SPAN Comparison Opendnase.ipynb

{
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  {
   "cell_type": "markdown",
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   "source": [
    "# Comparison of span vs other peak calling tools\n",
    "\n",
    "Method based on F score described in original paper:\n",
    "Koohy H, Down TA, Spivakov M, Hubbard T (2014) \n",
    "A Comparison of Peak Callers Used for DNase-Seq Data. \n",
    "PLoS ONE 9(5): e96303. doi:10.1371/journal.pone.0096303\n",
    "\n",
    "http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096303\n",
    "\n",
    "## Requirements\n",
    "\n",
    "* span.jar\n",
    "* java8\n",
    "* bedtools\n",
    "* wget\n",
    "* awk\n",
    "* ~20G free space to download all the required bed and bam files"
   ]
  },
  {
   "cell_type": "code",
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    "collapsed": true,
    "ExecuteTime": {
     "end_time": "2024-10-16T14:53:04.378702Z",
     "start_time": "2024-10-16T14:53:04.358508Z"
    }
   },
   "source": [
    "%matplotlib inline\n",
    "import matplotlib.pyplot as plt\n",
    "from tqdm.auto import tqdm\n",
    "import os\n",
    "import sys\n",
    "from os import listdir\n",
    "def run(cmd):\n",
    "    print(cmd)\n",
    "    if os.system(cmd) != 0:\n",
    "        sys.exit(1)"
   ],
   "outputs": [],
   "execution_count": 1
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Download all the \"Reference peaks set\" mentioned in http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096303\n",
    "\n"
   ]
  },
  {
   "metadata": {
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     "start_time": "2024-10-16T14:53:10.080816Z"
    }
   },
   "cell_type": "code",
   "source": [
    "PATH = os.path.expanduser('~/data/2023_opendnase')\n",
    "RESOURCE = 'http://hgdownload.cse.ucsc.edu/goldenPath/hg19/encodeDCC/wgEncodeSydhTfbs'\n",
    "CELLS = ['GM12878', 'HelaS3', 'K562']"
   ],
   "outputs": [],
   "execution_count": 2
  },
  {
   "cell_type": "code",
   "execution_count": 31,
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     "start_time": "2023-12-12T12:19:13.842680Z"
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   "outputs": [
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     "name": "stdout",
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     "text": [
      "mkdir: cannot create directory ‘/home/jetbrains/data/2023_opendnase’: File exists\r\n",
      "URL transformed to HTTPS due to an HSTS policy\r\n",
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      "Connecting to journals.plos.org (journals.plos.org)|35.190.43.188|:443... connected.\r\n",
      "HTTP request sent, awaiting response... 301 Moved Permanently\r\n",
      "Location: /plosone/article/file?id=info%3Adoi/10.1371/journal.pone.0096303.s007&type=supplementary [following]\r\n",
      "URL transformed to HTTPS due to an HSTS policy\r\n",
      "--2023-12-12 13:19:14--  https://journals.plos.org/plosone/article/file?id=info%3Adoi/10.1371/journal.pone.0096303.s007&type=supplementary\r\n",
      "Reusing existing connection to journals.plos.org:443.\r\n",
      "HTTP request sent, awaiting response... 302 Found\r\n",
      "Location: https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0096303/1/pone.0096303.s007.zip?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20231212%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20231212T121914Z&X-Goog-Expires=86400&X-Goog-SignedHeaders=host&X-Goog-Signature=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 [following]\r\n",
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      "Length: 6514 (6,4K) [application/zip]\r\n",
      "Saving to: ‘supplementary.zip’\r\n",
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      "\r\n",
      "2023-12-12 13:19:14 (98,0 MB/s) - ‘supplementary.zip’ saved [6514/6514]\r\n",
      "\r\n",
      "Archive:  supplementary.zip\r\n",
      "replace Supplementary_Data/GM12878.txt? [y]es, [n]o, [A]ll, [N]one, [r]ename: ^C\r\n"
     ]
    }
   ],
   "source": [
    "! mkdir ~/data/2023_opendnase\n",
    "! cd ~/data/2023_opendnase && wget \"http://journals.plos.org/plosone/article/asset?unique&id=info:doi/10.1371/journal.pone.0096303.s007\" -O supplementary.zip\n",
    "! cd ~/data/2023_opendnase && unzip -x supplementary.zip"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Now that we have Supplemetary_Data/GM12878.txt, etc, we can download all the peaks automatically.\n",
    "Files are available here: http://journals.plos.org/plosone/article/asset?unique&id=info:doi/10.1371/journal.pone.0096303.s007"
   ]
  },
  {
   "cell_type": "code",
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-09-17T09:06:37.641228Z",
     "start_time": "2024-09-17T09:06:37.605736Z"
    }
   },
   "source": [
    "import pandas as pd\n",
    "\n",
    "for cell in tqdm(CELLS):\n",
    "    print(cell)\n",
    "    os.mkdir(PATH + '/' + cell)\n",
    "    df = pd.read_csv(PATH + f'/Supplementary_Data/{cell}.txt', sep=' ', header=None)\n",
    "    df.columns = ['file', 'checksum']\n",
    "    for f in df['file']:\n",
    "        ! cd {PATH} && wget {RESOURCE}/{f} -P {cell}"
   ],
   "outputs": [
    {
     "data": {
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     "output_type": "display_data"
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "GM12878\n"
     ]
    },
    {
     "ename": "FileExistsError",
     "evalue": "[Errno 17] File exists: '/home/jetbrains/data/2023_opendnase/GM12878'",
     "output_type": "error",
     "traceback": [
      "\u001B[0;31m---------------------------------------------------------------------------\u001B[0m",
      "\u001B[0;31mFileExistsError\u001B[0m                           Traceback (most recent call last)",
      "Cell \u001B[0;32mIn[3], line 7\u001B[0m\n\u001B[1;32m      5\u001B[0m \u001B[38;5;28;01mfor\u001B[39;00m cell \u001B[38;5;129;01min\u001B[39;00m tqdm(CELLS):\n\u001B[1;32m      6\u001B[0m     \u001B[38;5;28mprint\u001B[39m(cell)\n\u001B[0;32m----> 7\u001B[0m     \u001B[43mos\u001B[49m\u001B[38;5;241;43m.\u001B[39;49m\u001B[43mmkdir\u001B[49m\u001B[43m(\u001B[49m\u001B[43mPATH\u001B[49m\u001B[43m \u001B[49m\u001B[38;5;241;43m+\u001B[39;49m\u001B[43m \u001B[49m\u001B[38;5;124;43m'\u001B[39;49m\u001B[38;5;124;43m/\u001B[39;49m\u001B[38;5;124;43m'\u001B[39;49m\u001B[43m \u001B[49m\u001B[38;5;241;43m+\u001B[39;49m\u001B[43m \u001B[49m\u001B[43mcell\u001B[49m\u001B[43m)\u001B[49m\n\u001B[1;32m      8\u001B[0m     df \u001B[38;5;241m=\u001B[39m pd\u001B[38;5;241m.\u001B[39mread_csv(PATH \u001B[38;5;241m+\u001B[39m \u001B[38;5;124mf\u001B[39m\u001B[38;5;124m'\u001B[39m\u001B[38;5;124m/Supplementary_Data/\u001B[39m\u001B[38;5;132;01m{\u001B[39;00mcell\u001B[38;5;132;01m}\u001B[39;00m\u001B[38;5;124m.txt\u001B[39m\u001B[38;5;124m'\u001B[39m, sep\u001B[38;5;241m=\u001B[39m\u001B[38;5;124m'\u001B[39m\u001B[38;5;124m \u001B[39m\u001B[38;5;124m'\u001B[39m, header\u001B[38;5;241m=\u001B[39m\u001B[38;5;28;01mNone\u001B[39;00m)\n\u001B[1;32m      9\u001B[0m     df\u001B[38;5;241m.\u001B[39mcolumns \u001B[38;5;241m=\u001B[39m [\u001B[38;5;124m'\u001B[39m\u001B[38;5;124mfile\u001B[39m\u001B[38;5;124m'\u001B[39m, \u001B[38;5;124m'\u001B[39m\u001B[38;5;124mchecksum\u001B[39m\u001B[38;5;124m'\u001B[39m]\n",
      "\u001B[0;31mFileExistsError\u001B[0m: [Errno 17] File exists: '/home/jetbrains/data/2023_opendnase/GM12878'"
     ]
    }
   ],
   "execution_count": 3
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Now we should all the reference peaks using Bedops as described in the article, however Bedops FAILS with segfault.\n",
    "\n",
    "Bedtools for the rescue!"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2023-12-12T12:19:27.106492Z",
     "start_time": "2023-12-12T12:19:27.104576Z"
    }
   },
   "outputs": [],
   "source": [
    "# Lets merge them and filter chr22 to get reference peaks\n",
    "CELLS = ['GM12878', 'HelaS3', 'K562']\n",
    "! mkdir {PATH}/peaks\n",
    "for cell in tqdm(CELLS):\n",
    "    ! cd {PATH} && cat {cell}/*.gz > {cell}_all.bed\n",
    "    ! bedtools sort -i {PATH}/{cell}_all.bed > {PATH}/{cell}_sorted.bed\n",
    "    ! bedtools merge -i {PATH}/{cell}_sorted.bed > {PATH}/{cell}_peaks.bed\n",
    "    run(f'awk \\'$1==\"chr22\" {{print}}\\' {PATH}/{cell}_peaks.bed > {PATH}/peaks/{cell}_peaks_chr22.bed')\n",
    "! rm *_all.bed *_sorted.bed *_peaks.bed"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Download and convert reads."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "start_time": "2023-12-12T12:19:27.105383Z"
    }
   },
   "outputs": [],
   "source": [
    "! wget http://hgdownload.cse.ucsc.edu/goldenPath/hg19/encodeDCC/wgEncodeUwDnase/wgEncodeUwDnaseK562AlnRep1.bam -O {PATH}/K562.bam\n",
    "! wget http://hgdownload.cse.ucsc.edu/goldenPath/hg19/encodeDCC/wgEncodeUwDnase/wgEncodeUwDnaseGm12878AlnRep1.bam -O {PATH}/GM12878.bam\n",
    "! wget http://hgdownload.cse.ucsc.edu/goldenPath/hg19/encodeDCC/wgEncodeUwDnase/wgEncodeUwDnaseHelas3AlnRep1.bam -O {PATH}/HelaS3.bam\n",
    "\n",
    "print('Lets convert downloaded bam files to bed')\n",
    "for bam in tqdm([f for f in listdir(PATH) if f.endswith(\".bam\")]):\n",
    "    ! bamToBed -bed12 -i {PATH}/{bam} > {PATH}/{bam}.bed"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Now we can launch span to get enrichment for obtained bed tracks."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2023-12-12T12:19:27.107478Z",
     "start_time": "2023-12-12T12:19:27.106984Z"
    }
   },
   "outputs": [],
   "source": [
    "# ! cd {PATH} && wget https://download.jetbrains.com/biolabs/span/span-1.4.6197.jar\n",
    "! cd {PATH} && wget http://hgdownload.soe.ucsc.edu/goldenPath/hg19/bigZips/hg19.chrom.sizes"
   ]
  },
  {
   "cell_type": "code",
   "source": [
    "! mkdir {PATH}/span\n",
    "FDRS = [1e-40, 1e-20, 1e-15, 1e-10, 1e-8, 1e-6, 1e-4, 1e-3, 0.05, 0.1, 0.2, 0.5]\n",
    "for reads in tqdm([f for f in listdir(PATH) if f.endswith(\".bam.bed\")]):\n",
    "    for fdr in FDRS:\n",
    "        print(f'Processing {reads} FDR={fdr}')\n",
    "        ! cd {PATH} && java -jar span.jar analyze -cs hg19.chrom.sizes -t {reads} --peaks span/{reads}_{fdr}_span.bed --bin 100 --fdr {fdr} --keep-cache"
   ],
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:22:13.696204Z",
     "start_time": "2024-10-16T14:53:42.443431Z"
    }
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "mkdir: cannot create directory ‘/home/jetbrains/data/2023_opendnase/span’: File exists\r\n"
     ]
    },
    {
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    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "Processing K562.bam.bed FDR=1e-40\n",
      "[Oct 16, 2024 16:53:42] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 16:53:42] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-40_span.bed --bin 100 --fdr 1e-40 --keep-cache\r\n",
      "[Oct 16, 2024 16:53:42] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 16:53:42] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-40_span.log\r\n",
      "[Oct 16, 2024 16:53:42] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 16:53:42] CONTROL: none\r\n",
      "[Oct 16, 2024 16:53:42] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 16:53:42] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 16:53:42] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 16:53:42] BIN: 100\r\n",
      "[Oct 16, 2024 16:53:42] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 16:53:42] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 16:53:42] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 16:53:42] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 16:53:42] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 16:53:42] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 16:53:42] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 16:53:42] NOCLIP: false\r\n",
      "[Oct 16, 2024 16:53:43] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 16:53:43] FDR: 1.0E-40\r\n",
      "[Oct 16, 2024 16:53:43] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 16:53:43] THREADS: 8\r\n",
      "[Oct 16, 2024 16:53:43] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 16:53:43] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 16:53:43] Model fit: processing /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span...\r\n",
      "[Oct 16, 2024 16:53:43] Computing data model...\r\n",
      "[Oct 16, 2024 16:53:51] Target signal to noise ratio: 14.868246499242916\r\n",
      "[Oct 16, 2024 16:53:51] Target noise mean: 0.3\r\n",
      "[Oct 16, 2024 16:53:51] 0.00% (0/10), Elapsed time: 521 μs\r\n",
      "[Oct 16, 2024 16:54:34] 10.00% (1/10), Elapsed time: 43 s\r\n",
      "[Oct 16, 2024 16:55:26] 20.00% (2/10), Elapsed time: 1 min 34 s, Throughput: 1 items/min, ETA: 6 min 19 s\r\n",
      "[Oct 16, 2024 16:56:21] 30.00% (3/10), Elapsed time: 2 min 29 s, Throughput: 1 items/min, ETA: 5 min 49 s\r\n",
      "[Oct 16, 2024 16:57:14] 40.00% (4/10), Elapsed time: 3 min 22 s, Throughput: 1 items/min, ETA: 5 min 4 s\r\n",
      "[Oct 16, 2024 16:58:02] 50.00% (5/10), Elapsed time: 4 min 10 s, Throughput: 1 items/min, ETA: 4 min 10 s\r\n",
      "[Oct 16, 2024 16:58:07] WARN NB2ZHMM Signal-to-noise ratio 14.33092431909911 < 14.868246499242916, fixing...\r\n",
      "[Oct 16, 2024 16:58:48] 60.00% (6/10), Elapsed time: 4 min 56 s, Throughput: 1 items/min, ETA: 3 min 17 s\r\n",
      "[Oct 16, 2024 16:58:53] WARN NB2ZHMM Signal-to-noise ratio 11.675606431409696 < 14.868246499242916, fixing...\r\n",
      "[Oct 16, 2024 16:59:34] 70.00% (7/10), Elapsed time: 5 min 42 s, Throughput: 1 items/min, ETA: 2 min 26 s\r\n",
      "[Oct 16, 2024 16:59:36] WARN NB2ZHMM Signal-to-noise ratio 11.35396837212249 < 14.868246499242916, fixing...\r\n",
      "[Oct 16, 2024 17:00:25] 80.00% (8/10), Elapsed time: 6 min 34 s, Throughput: 1 items/min, ETA: 1 min 38 s\r\n",
      "[Oct 16, 2024 17:00:25] 100.00% (8/8), Elapsed time: 6 min 34 s, Throughput: 1 items/min\r\n",
      "[Oct 16, 2024 17:00:25] Done computing data model\r\n",
      "[Oct 16, 2024 17:00:25] Saving model information\r\n",
      "[Oct 16, 2024 17:00:25] Analyzing model states\r\n",
      "[Oct 16, 2024 17:02:13] Model fit: processing /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span: done in 8.503 min\r\n",
      "[Oct 16, 2024 17:02:13] Model saved: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:02:13] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:02:13] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:02:26] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:02:26] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:02:29] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:02:29] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:02:29] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:02:32] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:02:32] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:02:38] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:02:38] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:02:39] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:02:40] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:02:40] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 17:02:40] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-40_span.bed\r\n",
      "File size: 4 mb\r\n",
      "Count: 35,798\r\n",
      "Total length: 62,287,651\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 110\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,739\r\n",
      "Median length: 1,170\r\n",
      "FRIP: 0.3333736257957851\r\n",
      "Processing K562.bam.bed FDR=1e-20\n",
      "[Oct 16, 2024 17:02:41] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:02:41] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-20_span.bed --bin 100 --fdr 1e-20 --keep-cache\r\n",
      "[Oct 16, 2024 17:02:41] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:02:41] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-20_span.log\r\n",
      "[Oct 16, 2024 17:02:41] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:02:41] CONTROL: none\r\n",
      "[Oct 16, 2024 17:02:41] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:02:41] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:02:41] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:02:41] BIN: 100\r\n",
      "[Oct 16, 2024 17:02:41] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:02:41] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:02:41] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:02:41] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:02:41] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:02:41] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:02:41] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:02:41] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:02:41] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:02:41] FDR: 1.0E-20\r\n",
      "[Oct 16, 2024 17:02:41] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:02:41] THREADS: 8\r\n",
      "[Oct 16, 2024 17:02:42] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:02:42] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:02:42] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:02:43] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:02:43] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:02:43] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:02:44] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:02:44] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:02:56] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:02:56] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:03:01] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:03:01] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:03:01] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:03:04] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:03:04] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:03:12] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:03:12] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:03:12] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:03:13] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:03:13] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:03:13] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-20_span.bed\r\n",
      "File size: 5,9 mb\r\n",
      "Count: 53,081\r\n",
      "Total length: 73,602,591\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 100\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,386\r\n",
      "Median length: 850\r\n",
      "FRIP: 0.3660622941264819\r\n",
      "Processing K562.bam.bed FDR=1e-15\n",
      "[Oct 16, 2024 17:03:14] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:03:14] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-15_span.bed --bin 100 --fdr 1e-15 --keep-cache\r\n",
      "[Oct 16, 2024 17:03:14] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:03:14] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-15_span.log\r\n",
      "[Oct 16, 2024 17:03:14] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:03:14] CONTROL: none\r\n",
      "[Oct 16, 2024 17:03:14] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:03:14] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:03:14] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:03:14] BIN: 100\r\n",
      "[Oct 16, 2024 17:03:14] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:03:14] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:03:14] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:03:14] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:03:14] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:03:14] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:03:14] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:03:14] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:03:14] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:03:14] FDR: 1.0E-15\r\n",
      "[Oct 16, 2024 17:03:14] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:03:14] THREADS: 8\r\n",
