diff --git a/Lib/_pyrepl/simple_interact.py b/Lib/_pyrepl/simple_interact.py
index 8ab4dab757685e..3dfb1d7ad736e3 100644
--- a/Lib/_pyrepl/simple_interact.py
+++ b/Lib/_pyrepl/simple_interact.py
@@ -95,7 +95,7 @@ def runsource(self, source, filename="<input>", symbol="single"):
             the_symbol = symbol if stmt is last_stmt else "exec"
             item = wrapper([stmt])
             try:
-                code = compile(item, filename, the_symbol)
+                code = compile(item, filename, the_symbol, dont_inherit=True)
             except (OverflowError, ValueError):
                     self.showsyntaxerror(filename)
                     return False
diff --git a/Lib/test/test_pyrepl/test_interact.py b/Lib/test/test_pyrepl/test_interact.py
index 10e34045bcf92d..6ebd51fe14dd62 100644
--- a/Lib/test/test_pyrepl/test_interact.py
+++ b/Lib/test/test_pyrepl/test_interact.py
@@ -94,3 +94,12 @@ def test_runsource_shows_syntax_error_for_failed_compilation(self):
         with patch.object(console, "showsyntaxerror") as mock_showsyntaxerror:
             console.runsource(source)
             mock_showsyntaxerror.assert_called_once()
+
+    def test_no_active_future(self):
+        console = InteractiveColoredConsole()
+        source = "x: int = 1; print(__annotations__)"
+        f = io.StringIO()
+        with contextlib.redirect_stdout(f):
+            result = console.runsource(source)
+        self.assertFalse(result)
+        self.assertEqual(f.getvalue(), "{'x': <class 'int'>}\n")
diff --git a/Misc/NEWS.d/next/Library/2024-05-23-22-29-59.gh-issue-119443.KAGz6S.rst b/Misc/NEWS.d/next/Library/2024-05-23-22-29-59.gh-issue-119443.KAGz6S.rst
new file mode 100644
index 00000000000000..4470c566a37d88
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2024-05-23-22-29-59.gh-issue-119443.KAGz6S.rst
@@ -0,0 +1,2 @@
+The interactive REPL no longer runs with ``from __future__ import
+annotations`` enabled. Patch by Jelle Zijlstra.