0000590
name: promoter
comment: A stretch of DNA upstream of a transcription start site, to which a promoter and other transcription factors may bind to initiate or regulate expression.
is_a: SBO:0000369 ! gene regulatory region

[Term]
id: SBO:0000591
name: petri net transition
comment: A process that can modify the state of petri net 'places'[SBO:0000593].
is_a: SBO:0000464 ! state variable assignment

[Term]
id: SBO:0000592
name: discrete amount of an entity pool
comment: A discrete value attributed to an entity pool.
is_a: SBO:0000361 ! amount of an entity pool

[Term]
id: SBO:0000593
name: petri net place
comment: A defined entity pool state which can be modified by a petri net transition [SBO:0000591]. 
is_a: SBO:0000592 ! discrete amount of an entity pool

[Term]
id: SBO:0000594
name: neutral participant
comment: A participant whose presence does not alter the velocity of a process or event. 
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000595
name: dual-activity modifier
comment: A modifier that can exhibit either inhibitory or stimulatory effects on a\nprocess depending on the context in which it occurs. For example, the observed effect may be dependent upon the concentration of the modifier.
is_a: SBO:0000019 ! modifier

[Term]
id: SBO:0000596
name: modifier of unknown activity
comment: A modifier whose activity is not known or has not been specified.
is_a: SBO:0000019 ! modifier

[Term]
id: SBO:0000597
name: silencer
comment: A silencer is a modifier which acts in a manner that completely prevents an event or process from occurring. For example, a silencer in gene expression is usually a transcription factor that binds a DNA sequence in such a way as to completely prevent the binding of RNA polymerase, and thus fully suppresses transcription.
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000598
name: promoter
comment: A region of DNA to which various transcription factors and RNA polymerase must bind in order to initiate transcription for a gene.

[Term]
id: SBO:0000599
name: port
comment: A denotement that specifies a point of contact between variables or submodels in a hierarchical model.
is_a: SBO:0000473 ! denotement

[Term]
id: SBO:0000600
name: input port
comment: A connection point to an element in a model that indicates that the element's mathematical interpretation is defined outside the model.
is_a: SBO:0000599 ! port

[Term]
id: SBO:0000601
name: output port
comment: A connection point to an element in a model that indicates that the element's mathematical interpretation is defined within the model.
is_a: SBO:0000599 ! port

[Term]
id: SBO:0000602
name: logical parameter
comment: A parameter that takes only logical values.
is_a: SBO:0000546 ! qualitative systems description parameter

[Term]
id: SBO:0000603
name: side product
comment: A substance that is produced in a chemical reaction but is not itself the primary product or focus of that reaction. Examples include, but are not limited to, currency compounds such as ATP, NADPH and protons.
is_a: SBO:0000011 ! product

[Term]
id: SBO:0000604
name: side substrate
comment: A substance that is consumed in a chemical reaction but is not itself the primary substrate or focus of that reaction. Examples include, but are not limited to, currency compounds such as ATP, NADPH and protons.
is_a: SBO:0000015 ! substrate

[Term]
id: SBO:0000605
name: high affinity receptor
comment: A receptor where binding occurs through strong intermolecular forces such as Van der Waals, hydrogen bonds or ionic bonds.
is_a: SBO:0000244 ! receptor

[Term]
id: SBO:0000606
name: low affinity receptor
comment: A receptor where binding occurs through weak intermolecular forces.
is_a: SBO:0000244 ! receptor

[Term]
id: SBO:0000607
name: dimer
comment: A macromolecular complex composed of two monomeric units, which may or may not be identical. Monomers are usually non-covalently bound.
is_a: SBO:0000296 ! macromolecular complex

[Term]
id: SBO:0000608
name: homodimer
comment: A macromolecular complex composed of precisely two identical monomeric units, which are usually non-covalently bound.
is_a: SBO:0000607 ! dimer

[Term]
id: SBO:0000609
name: heterodimer
comment: A macromolecular complex composed of precisely two non-identical monomeric units, which are usually non-covalently bound.
is_a: SBO:0000607 ! dimer