      "[Oct 16, 2024 17:03:15] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:03:15] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:03:15] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:03:17] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:03:17] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:03:17] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:03:17] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:03:17] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:03:29] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:03:29] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:03:34] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:03:34] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:03:34] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:03:37] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:03:37] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:03:44] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:03:44] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:03:45] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:03:45] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:03:45] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:03:46] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-15_span.bed\r\n",
      "File size: 6,8 mb\r\n",
      "Count: 60,588\r\n",
      "Total length: 77,353,131\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 90\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,276\r\n",
      "Median length: 750\r\n",
      "FRIP: 0.3754166058860539\r\n",
      "Processing K562.bam.bed FDR=1e-10\n",
      "[Oct 16, 2024 17:03:46] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:03:46] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-10_span.bed --bin 100 --fdr 1e-10 --keep-cache\r\n",
      "[Oct 16, 2024 17:03:46] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:03:46] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-10_span.log\r\n",
      "[Oct 16, 2024 17:03:46] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:03:46] CONTROL: none\r\n",
      "[Oct 16, 2024 17:03:46] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:03:46] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:03:46] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:03:46] BIN: 100\r\n",
      "[Oct 16, 2024 17:03:46] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:03:46] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:03:46] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:03:46] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:03:46] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:03:46] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:03:46] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:03:46] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:03:46] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:03:46] FDR: 1.0E-10\r\n",
      "[Oct 16, 2024 17:03:46] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:03:46] THREADS: 8\r\n",
      "[Oct 16, 2024 17:03:47] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:03:47] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:03:47] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:03:49] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:03:49] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:03:49] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:03:49] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:03:50] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:04:07] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:04:07] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:04:13] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:04:13] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:04:13] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:04:17] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:04:17] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:04:26] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:04:26] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:04:27] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:04:28] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:04:28] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:04:28] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-10_span.bed\r\n",
      "File size: 7,9 mb\r\n",
      "Count: 70,836\r\n",
      "Total length: 81,634,761\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 80\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,152\r\n",
      "Median length: 640\r\n",
      "FRIP: 0.38540553742604694\r\n",
      "Processing K562.bam.bed FDR=1e-08\n",
      "[Oct 16, 2024 17:04:29] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:04:29] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-08_span.bed --bin 100 --fdr 1e-08 --keep-cache\r\n",
      "[Oct 16, 2024 17:04:29] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:04:29] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-08_span.log\r\n",
      "[Oct 16, 2024 17:04:29] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:04:29] CONTROL: none\r\n",
      "[Oct 16, 2024 17:04:29] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:04:29] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:04:29] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:04:29] BIN: 100\r\n",
      "[Oct 16, 2024 17:04:29] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:04:29] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:04:29] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:04:29] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:04:29] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:04:29] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:04:29] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:04:29] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:04:29] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:04:29] FDR: 1.0E-8\r\n",
      "[Oct 16, 2024 17:04:29] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:04:29] THREADS: 8\r\n",
      "[Oct 16, 2024 17:04:30] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:04:30] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:04:30] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:04:32] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:04:32] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:04:32] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:04:32] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:04:32] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:04:45] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:04:45] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:04:48] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:04:48] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:04:48] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:04:52] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:04:52] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:04:58] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:04:58] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:04:59] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:04:59] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:05:00] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:05:00] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-08_span.bed\r\n",
      "File size: 8,4 mb\r\n",
      "Count: 76,020\r\n",
      "Total length: 83,520,751\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 70\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,098\r\n",
      "Median length: 600\r\n",
      "FRIP: 0.3895643889926103\r\n",
      "Processing K562.bam.bed FDR=1e-06\n",
      "[Oct 16, 2024 17:05:01] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:05:01] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_1e-06_span.bed --bin 100 --fdr 1e-06 --keep-cache\r\n",
      "[Oct 16, 2024 17:05:01] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:05:01] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_1e-06_span.log\r\n",
      "[Oct 16, 2024 17:05:01] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:05:01] CONTROL: none\r\n",
      "[Oct 16, 2024 17:05:01] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:05:01] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:05:01] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:05:01] BIN: 100\r\n",
      "[Oct 16, 2024 17:05:01] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:05:01] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:05:01] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:05:01] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:05:01] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:05:01] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:05:01] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:05:01] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:05:01] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:05:01] FDR: 1.0E-6\r\n",
      "[Oct 16, 2024 17:05:01] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:05:01] THREADS: 8\r\n",
      "[Oct 16, 2024 17:05:01] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:05:01] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:05:01] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:05:03] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:05:03] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:05:03] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:05:04] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:05:04] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:05:15] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:05:15] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:05:19] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:05:19] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:05:19] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:05:23] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:05:23] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:05:29] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:05:29] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:05:30] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:05:30] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:05:31] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:05:31] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_1e-06_span.bed\r\n",
      "File size: 9,1 mb\r\n",
      "Count: 81,923\r\n",
      "Total length: 85,469,171\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 70\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 1,043\r\n",
      "Median length: 560\r\n",
      "FRIP: 0.39371805778597757\r\n",
      "Processing K562.bam.bed FDR=0.0001\n",
      "[Oct 16, 2024 17:05:32] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:05:32] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.0001_span.bed --bin 100 --fdr 0.0001 --keep-cache\r\n",
      "[Oct 16, 2024 17:05:32] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:05:32] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.0001_span.log\r\n",
      "[Oct 16, 2024 17:05:32] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:05:32] CONTROL: none\r\n",
      "[Oct 16, 2024 17:05:32] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:05:32] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:05:32] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:05:32] BIN: 100\r\n",
      "[Oct 16, 2024 17:05:32] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:05:32] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:05:32] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:05:32] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:05:32] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:05:32] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:05:32] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:05:32] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:05:32] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:05:32] FDR: 1.0E-4\r\n",
      "[Oct 16, 2024 17:05:32] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:05:32] THREADS: 8\r\n",
      "[Oct 16, 2024 17:05:32] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:05:32] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:05:32] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:05:34] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:05:34] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:05:34] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:05:34] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:05:34] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:05:46] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:05:46] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:05:49] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:05:49] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:05:49] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:05:53] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:05:53] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:06:00] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:06:00] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:06:00] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:06:01] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:06:01] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:06:01] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.0001_span.bed\r\n",
      "File size: 9,8 mb\r\n",
      "Count: 88,998\r\n",
      "Total length: 87,559,971\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 983\r\n",
      "Median length: 500\r\n",
      "FRIP: 0.3980255901586047\r\n",
      "Processing K562.bam.bed FDR=0.001\n",
      "[Oct 16, 2024 17:06:02] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:06:02] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.001_span.bed --bin 100 --fdr 0.001 --keep-cache\r\n",
      "[Oct 16, 2024 17:06:02] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:06:02] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.001_span.log\r\n",
      "[Oct 16, 2024 17:06:02] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:06:02] CONTROL: none\r\n",
      "[Oct 16, 2024 17:06:02] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:06:02] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:06:02] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:06:02] BIN: 100\r\n",
      "[Oct 16, 2024 17:06:02] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:06:02] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:06:02] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:06:02] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:06:02] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:06:02] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:06:02] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:06:02] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:06:02] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:06:02] FDR: 0.001\r\n",
      "[Oct 16, 2024 17:06:02] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:06:02] THREADS: 8\r\n",
      "[Oct 16, 2024 17:06:02] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:06:02] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:06:02] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:06:04] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:06:04] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:06:04] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:06:04] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:06:04] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:06:20] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:06:20] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:06:27] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:06:27] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:06:27] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:06:31] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:06:31] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:06:42] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:06:42] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:06:43] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:06:43] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:06:44] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:06:44] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.001_span.bed\r\n",
      "File size: 10,2 mb\r\n",
      "Count: 93,407\r\n",
      "Total length: 88,722,471\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 949\r\n",
      "Median length: 470\r\n",
      "FRIP: 0.4003934696625831\r\n",
      "Processing K562.bam.bed FDR=0.05\n",
      "[Oct 16, 2024 17:06:45] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:06:45] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.05_span.bed --bin 100 --fdr 0.05 --keep-cache\r\n",
      "[Oct 16, 2024 17:06:45] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:06:46] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.05_span.log\r\n",
      "[Oct 16, 2024 17:06:46] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:06:46] CONTROL: none\r\n",
      "[Oct 16, 2024 17:06:46] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:06:46] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:06:46] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:06:46] BIN: 100\r\n",
      "[Oct 16, 2024 17:06:46] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:06:46] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:06:46] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:06:46] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:06:46] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:06:46] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:06:46] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:06:46] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:06:46] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:06:46] FDR: 0.05\r\n",
      "[Oct 16, 2024 17:06:46] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:06:46] THREADS: 8\r\n",
      "[Oct 16, 2024 17:06:46] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:06:46] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:06:46] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:06:49] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:06:49] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:06:49] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:06:49] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:06:49] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:07:01] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:07:01] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:07:06] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:07:06] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:07:06] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:07:12] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:07:12] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:07:20] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:07:20] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:07:20] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:07:21] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:07:21] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:07:22] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.05_span.bed\r\n",
      "File size: 11,1 mb\r\n",
      "Count: 102,551\r\n",
      "Total length: 90,776,161\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 885\r\n",
      "Median length: 430\r\n",
      "FRIP: 0.40466202326179773\r\n",
      "Processing K562.bam.bed FDR=0.1\n",
      "[Oct 16, 2024 17:07:23] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:07:23] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.1_span.bed --bin 100 --fdr 0.1 --keep-cache\r\n",
      "[Oct 16, 2024 17:07:23] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:07:23] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.1_span.log\r\n",
      "[Oct 16, 2024 17:07:23] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:07:23] CONTROL: none\r\n",
      "[Oct 16, 2024 17:07:23] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:07:23] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:07:23] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:07:23] BIN: 100\r\n",
      "[Oct 16, 2024 17:07:23] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:07:23] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:07:23] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:07:23] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:07:23] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:07:23] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:07:23] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:07:23] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:07:23] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:07:23] FDR: 0.1\r\n",
      "[Oct 16, 2024 17:07:23] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:07:23] THREADS: 8\r\n",
