rtfNCA-Theoph.rtf

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{\pard\fi0\li0\f2\fs20\b Individual Noncompartmental Analysis Result\b0\line\par}
{\pard\fi0\f2\fs20\par}{\pard\fi0\li0\f2\fs20\b Table of Contents\b0\line\par}
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                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
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                       Package version 0.4.1 (2018-06-20 KST)\par}
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                          R version 3.5.1 (2018-07-02)\par}
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\par}
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Date and Time: 2018-08-06 17:37:34 Asia/Seoul\par}
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\par}
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Calculation Setting\par}
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-------------------\par}
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Drug Administration: Extravascular\par}
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Observation count excluding trailing zero: 11\par}
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Dose at time 0: 320 mg\par}
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AUC Calculation Method: Linear-up Linear-down\par}
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Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
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Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
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\par}
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\par}
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Fitting, AUC, AUMC Result\par}
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-------------------------\par}
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      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
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---------------------------------------------------------------------\par}
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     0.0000       0.7400                           0.0000     0.0000\par}
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     0.2500       2.8400                           0.4475     0.0888\par}
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     0.5700       6.5700                           1.9531     0.8015\par}
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     1.1200      10.5000                           6.6474     5.0654\par}
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     2.0200       9.6600                          15.7194    19.1383\par}
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     3.8200       8.5800                          32.1354    66.1982\par}
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     5.1000       8.3600                          42.9769   114.4617\par}
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     7.0300       7.4700                          58.2529   206.2815\par}
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     9.0500 *     6.8900     6.8912 -1.228e-03    72.7565   322.2988\par}
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    12.1200 *     5.9400     5.9387 +1.324e-03    92.4505   528.5219\par}
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    24.3700 *     3.2800     3.2801 -1.465e-04   148.9231  1459.0711\par}
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\par}
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*: Used for the calculation of Lambda z.\par}
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\par}
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\par}
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Calculated Values\par}
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-----------------\par}
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CMAX       Max Conc                                       10.5000 mg/L\par}
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CMAXD      Max Conc Norm by Dose                           0.0328 mg/L/mg\par}
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TMAX       Time of CMAX                                    1.1200 h\par}
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TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
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CLST       Last Nonzero Conc                               3.2800 mg/L\par}
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CLSTP      Last Nonzero Conc Pred                          3.2801 mg/L\par}
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TLST       Time of Last Nonzero Conc                      24.3700 h\par}
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LAMZHL     Half-Life Lambda z                             14.3044 h\par}
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LAMZ       Lambda z                                        0.0485 /h\par}
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LAMZLL     Lambda z Lower Limit                            9.0500 h\par}
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LAMZUL     Lambda z Upper Limit                           24.3700 h\par}
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LAMZNPT    Number of Points for Lambda z                   3\par}
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CORRXY     Correlation Between TimeX and Log ConcY        -1.0000 \par}
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R2         R Squared                                       1.0000 \par}
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R2ADJ      R Squared Adjusted                              1.0000 \par}
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AUCLST     AUC to Last Nonzero Conc                      148.9231 h*mg/L\par}
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AUCALL     AUC All                                       148.9231 h*mg/L\par}
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AUCIFO     AUC Infinity Obs                              216.6119 h*mg/L\par}
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AUCIFOD    AUC Infinity Obs Norm by Dose                   0.6769 h*mg/L/mg\par}
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AUCIFP     AUC Infinity Pred                             216.6150 h*mg/L\par}
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AUCIFPD    AUC Infinity Pred Norm by Dose                  0.6769 h*mg/L/mg\par}
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AUCPEO     AUC %Extrapolation Obs                         31.2489 %\par}
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AUCPEP     AUC %Extrapolation Pred                        31.2499 %\par}
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AUMCLST    AUMC to Last Nonzero Conc                    1459.0711 h2*mg/L\par}