[Term]
id: SBO:0000610
name: growth rate
comment: A measure of the rate of growth of an organism, usually in culture. This can be expressed as increase in cell number or, more usually as an increase in dry weight of cells (grams), measured over a unit time period. Usually expressed as hour -1.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000611
name: effective catalytic rate
comment: Under nutrient limited conditions, it may be assumed that enzymes are operating below their maximal capacity (Kcat). Keff represents the lumped turnover rate of a reaction, expressed in units per time.
is_a: SBO:0000009 ! kinetic constant

[Term]
id: SBO:0000612
name: rate of reaction
comment: The velocity at which a reaction occurs. This may be calculated through the accumulation of a product or consumption of a reactant, and expressed using entity concentrations or amounts per time interval. The rate of reaction may be influenced by temperature, pressure and other factors. Rate of reaction is often referred to as reaction rate or metabolic flux.
is_a: SBO:0000613 ! reaction parameter

[Term]
id: SBO:0000613
name: reaction parameter
comment: Parameters that pertain to chemical reactions.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000614
name: rate of reaction (concentration)
comment: Rate of reaction expressed as a change in concentration over time.
is_a: SBO:0000612 ! rate of reaction

[Term]
id: SBO:0000615
name: rate of reaction (amount)
comment: Rate of reaction expressed as a change in enumerated quantity over time.
is_a: SBO:0000612 ! rate of reaction

[Term]
id: SBO:0000616
name: extent of reaction
comment: The extent of a reaction is a measure of how far a reaction has proceeded towards equilibrium. It is denoted by the Greek letter ξ and is expressed in moles.
is_a: SBO:0000613 ! reaction parameter

[Term]
id: SBO:0000617
name: Gibbs free energy of reaction
comment: The Gibbs free energy change observed in a thermodynamic system when a substance undergoes a reaction under non standard conditions. The unit of measure is kJ/mol. Symbol: ΔG.
is_a: SBO:0000581 ! Gibbs free energy change

[Term]
id: SBO:0000618
name: reaction affinity
comment: Synonym: thermodynamic driving force 
is_a: SBO:0000581 ! Gibbs free energy change

[Term]
id: SBO:0000619
name: transformed Gibbs free energy change
comment: A Gibbs free energy that is calculated from the standard Gibbs value (at 298K), and extrapolated to a desired pH and ionic strength, and may be determined at a different temperature. Symbol: ΔG´.
is_a: SBO:0000580 ! Gibbs free energy

[Term]
id: SBO:0000620
name: transformed standard Gibbs free energy of reaction
comment: A Gibbs free energy of reaction that is calculated from the standard Gibbs value (at 298K), and extrapolated to a desired pH and ionic strength, and may be determined at a different temperature. Symbol ΔG´.
is_a: SBO:0000619 ! transformed Gibbs free energy change

[Term]
id: SBO:0000621
name: transformed standard Gibbs free energy of formation
comment: A Gibbs free energy of formation that is calculated from the standard Gibbs value (at 298K), and extrapolated to a desired pH and ionic strength, and may be determined at a different temperature. Symbol ΔGf´.
is_a: SBO:0000619 ! transformed Gibbs free energy change

[Term]
id: SBO:0000622
name: transformed Gibbs free energy of reaction
comment: The Gibbs free energy change observed in a thermodynamic system when a substance undergoes a reaction under non standard conditions, which is extrapolated to a desired pH and ionic strength, and may be determined at a different temperature. Symbol: ΔG´.
is_a: SBO:0000619 ! transformed Gibbs free energy change

[Term]
id: SBO:0000623
name: ionic strength
comment: A combined (weighted) measure of the concentration of all electrolytes present in a solution. It is calculated as a half of the sum over all the ions in the solution multiplied by the square of individual ionic valencies. Monovalent electrolytes have a concentration equal to their ionic strength while multivalent electrolytes have greater ionic strength, directly proportional to ionic valency. Symbol: I
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000624
name: flux balance framework
comment: Modelling approach, typically used for metabolic models, where the flow of metabolites (flux) through a network can be calculated. This approach will generally produce a set of solutions (solution space), which may be reduced using objective functions and constraints on individual fluxes.
is_a: SBO:0000694 ! optimization framework

