Repository containing data analysis scripts and figures for the FungAMR paper. A searchable version of Supplementary Table 1 is available at the Comprehensive Antibiotic Resistance Database.
bioRxiv: FungAMR: A comprehensive portrait of antimicrobial resistance mutations in fungi.
| Confidence Score | Description |
|---|---|
| 1 | The mutation was created in the same susceptible species background and effect on resistance was confirmed by measurements. |
| 2 | The mutation was created in the same gene but expressed in another species with potentially non endogenous level of expression and effect on resistance was confirmed by experimental measurements. |
| 3 | The effect of the mutation was quantified by bulk competition assays such as Deep Mutational Scanning. |
| 4 | The mutation was identified by experimental evolution where its high frequency in independent replicates suggests it causes resistance. |
| 5 | The deletion of the gene causes resistance. |
| 6 | The overexpression or duplication of the gene causes resistance. |
| 7 | Significant association between the mutation and resistance in a population as determined by GWAS (or other population-based association such as QTL or classical genetics). |
| 8 | The mutation was identified in a 'natural' strain (e.g. a clinical isolate) that is resistant but without any further validations. |
| Negative scores (-) | Any confidence score where the mutation was found not to cause resistance using the approach of the corresponding positive score. |