diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 2bb9bc49bc..17fd4e7218 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -59,6 +59,9 @@ Changed
 * Update CI from testing with mongo 4.4 to testing with MongoDB 7.0. #6246
   Contributed by @guzzijones
 
+* Relaxed `dnspython` pinning for compatibility with python 3.10 and greater. #6265
+  Contributed by @nzlosh
+
 Added
 ~~~~~
 * Continue introducing `pants <https://www.pantsbuild.org/docs>`_ to improve DX (Developer Experience)
diff --git a/Makefile b/Makefile
index b06a9dac78..57c5e524c4 100644
--- a/Makefile
+++ b/Makefile
@@ -60,7 +60,7 @@ ST2TESTS_REDIS_PORT := 6379
 # Pin common pip version here across all the targets
 # Note! Periodic maintenance pip upgrades are required to be up-to-date with the latest pip security fixes and updates
 PIP_VERSION ?= 24.2
-SETUPTOOLS_VERSION ?= 75.1.0
+SETUPTOOLS_VERSION ?= 75.2.0
 PIP_OPTIONS := $(ST2_PIP_OPTIONS)
 
 ifndef PYLINT_CONCURRENCY
diff --git a/fixed-requirements.txt b/fixed-requirements.txt
index 9212394fd4..bd59994ef9 100644
--- a/fixed-requirements.txt
+++ b/fixed-requirements.txt
@@ -4,9 +4,7 @@ amqp==5.2.0
 apscheduler==3.10.4
 chardet==3.0.4
 cffi==1.17.1
-# NOTE: 2.0 version breaks pymongo work with hosts
-dnspython==1.16.0
-cryptography==43.0.1
+cryptography==43.0.3
 eventlet==0.37.0
 flex==6.14.1
 # Note: installs gitpython==3.1.37 (security fixed) under py3.8 and gitpython==3.1.18 (latest available, vulnerable) under py3.6
@@ -15,7 +13,7 @@ gitpython==3.1.43
 # Needed by gitpython, old versions used to bundle it
 gitdb==4.0.11
 # Note: greenlet is used by eventlet
-greenlet==3.1.0
+greenlet==3.1.1
 gunicorn==23.0.0
 jsonpath-rw==1.4.0
 jsonschema==3.2.0
@@ -37,7 +35,7 @@ oslo.utils==7.3.0
 paramiko==3.5.0
 passlib==1.7.4
 # 202403: bump to 3.0.43 for py3.10 support
-prompt-toolkit==3.0.47
+prompt-toolkit==3.0.48
 pyinotify==0.9.6 ; platform_system=="Linux"
 pymongo==4.6.3
 pyparsing==3.1.4
@@ -52,7 +50,7 @@ python-keyczar==0.716
 pytz==2024.2
 pywinrm==0.5.0
 pyyaml==6.0.2
-redis==5.0.8
+redis==5.1.1
 requests==2.32.3
 retrying==1.3.4
 routes==2.5.1
@@ -69,9 +67,9 @@ stevedore==5.3.0
 tenacity==9.0.0
 tooz==6.3.0
 # Note: virtualenv embeds wheels for pip, wheel, and setuptools. So pinning virtualenv pins those as well.
-# virtualenv==20.26.5 (<21) has pip==24.2 wheel==0.44.0 setuptools==75.1.0
-# lockfiles/st2.lock has pip==24.2 wheel==0.44.0 setuptools==75.1.0
-virtualenv==20.26.5
+# virtualenv==20.26.5 (<21) has pip==24.2 wheel==0.44.0 setuptools==75.2.0
+# lockfiles/st2.lock has pip==24.2 wheel==0.44.0 setuptools==75.2.0
+virtualenv==20.27.0
 webob==1.8.8
 zake==0.2.2
 # test requirements below
@@ -80,7 +78,7 @@ jinja2==3.1.4
 mock==5.1.0
 nose-timer==1.0.1
 nose-parallel==0.4.0
-psutil==6.0.0
+psutil==6.1.0
 python-dateutil==2.9.0.post0
 python-statsd==2.1.0
 orjson==3.10.7
diff --git a/lockfiles/st2-constraints.txt b/lockfiles/st2-constraints.txt
index 3f5bfdc03e..af830bdf83 100644
--- a/lockfiles/st2-constraints.txt
+++ b/lockfiles/st2-constraints.txt
@@ -62,12 +62,6 @@ MarkupSafe<2.1.0,>=0.23
 # DROPS RESOLVED VERSION: 4.4.2
 #decorator==4.4.2
 