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AUMCIFO    AUMC Infinity Obs                            4505.5348 h2*mg/L\par}
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AUMCIFP    AUMC Infinity Pred                           4505.6709 h2*mg/L\par}
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AUMCPEO    AUMC %Extrapolation Obs                        67.6160 %\par}
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AUMCPEP    AUMC % Extrapolation Pred                      67.6170 %\par}
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VZFO       Vz Obs by F                                    30.4867 L\par}
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VZFP       Vz Pred by F                                   30.4863 L\par}
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CLFO       Total CL Obs by F                               1.4773 L/h\par}
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CLFP       Total CL Pred by F                              1.4773 L/h\par}
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MRTEVLST   MRT Extravasc to Last Nonzero Conc              9.7975 h\par}
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MRTEVIFO   MRT Extravasc Infinity Obs                     20.8000 h\par}
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MRTEVIFP   MRT Extravasc Infinity Pred                    20.8004 h\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=2\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:34 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2700       1.7200                           0.2322     0.0627\par}
{\pard\fi0\li0\f2\fs20
     0.5200       7.9100                           1.4360     0.6349\par}
{\pard\fi0\li0\f2\fs20
     1.0000       8.3100                           5.3287     3.6165\par}
{\pard\fi0\li0\f2\fs20
     1.9200       8.3300                          12.9832    14.7961\par}
{\pard\fi0\li0\f2\fs20
     3.5000       6.8500                          24.9754    46.3713\par}
{\pard\fi0\li0\f2\fs20
     5.0200       6.0800                          34.8022    87.7887\par}
{\pard\fi0\li0\f2\fs20
     7.0300 *     5.4000     5.3629 +3.707e-02    46.3396   156.6147\par}
{\pard\fi0\li0\f2\fs20
     9.0000 *     4.5500     4.3687 +1.813e-01    56.1403   234.3431\par}
{\pard\fi0\li0\f2\fs20
    12.0000 *     3.0100     3.1970 -1.870e-01    67.4803   349.9481\par}
{\pard\fi0\li0\f2\fs20
    24.3000 *     0.9000     0.8886 +1.136e-02    91.5268   706.5866\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        8.3300 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0260 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    1.9200 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               0.9000 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          0.8886 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.3000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              6.6593 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.1041 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            7.0300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.3000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   4\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9986 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9972 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9958 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       91.5268 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        91.5268 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              100.1735 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3130 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             100.0643 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3127 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                          8.6317 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                         8.5320 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     706.5866 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                             999.7723 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                            996.0716 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        29.3252 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      29.0627 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    30.6904 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   30.7239 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.1945 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.1979 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              7.7200 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                      9.9804 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                     9.9543 h\par}
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{\pard\fi0\li0\f2\fs20
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=3\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:35 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2700       4.4000                           0.5940     0.1604\par}
{\pard\fi0\li0\f2\fs20
     0.5800       6.9000                           2.3455     0.9648\par}
{\pard\fi0\li0\f2\fs20
     1.0200       8.2000                           5.6675     3.6854\par}
{\pard\fi0\li0\f2\fs20
     2.0200       7.8000                          13.6675    15.7453\par}
{\pard\fi0\li0\f2\fs20
     3.6200       7.5000                          25.9075    50.0702\par}
{\pard\fi0\li0\f2\fs20
     5.0800       6.2000                          35.9085    92.8817\par}
{\pard\fi0\li0\f2\fs20
     7.0700       5.3000                          47.3510   161.5039\par}
{\pard\fi0\li0\f2\fs20
     9.0000 *     4.9000     4.9914 -9.138e-02    57.1940   240.2199\par}
{\pard\fi0\li0\f2\fs20
    12.1500 *     3.7000     3.6147 +8.528e-02    70.7390   380.4815\par}
{\pard\fi0\li0\f2\fs20
    24.1700 *     1.0500     1.0551 -5.097e-03    99.2865   803.1859\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        8.2000 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0256 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    1.0200 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.0500 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.0551 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.1700 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              6.7661 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.1024 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            9.0000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.1700 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9997 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9993 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9986 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       99.2865 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        99.2865 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              109.5360 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3423 