2023-10-19

[explodecomputer]

Lynsey introduction

DONE

mod_qos

• fail2ban - explore as an alternative

Jason's updates on user registration system

• email based system could be gamed by malicious user
• ideally have a 1-1 mapping of user to identity which would be easier with oauth2
• user registration system with oauth2 requirement
• consider using microsoft, GitHub, google
• email registration system might be simplest, with email verification required
• consider multiple options
• push version on TwoSampleMR and update message - link to documentation about traffic issues
• deploy current 'development' to OCI
• domain name
  • gwas.mrcieu.ac.uk not relevant in a few years
  • potentially move to opengwas.io
  • permanent redirect option
  • can use install.packages("TwoSampleMR", repos="https://mrcieu.r-universe.dev/") - update documentation
  • Potentially need to think about ownership

Tom Palmer - r-universe

• Precompiled binary packages for non cran/bioconductor packages
• https://mrcieu.r-universe.dev/builds
• Tom putting lots of MR packages on there
• Update documentation to tell people to use that by default, will drastically improve installation
• Need to check builds

Rita's updates

• LD matrix output from API could be modified for gwasglue2
• benefit from feedback

Data updates

• ebi-a - n=3746 (10 excluded)
• ubm-b - n=3935 (raw)
• We should implement automated pull down from EBI

Local LD proxies (Andrew)

• Two new options: allow local LD clumping, or user can provide list of IVs (and no pruning performed) n-mounier/MRlap#10

Communication plan

1. Blog on gwas.mrcieu.ac.uk – primary communication of news
2. Package documentation e.g. TwoSampleMR / ieugwasr etc
3. Twitter (X) – to announce updates / link to news on blog
4. Announce updates on TwoSampleMR package startup messages
5. Data changelog
6. API changelog

Programme manager

• job advert

Python ecosystem

• https://github.com/nishpatel512/Mandelian-Randomization - tom to reach out

Frequency of these meetings

• 15 minute meetings every week + 1hr every month e.g. 4pm