diff --git a/src/js/_enqueues/admin/tags.js b/src/js/_enqueues/admin/tags.js
index 2e55e2ed20d93..edc61c80c987f 100644
--- a/src/js/_enqueues/admin/tags.js
+++ b/src/js/_enqueues/admin/tags.js
@@ -59,7 +59,7 @@ jQuery( function($) {
 					tr.children().css('backgroundColor', '');
 
 				} else {
-					$('#ajax-response').empty().append('<div class="error"><p>' + wp.i18n.__( 'Something went wrong.' ) + '</p></div>');
+					$('#ajax-response').empty().append('<div class="error"><p>' + wp.i18n.__( 'An error occurred while processing your request. Please try again later.' ) + '</p></div>');
 					tr.children().css('backgroundColor', '');
 				}
 			});
diff --git a/src/js/_enqueues/lib/ajax-response.js b/src/js/_enqueues/lib/ajax-response.js
index af59d8183ad61..d1a05ca52c8b8 100644
--- a/src/js/_enqueues/lib/ajax-response.js
+++ b/src/js/_enqueues/lib/ajax-response.js
@@ -83,7 +83,7 @@ window.wpAjax = jQuery.extend( {
 		selector = jQuery( selector );
 		return !wpAjax.invalidateForm( selector.find('.form-required').filter( function() { return jQuery('input:visible', this).val() === ''; } ) ).length;
 	}
-}, wpAjax || { noPerm: 'Sorry, you are not allowed to do that.', broken: 'Something went wrong.' } );
+}, wpAjax || { noPerm: 'Sorry, you are not allowed to do that.', broken: 'An error occurred while processing your request. Please refresh the page and try again.' } );
 
 // Basic form validation.
 jQuery( function($){
diff --git a/src/js/_enqueues/wp/theme-plugin-editor.js b/src/js/_enqueues/wp/theme-plugin-editor.js
index 2fd866531f362..1e3ac0d904c77 100644
--- a/src/js/_enqueues/wp/theme-plugin-editor.js
+++ b/src/js/_enqueues/wp/theme-plugin-editor.js
@@ -226,7 +226,7 @@ wp.themePluginEditor = (function( $ ) {
 			var notice = $.extend(
 				{
 					code: 'save_error',
-					message: __( 'Something went wrong. Your change may not have been saved. Please try again. There is also a chance that you may need to manually fix and upload the file over FTP.' )
+					message: __( 'An error occurred while saving your changes. Please try again. If the problem persists, you may need to manually update the file via FTP.' )
 				},
 				response,
 				{
diff --git a/src/js/_enqueues/wp/updates.js b/src/js/_enqueues/wp/updates.js
index 396fcbb6ffe06..b0846d6eafa54 100644
--- a/src/js/_enqueues/wp/updates.js
+++ b/src/js/_enqueues/wp/updates.js
@@ -2333,7 +2333,7 @@
 	 *                                                'update' or 'install'.
 	 */
 	wp.updates.isValidResponse = function( response, action ) {
-		var error = __( 'Something went wrong.' ),
+		var error = __( 'An error occurred during the update process. Please try again or contact support for assistance.' ),
 			errorMessage;
 
 		// Make sure the response is a valid data object and not a Promise object.
diff --git a/src/wp-admin/customize.php b/src/wp-admin/customize.php
index b27292d9eb949..9fe0b3f6d3912 100644
--- a/src/wp-admin/customize.php
+++ b/src/wp-admin/customize.php
@@ -76,8 +76,8 @@
 
 	if ( in_array( get_post_status( $changeset_post->ID ), array( 'publish', 'trash' ), true ) ) {
 		wp_die(
-			'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
-			'<p>' . __( 'This changeset cannot be further modified.' ) . '</p>' .
+			'<h1>' . __( 'An error occurred while saving your changeset.' ) . '</h1>' .
+			'<p>' . __( 'Please try again or start a new changeset. This changeset cannot be further modified.' ) . '</p>' .
 			'<p><a href="' . esc_url( remove_query_arg( 'changeset_uuid' ) ) . '">' . __( 'Customize New Changes' ) . '</a></p>',
 			403
 		);
diff --git a/src/wp-admin/includes/class-custom-image-header.php b/src/wp-admin/includes/class-custom-image-header.php
index 2e1bf47fdaf5e..54be1d90e4228 100644
--- a/src/wp-admin/includes/class-custom-image-header.php
+++ b/src/wp-admin/includes/class-custom-image-header.php
@@ -830,8 +830,8 @@ public function step_2() {
 
 		if ( ! current_theme_supports( 'custom-header', 'uploads' ) ) {
 			wp_die(
-				'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
-				'<p>' . __( 'The active theme does not support uploading a custom header image.' ) . '</p>',
+				'<h1>' . __( 'An error occurred while processing your header image.' ) . '</h1>' .
+				'<p>' . __( 'The active theme does not support uploading a custom header image. Please ensure your theme supports custom headers and try again.' ) . '</p>',
 				403
 			);
 		}
@@ -1018,8 +1018,8 @@ public function step_3() {
 
