-
Notifications
You must be signed in to change notification settings - Fork 1
/
Copy pathaddl.html
79 lines (59 loc) · 2.89 KB
/
addl.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
<HTML><HEAD> <TITLE> addl.dat</TITLE><HEAD>
<BODY BGCOLOR="#FFFFFF">
<PRE>
+--------------------------------------------------------------------+
| |
| ADDL DATA ITEM |
| |
+--------------------------------------------------------------------+
MEANING: Additional Dose (ADDL) data item for PREDPP
CONTEXT: $INPUT record and NONMEM data set
USAGE:
$INPUT ... ADDL ...
DISCUSSION:
ADDL labels PREDPP's additional dose (ADDL) data item. The additional
dose data item is optional. In a dose or reset-dose event record it
describes how many additional doses, exactly like the present ("initi-
ating") dose, should be given. The interdose interval (II) data item
gives the time between the additional doses (See <A HREF="i.html#ii">ii</A>).
When ADDL is 0, no additional doses are given.
For non-steady-state doses, ADDL should be a positive number if and
only if the II data item is a positive number. II gives the time
between additional doses.
For steady-state infusions, ADDL must be 0.
For other steady-state doses, ADDL is optional. If it is a positive
number, it continues the pattern of implied doses beyond the steady-
state dose. The additional doses of the pattern are non-steady state
doses.
With NM75 there is a new way of computing SS, the Empirical method, in
which there is no SS data item, and a negative value of ADDL requests
the computation. This is described separately.
(See <A HREF="e.html#empirical_ss">empirical_SS</A>).
(See Guide Introduction_7 "An Empirical Method of Achieving Steady
State")
For observation, other-type and reset event records, ADDL should be
zero.
The following two data record fragments specify the same set of doses:
TIME AMT ADDL II DV
10. 15. 0 0 .
15. . . . 25.7
20. 10. 0 0 .
22. 15. 0 0 .
34. 15. 0 0 .
36. . . . 30.2
TIME AMT ADDL II DV
10. 15. 2 12. .
15. . . . 25.7
20. 10. 0 0 .
36. . . . 30.2
The observation at time 15 and the extra dose at time 20 do not affect
the regular dosing regimen (doses at times 10, 22, and 34).
There is a discussion of user (concomitant) data items used to compute
PK parameters that are relevant to ADDL doses; (See <A HREF="$.html#$bind">$BIND</A>).
REFERENCES: Guide VI Section <a href="VI/V.html#K.">V.K<a/>
<pre>Go to <A HREF=index.html>main index</A>.</pre>
<pre>
<hr ALIGN=LEFT WIDTH="450"></pre>
<i><font size=-1>Created by nmhelp2html v. 1.0 written by Niclas Jonsson (Modified by AJB 5/2006,11/2007,10/2012)</font>
</i><br>
</BODY></HTML>