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             109.5857 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3425 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                          9.3572 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                         9.3983 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     803.1859 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1150.9648 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1152.6529 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        30.2163 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      30.3185 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    28.5171 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   28.5042 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               2.9214 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              2.9201 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.0896 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     10.5076 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    10.5183 h\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=4\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:35 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.3500       1.8900                           0.3308     0.1158\par}
{\pard\fi0\li0\f2\fs20
     0.6000       4.6000                           1.1420     0.5435\par}
{\pard\fi0\li0\f2\fs20
     1.0700       8.6000                           4.2440     3.3545\par}
{\pard\fi0\li0\f2\fs20
     2.1300       8.3800                          13.2434    17.6918\par}
{\pard\fi0\li0\f2\fs20
     3.5000       7.5400                          24.1486    47.9958\par}
{\pard\fi0\li0\f2\fs20
     5.0200       6.8800                          35.1078    94.3007\par}
{\pard\fi0\li0\f2\fs20
     7.0200       5.7800                          47.7678   169.4139\par}
{\pard\fi0\li0\f2\fs20
     9.0200 *     5.3300     5.4586 -1.286e-01    58.8778   258.0661\par}
{\pard\fi0\li0\f2\fs20
    11.9800 *     4.1900     4.0686 +1.214e-01    72.9674   403.5099\par}
{\pard\fi0\li0\f2\fs20
    24.6500 *     1.1500     1.1564 -6.422e-03   106.7963   901.0842\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        8.6000 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0269 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    1.0700 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.1500 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.1564 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.6500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              6.9812 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0993 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            9.0200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.6500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9995 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9989 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9978 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                      106.7963 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                       106.7963 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              118.3789 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3699 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             118.4436 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3701 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                          9.7843 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                         9.8336 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     901.0842 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1303.2524 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1305.4981 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        30.8588 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      30.9777 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    27.2260 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   27.2111 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               2.7032 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              2.7017 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.4374 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     11.0092 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    11.0221 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=4\b0\line\par}
{\pard\fi0\li0\f2\fs20
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=5\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:36 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.3000       2.0200                           0.3030     0.0909\par}
{\pard\fi0\li0\f2\fs20
     0.5200       5.6300                           1.1445     0.4796\par}
{\pard\fi0\li0\f2\fs20
     1.0000      11.4000                           5.2317     3.9182\par}
{\pard\fi0\li0\f2\fs20
     2.0200       9.3300                          15.8040    19.3440\par}
{\pard\fi0\li0\f2\fs20
     3.5000       8.7400                          29.1758    55.9271\par}
{\pard\fi0\li0\f2\fs20
     5.0200       7.5600                          41.5638   108.0184\par}
{\pard\fi0\li0\f2\fs20
     7.0200 *     7.0900     6.9799 +1.101e-01    56.2138   195.7414\par}
{\pard\fi0\li0\f2\fs20
     9.1000 *     5.9000     5.8291 +7.091e-02    69.7234   303.3417\par}
{\pard\fi0\li0\f2\fs20
    12.0000 *     4.3700     4.5343 -1.643e-01    84.6149   457.2302\par}
{\pard\fi0\li0\f2\fs20
    24.3500 *     1.5700     1.5557 +1.430e-02   121.2944  1017.1143\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                       11.4000 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0356 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    1.0000 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.5700 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.5557 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.3500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              8.0023 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0866 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            7.0200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.3500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   4\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9993 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9986 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9980 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                      121.2944 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                       121.2944 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              139.4198 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.4357 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             139.2546 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.4352 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         13.0006 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        12.8974 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                    1017.1143 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1667.7216 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1661.7937 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        39.0117 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      38.7942 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    26.4980 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   26.5294 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               2.2952 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              2.2979 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.3855 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     11.9619 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    11.9335 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=5\b0\line\par}