[Term]
id: SBO:0000625
name: flux bound
comment: A parameter that limits the upper or lower value that a flux may assume. This parameter may be determined experimentally, or may be the result of theoretical investigation.
is_a: SBO:0000613 ! reaction parameter

[Term]
id: SBO:0000626
name: default flux bound
comment: A value used for flux bound in cases where a precise value, supported experimentally or theoretically, is not available.
is_a: SBO:0000625 ! flux bound

[Term]
id: SBO:0000627
name: exchange reaction
comment: A modeling process to provide matter influx or efflux to a model, for example to replenish a metabolic network with raw materials (eg carbon / energy sources). Such reactions are conceptual, created solely for modeling purposes, and do not have a physical correspondence. Exchange reactions, often represented as 'R_EX_', can operate in the negative (uptake) direction or positive (secretion) direction. By convention, a negative flux through an exchange reaction represents uptake of the corresponding metabolite, and a positive flux represent discharge.
is_a: SBO:0000631 ! pseudoreaction

[Term]
id: SBO:0000628
name: demand reaction
comment: A modeling process analogous to exchange reaction, but which operates upon "internal" metabolites. Metabolites that are consumed by these reactions are assumed to be used in intra-cellular processes that are not part of the model. Demand reactions, often represented 'R_DM_', can also deliver metabolites (from intra-cellular processes that are not considered in the model).
is_a: SBO:0000631 ! pseudoreaction

[Term]
id: SBO:0000629
name: biomass production
comment: Biomass production, often represented 'R_BIOMASS_', is usually the optimization target reaction of constraint-based models, and can consume multiple reactants to produce multiple products. It is also assumed that parts of the reactants are also consumed in unrepresented processes and hence products do not have to reflect all the atom composition of the reactants. Formulation of a biomass production process entails definition of the macromolecular content (eg. cellular protein fraction), metabolic constitution of each fraction (eg. amino acids), and subsequently the atomic composition (eg. nitrogen atoms). More complex biomass functions can additionally incorporate details of essential vitamins and cofactors required for growth.
is_a: SBO:0000395 ! encapsulating process

[Term]
id: SBO:0000630
name: ATP maintenance
comment: Synonym: maintenance energy 
is_a: SBO:0000395 ! encapsulating process

[Term]
id: SBO:0000631
name: pseudoreaction
comment: A conceptual process used for modeling purposes, often created solely to complete model structure, with respect to providing inflow or outflow of matter or material. Unlike other reactions, pseudoreactions are not usually subjected to mass balance considerations.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000632
name: sink reaction
comment: Synonym: source/sink 
is_a: SBO:0000631 ! pseudoreaction

[Term]
id: SBO:0000633
name: subsystem
comment: Term used to indicate the grouping of model components, largely reactions, by some criterion, often processual. This can be used to indicate, for example, the subsystem of a model that is concerned with 'transport'. A designated subsystem includes reactions annotated with the term, as well as reactions participants such as enzymes, modifiers and genes encoding these subsystem components.
is_a: SBO:0000473 ! denotement

[Term]
id: SBO:0000634
name: DNA segment
comment: Fragment or region of a DNA macromolecule.
is_a: SBO:0000354 ! informational molecule segment

[Term]
id: SBO:0000635
name: RNA segment
comment: Fragment or region of an RNA macromolecule.
is_a: SBO:0000354 ! informational molecule segment

[Term]
id: SBO:0000636
name: allosteric activator
comment: Synonym: positive allosteric modulation 
is_a: SBO:0000021 ! potentiator

[Term]
id: SBO:0000637
name: non-allosteric activator
comment: Describes an activator (ligand) which binds to the enzyme, which does not result in a conformational change, but which enhances the enzyme's activity.
is_a: SBO:0000021 ! potentiator

