diff --git a/app/package.json b/app/package.json
index 035d2b0..433bf69 100644
--- a/app/package.json
+++ b/app/package.json
@@ -23,8 +23,8 @@
   "license": "Apache-2.0",
   "homepage": "https://github.com/KitwareMedical/ITKIOScanco#readme",
   "dependencies": {
-    "itk-image-io": "1.0.0-b.132",
-    "itk-wasm": "1.0.0-b.132"
+    "@itk-wasm/image-io": "^0.3.0",
+    "itk-wasm": "1.0.0-b.149"
   },
   "devDependencies": {
     "@itk-wasm/dam": "^1.0.1",
@@ -38,4 +38,4 @@
     "type": "git",
     "url": "https://github.com/KitwareMedical/ITKIOScanco"
   }
-}
\ No newline at end of file
+}
diff --git a/app/pnpm-lock.yaml b/app/pnpm-lock.yaml
index db8ab5a..baeec34 100644
--- a/app/pnpm-lock.yaml
+++ b/app/pnpm-lock.yaml
@@ -5,12 +5,12 @@ settings:
   excludeLinksFromLockfile: false
 
 dependencies:
-  itk-image-io:
-    specifier: 1.0.0-b.132
-    version: 1.0.0-b.132
+  '@itk-wasm/image-io':
+    specifier: ^0.3.0
+    version: 0.3.0
   itk-wasm:
-    specifier: 1.0.0-b.132
-    version: 1.0.0-b.132
+    specifier: 1.0.0-b.149
+    version: 1.0.0-b.149
 
 devDependencies:
   '@itk-wasm/dam':
@@ -313,6 +313,14 @@ packages:
       - debug
     dev: true
 
+  /@itk-wasm/image-io@0.3.0:
+    resolution: {integrity: sha512-xXOmQdQ2Pp7N7xgaHeHriVRKav694uXUPikqsesfWcf++zHaJc2RoRvN4/kWcewanWc/zM7RlTLF3Jnxype74Q==}
+    dependencies:
+      itk-wasm: 1.0.0-b.149
+    transitivePeerDependencies:
+      - debug
+    dev: false
+
   /@lit-labs/react@1.2.1:
     resolution: {integrity: sha512-DiZdJYFU0tBbdQkfwwRSwYyI/mcWkg3sWesKRsHUd4G+NekTmmeq9fzsurvcKTNVa0comNljwtg4Hvi1ds3V+A==}
     dev: true
@@ -449,6 +457,10 @@ packages:
       qr-creator: 1.0.0
     dev: true
 
+  /@thewtex/zstddec@0.1.2:
+    resolution: {integrity: sha512-Bv50pouFqlmIZDcAA2Nrpk9tjJpAPlqHHeD5h0noK+oNXMimrZ/hMbJK2N09Svr6TI/S6nT63dzkWoim4ZzTuw==}
+    dev: false
+
   /@types/emscripten@1.39.7:
     resolution: {integrity: sha512-tLqYV94vuqDrXh515F/FOGtBcRMTPGvVV1LzLbtYDcQmmhtpf/gLYf+hikBbQk8MzOHNz37wpFfJbYAuSn8HqA==}
     dev: false
@@ -930,19 +942,12 @@ packages:
     engines: {node: '>=16.0.0', npm: '>=7.0.0'}
     dev: true
 