{\pard\fi0\li0\f2\fs20
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=6\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:36 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2700       1.2900                           0.1742     0.0470\par}
{\pard\fi0\li0\f2\fs20
     0.5800       3.0800                           0.8515     0.3779\par}
{\pard\fi0\li0\f2\fs20
     1.1500       6.4400                           3.5647     2.9977\par}
{\pard\fi0\li0\f2\fs20
     2.0300 *     6.3200     6.3928 -7.284e-02     9.1791    11.9014\par}
{\pard\fi0\li0\f2\fs20
     3.5700 *     5.5300     5.5844 -5.438e-02    18.3036    36.9816\par}
{\pard\fi0\li0\f2\fs20
     5.0000 *     4.9400     4.9255 +1.450e-02    25.7897    68.7577\par}
{\pard\fi0\li0\f2\fs20
     7.0000 *     4.0200     4.1323 -1.123e-01    34.7497   121.5977\par}
{\pard\fi0\li0\f2\fs20
     9.2200 *     3.4600     3.4005 +5.948e-02    43.0525   188.2434\par}
{\pard\fi0\li0\f2\fs20
    12.1000 *     2.7800     2.6408 +1.392e-01    52.0381   282.6199\par}
{\pard\fi0\li0\f2\fs20
    23.8500 *     0.9200     0.9413 -2.127e-02    73.7756   609.1524\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        6.4400 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0201 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    1.1500 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               0.9200 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          0.9413 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      23.8500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              7.8950 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0878 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            2.0300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           23.8500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   7\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9991 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9982 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9979 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       73.7756 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        73.7756 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                               84.2544 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.2633 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                              84.4967 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.2641 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         12.4372 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        12.6882 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     609.1524 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                             978.4285 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                            986.9665 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        37.7418 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      38.2803 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    43.2597 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   43.1357 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.7980 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.7871 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.2568 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     11.6128 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    11.6805 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=6\b0\line\par}
{\pard\fi0\li0\f2\fs20
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=7\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:37 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.1500                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2500       0.8500                           0.1250     0.0266\par}
{\pard\fi0\li0\f2\fs20
     0.5000       2.3500                           0.5250     0.2000\par}
{\pard\fi0\li0\f2\fs20
     1.0200       5.0200                           2.4412     1.8368\par}
{\pard\fi0\li0\f2\fs20
     2.0200       6.5800                           8.2412    11.0428\par}
{\pard\fi0\li0\f2\fs20
     3.4800       7.0900                          18.2203    38.7571\par}
{\pard\fi0\li0\f2\fs20
     5.0000       6.6600                          28.6703    82.8167\par}
{\pard\fi0\li0\f2\fs20
     6.9800 *     5.2500     5.3226 -7.260e-02    40.4612   152.0623\par}
{\pard\fi0\li0\f2\fs20
     9.0000 *     4.3900     4.4527 -6.275e-02    50.1976   228.9788\par}
{\pard\fi0\li0\f2\fs20
    12.0500 *     3.5300     3.4011 +1.289e-01    62.2756   354.0998\par}
{\pard\fi0\li0\f2\fs20
    24.2200 *     1.1500     1.1607 -1.072e-02    90.7534   782.4199\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        7.0900 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0222 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    3.4800 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.1500 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.1607 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.2200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              7.8467 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0883 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            6.9800 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.2200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   4\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9993 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9987 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9980 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       90.7534 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        90.7534 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              103.7718 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3243 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             103.8931 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3247 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         12.5452 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        