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<style type="text/css" media="screen">
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<article class="guide" ng-controller="AdLibDataController">
<carousel class="deck container-fluid">
<!--slide class="row-fluid">
<div class="col-sm-3">
<h3>Does Bupropion treat nicotine dependence?</h3>
<p class="lead">Information</p>
<!dl>
<dt>author"</dt><dd>Daniel Himmelstein</dd>
</dl>
</div>
<div class="col-sm-9">
<figure>
<img style="width:300px" src=""/>
</figure>
</div>
</slide-->
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Does Bupropion treat nicotine dependence?</h3>
<br/>
<div>
<div class="paragraph">
<p>Project Rephetio predicted a <strong>probability of 1.265%</strong> that Bupropion (<a href="http://www.drugbank.ca/drugs/DB01156"><code>DB01156</code></a>) treats nicotine dependence (<a href="http://www.disease-ontology.org/?id=DOID:0050742"><code>DOID:0050742</code></a>). This probability represents a 2.50-fold enrichment over the background prevalence of treatment. This prediction is in the 96.3<sup>th</sup> percentile for Bupropion and the 99.5<sup>th</sup> percentile for nicotine dependence.</p>
</div>
<h4>Most supportive network paths</h4>
<div class="paragraph">
<p>Run the following query to show the 10 paths which contributed most to this prediction.
Toggle <code>AUTO-COMPLETE</code> to <code>OFF</code> to only show relationships that are in these paths.</p>
</div>
<div class="listingblock">
<div class="content">
<pre mode="cypher" class="highlight pre-scrollable programlisting cm-s-neo code runnable standalone-example ng-binding" data-lang="cypher" lang="cypher"><!--code class="cypher language-cypher"-->MATCH p0 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p1 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:BINDS_CbG]-(:Compound {identifier: "DB01273"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:0050742"})
MATCH p2 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "WP1603_r78574"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 1143})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p3 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_4468"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 1142})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p4 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_4468"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 8973})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p5 = (:Compound {identifier: "DB01156"})-[:CAUSES_CcSE]-(:SideEffect {identifier: "C0541798"})-[:CAUSES_CcSE]-(:Compound {identifier: "DB01273"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:0050742"})
MATCH p6 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_4469"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 1142})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p7 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_4469"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 8973})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p8 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_4470"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 1143})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
MATCH p9 = (:Compound {identifier: "DB01156"})-[:BINDS_CbG]-(:Gene {identifier: 1136})-[:PARTICIPATES_GpPW]-(:Pathway {identifier: "PC7_6571"})-[:PARTICIPATES_GpPW]-(:Gene {identifier: 1142})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:0050742"})
RETURN [p0, p1, p2, p3, p4, p5, p6, p7, p8, p9]<!--/code--></pre>
</div>
</div>
<h4>Is this a known treatment?</h4>
<div class="paragraph">
<p><a href="https://doi.org/10.15363/thinklab.d182">PharmacotherapyDB v1.0</a> does not contain an indication between Bupropion and nicotine dependence. ClinicalTrials.gov contains 40 clinical trials investigating whether Bupropion treats nicotine dependence (<a href="https://clinicaltrials.gov/ct2/show/NCT00006170"><span class="small">NCT00006170</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00063323"><span class="small">NCT00063323</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00086385"><span class="small">NCT00086385</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00086411"><span class="small">NCT00086411</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00087880"><span class="small">NCT00087880</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00104598"><span class="small">NCT00104598</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00119210"><span class="small">NCT00119210</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00124683"><span class="small">NCT00124683</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00129272"><span class="small">NCT00129272</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00133757"><span class="small">NCT00133757</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00136747"><span class="small">NCT00136747</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00136760"><span class="small">NCT00136760</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00136786"><span class="small">NCT00136786</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00142831"><span class="small">NCT00142831</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00176449"><span class="small">NCT00176449</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00218231"><span class="small">NCT00218231</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00236288"><span class="small">NCT00236288</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00248118"><span class="small">NCT00248118</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00296647"><span class="small">NCT00296647</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00307203"><span class="small">NCT00307203</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00308763"><span class="small">NCT00308763</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00330187"><span class="small">NCT00330187</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00396669"><span class="small">NCT00396669</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00419731"><span class="small">NCT00419731</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00484692"><span class="small">NCT00484692</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00507728"><span class="small">NCT00507728</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00511134"><span class="small">NCT00511134</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00534001"><span class="small">NCT00534001</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00563563"><span class="small">NCT00563563</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00587769"><span class="small">NCT00587769</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00666978"><span class="small">NCT00666978</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00749658"><span class="small">NCT00749658</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01015170"><span class="small">NCT01015170</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01023659"><span class="small">NCT01023659</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01390246"><span class="small">NCT01390246</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01576640"><span class="small">NCT01576640</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01892813"><span class="small">NCT01892813</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT01965405"><span class="small">NCT01965405</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT02146911"><span class="small">NCT02146911</span></a>, <a href="https://clinicaltrials.gov/ct2/show/NCT02245308"><span class="small">NCT02245308</span></a>).</p>
</div>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by path</h3>
<br/>
<div>
<div class="paragraph">
<p>Which paths provided the most support for this prediction? The following table shows the percent contribution of each path. The number of reported paths is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 55.5556%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Percent of DWPC</th>
<th class="tableblock halign-left valign-top">Metapath</th>
<th class="tableblock halign-left valign-top">Length</th>
<th class="tableblock halign-left valign-top">Verbose Path</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">41.30%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">100.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">38.50%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">100.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–binds–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.52%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5.47%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Nicotine Activity on Chromaffin Cells–participates–CHRNB4–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.41%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.35%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable nicotinic acetylcholine receptors–participates–CHRNB3–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.39%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.12%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable nicotinic acetylcholine receptors–participates–CHRNA6–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.37%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.59%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Terminal insomnia–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.35%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.70%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable postsynaptic nicotinic acetylcholine receptors–participates–CHRNB3–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.33%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.51%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable postsynaptic nicotinic acetylcholine receptors–participates–CHRNA6–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.33%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.49%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly sodium permeable acetylcholine nicotinic receptors–participates–CHRNB4–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.33%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.46%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Presynaptic nicotinic acetylcholine receptors–participates–CHRNB3–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.32%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.11%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Snoring–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.31%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Presynaptic