-# REQUIRED BY: eventlet, pymongo
-# REASON: 2.0 version breaks pymongo work with hosts
-# NOTE: try to remove this later
-# DROPS RESOLVED VERSION: 1.16
-dnspython>=1.16.0,<2.0.0
-
 # REQUIRED BY: eventlet
 # REASON: eventlet is difficult to upgrade.
 #         greenlet 2 adds py3.11 support, platform compat changes, and better error checking
diff --git a/lockfiles/st2.lock b/lockfiles/st2.lock
index 2eb8205f63..5b222e05da 100644
--- a/lockfiles/st2.lock
+++ b/lockfiles/st2.lock
@@ -87,8 +87,7 @@
 //   ],
 //   "manylinux": "manylinux2014",
 //   "requirement_constraints": [
-//     "MarkupSafe<2.1.0,>=0.23",
-//     "dnspython<2.0.0,>=1.16.0"
+//     "MarkupSafe<2.1.0,>=0.23"
 //   ],
 //   "only_binary": [],
 //   "no_binary": []
@@ -101,8 +100,7 @@
   "allow_wheels": true,
   "build_isolation": true,
   "constraints": [
-    "MarkupSafe<2.1.0,>=0.23",
-    "dnspython<2.0.0,>=1.16.0"
+    "MarkupSafe<2.1.0,>=0.23"
   ],
   "excluded": [],
   "locked_resolves": [
@@ -169,13 +167,13 @@
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+              "hash": "1a1d148bdaa3e3b93454900163403df41448a248af01b6e849edc5ac08e6c363",
+              "url": "https://files.pythonhosted.org/packages/f7/be/a606a6701d491cfae75583c80a6583f8abe9c36c0b9666e867e7cdd62fe8/argcomplete-3.5.1-py3-none-any.whl"
             },
             {
               "algorithm": "sha256",
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-              "url": "https://files.pythonhosted.org/packages/75/33/a3d23a2e9ac78f9eaf1fce7490fee430d43ca7d42c65adabbb36a2b28ff6/argcomplete-3.5.0.tar.gz"
+              "hash": "eb1ee355aa2557bd3d0145de7b06b2a45b0ce461e1e7813f5d066039ab4177b4",
+              "url": "https://files.pythonhosted.org/packages/5f/39/27605e133e7f4bb0c8e48c9a6b87101515e3446003e0442761f6a02ac35e/argcomplete-3.5.1.tar.gz"
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           ],
           "project_name": "argcomplete",
@@ -187,7 +185,7 @@
             "wheel; extra == \"test\""
           ],
           "requires_python": ">=3.8",
-          "version": "3.5.0"
+          "version": "3.5.1"
         },
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diff --git a/requirements.txt b/requirements.txt
index e7bd73b527..754f55fa7e 100644
--- a/requirements.txt
+++ b/requirements.txt
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 cffi==1.17.1
 chardet==3.0.4
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index bfb2343f0a..f16fe212e3 100644
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index 3a32c235cf..f4eb409967 100644
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-greenlet==3.1.0
+greenlet==3.1.1
 jinja2==3.1.4
 jsonpath-rw==1.4.0
 jsonschema==3.2.0
@@ -35,7 +35,7 @@ pymongo==4.6.3
 python-dateutil==2.9.0.post0
 python-statsd==2.1.0
 pyyaml==6.0.2
-redis==5.0.8
+redis==5.1.1
 requests==2.32.3
 retrying==1.3.4
 routes==2.5.1
diff --git a/st2tests/requirements.txt b/st2tests/requirements.txt
index 142ce32595..fd28f0d7f3 100644
--- a/st2tests/requirements.txt
+++ b/st2tests/requirements.txt
@@ -10,7 +10,7 @@ mock==5.1.0
 nose
 nose-parallel==0.4.0
 nose-timer==1.0.1
-psutil==6.0.0
+psutil==6.1.0
 pyrabbit
 rednose
 unittest2