12.6474 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     782.4199 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1245.0984 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1249.4111 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        37.1600 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      37.3769 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    34.9084 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   34.8677 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.0837 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.0801 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.6214 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     11.9984 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    12.0259 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=7\b0\line\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=8\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:37 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2500       3.0500                           0.3813     0.0953\par}
{\pard\fi0\li0\f2\fs20
     0.5200       3.0500                           1.2048     0.4124\par}
{\pard\fi0\li0\f2\fs20
     0.9800       7.3100                           3.5875     2.4248\par}
{\pard\fi0\li0\f2\fs20
     2.0200       7.5600                          11.3200    14.0910\par}
{\pard\fi0\li0\f2\fs20
     3.5300 *     6.5900     6.5724 +1.758e-02    22.0032    43.1841\par}
{\pard\fi0\li0\f2\fs20
     5.0500 *     5.8800     5.8071 +7.292e-02    31.4804    83.4312\par}
{\pard\fi0\li0\f2\fs20
     7.1500 *     4.7300     4.8941 -1.641e-01    42.6209   150.1204\par}
{\pard\fi0\li0\f2\fs20
     9.0700 *     4.5700     4.1856 +3.844e-01    51.5489   222.3790\par}
{\pard\fi0\li0\f2\fs20
    12.1000 *     3.0000     3.2702 -2.702e-01    63.0175   340.1701\par}
{\pard\fi0\li0\f2\fs20
    24.1200 *     1.2500     1.2285 +2.147e-02    88.5600   739.5346\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        7.5600 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0236 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    2.0200 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.2500 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.2285 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.1200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              8.5100 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0815 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            3.5300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.1200 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   6\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9955 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9910 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9888 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       88.5600 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        88.5600 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              103.9067 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3247 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             103.6431 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3239 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         14.7697 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        14.5529 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     739.5346 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1298.1158 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1288.5201 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        43.0302 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      42.6059 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    37.8105 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   37.9067 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.0797 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.0875 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.3507 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     12.4931 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    12.4323 h\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=9\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:38 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.3000       7.3700                           1.1055     0.3316\par}
{\pard\fi0\li0\f2\fs20
     0.6300       9.0300                           3.8115     1.6351\par}
{\pard\fi0\li0\f2\fs20
     1.0500       7.1400                           7.2072     4.4042\par}
{\pard\fi0\li0\f2\fs20
     2.0200       6.3300                          13.7402    14.2417\par}
{\pard\fi0\li0\f2\fs20
     3.5300       5.6600                          22.7926    38.9804\par}
{\pard\fi0\li0\f2\fs20
     5.0200       5.6700                          31.2335    75.0705\par}
{\pard\fi0\li0\f2\fs20
     7.1700       4.2400                          41.8867   138.3495\par}
{\pard\fi0\li0\f2\fs20
     8.8000 *     4.1100     4.0512 +5.880e-02    48.6920   192.6031\par}
{\pard\fi0\li0\f2\fs20
    11.6000 *     3.1600     3.2160 -5.597e-02    58.8700   294.5567\par}
{\pard\fi0\li0\f2\fs20
    24.4300 *     1.1200     1.1165 +3.517e-03    86.3262   705.2296\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        9.0300 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0282 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    0.6300 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.1200 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.1165 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.4300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              8.4060 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0825 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            8.8000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.4300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9997 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9994 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9989 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       86.3262 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        86.3262 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                               99.9087 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.3122 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                              99.8661 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.3121 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         13.5950 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        13.5581 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     705.2296 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1201.7715 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1200.2124 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        41.3175 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      41.2413 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    38.8428 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   38.8594 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.2029 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.2043 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.1694 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     12.0287 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    12.0182 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=9\b0\line\par}
