diff --git a/packages/specification/schemas/components/MedicationRequest/CancelRequestMedicationRequest.yaml b/packages/specification/schemas/components/MedicationRequest/CancelRequestMedicationRequest.yaml
index e7904ec00b..6f3e562780 100644
--- a/packages/specification/schemas/components/MedicationRequest/CancelRequestMedicationRequest.yaml
+++ b/packages/specification/schemas/components/MedicationRequest/CancelRequestMedicationRequest.yaml
@@ -146,7 +146,10 @@ properties:
             example: "2022-10-21"
           end:
             type: string
-            description: For eRD prescriptions only. The end date of a prescription.
+            description: |
+              For eRD prescriptions only. The end date of a prescription.
+              Must be in date-time format with the time set to 23:59:59 on the last valid day of the prescription, including for single-day prescriptions. 
+              Example: "2022-10-21T23:59:59Z"
             format: date-time
             example: "2022-10-21T23:59:59Z"
       expectedSupplyDuration:
diff --git a/packages/specification/schemas/components/MedicationRequest/DispenseNotificationMedicationRequest.yaml b/packages/specification/schemas/components/MedicationRequest/DispenseNotificationMedicationRequest.yaml
index 7f793d3900..51a796a838 100644
--- a/packages/specification/schemas/components/MedicationRequest/DispenseNotificationMedicationRequest.yaml
+++ b/packages/specification/schemas/components/MedicationRequest/DispenseNotificationMedicationRequest.yaml
@@ -160,8 +160,10 @@ properties:
             description: |
               End date of an issue; capped at 12 months and cannot exceed the prescription's end date.
               Overall validity of the drug.
-            format: date-time
-            example: "2022-10-21T23:59:59Z"
+              Must be in date-time format with the time set to 23:59:59 on the last valid day of the prescription, including for single-day prescriptions. 
+              Example: "2022-10-21T23:59:59Z"
+            format: date-time   
+            example: "2022-10-21T23:59:59Z"        
       expectedSupplyDuration:
         type: object
         description: |
diff --git a/packages/specification/schemas/components/MedicationRequest/MedicationRequest.yaml b/packages/specification/schemas/components/MedicationRequest/MedicationRequest.yaml
index 6d6dfe0d49..7e2cff48d0 100644
--- a/packages/specification/schemas/components/MedicationRequest/MedicationRequest.yaml
+++ b/packages/specification/schemas/components/MedicationRequest/MedicationRequest.yaml
@@ -156,6 +156,8 @@ properties:
             description: |
               End date of an issue; capped at 12 months and cannot exceed the prescription's end date.
               Overall validity of the drug.
+              Must be in date-time format with the time set to 23:59:59 on the last valid day of the prescription, including for single-day prescriptions. 
+              Example: "2022-10-21T23:59:59Z"
             format: date-time
             example: "2022-10-21T23:59:59Z"
       expectedSupplyDuration:
diff --git a/packages/specification/schemas/components/MedicationRequest/ReleaseMedicationRequest.yaml b/packages/specification/schemas/components/MedicationRequest/ReleaseMedicationRequest.yaml
index 6c5613c3f4..f793d067a2 100644
--- a/packages/specification/schemas/components/MedicationRequest/ReleaseMedicationRequest.yaml
+++ b/packages/specification/schemas/components/MedicationRequest/ReleaseMedicationRequest.yaml
@@ -153,6 +153,8 @@ properties:
             description: |
               End date of an issue; capped at 12 months and cannot exceed the prescription's end date.
               Overall validity of the drug.
+              Must be in date-time format with the time set to 23:59:59 on the last valid day of the prescription, including for single-day prescriptions. 
+              Example: "2022-10-21T23:59:59Z"
             format: date-time
             example: "2022-10-21T23:59:59Z"
       expectedSupplyDuration: