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<style type="text/css" media="screen">
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<article class="guide" ng-controller="AdLibDataController">
<carousel class="deck container-fluid">
<!--slide class="row-fluid">
<div class="col-sm-3">
<h3>Does Clofarabine treat multiple sclerosis?</h3>
<p class="lead">Information</p>
<!dl>
<dt>author"</dt><dd>Daniel Himmelstein</dd>
</dl>
</div>
<div class="col-sm-9">
<figure>
<img style="width:300px" src=""/>
</figure>
</div>
</slide-->
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Does Clofarabine treat multiple sclerosis?</h3>
<br/>
<div>
<div class="paragraph">
<p>Project Rephetio predicted a <strong>probability of 8.798%</strong> that Clofarabine (<a href="http://www.drugbank.ca/drugs/DB00631"><code>DB00631</code></a>) treats multiple sclerosis (<a href="http://www.disease-ontology.org/?id=DOID:2377"><code>DOID:2377</code></a>). This probability represents a 23.37-fold enrichment over the background prevalence of treatment. This prediction is in the 98.5<sup>th</sup> percentile for Clofarabine and the 99.8<sup>th</sup> percentile for multiple sclerosis.</p>
</div>
<h4>Most supportive network paths</h4>
<div class="paragraph">
<p>Run the following query to show the 10 paths which contributed most to this prediction.
Toggle <code>AUTO-COMPLETE</code> to <code>OFF</code> to only show relationships that are in these paths.</p>
</div>
<div class="listingblock">
<div class="content">
<pre mode="cypher" class="highlight pre-scrollable programlisting cm-s-neo code runnable standalone-example ng-binding" data-lang="cypher" lang="cypher"><!--code class="cypher language-cypher"-->MATCH p0 = (:Compound {identifier: "DB00631"})-[:INCLUDES_PCiC]-(:PharmacologicClass {identifier: "N0000000233"})-[:INCLUDES_PCiC]-(:Compound {identifier: "DB00993"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p1 = (:Compound {identifier: "DB00631"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p2 = (:Compound {identifier: "DB00631"})-[:BINDS_CbG]-(:Gene {identifier: 6240})-[:ASSOCIATES_DaG]-(:Disease {identifier: "DOID:2377"})
MATCH p3 = (:Compound {identifier: "DB00631"})-[:BINDS_CbG]-(:Gene {identifier: 6241})-[:BINDS_CbG]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p4 = (:Compound {identifier: "DB00631"})-[:BINDS_CbG]-(:Gene {identifier: 6240})-[:BINDS_CbG]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p5 = (:Compound {identifier: "DB00631"})-[:BINDS_CbG]-(:Gene {identifier: 5422})-[:BINDS_CbG]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p6 = (:Compound {identifier: "DB00631"})-[:BINDS_CbG]-(:Gene {identifier: 1633})-[:BINDS_CbG]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p7 = (:Compound {identifier: "DB00631"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB06213"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p8 = (:Compound {identifier: "DB00631"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB01073"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
MATCH p9 = (:Compound {identifier: "DB00631"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB01280"})-[:RESEMBLES_CrC]-(:Compound {identifier: "DB00242"})-[:TREATS_CtD]-(:Disease {identifier: "DOID:2377"})
RETURN [p0, p1, p2, p3, p4, p5, p6, p7, p8, p9]<!--/code--></pre>
</div>
</div>
<h4>Is this a known treatment?</h4>
<div class="paragraph">
<p><a href="https://doi.org/10.15363/thinklab.d182">PharmacotherapyDB v1.0</a> does not contain an indication between Clofarabine and multiple sclerosis. No matching clinical trials were found in ClinicalTrials.gov.</p>
</div>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by path</h3>
<br/>
<div>
<div class="paragraph">
<p>Which paths provided the most support for this prediction? The following table shows the percent contribution of each path. The number of reported paths is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 11.1111%;">
<col style="width: 55.5556%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Percent of DWPC</th>
<th class="tableblock halign-left valign-top">Metapath</th>
<th class="tableblock halign-left valign-top">Length</th>
<th class="tableblock halign-left valign-top">Verbose Path</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">24.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">100.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CiPCiCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–includes–Nucleic Acid Synthesis Inhibitors–includes–Azathioprine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">23.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">100.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">15.30%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">100.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–RRM1–associates–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">27.20%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–RRM2–binds–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">27.20%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–RRM1–binds–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.24%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">23.50%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–POLA1–binds–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.61%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">14.50%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–DCK–binds–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.10%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">14.60%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Regadenoson–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.97%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">13.70%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Fludarabine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.85%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">12.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Nelarabine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.85%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">12.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Adenosine monophosphate–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11.60%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Vidarabine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11.60%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Azacitidine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11.60%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Adenosine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.59%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">11.10%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–resembles–Decitabine–resembles–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.56%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.09%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–ABCG2–binds–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.41%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.25%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–ABCG2–binds–Mitoxantrone–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.21%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.17%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–ABCG2–binds–Dexamethasone–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.18%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5.72%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–causes–Death–causes–Fingolimod–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.17%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.94%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–ABCG2–binds–Methotrexate–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.13%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">16.80%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–RRM1–participates–Nucleotide Metabolism–participates–SRM–associates–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.11%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">13.80%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–RRM2–participates–Nucleotide Metabolism–participates–SRM–associates–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.10%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.24%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–causes–Death–causes–Cladribine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.08%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.64%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–causes–Venoocclusive disease–causes–Azathioprine–treats–multiple sclerosis</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">9.44%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine–binds–POLA1–participates–Nucleotide Metabolism–participates–SRM–associates–multiple sclerosis</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by metapath</h3>
<br/>
<div>
<div class="paragraph">
<p>Which types of paths provided the most support for this prediction? The following table shows the percent contribution of each metapath.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 12.5%;">
<col style="width: 50%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Metapath</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Length</th>