      "[Oct 16, 2024 17:07:24] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:07:24] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:07:24] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:07:27] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:07:27] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:07:27] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:07:27] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:07:27] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:07:40] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:07:40] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:07:44] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:07:44] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:07:44] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:07:50] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:07:50] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:07:57] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:07:57] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:07:58] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:07:58] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:07:59] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:07:59] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.1_span.bed\r\n",
      "File size: 11,2 mb\r\n",
      "Count: 104,217\r\n",
      "Total length: 91,087,251\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 874\r\n",
      "Median length: 420\r\n",
      "FRIP: 0.40534744501698494\r\n",
      "Processing K562.bam.bed FDR=0.2\n",
      "[Oct 16, 2024 17:08:00] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:08:00] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.2_span.bed --bin 100 --fdr 0.2 --keep-cache\r\n",
      "[Oct 16, 2024 17:08:00] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:08:00] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.2_span.log\r\n",
      "[Oct 16, 2024 17:08:00] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:08:00] CONTROL: none\r\n",
      "[Oct 16, 2024 17:08:00] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:08:00] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:08:00] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:08:00] BIN: 100\r\n",
      "[Oct 16, 2024 17:08:00] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:08:00] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:08:00] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:08:00] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:08:00] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:08:00] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:08:00] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:08:00] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:08:00] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:08:00] FDR: 0.2\r\n",
      "[Oct 16, 2024 17:08:00] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:08:00] THREADS: 8\r\n",
      "[Oct 16, 2024 17:08:00] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:08:00] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:08:00] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:08:02] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:08:02] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:08:02] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:08:02] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:08:02] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:08:15] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:08:15] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:08:19] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:08:19] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:08:19] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:08:23] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:08:23] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:08:28] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:08:28] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:08:29] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:08:30] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:08:30] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:08:31] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.2_span.bed\r\n",
      "File size: 11,5 mb\r\n",
      "Count: 106,869\r\n",
      "Total length: 91,512,931\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 856\r\n",
      "Median length: 400\r\n",
      "FRIP: 0.40637649543251914\r\n",
      "Processing K562.bam.bed FDR=0.5\n",
      "[Oct 16, 2024 17:08:31] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:08:31] COMMAND: analyze -cs hg19.chrom.sizes -t K562.bam.bed --peaks span/K562.bam.bed_0.5_span.bed --bin 100 --fdr 0.5 --keep-cache\r\n",
      "[Oct 16, 2024 17:08:31] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:08:31] LOG: /home/jetbrains/data/2023_opendnase/K562.bam.bed_0.5_span.log\r\n",
      "[Oct 16, 2024 17:08:31] TREATMENT: /home/jetbrains/data/2023_opendnase/K562.bam.bed\r\n",
      "[Oct 16, 2024 17:08:31] CONTROL: none\r\n",
      "[Oct 16, 2024 17:08:31] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:08:31] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:08:31] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:08:31] BIN: 100\r\n",
      "[Oct 16, 2024 17:08:31] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:08:31] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:08:31] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:08:31] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:08:31] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:08:31] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:08:31] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:08:31] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:08:31] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:08:31] FDR: 0.5\r\n",
      "[Oct 16, 2024 17:08:31] PEAKS: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:08:31] THREADS: 8\r\n",
      "[Oct 16, 2024 17:08:32] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:08:32] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:08:32] Loading model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:08:34] Loading states data frame K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:08:34] Completed loading model: K562_bam_100_unique\r\n",
      "[Oct 16, 2024 17:08:34] Model: /home/jetbrains/data/2023_opendnase/K562_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 7.849144489370882\r\n",
      "Noise mean: 0.5279132606370601\r\n",
      "Signal to noise: 14.868246496615923\r\n",
      "Out of signal-to-noise range down: true\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:08:34] Library: K562.bam.bed, Depth: 18,522,912, Reads: single-ended, Fragment size: 80 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:08:34] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:08:46] Result beforeMerge: 26: -8.649088441929537, stable: 53: -0.10525879052580692, beforeNoise: 80: -0.0012809919863050845\r\n",
      "[Oct 16, 2024 17:08:46] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:08:50] Minimal additional 43: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:08:50] Candidates selection with sensitivity: -0.5387793651246864\r\n",
      "[Oct 16, 2024 17:08:50] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:08:54] Average autocorrelation score: 0.11935727186646146\r\n",
      "[Oct 16, 2024 17:08:54] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:09:00] Average fragmentation score: 38.57213785046729\r\n",
      "[Oct 16, 2024 17:09:00] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:09:01] Adjusting pvalues Benjamini-Hochberg, N=112992\r\n",
      "[Oct 16, 2024 17:09:01] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:09:02] Peaks saved to /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:09:02] File: /home/jetbrains/data/2023_opendnase/span/K562.bam.bed_0.5_span.bed\r\n",
      "File size: 11,9 mb\r\n",
      "Count: 111,168\r\n",
      "Total length: 92,006,101\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 78,010\r\n",
      "Mean length: 827\r\n",
      "Median length: 400\r\n",
      "FRIP: 0.40786616481585874\r\n",
      "Processing GM12878.bam.bed FDR=1e-40\n",
      "[Oct 16, 2024 17:09:03] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:09:03] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-40_span.bed --bin 100 --fdr 1e-40 --keep-cache\r\n",
      "[Oct 16, 2024 17:09:03] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:03] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-40_span.log\r\n",
      "[Oct 16, 2024 17:09:03] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:09:03] CONTROL: none\r\n",
      "[Oct 16, 2024 17:09:03] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:09:03] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:03] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:09:03] BIN: 100\r\n",
      "[Oct 16, 2024 17:09:03] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:09:03] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:09:03] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:09:03] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:09:03] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:09:03] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:09:03] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:09:03] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:09:03] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:09:03] FDR: 1.0E-40\r\n",
      "[Oct 16, 2024 17:09:03] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 17:09:03] THREADS: 8\r\n",
      "[Oct 16, 2024 17:09:03] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:09:03] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:03] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:09:05] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:05] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:05] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:09:05] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:05] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:09:16] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:09:16] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:09:18] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:09:18] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:09:18] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:09:22] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:09:22] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:09:27] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:09:27] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:09:28] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:09:28] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:09:28] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 17:09:29] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-40_span.bed\r\n",
      "File size: 2,7 mb\r\n",
      "Count: 23,881\r\n",
      "Total length: 53,937,831\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 2,258\r\n",
      "Median length: 1,300\r\n",
      "FRIP: 0.25378877291561974\r\n",
      "Processing GM12878.bam.bed FDR=1e-20\n",
      "[Oct 16, 2024 17:09:29] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:09:29] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-20_span.bed --bin 100 --fdr 1e-20 --keep-cache\r\n",
      "[Oct 16, 2024 17:09:29] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:29] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-20_span.log\r\n",
      "[Oct 16, 2024 17:09:29] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:09:29] CONTROL: none\r\n",
      "[Oct 16, 2024 17:09:29] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:09:29] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:29] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:09:29] BIN: 100\r\n",
      "[Oct 16, 2024 17:09:29] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:09:29] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:09:29] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:09:29] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:09:29] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:09:29] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:09:29] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:09:29] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:09:29] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:09:29] FDR: 1.0E-20\r\n",
      "[Oct 16, 2024 17:09:29] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:09:29] THREADS: 8\r\n",
      "[Oct 16, 2024 17:09:30] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:09:30] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:30] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:09:32] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:32] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:32] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:09:32] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:32] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:09:43] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:09:43] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:09:45] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:09:45] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:09:45] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:09:48] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:09:48] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:09:52] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:09:52] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:09:53] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:09:53] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:09:53] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:09:54] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-20_span.bed\r\n",
      "File size: 4 mb\r\n",
      "Count: 35,895\r\n",
      "Total length: 61,969,621\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,726\r\n",
      "Median length: 920\r\n",
      "FRIP: 0.27444894379363827\r\n",
      "Processing GM12878.bam.bed FDR=1e-15\n",
      "[Oct 16, 2024 17:09:54] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:09:54] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-15_span.bed --bin 100 --fdr 1e-15 --keep-cache\r\n",
      "[Oct 16, 2024 17:09:54] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:54] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-15_span.log\r\n",
      "[Oct 16, 2024 17:09:54] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:09:54] CONTROL: none\r\n",
      "[Oct 16, 2024 17:09:54] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:09:54] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:09:54] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:09:54] BIN: 100\r\n",
      "[Oct 16, 2024 17:09:54] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:09:54] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:09:54] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:09:54] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:09:54] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:09:54] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:09:54] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:09:54] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:09:54] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:09:54] FDR: 1.0E-15\r\n",
      "[Oct 16, 2024 17:09:54] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:09:54] THREADS: 8\r\n",
      "[Oct 16, 2024 17:09:55] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:09:55] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:55] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:09:57] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:57] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:09:57] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:09:57] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:09:57] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:10:10] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:10:10] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:10:12] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:10:12] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:10:12] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:10:16] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:10:16] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:10:23] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:10:23] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:10:23] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:10:24] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:10:24] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:10:24] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-15_span.bed\r\n",
      "File size: 4,7 mb\r\n",
      "Count: 41,484\r\n",
      "Total length: 64,836,561\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,562\r\n",
      "Median length: 800\r\n",
      "FRIP: 0.2809893945481956\r\n",
      "Processing GM12878.bam.bed FDR=1e-10\n",
      "[Oct 16, 2024 17:10:25] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:10:25] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-10_span.bed --bin 100 --fdr 1e-10 --keep-cache\r\n",
      "[Oct 16, 2024 17:10:25] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:10:25] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-10_span.log\r\n",
      "[Oct 16, 2024 17:10:25] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:10:25] CONTROL: none\r\n",
      "[Oct 16, 2024 17:10:25] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:10:25] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:10:25] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:10:25] BIN: 100\r\n",
      "[Oct 16, 2024 17:10:25] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:10:25] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:10:25] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:10:25] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:10:25] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:10:25] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:10:25] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:10:25] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:10:25] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:10:25] FDR: 1.0E-10\r\n",
      "[Oct 16, 2024 17:10:25] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:10:25] THREADS: 8\r\n",
      "[Oct 16, 2024 17:10:25] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:10:25] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:10:25] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:10:27] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:10:27] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:10:27] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:10:28] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:10:28] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:10:40] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:10:40] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:10:42] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:10:42] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:10:42] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:10:46] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:10:46] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:10:52] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:10:52] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:10:52] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:10:53] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:10:53] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:10:53] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-10_span.bed\r\n",
      "File size: 5,6 mb\r\n",
      "Count: 49,318\r\n",
      "Total length: 68,253,391\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,383\r\n",
      "Median length: 680\r\n",
      "FRIP: 0.2883174270789948\r\n",
      "Processing GM12878.bam.bed FDR=1e-08\n",
      "[Oct 16, 2024 17:10:54] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:10:54] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-08_span.bed --bin 100 --fdr 1e-08 --keep-cache\r\n",
      "[Oct 16, 2024 17:10:54] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:10:54] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-08_span.log\r\n",
      "[Oct 16, 2024 17:10:54] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:10:54] CONTROL: none\r\n",