[Term]
id: SBO:0000638
name: irreversible inhibitor
comment: An inhibitor which binds irreversibly with the enzyme such that it cannot be removed, and abolishes enzymatic function.
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000639
name: allosteric inhibitor
comment: An inhibitor whose binding to an enzyme results in a conformational change, resulting in a loss of enzymatic activity. This activity can be restored upon removal of the inhibitor.
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000640
name: uncompetitive inhibitor
comment: Synonym: anti-competitive inhibitor 
is_a: SBO:0000020 ! inhibitor

[Term]
id: SBO:0000641
name: pMg
comment: An enumeration of the concentration of magnesium (Mg) in solution (pMg = -log10[Mg2+]).
is_a: SBO:0000303 ! biochemical potential

[Term]
id: SBO:0000642
name: inhibited
comment: Conceptual or material entity that is the object of an inhibition process, and is acted upon by an inhibitor.
is_a: SBO:0000644 ! modified

[Term]
id: SBO:0000643
name: stimulated
comment: Conceptual or material entity that is the object of a stimulation process, and is acted upon by a stimulator.
is_a: SBO:0000644 ! modified

[Term]
id: SBO:0000644
name: modified
comment: Conceptual or material entity that is the object of a modification process, and is acted upon by a modifier.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000645
name: template
comment: An entity that acts as the starting material for genetic production (http://identifiers.org/biomodels.sbo/SBO:0000589).
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000646
name: mass action rate law for reversible reactions, continuous schema
comment: Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme includes a reverse process that creates the reactants from the products. It is to be used in a reaction modelled using a continuous framework.
is_a: SBO:0000042 ! mass action rate law for reversible reactions
property_value: seeAlso "<mathml:math xmlns:mathml=\"http://www.w3.org/1998/Math/MathML\">\n<semantics definitionURL=\"http://biomodels.net/SBO/#SBO:0000062\"> <lambda> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:000035\">k1</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000157\">n1</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000158\">mu1</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000509\">R</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000039\">k2</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000490\">n2</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000158\">mu2</ci></bvar> <bvar><ci definitionURL=\"http://biomodels.net/SBO/#SBO:0000512\">P</ci></bvar> <apply> <minus></minus> <apply> <times></times> <ci>k1</ci> <apply> <product></product> <bvar><ci> i </ci></bvar> <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit> <uplimit><ci> n1 </ci></uplimit> <apply> <power></power> <apply> <selector></selector> <ci type=\"vector\">R</ci> <ci> i </ci> </apply> <apply> <selector></selector> <ci type=\"vector\">mu1</ci> <ci> i </ci> </apply> </apply> </apply> </apply> <apply> <times></times> <ci>k2</ci> <apply> <product></product> <bvar><ci> i </ci></bvar> <lowlimit><cn type=\"integer\"> 0 </cn></lowlimit> <uplimit><ci> n2 </ci></uplimit> <apply> <power></power> <apply> <selector></selector> <ci type=\"vector\">P</ci> <ci> i </ci> </apply> <apply> <selector></selector> <ci type=\"vector\">mu2</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics>\n</mathml:math>" http://www.w3.org/1999/02/22-rdf-syntax-ns#XMLLiteral

[Term]
id: SBO:0000647
name: molecular mass
comment: Synonym: molecular weight 
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000648
name: protein molecular mass
comment: Synonym: protein molecular weight 
is_a: SBO:0000647 ! molecular mass

[Term]
id: SBO:0000649
name: biomass
comment: A composite representation of material entities required for organismal growth. It includes macromolecular content (eg. cellular protein fraction), metabolic constitution of each fraction (eg. amino acids), and atomic composition (eg. nitrogen atoms).
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000650
name: reversible process
comment: A sequential series of actions, motions, or occurrences, such as chemical reactions, where a reversal of states that bring the system back to its original state in a characteristic manner occurs.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000651
name: irreversible process
comment: A sequential series of actions, motions, or occurrences, such as chemical reactions, where a reversal of states that bring the system back to its original state in a characteristic manner does not occur.
is_a: SBO:0000375 ! process

