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The best national source of data on drug overdoses is the US Vital Statistics records, which include data on every death in the United States. Because their interface is a pain (e.g. you can only pull 75,000 records at a time, and picking the right variables to download is really annoying), I’ve pre-downloaded their summary of mortality for drug and non-drug-related causes for every US county from 2003-2015 for your use. You can download that data here.
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