main.py

from fbs_runtime.application_context import ApplicationContext, cached_property
from PyQt5.QtCore import Qt
from PyQt5.QtWidgets import QWidget, QLabel, QPushButton, QVBoxLayout

import requests
import sys

class AppContext(ApplicationContext):
    def run(self):
        stylesheet = self.get_resource('styles.qss')
        self.app.setStyleSheet(open(stylesheet).read())
        self.window.show()
        return self.app.exec_()
    @cached_property
    def window(self):
        return MainWindow()

class MainWindow(QWidget):
    def __init__(self):
        super().__init__()
        text = QLabel()
        text.setWordWrap(True)
        button = QPushButton('Next quote >')
        button.clicked.connect(lambda: text.setText(_get_quote()))
        layout = QVBoxLayout()
        layout.addWidget(text)
        layout.addWidget(button)
        layout.setAlignment(button, Qt.AlignHCenter)
        self.setLayout(layout)

def _get_quote():
    response = requests.get('https://talaikis.com/api/quotes/random/')
    return response.json()['quote']

if __name__ == '__main__':
    appctxt = AppContext()
    exit_code = appctxt.run()
    sys.exit(exit_code)