[Term]
id: SBO:0000652
name: polymerization
comment: A chemical reaction in which one or more monomer molecules combine to form a larger polymer molecule with repeated structural units.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000653
name: depolymerization
comment: A chemical reaction in which a large polymer breaks into its constituent monomers (or mixture of monomers).
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000654
name: co-transport reaction
comment: A biochemical process involving the simultaneous transport of two or more substances across a membrane via a protein or protein complex.
is_a: SBO:0000655 ! transport reaction

[Term]
id: SBO:0000655
name: transport reaction
comment: The movement of an entity/entities across a biological membrane mediated by a transporter protein.
is_a: SBO:0000167 ! biochemical or transport reaction

[Term]
id: SBO:0000656
name: activation
comment: A conformational change in a protein resulting in its activation.
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000657
name: active transport
comment: Protein assisted movement of molecules across a membrane from a region of low concentration to high concentration involving the consumption of cellular energy (ATP molecules).
is_a: SBO:0000655 ! transport reaction

[Term]
id: SBO:0000658
name: passive transport
comment: Movement of molecules without the need for external energy, and usually from a region of high concentration to low concentration.
is_a: SBO:0000655 ! transport reaction

[Term]
id: SBO:0000659
name: symporter-mediated transport
comment: A membrane protein mediated transport of two ore more molecules in the same relative direction across a membrane.
is_a: SBO:0000654 ! co-transport reaction

[Term]
id: SBO:0000660
name: antiporter-mediated transport
comment: A membrane protein mediated transport of two or more molecules in opposite directions across a membrane.
is_a: SBO:0000654 ! co-transport reaction

[Term]
id: SBO:0000661
name: capacity
comment: Total amount that can be contained or produced by a specific entity. This can refer to diverse items, such as the carrying capacity of a membrane with respect to proteins, the capacity of high-energy phosphate bonds, or the maximal count of bacteria in the gut, etc.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000662
name: occupancy
comment: Occopancy is a quantitative systemic property that indicates which number of available places is occupied. This can refer to diverse things, such as the number of occupied high-energy phosphate bonds in ATP, the number of bacteria in the gut, or the number of electrons loaded onto redox carriers, etc.
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000663
name: fractional occupancy
comment: Fractional occupancy is a quantitative dynamic property of a system that can be calculated as the fraction of occupancy over capacity.
is_a: SBO:0000545 ! systems description parameter

[Term]
id: SBO:0000664
name: contained entity
comment: an entity which physical constituents are partially or totally contained in a defined compartment.
is_a: SBO:0000003 ! participant role

[Term]
id: SBO:0000665
name: inactivation
comment: a conformation changes to a protein leading to its inactivation
is_a: SBO:0000182 ! conversion

[Term]
id: SBO:0000666
name: chain length
comment: describes the number of amino acids,nucleic acid in a protein/DNA/RNA chain
is_a: SBO:0000002 ! quantitative systems description parameter

[Term]
id: SBO:0000667
name: protein chain length
comment: length of amino acid sequence in a protein
is_a: SBO:0000666 ! chain length

[Term]
id: SBO:0000668
name: yield
comment: output generated as biomass or product from a/set of chemical reaction/s.
is_a: SBO:0000241 ! functional entity

[Term]
id: SBO:0000669
name: biomass yield on substrate
comment: generation of biomass for an substrate through a defined reaction/s.
is_a: SBO:0000668 ! yield

[Term]
id: SBO:0000670
name: product yield on substrate
comment: generation of product from substrate in a defined chemical reaction.
is_a: SBO:0000668 ! yield

[Term]
id: SBO:0000671
name: non-enzymatic catalyst
comment: agent driving non-enzymatic reaction. Non-enzymatic reactions resemble catalytic mechanisms as found in all major enzyme classes and occur spontaneously, small molecule (e.g. metal-) catalyzed or light-induced.
is_a: SBO:0000013 ! catalyst