      "[Oct 16, 2024 17:10:54] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:10:54] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:10:54] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:10:54] BIN: 100\r\n",
      "[Oct 16, 2024 17:10:54] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:10:54] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:10:54] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:10:54] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:10:54] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:10:54] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:10:54] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:10:54] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:10:54] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:10:54] FDR: 1.0E-8\r\n",
      "[Oct 16, 2024 17:10:54] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:10:54] THREADS: 8\r\n",
      "[Oct 16, 2024 17:10:54] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:10:54] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:10:54] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:10:57] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:10:57] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:10:57] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:10:57] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:10:57] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:11:10] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:11:10] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:11:12] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:11:12] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:11:12] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:11:16] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:11:16] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:11:24] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:11:24] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:11:24] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:11:25] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:11:25] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:11:25] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-08_span.bed\r\n",
      "File size: 6 mb\r\n",
      "Count: 53,310\r\n",
      "Total length: 69,799,181\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,309\r\n",
      "Median length: 620\r\n",
      "FRIP: 0.2914627084650029\r\n",
      "Processing GM12878.bam.bed FDR=1e-06\n",
      "[Oct 16, 2024 17:11:27] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:11:27] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_1e-06_span.bed --bin 100 --fdr 1e-06 --keep-cache\r\n",
      "[Oct 16, 2024 17:11:27] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:11:27] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_1e-06_span.log\r\n",
      "[Oct 16, 2024 17:11:27] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:11:27] CONTROL: none\r\n",
      "[Oct 16, 2024 17:11:27] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:11:27] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:11:27] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:11:27] BIN: 100\r\n",
      "[Oct 16, 2024 17:11:27] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:11:27] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:11:27] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:11:27] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:11:27] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:11:27] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:11:27] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:11:27] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:11:27] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:11:27] FDR: 1.0E-6\r\n",
      "[Oct 16, 2024 17:11:27] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:11:27] THREADS: 8\r\n",
      "[Oct 16, 2024 17:11:27] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:11:28] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:11:28] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:11:30] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:11:30] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:11:30] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:11:30] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:11:31] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:11:45] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:11:45] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:11:49] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:11:49] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:11:49] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:11:54] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:11:54] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:12:02] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:12:02] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:12:03] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:12:03] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:12:04] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:12:04] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_1e-06_span.bed\r\n",
      "File size: 6,5 mb\r\n",
      "Count: 58,113\r\n",
      "Total length: 71,504,171\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,230\r\n",
      "Median length: 570\r\n",
      "FRIP: 0.2947979286973967\r\n",
      "Processing GM12878.bam.bed FDR=0.0001\n",
      "[Oct 16, 2024 17:12:05] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:12:05] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.0001_span.bed --bin 100 --fdr 0.0001 --keep-cache\r\n",
      "[Oct 16, 2024 17:12:05] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:12:05] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.0001_span.log\r\n",
      "[Oct 16, 2024 17:12:05] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:12:05] CONTROL: none\r\n",
      "[Oct 16, 2024 17:12:05] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:12:05] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:12:05] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:12:05] BIN: 100\r\n",
      "[Oct 16, 2024 17:12:05] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:12:05] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:12:05] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:12:05] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:12:05] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:12:05] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:12:05] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:12:05] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:12:05] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:12:05] FDR: 1.0E-4\r\n",
      "[Oct 16, 2024 17:12:05] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:12:05] THREADS: 8\r\n",
      "[Oct 16, 2024 17:12:06] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:12:06] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:12:06] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:12:09] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:12:09] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:12:09] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:12:10] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:12:10] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:12:25] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:12:25] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:12:28] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:12:28] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:12:28] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:12:33] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:12:33] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:12:40] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:12:40] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:12:41] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:12:42] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:12:42] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:12:43] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.0001_span.bed\r\n",
      "File size: 7,1 mb\r\n",
      "Count: 64,132\r\n",
      "Total length: 73,456,381\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,145\r\n",
      "Median length: 520\r\n",
      "FRIP: 0.29845427646912975\r\n",
      "Processing GM12878.bam.bed FDR=0.001\n",
      "[Oct 16, 2024 17:12:44] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:12:44] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.001_span.bed --bin 100 --fdr 0.001 --keep-cache\r\n",
      "[Oct 16, 2024 17:12:44] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:12:44] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.001_span.log\r\n",
      "[Oct 16, 2024 17:12:44] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:12:44] CONTROL: none\r\n",
      "[Oct 16, 2024 17:12:44] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:12:44] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:12:44] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:12:44] BIN: 100\r\n",
      "[Oct 16, 2024 17:12:44] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:12:44] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:12:44] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:12:44] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:12:44] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:12:44] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:12:44] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:12:44] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:12:44] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:12:44] FDR: 0.001\r\n",
      "[Oct 16, 2024 17:12:44] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:12:44] THREADS: 8\r\n",
      "[Oct 16, 2024 17:12:45] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:12:45] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:12:45] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:12:47] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:12:47] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:12:47] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:12:48] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:12:48] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:13:02] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:13:02] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:13:05] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:13:05] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:13:05] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:13:10] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:13:10] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:13:18] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:13:18] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:13:19] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:13:19] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:13:20] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:13:20] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.001_span.bed\r\n",
      "File size: 7,5 mb\r\n",
      "Count: 67,900\r\n",
      "Total length: 74,569,541\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,098\r\n",
      "Median length: 490\r\n",
      "FRIP: 0.3005013396383838\r\n",
      "Processing GM12878.bam.bed FDR=0.05\n",
      "[Oct 16, 2024 17:13:21] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:13:21] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.05_span.bed --bin 100 --fdr 0.05 --keep-cache\r\n",
      "[Oct 16, 2024 17:13:21] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:13:21] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.05_span.log\r\n",
      "[Oct 16, 2024 17:13:22] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:13:22] CONTROL: none\r\n",
      "[Oct 16, 2024 17:13:22] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:13:22] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:13:22] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:13:22] BIN: 100\r\n",
      "[Oct 16, 2024 17:13:22] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:13:22] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:13:22] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:13:22] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:13:22] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:13:22] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:13:22] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:13:22] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:13:22] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:13:22] FDR: 0.05\r\n",
      "[Oct 16, 2024 17:13:22] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:13:22] THREADS: 8\r\n",
      "[Oct 16, 2024 17:13:22] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:13:22] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:13:23] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:13:26] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:13:26] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:13:26] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:13:26] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:13:26] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:13:41] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:13:41] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:13:44] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:13:44] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:13:44] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:13:49] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:13:49] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:13:56] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:13:56] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:13:57] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:13:58] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:13:58] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:13:58] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.05_span.bed\r\n",
      "File size: 8,4 mb\r\n",
      "Count: 76,546\r\n",
      "Total length: 76,852,231\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 1,004\r\n",
      "Median length: 430\r\n",
      "FRIP: 0.3046674548978919\r\n",
      "Processing GM12878.bam.bed FDR=0.1\n",
      "[Oct 16, 2024 17:13:59] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:13:59] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.1_span.bed --bin 100 --fdr 0.1 --keep-cache\r\n",
      "[Oct 16, 2024 17:13:59] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:14:00] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.1_span.log\r\n",
      "[Oct 16, 2024 17:14:00] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:14:00] CONTROL: none\r\n",
      "[Oct 16, 2024 17:14:00] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:14:00] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:14:00] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:14:00] BIN: 100\r\n",
      "[Oct 16, 2024 17:14:00] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:14:00] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:14:00] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:14:00] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:14:00] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:14:00] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:14:00] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:14:00] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:14:00] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:14:00] FDR: 0.1\r\n",
      "[Oct 16, 2024 17:14:00] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:14:00] THREADS: 8\r\n",
      "[Oct 16, 2024 17:14:00] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:14:00] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:14:01] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:14:04] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:14:04] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:14:04] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:14:04] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:14:05] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:14:19] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:14:19] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:14:23] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:14:23] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:14:23] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:14:27] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:14:27] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:14:36] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:14:36] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:14:36] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:14:37] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:14:37] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:14:37] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.1_span.bed\r\n",
      "File size: 8,5 mb\r\n",
      "Count: 78,949\r\n",
      "Total length: 77,378,301\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 980\r\n",
      "Median length: 410\r\n",
      "FRIP: 0.3056960821590921\r\n",
      "Processing GM12878.bam.bed FDR=0.2\n",
      "[Oct 16, 2024 17:14:38] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:14:38] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.2_span.bed --bin 100 --fdr 0.2 --keep-cache\r\n",
      "[Oct 16, 2024 17:14:38] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:14:38] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.2_span.log\r\n",
      "[Oct 16, 2024 17:14:38] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:14:38] CONTROL: none\r\n",
      "[Oct 16, 2024 17:14:38] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:14:38] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:14:38] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:14:38] BIN: 100\r\n",
      "[Oct 16, 2024 17:14:38] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:14:38] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:14:38] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:14:38] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:14:38] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:14:38] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:14:38] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:14:38] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:14:38] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:14:38] FDR: 0.2\r\n",
      "[Oct 16, 2024 17:14:38] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:14:38] THREADS: 8\r\n",
      "[Oct 16, 2024 17:14:39] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:14:39] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:14:39] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:14:40] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:14:40] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:14:40] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:14:41] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:14:41] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:14:58] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:14:58] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:15:01] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:15:01] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:15:01] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:15:05] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:15:05] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:15:13] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:15:13] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:15:14] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:15:15] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:15:15] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:15:15] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.2_span.bed\r\n",
      "File size: 8,8 mb\r\n",
      "Count: 81,629\r\n",
      "Total length: 77,896,631\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 954\r\n",
      "Median length: 400\r\n",
      "FRIP: 0.3067772648296553\r\n",
      "Processing GM12878.bam.bed FDR=0.5\n",
      "[Oct 16, 2024 17:15:16] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:15:16] COMMAND: analyze -cs hg19.chrom.sizes -t GM12878.bam.bed --peaks span/GM12878.bam.bed_0.5_span.bed --bin 100 --fdr 0.5 --keep-cache\r\n",