-  /itk-image-io@1.0.0-b.132:
-    resolution: {integrity: sha512-WHvubOh9zaXLnAGJO0wmElRoBxaq9JvHmrmP05obujBjP1n1LwkH4WXtud6LcWHfSp9BuTM7rdUGyzMigLZbmw==}
-    dependencies:
-      itk-wasm: 1.0.0-b.132
-    transitivePeerDependencies:
-      - debug
-    dev: false
-
-  /itk-wasm@1.0.0-b.132:
-    resolution: {integrity: sha512-sGiOR2hKqdGxDywESg71cdDUzFo3d5RJ882DB5Tdc6j2idGDyguKiJ2BcbjRdpFD+sXmpehgAI/Vmb0me0d9iw==}
+  /itk-wasm@1.0.0-b.149:
+    resolution: {integrity: sha512-G1wvURAGMz/0XjHK1TKb4dZLwMV4+zsUZcuEkokH2fVtxWotj93OL3mrJvs7fhQ0Jenusf4COFN4yZ9Xt37SEA==}
     hasBin: true
     dependencies:
       '@babel/runtime': 7.22.6
+      '@thewtex/zstddec': 0.1.2
       '@types/emscripten': 1.39.7
       axios: 1.4.0
       commander: 9.5.0
diff --git a/app/src/conversion-controller.ts b/app/src/conversion-controller.ts
index 658e196..c45bcfa 100644
--- a/app/src/conversion-controller.ts
+++ b/app/src/conversion-controller.ts
@@ -1,4 +1,4 @@
-import { readImageArrayBuffer, writeImageArrayBuffer } from "itk-wasm"
+import { readImage, writeImage } from "@itk-wasm/image-io"
 
 import conversionLoadSampleInputs from "./conversion-load-sample-inputs.js"
 import { notify, downloadFile } from "./utilities.js"
@@ -91,19 +91,18 @@ class ConversionController  {
         runButton.loading = true
         const t0 = performance.now()
 
-        const { webWorker, image } = await readImageArrayBuffer(this.webWorker,
-          model.inputVolume.slice(),
-          'volume.aim'
+        const { webWorker, image } = await readImage(this.webWorker,
+          { data: model.inputVolume.slice(), path: 'volume.isq' }
         )
         this.webWorker = webWorker
         // Avoid later use of detached buffer
         const direction = image.direction.slice()
-        const { arrayBuffer } = await writeImageArrayBuffer(webWorker, image, `${model.inputFileName}.${model.outputFormat}`)
+        const { serializedImage } = await writeImage(webWorker, image, `${model.inputFileName}.${model.outputFormat}`)
 
         const t1 = performance.now()
         notify("conversion successfully completed", `in ${t1 - t0} milliseconds.`, "success", "rocket-fill")
 
-        model.outputVolume = new Uint8Array(arrayBuffer)
+        model.outputVolume = new Uint8Array(serializedImage.data)
 
         outputOutputDownload.variant = "success"
         outputOutputDownload.disabled = false
diff --git a/app/src/index.ts b/app/src/index.ts
index fed2a3d..21e5cee 100644
--- a/app/src/index.ts
+++ b/app/src/index.ts
@@ -1,2 +1,8 @@
+import * as imageIo from '@itk-wasm/image-io'
+
+// Use local, vendored WebAssembly module assets
+const pipelinesBaseUrl: string | URL = new URL('/itk/image-io', document.location.origin).href
+imageIo.setPipelinesBaseUrl(pipelinesBaseUrl)
+
 import './conversion-controller.js'
 // import './calibration-controller.js'
diff --git a/app/vite.config.js b/app/vite.config.js
index cb40710..393c02b 100644
--- a/app/vite.config.js
+++ b/app/vite.config.js
@@ -9,23 +9,18 @@ export default defineConfig({
     outDir: 'dist',
     emptyOutDir: true,
   },
+  worker: {
+    format: 'es'
+  },
+  optimizeDeps: {
+    exclude: ['@itk-wasm/image-io']
+  },
   plugins: [
     // put lazy loaded JavaScript and Wasm bundles in dist directory
     viteStaticCopy({
       targets: [
-        { src: 'node_modules/itk-wasm/dist/web-workers/*', dest: 'itk/web-workers' },
-        {
-          src: 'node_modules/itk-image-io/*',
-          dest: 'itk/image-io',
-        },
+        { src: 'node_modules/@itk-wasm/image-io/dist/pipelines/*.{js,wasm.zst}', dest: 'itk/image-io' },
       ],
     })
   ],
-  resolve: {
-    // where itk-wasm code has 'import ../itkConfig.js` point to the path of itkConfig
-    alias: {
-      '../itkConfig.js': itkConfig,
-      '../../itkConfig.js': itkConfig
-    }
-  }
 })