<th class="tableblock halign-left valign-top">Verbose</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CiPCiCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">24.88%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–includes–Pharmacologic Class–includes–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">23.01%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–resembles–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGbCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">18.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–binds–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">15.34%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–associates–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">14.35%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–resembles–Compound–resembles–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CcSEcCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3.09%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">613</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–causes–Side Effect–causes–Compound–treats–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGpPWpGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.79%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">93</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–participates–Pathway–participates–Gene–associates–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGeAlD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.36%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">27</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–expresses–Anatomy–localizes–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CrCbGaD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.11%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–resembles–Compound–binds–Gene–associates–Disease</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">CbGdCrCtD</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">14</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">Compound–binds–Gene–downregulates–Compound–resembles–Compound–treats–Disease</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by source edge</h3>
<br/>
<div>
<div class="paragraph">
<p>The source edge of a path refers to its first edge. The following table shows the total contribution of each source edge across all paths. The number of displayed edges is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 57.1428%;">
<col style="width: 14.2857%;">
<col style="width: 14.2857%;">
<col style="width: 14.2858%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Source Edge</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Distinct Metapaths</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—includes—Nucleic Acid Synthesis Inhibitors</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">24.90%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Cladribine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">23.02%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—binds—RRM1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">20.52%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">29</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—binds—RRM2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5.30%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">29</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—binds—POLA1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4.47%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">26</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—binds—DCK</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.80%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">33</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Regadenoson</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.10%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Fludarabine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2.00%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Nelarabine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.85%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Adenosine monophosphate</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.85%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Vidarabine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Azacitidine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Adenosine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.66%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—Decitabine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.59%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—binds—ABCG2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1.42%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">26</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Death</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.28%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Tumour lysis syndrome</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.08%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Venoocclusive disease</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.08%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Lymphopenia</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Petechiae</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">9</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—resembles—S-Adenosylmethionine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.07%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Herpes zoster</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.06%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Bacteraemia</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.06%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Fungal infection</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.06%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">7</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">Clofarabine—causes—Bacterial infection</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.05%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
</tbody>
</table>
</div>
</div>
</slide>
<slide class="row-fluid">
<div class="col-sm-12">
<h3>Contribution by target edge</h3>
<br/>
<div>
<div class="paragraph">
<p>The target edge of a path refers to its last edge. The following table shows the total contribution of each target edge across all paths. The number of displayed edges is limited to 25.</p>
</div>
<table class="tableblock frame-all grid-all spread table-striped table-bordered text-center">
<colgroup>
<col style="width: 57.1428%;">
<col style="width: 14.2857%;">
<col style="width: 14.2857%;">
<col style="width: 14.2858%;">
</colgroup>
<thead>
<tr>
<th class="tableblock halign-left valign-top">Target Edge</th>
<th class="tableblock halign-left valign-top">Percent of Prediction</th>
<th class="tableblock halign-left valign-top">Path Count</th>
<th class="tableblock halign-left valign-top">Distinct Metapaths</th>
</tr>
</thead>
<tbody>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Cladribine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">55.45%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">109</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Azathioprine</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">25.23%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">49</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—RRM1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">15.68%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">19</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Mitoxantrone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.75%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">73</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Fingolimod</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.54%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">36</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Methotrexate</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.42%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">95</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—SRM</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.39%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">8</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Dexamethasone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.36%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">53</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Prednisone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.15%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">63</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Betamethasone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.15%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">52</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Methylprednisolone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.14%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">51</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Triamcinolone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.11%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">39</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—treats—Prednisolone</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.08%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">25</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—retina</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.08%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—brain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.05%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—cerebellum</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—nervous system</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—medulla oblongata</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—central nervous system</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—MYC</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">19</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—midbrain</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—localizes—spinal cord</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.04%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">3</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—BCHE</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.02%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">5</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—TNFRSF1A</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.01%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">2</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
<tr>
<td class="tableblock halign-left valign-top"><p class="tableblock">multiple sclerosis—associates—CYP27B1</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">0.01%</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">4</p></td>
<td class="tableblock halign-left valign-top"><p class="tableblock">1</p></td>
</tr>
</tbody>
</table>
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