[Term]
id: SBO:0000672
name: spontaneous reaction
comment: Reaction with no catalyst (no enzyme in particular) is needed to proceed.
is_a: SBO:0000176 ! biochemical reaction

[Term]
id: SBO:0000673
name: forward effective catalytic rate
comment: it represent the catalytic rate driving the reaction in forward direction.
is_a: SBO:0000611 ! effective catalytic rate

[Term]
id: SBO:0000674
name: reverse effective catalytic rate
comment: it represent the catalytic rate driving the reaction in backward direction.
is_a: SBO:0000611 ! effective catalytic rate

[Term]
id: SBO:0000675
name: deterministic non-spatial continuous framework
comment: Modeling approach where the quantities of participants are considered deterministic continuous variables, and represented by real values. The associated simulation methods make use of ordinary differential equations.
is_a: SBO:0000293 ! non-spatial continuous framework

[Term]
id: SBO:0000676
name: stochastic non-spatial continuous framework
comment: Modeling approach where the quantities of participants are considered stochastic continuous variables, and represented by real values. The associated simulation methods make use of stochastic differential equations. The models do take into account the distribution of the entities.
is_a: SBO:0000293 ! non-spatial continuous framework

[Term]
id: SBO:0000677
name: population-based discrete spatial simulation
comment: Modeling approach which tracks the sizes of populations of participants in each spatial localization. For biochemical simulations, such populations could represent types of molecular species.
is_a: SBO:0000294 ! spatial discrete framework

[Term]
id: SBO:0000678
name: particle-based discrete spatial simulation
comment: Modeling approach which tracks the state of individual particles in each spatial localization. For biochemical simulations, such particles could represent individual molecules.
is_a: SBO:0000294 ! spatial discrete framework

[Term]
id: SBO:0000679
name: population-based discrete non-spatial simulation
comment: Modeling approach which tracks the sizes of populations of participants with minimal or no spatial resolution. For biochemical simulations, such populations could represent types of molecular species.
is_a: SBO:0000295 ! non-spatial discrete framework

[Term]
id: SBO:0000680
name: particle-based discrete non-spatial simulation
comment: Modeling approach which tracks the state of individual particles with miimal or no spatial resolution. For biochemical simulations, such particles could represent individual molecules.
is_a: SBO:0000295 ! non-spatial discrete framework

[Term]
id: SBO:0000681
name: hybrid framework
comment: Modeling approach which combines multiple canonical modeling frameworks. For example, a hybrid model could consider both continuous (represented by real values) and discrete (represented by integers) participants. Hybrid models are executed with hybrid simulation algorithms. For example, a hybrid continuous-discrete model may be simulation using a combination of stochastic simulation and ordinary differential equations.
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000682
name: hybrid spatial framework
comment: Modeling approach which combines multiple canonical spatial modeling frameworks. For example, a hybrid model could consider both continuous (represented by real values) and discrete (represented by integers) participants. Hybrid models are executed with hybrid simulation algorithms. For example, a hybrid continuous-discrete model may be simulation using a combination of stochastic simulation and partial differential equations.
is_a: SBO:0000681 ! hybrid framework

[Term]
id: SBO:0000683
name: hybrid non-spatial framework
comment: Modeling approach which combines multiple canonical non-spatial modeling frameworks. For example, a hybrid model could consider both continuous (represented by real values) and discrete (represented by integers) participants. Hybrid models are executed with hybrid simulation algorithms. For example, a hybrid continuous-discrete model may be simulation using a combination of stochastic simulation and ordinary differential equations.
is_a: SBO:0000681 ! hybrid framework