      "[Oct 16, 2024 17:15:16] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:15:16] LOG: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed_0.5_span.log\r\n",
      "[Oct 16, 2024 17:15:16] TREATMENT: /home/jetbrains/data/2023_opendnase/GM12878.bam.bed\r\n",
      "[Oct 16, 2024 17:15:16] CONTROL: none\r\n",
      "[Oct 16, 2024 17:15:16] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:15:16] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:15:16] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:15:16] BIN: 100\r\n",
      "[Oct 16, 2024 17:15:16] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:15:16] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:15:16] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:15:16] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:15:16] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:15:16] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:15:16] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:15:16] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:15:16] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:15:16] FDR: 0.5\r\n",
      "[Oct 16, 2024 17:15:16] PEAKS: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:15:16] THREADS: 8\r\n",
      "[Oct 16, 2024 17:15:16] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:15:16] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:15:16] Loading model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:15:18] Loading states data frame GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:15:18] Completed loading model: GM12878_bam_100_unique\r\n",
      "[Oct 16, 2024 17:15:18] Model: /home/jetbrains/data/2023_opendnase/GM12878_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 6.361546802032364\r\n",
      "Noise mean: 0.6938752882117507\r\n",
      "Signal to noise: 9.168141464744295\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:15:18] Library: GM12878.bam.bed, Depth: 20,016,969, Reads: single-ended, Fragment size: 56 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:15:18] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:15:32] Result beforeMerge: 26: -7.3411987275849615, stable: 44: -0.27994289065815975, beforeNoise: 76: -8.412798490553303E-4\r\n",
      "[Oct 16, 2024 17:15:32] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:15:35] Minimal additional 43: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:15:35] Candidates selection with sensitivity: -0.33564947532465805\r\n",
      "[Oct 16, 2024 17:15:35] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:15:38] Average autocorrelation score: 0.16089192232799512\r\n",
      "[Oct 16, 2024 17:15:38] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:15:43] Average fragmentation score: 37.87209505695109\r\n",
      "[Oct 16, 2024 17:15:43] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:15:44] Adjusting pvalues Benjamini-Hochberg, N=91482\r\n",
      "[Oct 16, 2024 17:15:44] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:15:44] Peaks saved to /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:15:44] File: /home/jetbrains/data/2023_opendnase/span/GM12878.bam.bed_0.5_span.bed\r\n",
      "File size: 9,5 mb\r\n",
      "Count: 87,518\r\n",
      "Total length: 78,753,311\r\n",
      "Genome coverage: 0.03%\r\n",
      "Min length: 60\r\n",
      "Max length: 69,710\r\n",
      "Mean length: 899\r\n",
      "Median length: 370\r\n",
      "FRIP: 0.30885235422006196\r\n",
      "Processing HelaS3.bam.bed FDR=1e-40\n",
      "[Oct 16, 2024 17:15:45] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:15:45] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-40_span.bed --bin 100 --fdr 1e-40 --keep-cache\r\n",
      "[Oct 16, 2024 17:15:45] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:15:45] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-40_span.log\r\n",
      "[Oct 16, 2024 17:15:45] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:15:45] CONTROL: none\r\n",
      "[Oct 16, 2024 17:15:45] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:15:45] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:15:45] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:15:45] BIN: 100\r\n",
      "[Oct 16, 2024 17:15:45] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:15:45] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:15:45] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:15:45] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:15:45] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:15:45] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:15:45] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:15:45] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:15:45] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:15:45] FDR: 1.0E-40\r\n",
      "[Oct 16, 2024 17:15:45] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 17:15:45] THREADS: 8\r\n",
      "[Oct 16, 2024 17:15:45] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:15:45] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:15:45] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:15:47] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:15:47] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:15:47] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:15:47] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:15:47] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:15:54] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:15:54] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:15:57] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:15:57] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:15:57] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:16:00] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:16:00] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:16:04] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:16:04] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:16:05] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:16:05] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:16:05] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-40_span.bed\r\n",
      "[Oct 16, 2024 17:16:05] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-40_span.bed\r\n",
      "File size: 4,8 mb\r\n",
      "Count: 42,683\r\n",
      "Total length: 48,632,511\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 150\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 1,139\r\n",
      "Median length: 830\r\n",
      "FRIP: 0.3367162262246391\r\n",
      "Processing HelaS3.bam.bed FDR=1e-20\n",
      "[Oct 16, 2024 17:16:06] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:16:06] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-20_span.bed --bin 100 --fdr 1e-20 --keep-cache\r\n",
      "[Oct 16, 2024 17:16:06] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:16:06] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-20_span.log\r\n",
      "[Oct 16, 2024 17:16:06] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:16:06] CONTROL: none\r\n",
      "[Oct 16, 2024 17:16:06] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:16:06] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:16:06] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:16:06] BIN: 100\r\n",
      "[Oct 16, 2024 17:16:06] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:16:06] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:16:06] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:16:06] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:16:06] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:16:06] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:16:06] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:16:06] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:16:06] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:16:06] FDR: 1.0E-20\r\n",
      "[Oct 16, 2024 17:16:06] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:16:06] THREADS: 8\r\n",
      "[Oct 16, 2024 17:16:06] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:16:06] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:16:06] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:16:08] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:16:08] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:16:08] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:16:08] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:16:08] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:16:17] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:16:17] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:16:19] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:16:19] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:16:19] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:16:23] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:16:23] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:16:30] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:16:30] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:16:30] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:16:31] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:16:31] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-20_span.bed\r\n",
      "[Oct 16, 2024 17:16:31] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-20_span.bed\r\n",
      "File size: 6,7 mb\r\n",
      "Count: 59,143\r\n",
      "Total length: 56,246,931\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 100\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 951\r\n",
      "Median length: 660\r\n",
      "FRIP: 0.36080799682345766\r\n",
      "Processing HelaS3.bam.bed FDR=1e-15\n",
      "[Oct 16, 2024 17:16:32] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:16:32] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-15_span.bed --bin 100 --fdr 1e-15 --keep-cache\r\n",
      "[Oct 16, 2024 17:16:32] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:16:32] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-15_span.log\r\n",
      "[Oct 16, 2024 17:16:32] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:16:32] CONTROL: none\r\n",
      "[Oct 16, 2024 17:16:32] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:16:32] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:16:32] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:16:32] BIN: 100\r\n",
      "[Oct 16, 2024 17:16:32] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:16:32] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:16:32] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:16:32] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:16:32] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:16:32] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:16:32] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:16:32] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:16:32] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:16:32] FDR: 1.0E-15\r\n",
      "[Oct 16, 2024 17:16:32] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:16:32] THREADS: 8\r\n",
      "[Oct 16, 2024 17:16:32] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:16:32] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:16:32] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:16:35] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:16:35] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:16:35] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:16:35] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:16:35] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:16:48] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:16:48] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:16:51] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:16:51] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:16:51] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:16:55] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:16:55] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:17:01] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:17:01] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:17:02] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:17:03] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:17:03] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-15_span.bed\r\n",
      "[Oct 16, 2024 17:17:03] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-15_span.bed\r\n",
      "File size: 7,5 mb\r\n",
      "Count: 66,170\r\n",
      "Total length: 58,855,961\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 889\r\n",
      "Median length: 600\r\n",
      "FRIP: 0.36768028764578853\r\n",
      "Processing HelaS3.bam.bed FDR=1e-10\n",
      "[Oct 16, 2024 17:17:05] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:17:05] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-10_span.bed --bin 100 --fdr 1e-10 --keep-cache\r\n",
      "[Oct 16, 2024 17:17:05] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:17:05] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-10_span.log\r\n",
      "[Oct 16, 2024 17:17:05] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:17:05] CONTROL: none\r\n",
      "[Oct 16, 2024 17:17:05] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:17:05] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:17:05] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:17:05] BIN: 100\r\n",
      "[Oct 16, 2024 17:17:05] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:17:05] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:17:05] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:17:05] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:17:05] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:17:05] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:17:05] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:17:05] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:17:05] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:17:05] FDR: 1.0E-10\r\n",
      "[Oct 16, 2024 17:17:05] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:17:05] THREADS: 8\r\n",
      "[Oct 16, 2024 17:17:05] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:17:06] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:17:06] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:17:09] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:17:09] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:17:09] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:17:09] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:17:09] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:17:23] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:17:23] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:17:27] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:17:27] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:17:27] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:17:32] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:17:32] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:17:40] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:17:40] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:17:41] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:17:42] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:17:42] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-10_span.bed\r\n",
      "[Oct 16, 2024 17:17:43] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-10_span.bed\r\n",
      "File size: 8,5 mb\r\n",
      "Count: 75,426\r\n",
      "Total length: 61,870,491\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 80\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 820\r\n",
      "Median length: 530\r\n",
      "FRIP: 0.37484399137058855\r\n",
      "Processing HelaS3.bam.bed FDR=1e-08\n",
      "[Oct 16, 2024 17:17:44] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:17:44] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-08_span.bed --bin 100 --fdr 1e-08 --keep-cache\r\n",
      "[Oct 16, 2024 17:17:44] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:17:44] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-08_span.log\r\n",
      "[Oct 16, 2024 17:17:44] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:17:44] CONTROL: none\r\n",
      "[Oct 16, 2024 17:17:44] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:17:44] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:17:44] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:17:44] BIN: 100\r\n",
      "[Oct 16, 2024 17:17:44] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:17:44] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:17:44] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:17:44] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:17:44] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:17:44] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:17:44] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:17:44] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:17:44] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:17:44] FDR: 1.0E-8\r\n",
      "[Oct 16, 2024 17:17:44] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:17:44] THREADS: 8\r\n",
      "[Oct 16, 2024 17:17:44] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:17:45] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:17:45] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:17:47] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:17:47] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:17:47] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:17:48] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:17:48] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:18:01] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:18:01] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:18:04] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:18:04] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:18:04] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:18:09] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:18:09] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:18:16] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:18:16] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:18:17] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:18:17] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:18:18] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-08_span.bed\r\n",
      "[Oct 16, 2024 17:18:18] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-08_span.bed\r\n",
      "File size: 8,9 mb\r\n",
      "Count: 80,025\r\n",
      "Total length: 63,177,831\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 789\r\n",
      "Median length: 500\r\n",
      "FRIP: 0.37778348323622485\r\n",
      "Processing HelaS3.bam.bed FDR=1e-06\n",
      "[Oct 16, 2024 17:18:19] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:18:19] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_1e-06_span.bed --bin 100 --fdr 1e-06 --keep-cache\r\n",
      "[Oct 16, 2024 17:18:19] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:18:20] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_1e-06_span.log\r\n",
      "[Oct 16, 2024 17:18:20] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:18:20] CONTROL: none\r\n",
      "[Oct 16, 2024 17:18:20] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:18:20] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:18:20] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:18:20] BIN: 100\r\n",
      "[Oct 16, 2024 17:18:20] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:18:20] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:18:20] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:18:20] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:18:20] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:18:20] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:18:20] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:18:20] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:18:20] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:18:20] FDR: 1.0E-6\r\n",
      "[Oct 16, 2024 17:18:20] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:18:20] THREADS: 8\r\n",
