diff --git a/pyproject.toml b/pyproject.toml
new file mode 100644
index 0000000..bdd2c00
--- /dev/null
+++ b/pyproject.toml
@@ -0,0 +1,111 @@
+[build-system]
+requires = ["scikit-build-core"]
+build-backend = "scikit_build_core.build"
+
+[project]
+name = "itk-skullstripping"
+version = "0.1.0"
+description = "Automatic skull-stripping for neuroimage analysis"
+readme = "README.rst"
+license = {file = "LICENSE"}
+authors = [
+    { name = "Stefan Bauer", email = "stefan.bauer@istb.unibe.ch" },
+]
+keywords = [
+    "itk",
+    "InsightToolkit",
+    "neuroimaging",
+    "neuroimaging-analysis",
+]
+classifiers = [
+    "Development Status :: 4 - Beta",
+    "Intended Audience :: Developers",
+    "Intended Audience :: Education",
+    "Intended Audience :: Healthcare Industry",
+    "Intended Audience :: Science/Research",
+    "License :: OSI Approved :: Apache Software License",
+    "Operating System :: Android",
+    "Operating System :: MacOS",
+    "Operating System :: Microsoft :: Windows",
+    "Operating System :: POSIX",
+    "Operating System :: Unix",
+    "Programming Language :: C++",
+    "Programming Language :: Python",
+    "Topic :: Scientific/Engineering",
+    "Topic :: Scientific/Engineering :: Information Analysis",
+    "Topic :: Scientific/Engineering :: Medical Science Apps.",
+    "Topic :: Software Development :: Libraries",
+]
+requires-python = ">=3.8"
+dependencies = [
+    "itk == 5.4.*",
+]
+
+[project.urls]
+Download = "https://github.com/InsightSoftwareConsortium/ITKSkullStrip"
+Homepage = "https://github.com/InsightSoftwareConsortium/ITKSkullStrip"
+
+[tool.scikit-build]
+# The versions of CMake to allow. If CMake is not present on the system or does
+# not pass this specifier, it will be downloaded via PyPI if possible. An empty
+# string will disable this check.
+cmake.version = ">=3.16.3"
+
+# A list of args to pass to CMake when configuring the project. Setting this in
+# config or envvar will override toml. See also ``cmake.define``.
+cmake.args = []
+
+# A table of defines to pass to CMake when configuring the project. Additive.
+cmake.define = {}
+
+# Verbose printout when building.
+cmake.verbose = true
+
+# The build type to use when building the project. Valid options are: "Debug",
+# "Release", "RelWithDebInfo", "MinSizeRel", "", etc.
+cmake.build-type = "Release"
+
+# The source directory to use when building the project. Currently only affects
+# the native builder (not the setuptools plugin).
+cmake.source-dir = "."
+
+# The versions of Ninja to allow. If Ninja is not present on the system or does
+# not pass this specifier, it will be downloaded via PyPI if possible. An empty
+# string will disable this check.
+ninja.version = ">=1.11"
+
+# The logging level to display, "DEBUG", "INFO", "WARNING", and "ERROR" are
+# possible options.
+logging.level = "INFO"
+
+# Files to include in the SDist even if they are skipped by default. Supports
+# gitignore syntax.
+sdist.include = []
+
+# Files to exclude from the SDist even if they are included by default. Supports
+# gitignore syntax.
+sdist.exclude = []
+
+# A list of license files to include in the wheel. Supports glob patterns.
+wheel.license-files = ["LICEN[CS]E*",]
+
+# Target the platlib or the purelib. If not set, the default is to target the
+# platlib if wheel.cmake is true, and the purelib otherwise.
+wheel.platlib = "false"
+
+# If CMake is less than this value, backport a copy of FindPython. Set to 0
+# disable this, or the empty string.
+backport.find-python = "3.26.1"
+
+# Select the editable mode to use. Can be "redirect" (default) or "inplace".
+editable.mode = "redirect"
+
+# Rebuild the project when the package is imported. The build-directory must be
+# set.
+editable.rebuild = false
+
+# If set, this will provide a method for scikit-build-core backward compatibility.
+minimum-version = "0.8.2"
+
+# The build directory. Defaults to a temporary directory, but can be set.
+build-dir = "build/{wheel_tag}"
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 6d0cbc6..0000000
--- a/setup.py
+++ /dev/null
@@ -1,54 +0,0 @@
-# -*- coding: utf-8 -*-
-from __future__ import print_function
-from os import sys
-
-try:
-    from skbuild import setup
-except ImportError:
-    print('scikit-build is required to build from source.', file=sys.stderr)
-    print('Please run:', file=sys.stderr)
-    print('', file=sys.stderr)
-    print('  python -m pip install scikit-build')
-    sys.exit(1)
-
-setup(
-    name='itk-skullstripping',
-    version='0.1.0',
-    author='Stefan Bauer',
-    author_email='stefan.bauer@istb.unibe.ch',
-    packages=['itk'],
-    package_dir={'itk': 'itk'},
-    download_url=r'https://github.com/InsightSoftwareConsortium/ITKSkullStrip',
-    description=r'Automatic skull-stripping for neuroimage analysis',
-    long_description='ITKSkullStrip provides a class to perform automatic'
-                     'skull-stripping for neuroimage analysis.\n'
-                     'Please refer to:'
-                     'Bauer S., Fejes T., Reyes M.,'
-                     '“Skull-Stripping Filter for ITK”, '
-                     'Insight Journal, https://hdl.handle.net/10380/3353, 2012.',
-    classifiers=[
-        "License :: OSI Approved :: Apache Software License",
-        "Programming Language :: Python",
-        "Programming Language :: C++",
-        "Development Status :: 4 - Beta",
-        "Intended Audience :: Developers",
-        "Intended Audience :: Education",
-        "Intended Audience :: Healthcare Industry",
-        "Intended Audience :: Science/Research",
-        "Topic :: Scientific/Engineering",
-        "Topic :: Scientific/Engineering :: Medical Science Apps.",
-        "Topic :: Scientific/Engineering :: Information Analysis",
-        "Topic :: Software Development :: Libraries",
-        "Operating System :: Android",
-        "Operating System :: Microsoft :: Windows",
-        "Operating System :: POSIX",
-        "Operating System :: Unix",
-        "Operating System :: MacOS"
-        ],
-    license='Apache',
-    keywords='ITK InsightToolkit neuroimaging neuroimaging-analysis',
-    url=r'https://github.com/InsightSoftwareConsortium/ITKSkullStrip',
-    install_requires=[
-        r'itk>=5.2.0.post2'
-    ]
-    )