{\pard\fi0\li0\f2\fs20
{\rtf1\ansi\deff0{\pict\pngblip\picwgoal8640\pichgoal5760 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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=10\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:38 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.2400                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.3700       2.8900                           0.5790     0.1978\par}
{\pard\fi0\li0\f2\fs20
     0.7700       5.2200                           2.2011     1.2156\par}
{\pard\fi0\li0\f2\fs20
     1.0200       6.4100                           3.6548     2.5353\par}
{\pard\fi0\li0\f2\fs20
     2.0500       7.8300                          10.9884    14.1690\par}
{\pard\fi0\li0\f2\fs20
     3.5500      10.2100                          24.5184    53.3917\par}
{\pard\fi0\li0\f2\fs20
     5.0500       9.1800                          39.0609   115.3451\par}
{\pard\fi0\li0\f2\fs20
     7.0800       8.0200                          56.5189   220.0328\par}
{\pard\fi0\li0\f2\fs20
     9.3800 *     7.1400     7.0610 +7.903e-02    73.9529   362.3508\par}
{\pard\fi0\li0\f2\fs20
    12.1000 *     5.6800     5.7586 -7.858e-02    91.3881   546.9044\par}
{\pard\fi0\li0\f2\fs20
    23.7000 *     2.4200     2.4137 +6.308e-03   138.3681  1278.1800\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                       10.2100 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0319 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    3.5500 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               2.4200 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          2.4137 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      23.7000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              9.2469 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0750 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            9.3800 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           23.7000 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9998 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9995 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9990 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                      138.3681 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                       138.3681 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              170.6521 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.5333 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             170.5679 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.5330 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         18.9180 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        18.8780 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                    1278.1800 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            2473.9934 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           2470.8765 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        48.3354 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      48.2702 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    25.0155 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   25.0279 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               1.8752 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              1.8761 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              9.2375 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     14.4973 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    14.4862 h\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=11\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:39 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2500       4.8600                           0.6075     0.1519\par}
{\pard\fi0\li0\f2\fs20
     0.5000       7.2400                           2.1200     0.7563\par}
{\pard\fi0\li0\f2\fs20
     0.9800       8.0000                           5.7776     3.5067\par}
{\pard\fi0\li0\f2\fs20
     1.9800       6.8100                          13.1826    14.1686\par}
{\pard\fi0\li0\f2\fs20
     3.6000       5.8700                          23.4534    42.2073\par}
{\pard\fi0\li0\f2\fs20
     5.0200       5.2200                          31.3273    75.8162\par}
{\pard\fi0\li0\f2\fs20
     7.0300       4.4500                          41.0457   133.5915\par}
{\pard\fi0\li0\f2\fs20
     9.0300 *     3.6200     3.6169 +3.150e-03    49.1156   197.5636\par}
{\pard\fi0\li0\f2\fs20
    12.1200 *     2.6900     2.6929 -2.948e-03    58.8646   298.4388\par}
{\pard\fi0\li0\f2\fs20
    24.0800 *     0.8600     0.8598 +1.934e-04    80.0936   617.2422\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        8.0000 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0250 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    0.9800 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               0.8600 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          0.8598 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.0800 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              7.2612 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.0955 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            9.0300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.0800 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -1.0000 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       1.0000 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              1.0000 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                       80.0936 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                        80.0936 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                               89.1027 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.2784 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                              89.1007 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.2784 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                         10.1110 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                        10.1089 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     617.2422 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                             928.5600 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                            928.4900 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        33.5269 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      33.5219 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    37.6222 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   37.6230 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               3.5914 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              3.5914 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              7.7065 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     10.4212 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    10.4207 h\par}