 		if ( ! current_theme_supports( 'custom-header', 'uploads' ) ) {
 			wp_die(
-				'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
-				'<p>' . __( 'The active theme does not support uploading a custom header image.' ) . '</p>',
+				'<h1>' . __( 'An error occurred while processing your header image.' ) . '</h1>' .
+				'<p>' . __( 'The active theme does not support uploading a custom header image. Please ensure your theme supports custom headers and try again.' ) . '</p>',
 				403
 			);
 		}
@@ -1029,7 +1029,7 @@ public function step_3() {
 			&& ! current_theme_supports( 'custom-header', 'flex-width' )
 		) {
 			wp_die(
-				'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
+				'<h1>' . __( 'An error occurred while processing your header image.' ) . '</h1>' .
 				'<p>' . __( 'The active theme does not support a flexible sized header image.' ) . '</p>',
 				403
 			);
diff --git a/src/wp-admin/includes/file.php b/src/wp-admin/includes/file.php
index b1ea3fba1bda2..505c02278c0d8 100644
--- a/src/wp-admin/includes/file.php
+++ b/src/wp-admin/includes/file.php
@@ -635,7 +635,7 @@ function wp_edit_theme_plugin_file( $args ) {
 			wp_opcache_invalidate( $real_file, true );
 
 			if ( ! isset( $result['message'] ) ) {
-				$message = __( 'Something went wrong.' );
+				$message = __( 'An unexpected error occurred. Please try again later or contact support.' );
 			} else {
 				$message = $result['message'];
 				unset( $result['message'] );
diff --git a/src/wp-admin/includes/revision.php b/src/wp-admin/includes/revision.php
index ab3842fc552bc..df7201e958098 100644
--- a/src/wp-admin/includes/revision.php
+++ b/src/wp-admin/includes/revision.php
@@ -466,7 +466,7 @@ function wp_print_revision_templates() {
 
 	<script id="tmpl-revisions-diff" type="text/html">
 		<div class="loading-indicator"><span class="spinner"></span></div>
-		<div class="diff-error"><?php _e( 'Sorry, something went wrong. The requested comparison could not be loaded.' ); ?></div>
+		<div class="diff-error"><?php _e( 'An error occurred while loading the comparison. Please refresh the page and try again.' ); ?></div>
 		<div class="diff">
 		<# _.each( data.fields, function( field ) { #>
 			<h2>{{ field.name }}</h2>
diff --git a/src/wp-admin/media-upload.php b/src/wp-admin/media-upload.php
index 015bc9d63de69..3906ece6d9dd4 100644
--- a/src/wp-admin/media-upload.php
+++ b/src/wp-admin/media-upload.php
@@ -35,8 +35,8 @@
 // Require an ID for the edit screen.
 if ( isset( $action ) && 'edit' === $action && ! $ID ) { // phpcs:ignore WordPress.NamingConventions.ValidVariableName
 	wp_die(
-		'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
-		'<p>' . __( 'Invalid item ID.' ) . '</p>',
+		'<h1>' . __( 'An error occurred during the upload process.' ) . '</h1>' .
+		'<p>' . __( 'Invalid item ID. Please try again.' ) . '</p>',
 		403
 	);
 }
diff --git a/src/wp-admin/network/site-users.php b/src/wp-admin/network/site-users.php
index 78af65b9ed7a8..72a8040261e87 100644
--- a/src/wp-admin/network/site-users.php
+++ b/src/wp-admin/network/site-users.php
@@ -155,7 +155,7 @@
 					// If the user doesn't already belong to the blog, bail.
 					if ( ! is_user_member_of_blog( $user_id ) ) {
 						wp_die(
-							'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
+							'<h1>' . __( 'An unexpected error occurred.' ) . '</h1>' .
 							'<p>' . __( 'One of the selected users is not a member of this site.' ) . '</p>',
 							403
 						);
diff --git a/src/wp-admin/themes.php b/src/wp-admin/themes.php
index 4c814dd42b6d1..fb0e51361de1d 100644
--- a/src/wp-admin/themes.php
+++ b/src/wp-admin/themes.php
@@ -24,7 +24,7 @@
 
 		if ( ! $theme->exists() || ! $theme->is_allowed() ) {
 			wp_die(
-				'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
+				'<h1>' . __( 'An unexpected error occurred.' ) . '</h1>' .
 				'<p>' . __( 'The requested theme does not exist.' ) . '</p>',
 				403
 			);
@@ -67,7 +67,7 @@
 