      "[Oct 16, 2024 17:18:20] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:18:21] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:18:21] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:18:24] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:18:24] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:18:24] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:18:24] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:18:24] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:18:39] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:18:39] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:18:42] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:18:42] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:18:42] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:18:48] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:18:48] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:18:55] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:18:55] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:18:56] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:18:56] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:18:57] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-06_span.bed\r\n",
      "[Oct 16, 2024 17:18:57] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_1e-06_span.bed\r\n",
      "File size: 9,5 mb\r\n",
      "Count: 85,336\r\n",
      "Total length: 64,626,911\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 757\r\n",
      "Median length: 480\r\n",
      "FRIP: 0.38078206060283176\r\n",
      "Processing HelaS3.bam.bed FDR=0.0001\n",
      "[Oct 16, 2024 17:18:58] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:18:58] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.0001_span.bed --bin 100 --fdr 0.0001 --keep-cache\r\n",
      "[Oct 16, 2024 17:18:58] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:18:59] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.0001_span.log\r\n",
      "[Oct 16, 2024 17:18:59] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:18:59] CONTROL: none\r\n",
      "[Oct 16, 2024 17:18:59] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:18:59] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:18:59] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:18:59] BIN: 100\r\n",
      "[Oct 16, 2024 17:18:59] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:18:59] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:18:59] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:18:59] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:18:59] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:18:59] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:18:59] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:18:59] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:18:59] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:18:59] FDR: 1.0E-4\r\n",
      "[Oct 16, 2024 17:18:59] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:18:59] THREADS: 8\r\n",
      "[Oct 16, 2024 17:18:59] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:19:00] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:19:00] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:19:02] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:19:02] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:19:02] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:19:02] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:19:03] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:19:22] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:19:22] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:19:27] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:19:27] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:19:27] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:19:33] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:19:33] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:19:44] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:19:44] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:19:45] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:19:46] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:19:46] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.0001_span.bed\r\n",
      "[Oct 16, 2024 17:19:47] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.0001_span.bed\r\n",
      "File size: 10,2 mb\r\n",
      "Count: 91,731\r\n",
      "Total length: 66,186,851\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 721\r\n",
      "Median length: 460\r\n",
      "FRIP: 0.38390419326163633\r\n",
      "Processing HelaS3.bam.bed FDR=0.001\n",
      "[Oct 16, 2024 17:19:48] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:19:48] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.001_span.bed --bin 100 --fdr 0.001 --keep-cache\r\n",
      "[Oct 16, 2024 17:19:48] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:19:48] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.001_span.log\r\n",
      "[Oct 16, 2024 17:19:48] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:19:48] CONTROL: none\r\n",
      "[Oct 16, 2024 17:19:48] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:19:48] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:19:48] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:19:48] BIN: 100\r\n",
      "[Oct 16, 2024 17:19:48] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:19:48] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:19:48] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:19:48] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:19:48] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:19:48] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:19:48] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:19:48] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:19:48] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:19:48] FDR: 0.001\r\n",
      "[Oct 16, 2024 17:19:48] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:19:48] THREADS: 8\r\n",
      "[Oct 16, 2024 17:19:49] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:19:49] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:19:49] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:19:52] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:19:52] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:19:52] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:19:52] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:19:52] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:20:06] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:20:06] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:20:09] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:09] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:09] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:20:12] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:20:12] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:20:17] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:20:17] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:20:18] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:20:18] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:20:18] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.001_span.bed\r\n",
      "[Oct 16, 2024 17:20:18] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.001_span.bed\r\n",
      "File size: 10,6 mb\r\n",
      "Count: 95,600\r\n",
      "Total length: 67,059,731\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 701\r\n",
      "Median length: 440\r\n",
      "FRIP: 0.385587775809678\r\n",
      "Processing HelaS3.bam.bed FDR=0.05\n",
      "[Oct 16, 2024 17:20:19] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:20:19] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.05_span.bed --bin 100 --fdr 0.05 --keep-cache\r\n",
      "[Oct 16, 2024 17:20:19] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:20:19] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.05_span.log\r\n",
      "[Oct 16, 2024 17:20:19] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:20:19] CONTROL: none\r\n",
      "[Oct 16, 2024 17:20:19] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:20:19] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:20:19] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:20:19] BIN: 100\r\n",
      "[Oct 16, 2024 17:20:19] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:20:19] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:20:19] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:20:19] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:20:19] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:20:19] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:20:19] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:20:19] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:20:19] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:20:19] FDR: 0.05\r\n",
      "[Oct 16, 2024 17:20:19] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:20:19] THREADS: 8\r\n",
      "[Oct 16, 2024 17:20:19] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:20:19] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:20:19] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:20:21] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:20:21] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:20:21] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:20:21] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:20:21] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:20:30] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:20:30] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:20:32] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:32] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:32] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:20:36] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:20:36] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:20:40] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:20:40] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:20:41] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:20:41] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:20:41] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.05_span.bed\r\n",
      "[Oct 16, 2024 17:20:42] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.05_span.bed\r\n",
      "File size: 11,5 mb\r\n",
      "Count: 105,072\r\n",
      "Total length: 68,893,431\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 655\r\n",
      "Median length: 400\r\n",
      "FRIP: 0.3891151943868113\r\n",
      "Processing HelaS3.bam.bed FDR=0.1\n",
      "[Oct 16, 2024 17:20:42] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:20:42] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.1_span.bed --bin 100 --fdr 0.1 --keep-cache\r\n",
      "[Oct 16, 2024 17:20:42] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:20:42] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.1_span.log\r\n",
      "[Oct 16, 2024 17:20:42] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:20:42] CONTROL: none\r\n",
      "[Oct 16, 2024 17:20:42] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:20:42] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:20:42] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:20:42] BIN: 100\r\n",
      "[Oct 16, 2024 17:20:42] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:20:42] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:20:42] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:20:42] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:20:42] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:20:42] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:20:42] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:20:42] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:20:42] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:20:42] FDR: 0.1\r\n",
      "[Oct 16, 2024 17:20:42] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:20:42] THREADS: 8\r\n",
      "[Oct 16, 2024 17:20:43] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:20:43] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:20:43] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:20:44] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:20:44] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:20:44] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:20:44] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:20:44] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:20:52] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:20:52] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:20:54] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:54] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:20:54] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:20:58] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:20:58] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:21:03] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:21:03] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:21:04] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:21:05] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:21:05] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.1_span.bed\r\n",
      "[Oct 16, 2024 17:21:05] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.1_span.bed\r\n",
      "File size: 11,7 mb\r\n",
      "Count: 107,471\r\n",
      "Total length: 69,274,371\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 644\r\n",
      "Median length: 390\r\n",
      "FRIP: 0.3898994115395825\r\n",
      "Processing HelaS3.bam.bed FDR=0.2\n",
      "[Oct 16, 2024 17:21:06] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:21:06] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.2_span.bed --bin 100 --fdr 0.2 --keep-cache\r\n",
      "[Oct 16, 2024 17:21:06] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:21:06] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.2_span.log\r\n",
      "[Oct 16, 2024 17:21:06] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:21:06] CONTROL: none\r\n",
      "[Oct 16, 2024 17:21:06] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:21:06] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:21:06] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:21:06] BIN: 100\r\n",
      "[Oct 16, 2024 17:21:06] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:21:06] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:21:06] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:21:06] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:21:06] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:21:06] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:21:06] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:21:06] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:21:06] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:21:06] FDR: 0.2\r\n",
      "[Oct 16, 2024 17:21:06] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:21:06] THREADS: 8\r\n",
      "[Oct 16, 2024 17:21:06] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:21:06] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:21:06] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:21:08] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:21:08] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:21:08] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:21:09] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:21:09] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:21:22] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:21:22] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:21:25] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:21:25] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:21:25] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:21:28] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:21:28] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:21:35] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:21:35] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:21:35] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:21:36] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:21:36] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.2_span.bed\r\n",
      "[Oct 16, 2024 17:21:36] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.2_span.bed\r\n",
      "File size: 11,9 mb\r\n",
      "Count: 110,029\r\n",
      "Total length: 69,650,171\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 633\r\n",
      "Median length: 380\r\n",
      "FRIP: 0.39067427703032964\r\n",
      "Processing HelaS3.bam.bed FDR=0.5\n",
      "[Oct 16, 2024 17:21:37] SPAN 2.0.build built on October 16, 2024\r\n",
      "[Oct 16, 2024 17:21:37] COMMAND: analyze -cs hg19.chrom.sizes -t HelaS3.bam.bed --peaks span/HelaS3.bam.bed_0.5_span.bed --bin 100 --fdr 0.5 --keep-cache\r\n",
      "[Oct 16, 2024 17:21:37] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:21:37] LOG: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed_0.5_span.log\r\n",
      "[Oct 16, 2024 17:21:37] TREATMENT: /home/jetbrains/data/2023_opendnase/HelaS3.bam.bed\r\n",
      "[Oct 16, 2024 17:21:37] CONTROL: none\r\n",
      "[Oct 16, 2024 17:21:37] BLACKLIST FILE: null\r\n",
      "[Oct 16, 2024 17:21:37] WORKING DIR: /home/jetbrains/data/2023_opendnase\r\n",
      "[Oct 16, 2024 17:21:37] CHROM.SIZES: /home/jetbrains/data/2023_opendnase/hg19.chrom.sizes\r\n",
      "[Oct 16, 2024 17:21:37] BIN: 100\r\n",
      "[Oct 16, 2024 17:21:37] FRAGMENT: auto\r\n",
      "[Oct 16, 2024 17:21:37] KEEP DUPLICATES: false\r\n",
      "[Oct 16, 2024 17:21:37] CONVERGENCE THRESHOLD: 1.0E-4\r\n",
      "[Oct 16, 2024 17:21:37] MAX ITERATIONS: 10\r\n",
      "[Oct 16, 2024 17:21:37] MODEL TYPE: Negative binomial HMM 2 states with zero inflation\r\n",
      "[Oct 16, 2024 17:21:37] EXTENDED MODEL INFO: false\r\n",
      "[Oct 16, 2024 17:21:37] KEEP-CACHE: true\r\n",
      "[Oct 16, 2024 17:21:37] NOCLIP: false\r\n",
      "[Oct 16, 2024 17:21:37] MULTIPLE TEST CORRECTION: Benjamini-Hochberg\r\n",
      "[Oct 16, 2024 17:21:37] FDR: 0.5\r\n",
      "[Oct 16, 2024 17:21:37] PEAKS: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:21:37] THREADS: 8\r\n",
      "[Oct 16, 2024 17:21:38] Chromosomes with no reads detected are ignored. Use --debug for details.\r\n",
      "[Oct 16, 2024 17:21:38] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:21:38] Loading model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "[Oct 16, 2024 17:21:41] Loading states data frame HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:21:41] Completed loading model: HelaS3_bam_100_unique\r\n",
      "[Oct 16, 2024 17:21:41] Model: /home/jetbrains/data/2023_opendnase/HelaS3_bam_100_unique.span\r\n",
      "Model type: Negative binomial HMM 2 states with zero inflation\r\n",
      "Signal mean: 8.729852272957553\r\n",
      "Noise mean: 0.6772090044883644\r\n",
      "Signal to noise: 12.89092763668126\r\n",
      "Out of signal-to-noise range down: false\r\n",
      "Out of low noise level down: false\r\n",
      "[Oct 16, 2024 17:21:41] Library: HelaS3.bam.bed, Depth: 21,172,735, Reads: single-ended, Fragment size: 99 bp (cross-correlation estimate)\r\n",
      "[Oct 16, 2024 17:21:41] Adjusting sensitivity...\r\n",
      "[Oct 16, 2024 17:21:54] Result beforeMerge: 23: -12.494675087952212, stable: 44: -0.266175671204409, beforeNoise: 79: -4.357532909160884E-4\r\n",
      "[Oct 16, 2024 17:21:54] Analysing candidates additive numbers...\r\n",
      "[Oct 16, 2024 17:21:58] Minimal additional 41: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:21:58] Candidates selection with sensitivity: -0.46127738095944354\r\n",
      "[Oct 16, 2024 17:21:58] Analysing pvalues autocorrelation...\r\n",
      "[Oct 16, 2024 17:22:03] Average autocorrelation score: 0.10987971197806128\r\n",
      "[Oct 16, 2024 17:22:03] Analysing fragmentation...\r\n",
      "[Oct 16, 2024 17:22:10] Average fragmentation score: 39.387755793181114\r\n",
      "[Oct 16, 2024 17:22:10] Candidates selection with gap: 0\r\n",
      "[Oct 16, 2024 17:22:11] Adjusting pvalues Benjamini-Hochberg, N=118113\r\n",
      "[Oct 16, 2024 17:22:12] Format chromosome, start, end, name, score, strand, signal, -log(p), -log(q)\r\n",
      "[Oct 16, 2024 17:22:12] Peaks saved to /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.5_span.bed\r\n",
      "[Oct 16, 2024 17:22:13] File: /home/jetbrains/data/2023_opendnase/span/HelaS3.bam.bed_0.5_span.bed\r\n",
      "File size: 12,5 mb\r\n",
      "Count: 115,272\r\n",
      "Total length: 70,208,201\r\n",
      "Genome coverage: 0.02%\r\n",
      "Min length: 60\r\n",
      "Max length: 37,210\r\n",
      "Mean length: 609\r\n",
      "Median length: 360\r\n",
      "FRIP: 0.3921142912901973\r\n"
     ]
    }
   ],
   "execution_count": 4
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "    Let us perform intersection of reference peaks with span ones."