nicotinic acetylcholine receptors–participates–CHRNA6–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.29%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.05%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Acetylcholine Binding And Downstream Events–participates–CHRNB3–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.75%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Cardiac flutter–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.75%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Middle insomnia–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.27%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Acetylcholine Binding And Downstream Events–participates–CHRNA6–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.27%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.86%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable nicotinic acetylcholine receptors–participates–CHRNB4–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.47%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Chest wall pain–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.47%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Initial insomnia–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.25%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable nicotinic acetylcholine receptors–participates–CHRNA5–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.25%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Panic reaction–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.25%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–causes–Somnambulism–causes–Varenicline–treats–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.43%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly calcium permeable postsynaptic nicotinic acetylcholine receptors–participates–CHRNB4–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.22%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.33%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Highly sodium permeable acetylcholine nicotinic receptors–participates–CHRNB2–associates–nicotine dependence</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.21%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.27%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion–binds–CHRNA3–participates–Presynaptic nicotinic acetylcholine receptors–participates–CHRNB4–associates–nicotine dependence</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by metapath</h3>
<br/>
<div>
<div class="paragraph">
<p>Which types of paths provided the most support for this prediction? The following table shows the percent contribution of each metapath.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 50%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Metapath</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Length</th>
<th class="tableblock halign-left valign-top">Verbose</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">41.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–associates–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">38.48%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–binds–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">10.36%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">208</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–causes–Side Effect–causes–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">9.47%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">142</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–participates–Pathway–participates–Gene–associates–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGeAlD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.42%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">13</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–expresses–Anatomy–localizes–Disease</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by source edge</h3>
<br/>
<div>
<div class="paragraph">
<p>The source edge of a path refers to its first edge. The following table shows the total contribution of each source edge across all paths. The number of displayed edges is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 57.1428%;">
<col style="width: 14.2857%;">
<col style="width: 14.2857%;">
<col style="width: 14.2858%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Source Edge</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Distinct Metapaths</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CHRNA3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">87.77%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">57</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Terminal insomnia</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.37%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Snoring</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.32%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2B6</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.31%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">12</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Middle insomnia</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Cardiac flutter</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2A6</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Chest wall pain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Initial insomnia</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.26%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2E1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.24%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Somnambulism</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Panic reaction</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Gingival pain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.21%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—SLC6A3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.21%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">19</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Vitreous floaters</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.21%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—ORM1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.20%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2D6</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.20%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2C8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.19%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">10</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—binds—CYP2C9</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.17%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">10</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Joint stiffness</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.15%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Sensory disturbance</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.15%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Anger</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.13%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Respiratory tract congestion</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.13%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Musculoskeletal chest pain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.12%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Bupropion—causes—Drug hypersensitivity</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.12%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by target edge</h3>
<br/>
<div>
<div class="paragraph">
<p>The target edge of a path refers to its last edge. The following table shows the total contribution of each target edge across all paths. The number of displayed edges is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 57.1428%;">
<col style="width: 14.2857%;">
<col style="width: 14.2857%;">
<col style="width: 14.2858%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Target Edge</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Distinct Metapaths</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—treats—Varenicline</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">48.86%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">209</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNA3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">41.31%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNB4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.85%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNA6</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.64%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">10</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNB3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.52%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">9</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CYP2A7</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.32%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">63</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNA5</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.05%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">10</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNB2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.98%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—CHRNA4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.89%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—localizes—saliva</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.20%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—localizes—brain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.13%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—GABRA4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.10%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">7</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—DRD2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—localizes—cardiovascular system</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.06%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—associates—AKR1B10</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.05%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">7</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">nicotine dependence—localizes—midbrain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.03%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
</tbody>
</table>
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