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\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b\s1 Subject=12\b0\line\par}
{\pard\fi0\li0\f2\fs20
                        NONCOMPARTMENTAL ANALYSIS REPORT\par}
{\pard\fi0\li0\f2\fs20
                       Package version 0.4.1 (2018-06-20 KST)\par}
{\pard\fi0\li0\f2\fs20
                          R version 3.5.1 (2018-07-02)\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Date and Time: 2018-08-06 17:37:40 Asia/Seoul\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculation Setting\par}
{\pard\fi0\li0\f2\fs20
-------------------\par}
{\pard\fi0\li0\f2\fs20
Drug Administration: Extravascular\par}
{\pard\fi0\li0\f2\fs20
Observation count excluding trailing zero: 11\par}
{\pard\fi0\li0\f2\fs20
Dose at time 0: 320 mg\par}
{\pard\fi0\li0\f2\fs20
AUC Calculation Method: Linear-up Linear-down\par}
{\pard\fi0\li0\f2\fs20
Weighting for lambda z: Uniform (Ordinary Least Square, OLS)\par}
{\pard\fi0\li0\f2\fs20
Lambda z selection criterion: Heighest adjusted R-squared value with precision=1e-4\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Fitting, AUC, AUMC Result\par}
{\pard\fi0\li0\f2\fs20
-------------------------\par}
{\pard\fi0\li0\f2\fs20
      Time         Conc.      Pred.   Residual       AUC       AUMC\par}
{\pard\fi0\li0\f2\fs20
---------------------------------------------------------------------\par}
{\pard\fi0\li0\f2\fs20
     0.0000       0.0000                           0.0000     0.0000\par}
{\pard\fi0\li0\f2\fs20
     0.2500       1.2500                           0.1563     0.0391\par}
{\pard\fi0\li0\f2\fs20
     0.5000       3.9600                           0.8075     0.3256\par}
{\pard\fi0\li0\f2\fs20
     1.0000       7.8200                           3.7525     2.7756\par}
{\pard\fi0\li0\f2\fs20
     2.0000       9.7200                          12.5225    16.4056\par}
{\pard\fi0\li0\f2\fs20
     3.5200       9.7500                          27.3197    57.2632\par}
{\pard\fi0\li0\f2\fs20
     5.0700       8.5700                          41.5177   117.5349\par}
{\pard\fi0\li0\f2\fs20
     7.0700       6.5900                          56.6777   207.5761\par}
{\pard\fi0\li0\f2\fs20
     9.0300 *     6.1100     6.2267 -1.167e-01    69.1237   307.3054\par}
{\pard\fi0\li0\f2\fs20
    12.0500 *     4.5700     4.4632 +1.068e-01    85.2505   473.7705\par}
{\pard\fi0\li0\f2\fs20
    24.1500 *     1.1700     1.1755 -5.539e-03   119.9775   977.8807\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
*: Used for the calculation of Lambda z.\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
\par}
{\pard\fi0\li0\f2\fs20
Calculated Values\par}
{\pard\fi0\li0\f2\fs20
-----------------\par}
{\pard\fi0\li0\f2\fs20
CMAX       Max Conc                                        9.7500 mg/L\par}
{\pard\fi0\li0\f2\fs20
CMAXD      Max Conc Norm by Dose                           0.0305 mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
TMAX       Time of CMAX                                    3.5200 h\par}
{\pard\fi0\li0\f2\fs20
TLAG       Time Until First Nonzero Conc                   0.0000 h\par}
{\pard\fi0\li0\f2\fs20
CLST       Last Nonzero Conc                               1.1700 mg/L\par}
{\pard\fi0\li0\f2\fs20
CLSTP      Last Nonzero Conc Pred                          1.1755 mg/L\par}
{\pard\fi0\li0\f2\fs20
TLST       Time of Last Nonzero Conc                      24.1500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZHL     Half-Life Lambda z                              6.2865 h\par}
{\pard\fi0\li0\f2\fs20
LAMZ       Lambda z                                        0.1103 /h\par}
{\pard\fi0\li0\f2\fs20
LAMZLL     Lambda z Lower Limit                            9.0300 h\par}
{\pard\fi0\li0\f2\fs20
LAMZUL     Lambda z Upper Limit                           24.1500 h\par}
{\pard\fi0\li0\f2\fs20
LAMZNPT    Number of Points for Lambda z                   3\par}
{\pard\fi0\li0\f2\fs20
CORRXY     Correlation Between TimeX and Log ConcY        -0.9997 \par}
{\pard\fi0\li0\f2\fs20
R2         R Squared                                       0.9994 \par}
{\pard\fi0\li0\f2\fs20
R2ADJ      R Squared Adjusted                              0.9988 \par}
{\pard\fi0\li0\f2\fs20
AUCLST     AUC to Last Nonzero Conc                      119.9775 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCALL     AUC All                                       119.9775 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFO     AUC Infinity Obs                              130.5888 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFOD    AUC Infinity Obs Norm by Dose                   0.4081 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCIFP     AUC Infinity Pred                             130.6391 h*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUCIFPD    AUC Infinity Pred Norm by Dose                  0.4082 h*mg/L/mg\par}
{\pard\fi0\li0\f2\fs20
AUCPEO     AUC %Extrapolation Obs                          8.1258 %\par}
{\pard\fi0\li0\f2\fs20
AUCPEP     AUC %Extrapolation Pred                         8.1611 %\par}
{\pard\fi0\li0\f2\fs20
AUMCLST    AUMC to Last Nonzero Conc                     977.8807 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFO    AUMC Infinity Obs                            1330.3840 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCIFP    AUMC Infinity Pred                           1332.0528 h2*mg/L\par}
{\pard\fi0\li0\f2\fs20
AUMCPEO    AUMC %Extrapolation Obs                        26.4964 %\par}
{\pard\fi0\li0\f2\fs20
AUMCPEP    AUMC % Extrapolation Pred                      26.5884 %\par}
{\pard\fi0\li0\f2\fs20
VZFO       Vz Obs by F                                    22.2243 L\par}
{\pard\fi0\li0\f2\fs20
VZFP       Vz Pred by F                                   22.2157 L\par}
{\pard\fi0\li0\f2\fs20
CLFO       Total CL Obs by F                               2.4504 L/h\par}
{\pard\fi0\li0\f2\fs20
CLFP       Total CL Pred by F                              2.4495 L/h\par}
{\pard\fi0\li0\f2\fs20
MRTEVLST   MRT Extravasc to Last Nonzero Conc              8.1505 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFO   MRT Extravasc Infinity Obs                     10.1876 h\par}
{\pard\fi0\li0\f2\fs20
MRTEVIFP   MRT Extravasc Infinity Pred                    10.1964 h\par}
\pard{\f1\sect}\sectd\paperw12240\paperh15840\widowctrl\ftnbj\fet0\sectd\linex0\margl1440\margr1440\margt1440\margb1440\left\widctlpar\fi0\f2\fs18{\pard\fi0\li0\f2\fs20\b Subject=12\b0\line\par}
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