   ]
  },
  {
   "cell_type": "code",
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:22:41.633203Z",
     "start_time": "2024-10-16T15:22:20.788014Z"
    }
   },
   "source": [
    "import tempfile\n",
    "import pandas as pd\n",
    "from pandas import DataFrame\n",
    "\n",
    "def bed_length(cell_file):\n",
    "    t = pd.read_csv(cell_file,  sep='\\t', header=None)\n",
    "    if len(t) > 0:\n",
    "        return (t[2] - t[1]).sum()\n",
    "    return 0\n",
    "\n",
    "def lines(cell_file):\n",
    "    t = pd.read_csv(cell_file,  sep='\\t', header=None)\n",
    "    return len(t)\n",
    "\n",
    "def last_col(file):\n",
    "    try:\n",
    "        cols = len(pd.read_csv(file, sep='\\t', nrows=1, header=None).columns)\n",
    "        return pd.read_csv(file, sep='\\t', header=None, usecols=[cols - 1])[cols - 1]\n",
    "    except:\n",
    "        return np.zeros(0)  # Empty file\n",
    "\n",
    "def sorted_file(file):\n",
    "    ts = tempfile.mktemp()\n",
    "    ! cat {file} | sort -k1,1 -k2,2n -k3,3n > {ts}\n",
    "    return ts\n",
    "\n",
    "t = tempfile.mktemp()\n",
    "\n",
    "results = DataFrame(columns=['cell', 'fdr', 'ref_peaks', 'ref_length',\n",
    "                             'span_peaks', 'span_length', 'intersection_peaks', 'intersection_length'])\n",
    "for cell in tqdm(CELLS):\n",
    "    cell_file = sorted_file(f'{PATH}/peaks/{cell}_peaks_chr22.bed')\n",
    "    cell_peaks = lines(cell_file)\n",
    "    cell_peaks_length = bed_length(cell_file)    \n",
    "    \n",
    "    for reads in [f for f in listdir(PATH) if f.endswith(\".bam.bed\")]:\n",
    "        for fdr in FDRS: \n",
    "            file = f'{PATH}/span/{reads}_{fdr}_span.bed'\n",
    "            if cell not in file:\n",
    "                continue\n",
    "            ! cat {file} | grep chr22 > {t}\n",
    "            t = sorted_file(t)\n",
    "            span_peaks = lines(t)\n",
    "            span_length = bed_length(t)\n",
    "            intersection_file = f'{PATH}/peaks/intersection_{cell}_{fdr}.bed'\n",
    "            ! bedtools intersect -a {cell_file} -b {t} -wo > {intersection_file}\n",
    "            intersection_peaks = lines(intersection_file)\n",
    "            intersection_length = int(last_col(intersection_file).sum())\n",
    "            results.loc[len(results)] = [cell, fdr, cell_peaks, cell_peaks_length,\n",
    "                                         span_peaks, span_length, intersection_peaks, intersection_length]\n",
    "results"
   ],
   "outputs": [
    {
     "data": {
      "text/plain": [
       "  0%|          | 0/3 [00:00<?, ?it/s]"
      ],
      "application/vnd.jupyter.widget-view+json": {
       "version_major": 2,
       "version_minor": 0,
       "model_id": "d1f8796a82db4222af662894abbce5ee"
      }
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/plain": [
       "       cell           fdr  ref_peaks  ref_length  span_peaks  span_length  \\\n",
       "0   GM12878  1.000000e-40       6253     3107182         616      1499480   \n",
       "1   GM12878  1.000000e-20       6253     3107182         895      1695760   \n",
       "2   GM12878  1.000000e-15       6253     3107182        1001      1761580   \n",
       "3   GM12878  1.000000e-10       6253     3107182        1165      1834200   \n",
       "4   GM12878  1.000000e-08       6253     3107182        1247      1866400   \n",
       "5   GM12878  1.000000e-06       6253     3107182        1339      1903630   \n",
       "6   GM12878  1.000000e-04       6253     3107182        1476      1953550   \n",
       "7   GM12878  1.000000e-03       6253     3107182        1540      1974560   \n",
       "8   GM12878  5.000000e-02       6253     3107182        1690      2015050   \n",
       "9   GM12878  1.000000e-01       6253     3107182        1731      2025410   \n",
       "10  GM12878  2.000000e-01       6253     3107182        1775      2033900   \n",
       "11  GM12878  5.000000e-01       6253     3107182        1908      2052740   \n",
       "12   HelaS3  1.000000e-40       4582     2484251         587       561950   \n",
       "13   HelaS3  1.000000e-20       4582     2484251         831       672710   \n",
       "14   HelaS3  1.000000e-15       4582     2484251         912       699390   \n",
       "15   HelaS3  1.000000e-10       4582     2484251        1037       737510   \n",
       "16   HelaS3  1.000000e-08       4582     2484251        1080       748660   \n",
       "17   HelaS3  1.000000e-06       4582     2484251        1158       767350   \n",
       "18   HelaS3  1.000000e-04       4582     2484251        1232       783720   \n",
       "19   HelaS3  1.000000e-03       4582     2484251        1267       790970   \n",
       "20   HelaS3  5.000000e-02       4582     2484251        1389       812260   \n",
       "21   HelaS3  1.000000e-01       4582     2484251        1411       815520   \n",
       "22   HelaS3  2.000000e-01       4582     2484251        1441       819570   \n",
       "23   HelaS3  5.000000e-01       4582     2484251        1489       824420   \n",
       "24     K562  1.000000e-40      11157     5694218         800      1936010   \n",
       "25     K562  1.000000e-20      11157     5694218        1200      2281650   \n",
       "26     K562  1.000000e-15      11157     5694218        1380      2399970   \n",
       "27     K562  1.000000e-10      11157     5694218        1604      2495110   \n",
       "28     K562  1.000000e-08      11157     5694218        1707      2532270   \n",
       "29     K562  1.000000e-06      11157     5694218        1809      2571720   \n",
       "30     K562  1.000000e-04      11157     5694218        1949      2617190   \n",
       "31     K562  1.000000e-03      11157     5694218        2033      2639240   \n",
       "32     K562  5.000000e-02      11157     5694218        2218      2679030   \n",
       "33     K562  1.000000e-01      11157     5694218        2248      2684580   \n",
       "34     K562  2.000000e-01      11157     5694218        2301      2692470   \n",
       "35     K562  5.000000e-01      11157     5694218        2373      2700350   \n",
       "\n",
       "    intersection_peaks  intersection_length  \n",
       "0                 1188              1075061  \n",
       "1                 1492              1185706  \n",
       "2                 1599              1218236  \n",
       "3                 1750              1256979  \n",
       "4                 1819              1273317  \n",
       "5                 1900              1294131  \n",
       "6                 2008              1318904  \n",
       "7                 2049              1327314  \n",
       "8                 2135              1343296  \n",
       "9                 2155              1346491  \n",
       "10                2174              1349194  \n",
       "11                2239              1357241  \n",
       "12                 643               513457  \n",
       "13                 880               596661  \n",
       "14                 950               615540  \n",
       "15                1063               645693  \n",
       "16                1101               654563  \n",
       "17                1160               666684  \n",
       "18                1219               677584  \n",
       "19                1245               682549  \n",
       "20                1328               694983  \n",
       "21                1341               696544  \n",
       "22                1362               698970  \n",
       "23                1396               701997  \n",
       "24                1701              1359327  \n",
       "25                2231              1548692  \n",
       "26                2425              1605852  \n",
       "27                2635              1660942  \n",
       "28                2741              1684574  \n",
       "29                2832              1703409  \n",
       "30                2937              1723875  \n",
       "31                3000              1736389  \n",
       "32                3130              1757961  \n",
       "33                3150              1761499  \n",
       "34                3180              1765502  \n",
       "35                3231              1770485  "
      ],
      "text/html": [
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       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>cell</th>\n",
       "      <th>fdr</th>\n",
       "      <th>ref_peaks</th>\n",
       "      <th>ref_length</th>\n",
       "      <th>span_peaks</th>\n",
       "      <th>span_length</th>\n",
       "      <th>intersection_peaks</th>\n",
       "      <th>intersection_length</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-40</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>616</td>\n",
       "      <td>1499480</td>\n",
       "      <td>1188</td>\n",
       "      <td>1075061</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>1</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-20</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>895</td>\n",
       "      <td>1695760</td>\n",
       "      <td>1492</td>\n",
       "      <td>1185706</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>2</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-15</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1001</td>\n",
       "      <td>1761580</td>\n",
       "      <td>1599</td>\n",
       "      <td>1218236</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>3</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-10</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1165</td>\n",
       "      <td>1834200</td>\n",
       "      <td>1750</td>\n",
       "      <td>1256979</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>4</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-08</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1247</td>\n",
       "      <td>1866400</td>\n",
       "      <td>1819</td>\n",
       "      <td>1273317</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>5</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-06</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1339</td>\n",
       "      <td>1903630</td>\n",
       "      <td>1900</td>\n",
       "      <td>1294131</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>6</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-04</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1476</td>\n",
       "      <td>1953550</td>\n",
       "      <td>2008</td>\n",
       "      <td>1318904</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>7</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-03</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1540</td>\n",
       "      <td>1974560</td>\n",
       "      <td>2049</td>\n",
       "      <td>1327314</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>8</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>5.000000e-02</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1690</td>\n",
       "      <td>2015050</td>\n",
       "      <td>2135</td>\n",
       "      <td>1343296</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>9</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-01</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1731</td>\n",
       "      <td>2025410</td>\n",
       "      <td>2155</td>\n",
       "      <td>1346491</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>10</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>2.000000e-01</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1775</td>\n",
       "      <td>2033900</td>\n",
       "      <td>2174</td>\n",
       "      <td>1349194</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>11</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>5.000000e-01</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>1908</td>\n",
       "      <td>2052740</td>\n",
       "      <td>2239</td>\n",
       "      <td>1357241</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>12</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-40</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>587</td>\n",
       "      <td>561950</td>\n",
       "      <td>643</td>\n",
       "      <td>513457</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>13</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-20</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>831</td>\n",
       "      <td>672710</td>\n",
       "      <td>880</td>\n",
       "      <td>596661</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>14</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-15</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>912</td>\n",
       "      <td>699390</td>\n",
       "      <td>950</td>\n",
       "      <td>615540</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>15</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-10</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1037</td>\n",
       "      <td>737510</td>\n",