 		if ( ! $theme->exists() ) {
 			wp_die(
-				'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
+				'<h1>' . __( 'An error occurred while deleting the theme.' ) . '</h1>' .
 				'<p>' . __( 'The requested theme does not exist.' ) . '</p>',
 				403
 			);
diff --git a/src/wp-admin/users.php b/src/wp-admin/users.php
index 4951a7e9bfb0b..d2e2016133674 100644
--- a/src/wp-admin/users.php
+++ b/src/wp-admin/users.php
@@ -155,7 +155,7 @@
 			// If the user doesn't already belong to the blog, bail.
 			if ( is_multisite() && ! is_user_member_of_blog( $id ) ) {
 				wp_die(
-					'<h1>' . __( 'Something went wrong.' ) . '</h1>' .
+					'<h1>' . __( 'An unexpected error occurred.' ) . '</h1>' .
 					'<p>' . __( 'One of the selected users is not a member of this site.' ) . '</p>',
 					403
 				);
diff --git a/src/wp-includes/class-wp-customize-manager.php b/src/wp-includes/class-wp-customize-manager.php
index 8d5e94af94b8d..46426e344db94 100644
--- a/src/wp-includes/class-wp-customize-manager.php
+++ b/src/wp-includes/class-wp-customize-manager.php
@@ -454,7 +454,7 @@ protected function wp_die( $ajax_message, $message = null ) {
 		}
 
 		if ( ! $message ) {
-			$message = __( 'Something went wrong.' );
+			$message = __( 'An unexpected error occurred while customizing. Please refresh the page and try again.' );
 		}
 
 		if ( $this->messenger_channel ) {
diff --git a/src/wp-includes/class-wp-xmlrpc-server.php b/src/wp-includes/class-wp-xmlrpc-server.php
index f94e2f3d46089..c9db11959d486 100644
--- a/src/wp-includes/class-wp-xmlrpc-server.php
+++ b/src/wp-includes/class-wp-xmlrpc-server.php
@@ -4020,7 +4020,7 @@ public function wp_newComment( $args ) {
 		}
 
 		if ( ! $comment_id ) {
-			return new IXR_Error( 403, __( 'Something went wrong.' ) );
+			return new IXR_Error( 403, __( 'An error occurred while processing your comment. Please ensure all fields are filled correctly and try again.' ) );
 		}
 
 		/**
@@ -5040,7 +5040,7 @@ public function blogger_getRecentPosts( $args ) {
 		$posts_list = wp_get_recent_posts( $query );
 
 		if ( ! $posts_list ) {
-			$this->error = new IXR_Error( 500, __( 'Either there are no posts, or something went wrong.' ) );
+			$this->error = new IXR_Error( 500, __( 'No posts found or an error occurred while retrieving posts.' ) );
 			return $this->error;
 		}
 
@@ -6523,7 +6523,7 @@ public function mt_getRecentPostTitles( $args ) {
 		$posts_list = wp_get_recent_posts( $query );
 
 		if ( ! $posts_list ) {
-			$this->error = new IXR_Error( 500, __( 'Either there are no posts, or something went wrong.' ) );
+			$this->error = new IXR_Error( 500, __( 'No posts found or an error occurred while retrieving posts.' ) );
 			return $this->error;
 		}
 
diff --git a/src/wp-includes/functions.php b/src/wp-includes/functions.php
index 6e1d97677d03c..fc23efb6d14ff 100644
--- a/src/wp-includes/functions.php
+++ b/src/wp-includes/functions.php
@@ -3672,7 +3672,7 @@ function get_allowed_mime_types( $user = null ) {
  */
 function wp_nonce_ays( $action ) {
 	// Default title and response code.
-	$title         = __( 'Something went wrong.' );
+	$title         = __( 'An unexpected error occurred. Please try again later.' );
 	$response_code = 403;
 
 	if ( 'log-out' === $action ) {
diff --git a/src/wp-includes/script-loader.php b/src/wp-includes/script-loader.php
index 19813615bd80e..cdc9adef16de2 100644
--- a/src/wp-includes/script-loader.php
+++ b/src/wp-includes/script-loader.php
@@ -810,7 +810,7 @@ function wp_default_scripts( $scripts ) {
 		'wpAjax',
 		array(
 			'noPerm' => __( 'Sorry, you are not allowed to do that.' ),
-			'broken' => __( 'Something went wrong.' ),
+			'broken' => __( 'An unexpected error occurred while processing your request. Please try again later.' ),
 		)
 	);
 
@@ -1292,7 +1292,7 @@ function wp_default_scripts( $scripts ) {
 			'close'                   => __( 'Close' ),
 			'action'                  => __( 'Action' ),
 			'discardChanges'          => __( 'Discard changes' ),
-			'cheatin'                 => __( 'Something went wrong.' ),
+			'cheatin'                 => __( 'An unexpected error occurred. Please try again later.' ),
 			'notAllowedHeading'       => __( 'You need a higher level of permission.' ),
 			'notAllowed'              => __( 'Sorry, you are not allowed to customize this site.' ),
 			'previewIframeTitle'      => __( 'Site Preview' ),
diff --git a/src/wp-mail.php b/src/wp-mail.php
index 7b18dd4ad1494..d55ac73717b9e 100644
--- a/src/wp-mail.php
+++ b/src/wp-mail.php
@@ -39,7 +39,7 @@
 $last_checked = get_transient( 'mailserver_last_checked' );
 
 if ( $last_checked ) {
-	wp_die( __( 'Slow down cowboy, no need to check for new mails so often!' ) );
+	wp_die( __( 'Please wait a moment before checking for new emails again.' ) );
 }
 
 set_transient( 'mailserver_last_checked', true, WP_MAIL_INTERVAL );