[Term]
id: SBO:0000684
name: hybrid flux balance-deterministic continuous non-spatial framework
comment: Modeling approach which combines flux-balance [SBO:0000624] and deterministic continuous non-spatial [SBO:0000675] simulation. For example, a metabolic network could be simulated using flux balance analysis, while a signaling network could be co-simulated with a method for integrating ordinary differential equations.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000685
name: hybrid flux balance-discrete non-spatial framework
comment: Modeling approach which combines flux-balance [SBO:0000624] and discrete non-spatial [SBO:0000295] simulation. For example, a metabolic network could be simulated using flux balance analysis, while the synthesis and turnover of enzymes could be co-simulated with a discrete simulation method such as Gillespie's algorithm.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000686
name: hybrid flux balance-logical-deterministic continuous non-spatial framework
comment: Modeling approach which combines flux-balance [SBO:0000624], non-spatial deterministic continuous [SBO:0000675], and logical [SBO:0000234] simulation. For example, a metabolic network could be simulated using flux balance analysis, while the expression metabolic enzymes could be co-simulated with a logical simulation method and a signaling network could be co-simulated with a method for integrating ordinary differential equations such as CVODE.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000687
name: hybrid flux balance-logical non-spatial framework
comment: Modeling approach which combines flux-balance [SBO:0000624] and logical [SBO:0000234] simulation. For example, a metabolic network could be simulated using flux balance analysis, while the expression metabolic enzymes could be co-simulated with a logical simulation method.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000688
name: hybrid flux logical-discrete non-spatial framework
comment: Modeling approach which combines logical [SBO:0000234] and non-spatial discrete [SBO:0000295] simulation. For example, the MaBoSS simulation method simulates logical regulatory graphs with an algorithm that is similar to Gillespie's algorithm.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000689
name: hybrid continuous-discrete non-spatial framework
comment: Modeling approach which combines continuous [SBO:0000293] and discrete [SBO:0000295] simulation, where some participants are represented as continuous variables and others are represented as discrete variables, without a detailed spatial representation of each participant. For example, a model may be simulated using a combination of a discrete simulation method such as Gillespie's algorithm and an ordinary differential equations integration method such as CVODE.
is_a: SBO:0000683 ! hybrid non-spatial framework

[Term]
id: SBO:0000690
name: hybrid deterministic continuous-discrete non-spatial framework
comment: Modeling approach which combines deterministic continuous [SBO:0000675] and discrete [SBO:0000295] simulation, where some participants are represented as deterministic, continuous variables and others are represented as discrete variables, without a detailed spatial representation of each participant. For example, a model may be simulated using a combination of a discrete simulation method such as Gillespie's algorithm and an ordinary differential equations integration method such as CVODE.
is_a: SBO:0000689 ! hybrid continuous-discrete non-spatial framework

[Term]
id: SBO:0000691
name: hybrid stochastic continuous-discrete non-spatial framework
comment: Modeling approach which combines stochastic continuous [SBO:0000676] and discrete [SBO:0000295] simulation, where some participants are represented as stochastic, continuous variables and others are represented as discrete variables, without a detailed spatial representation of each participant. For example, a model may be simulated using a combination of a discrete simulation method such as Gillespie's algorithm and an stochastic differential equations integration method.
is_a: SBO:0000689 ! hybrid continuous-discrete non-spatial framework

[Term]
id: SBO:0000692
name: resource balance framework
comment: Modeling approach where the flow of resources (flux) through a network can be calculated. This approach will generally produce a set of solutions (solution space), which may be reduced using objective functions and constraints on individual fluxes.
is_a: SBO:0000694 ! optimization framework

[Term]
id: SBO:0000693
name: constraint-based framework
comment: Modelling approach which captures bounds on the possible behavior of a system, which may be further reduced using an objective function.
is_a: SBO:0000004 ! modelling framework

[Term]
id: SBO:0000694
name: optimization framework
comment: Modelling approach for finding the optimal state of a system.
is_a: SBO:0000693 ! constraint-based framework

[Term]
id: SBO:0000695
name: ligation
comment: Formation of a covalent bond resulting in the creation of a link between the ends of one or more linear polymer molecules.
is_a: SBO:0000182 ! conversion

[Typedef]
id: part:of
name: part of
is_transitive: true