       "      <td>1063</td>\n",
       "      <td>645693</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>16</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-08</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1080</td>\n",
       "      <td>748660</td>\n",
       "      <td>1101</td>\n",
       "      <td>654563</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>17</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-06</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1158</td>\n",
       "      <td>767350</td>\n",
       "      <td>1160</td>\n",
       "      <td>666684</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>18</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-04</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1232</td>\n",
       "      <td>783720</td>\n",
       "      <td>1219</td>\n",
       "      <td>677584</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>19</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-03</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1267</td>\n",
       "      <td>790970</td>\n",
       "      <td>1245</td>\n",
       "      <td>682549</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>20</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>5.000000e-02</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1389</td>\n",
       "      <td>812260</td>\n",
       "      <td>1328</td>\n",
       "      <td>694983</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>21</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>1.000000e-01</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1411</td>\n",
       "      <td>815520</td>\n",
       "      <td>1341</td>\n",
       "      <td>696544</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>22</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>2.000000e-01</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1441</td>\n",
       "      <td>819570</td>\n",
       "      <td>1362</td>\n",
       "      <td>698970</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>23</th>\n",
       "      <td>HelaS3</td>\n",
       "      <td>5.000000e-01</td>\n",
       "      <td>4582</td>\n",
       "      <td>2484251</td>\n",
       "      <td>1489</td>\n",
       "      <td>824420</td>\n",
       "      <td>1396</td>\n",
       "      <td>701997</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>24</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-40</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>800</td>\n",
       "      <td>1936010</td>\n",
       "      <td>1701</td>\n",
       "      <td>1359327</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>25</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-20</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1200</td>\n",
       "      <td>2281650</td>\n",
       "      <td>2231</td>\n",
       "      <td>1548692</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>26</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-15</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1380</td>\n",
       "      <td>2399970</td>\n",
       "      <td>2425</td>\n",
       "      <td>1605852</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>27</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-10</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1604</td>\n",
       "      <td>2495110</td>\n",
       "      <td>2635</td>\n",
       "      <td>1660942</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>28</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-08</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1707</td>\n",
       "      <td>2532270</td>\n",
       "      <td>2741</td>\n",
       "      <td>1684574</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>29</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-06</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1809</td>\n",
       "      <td>2571720</td>\n",
       "      <td>2832</td>\n",
       "      <td>1703409</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>30</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-04</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>1949</td>\n",
       "      <td>2617190</td>\n",
       "      <td>2937</td>\n",
       "      <td>1723875</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>31</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-03</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>2033</td>\n",
       "      <td>2639240</td>\n",
       "      <td>3000</td>\n",
       "      <td>1736389</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>32</th>\n",
       "      <td>K562</td>\n",
       "      <td>5.000000e-02</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>2218</td>\n",
       "      <td>2679030</td>\n",
       "      <td>3130</td>\n",
       "      <td>1757961</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>33</th>\n",
       "      <td>K562</td>\n",
       "      <td>1.000000e-01</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>2248</td>\n",
       "      <td>2684580</td>\n",
       "      <td>3150</td>\n",
       "      <td>1761499</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>34</th>\n",
       "      <td>K562</td>\n",
       "      <td>2.000000e-01</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>2301</td>\n",
       "      <td>2692470</td>\n",
       "      <td>3180</td>\n",
       "      <td>1765502</td>\n",
       "    </tr>\n",
       "    <tr>\n",
       "      <th>35</th>\n",
       "      <td>K562</td>\n",
       "      <td>5.000000e-01</td>\n",
       "      <td>11157</td>\n",
       "      <td>5694218</td>\n",
       "      <td>2373</td>\n",
       "      <td>2700350</td>\n",
       "      <td>3231</td>\n",
       "      <td>1770485</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "execution_count": 5
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "Now that we have both reference peaks, span output and their intersection length, we can compute `TP`, `FP` and `FN` values."
   ]
  },
  {
   "cell_type": "code",
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:22:50.694786Z",
     "start_time": "2024-10-16T15:22:50.679482Z"
    }
   },
   "source": [
    "results['TP'] = results['intersection_length']\n",
    "results['FP'] = results['span_length'] - results['intersection_length']\n",
    "results['FN'] = results['ref_length'] - results['intersection_length']\n",
    "results['Spec'] = results['TP'] / (results['TP'] + results['FP'])\n",
    "results['Sen'] = results['TP'] / (results['TP'] + results['FN'])\n",
    "results.head(1)"
   ],
   "outputs": [
    {
     "data": {
      "text/plain": [
       "      cell           fdr  ref_peaks  ref_length  span_peaks  span_length  \\\n",
       "0  GM12878  1.000000e-40       6253     3107182         616      1499480   \n",
       "\n",
       "   intersection_peaks  intersection_length       TP      FP       FN  \\\n",
       "0                1188              1075061  1075061  424419  2032121   \n",
       "\n",
       "       Spec       Sen  \n",
       "0  0.716956  0.345992  "
      ],
      "text/html": [
       "<div>\n",
       "<style scoped>\n",
       "    .dataframe tbody tr th:only-of-type {\n",
       "        vertical-align: middle;\n",
       "    }\n",
       "\n",
       "    .dataframe tbody tr th {\n",
       "        vertical-align: top;\n",
       "    }\n",
       "\n",
       "    .dataframe thead th {\n",
       "        text-align: right;\n",
       "    }\n",
       "</style>\n",
       "<table border=\"1\" class=\"dataframe\">\n",
       "  <thead>\n",
       "    <tr style=\"text-align: right;\">\n",
       "      <th></th>\n",
       "      <th>cell</th>\n",
       "      <th>fdr</th>\n",
       "      <th>ref_peaks</th>\n",
       "      <th>ref_length</th>\n",
       "      <th>span_peaks</th>\n",
       "      <th>span_length</th>\n",
       "      <th>intersection_peaks</th>\n",
       "      <th>intersection_length</th>\n",
       "      <th>TP</th>\n",
       "      <th>FP</th>\n",
       "      <th>FN</th>\n",
       "      <th>Spec</th>\n",
       "      <th>Sen</th>\n",
       "    </tr>\n",
       "  </thead>\n",
       "  <tbody>\n",
       "    <tr>\n",
       "      <th>0</th>\n",
       "      <td>GM12878</td>\n",
       "      <td>1.000000e-40</td>\n",
       "      <td>6253</td>\n",
       "      <td>3107182</td>\n",
       "      <td>616</td>\n",
       "      <td>1499480</td>\n",
       "      <td>1188</td>\n",
       "      <td>1075061</td>\n",
       "      <td>1075061</td>\n",
       "      <td>424419</td>\n",
       "      <td>2032121</td>\n",
       "      <td>0.716956</td>\n",
       "      <td>0.345992</td>\n",
       "    </tr>\n",
       "  </tbody>\n",
       "</table>\n",
       "</div>"
      ]
     },
     "execution_count": 6,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "execution_count": 6
  },
  {
   "cell_type": "code",
   "source": [
    "import seaborn as sns\n",
    "plt.figure(figsize=(4.5, 3))\n",
    "g_results = sns.lineplot(data=results,\n",
    "                         x='fdr', y='span_peaks', hue='cell',\n",
    "                         errorbar='se', marker='o', markersize=8)\n",
    "g_results.axes.title.set_text(f'Peaks')\n",
    "# g_results.axes.legend(loc='center left', bbox_to_anchor=(1, 0.5))\n",
    "plt.tight_layout()\n",
    "# plt.savefig(f'{GSE26320_PATH_HG38}/pics/H3K4me1_jaccard2.pdf', bbox_inches='tight', dpi=300)\n",
    "plt.show()"
   ],
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:22:53.980305Z",
     "start_time": "2024-10-16T15:22:53.469233Z"
    }
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "<Figure size 450x300 with 1 Axes>"
      ],
      "image/png": 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"
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "execution_count": 7
  },
  {
   "cell_type": "code",
   "source": [
    "plt.figure(figsize=(4, 4))\n",
    "ax = plt.axes()\n",
    "for cell in tqdm(CELLS):\n",
    "    t = results[results['cell'] == cell].copy()\n",
    "    t.sort_values(by=['Sen', 'Spec'], inplace=True)\n",
    "    plt.plot(t['Sen'], t['Spec'], marker='o', label=cell)\n",
    "ax.set(xscale='log')\n",
    "plt.xlabel('Sensitivity')\n",
    "plt.ylabel('Specificity')\n",
    "plt.tight_layout()\n",
    "plt.show()"
   ],
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:22:58.715766Z",
     "start_time": "2024-10-16T15:22:58.192557Z"
    }
   },
   "outputs": [
    {
     "data": {
      "text/plain": [
       "  0%|          | 0/3 [00:00<?, ?it/s]"
      ],
      "application/vnd.jupyter.widget-view+json": {
       "version_major": 2,
       "version_minor": 0,
       "model_id": "5088cd3c5204417eb4e4c497e59062be"
      }
     },
     "metadata": {},
     "output_type": "display_data"
    },
    {
     "data": {
      "text/plain": [
       "<Figure size 400x400 with 1 Axes>"
      ],
      "image/png": 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"
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "execution_count": 8
  },
  {
   "cell_type": "code",
   "metadata": {
    "collapsed": false,
    "ExecuteTime": {
     "end_time": "2024-10-16T15:23:00.127155Z",
     "start_time": "2024-10-16T15:22:59.865500Z"
    }
   },
   "source": [
    "CELLS = ['GM12878', 'HelaS3', 'K562']\n",
    "\n",
    "def Fb(b, spec, sen):\n",
    "    return (1 + b*b) * spec * sen / (b * b * spec + sen)\n",
    "\n",
    "plt.figure(figsize=(3, 4))\n",
    "ax = plt.axes()\n",
    "Beta = 0.5\n",
    "colors = {'GM12878': 'red', 'K562': 'blue', 'HelaS3':'violet'}\n",
    "plt.title('SPAN')\n",
    "plt.xlabel('threshold')\n",
    "plt.ylabel('F_0.5')\n",
    "for cell in CELLS:\n",
    "    r = results[(results['cell'] == cell)]\n",
    "    plt.plot(r['fdr'], Fb(Beta, r['Spec'], r['Sen']), linewidth=3.0, c=colors[cell], label=cell)\n",
    "plt.axvline(x=0.05, linewidth=3.0, c='grey', linestyle='--')\n",
    "plt.ylim(0.25, 0.85)\n",
    "# ax.set(xscale='log')\n",
    "plt.tight_layout()\n",
    "plt.legend()\n",
    "plt.show()"
   ],
   "outputs": [
    {
     "data": {
      "text/plain": [
       "<Figure size 300x400 with 1 Axes>"
      ],
      "image/png": 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"
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "execution_count": 9
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Now we are ready to compare performance score F\n",
    "<img src=\"SPAN Comparison Opendnase.png\">"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "outputs": [],
   "source": [],
   "metadata": {
    "collapsed": false
   }
  }
 ],
 "metadata": {
  "kernelspec": {
   "name": "python3",
   "language": "python",
   "display_name": "Python 3 (ipykernel)"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 2
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython2",
   "version": "2.7.6"
  },
  "pycharm": {
   "stem_cell": {
    "cell_type": "raw",
    "source": [],
    "metadata": {
     "collapsed": false
    }
   }
  }
 },
 "nbformat": 4,
 "nbformat_minor": 0
}