diff --git a/frontend/src/lib/__tests__/utils.spec.ts b/frontend/src/lib/__tests__/utils.spec.ts
index 548f576b..09c205ab 100644
--- a/frontend/src/lib/__tests__/utils.spec.ts
+++ b/frontend/src/lib/__tests__/utils.spec.ts
@@ -7,6 +7,7 @@ import {
   infoFromQuery,
   isVariantMt,
   isVariantMtHomopolymer,
+  removeCommasFromNumbers,
   roundIt,
   search,
   separateIt
@@ -111,6 +112,33 @@ describe.concurrent('isVariantMtHomopolymer method', () => {
   })
 })
 
+describe.concurrent('removeCommasFromNumbers method', () => {
+  it('should remove commas from numbers', () => {
+    const result = removeCommasFromNumbers('1,234,567,890')
+    expect(result).toBe('1234567890')
+  })
+
+  it('should return the same string if no commas', () => {
+    const result = removeCommasFromNumbers('1234567890')
+    expect(result).toBe('1234567890')
+  })
+
+  it('should return the same string if empty', () => {
+    const result = removeCommasFromNumbers('')
+    expect(result).toBe('')
+  })
+
+  it('should not remove commas from strings', () => {
+    const result = removeCommasFromNumbers('foo,foo,bar')
+    expect(result).toBe('foo,foo,bar')
+  })
+
+  it('should not remove commas from numbers in strings', () => {
+    const result = removeCommasFromNumbers('foo,1,234,567,890,bar')
+    expect(result).toBe('foo,1234567890,bar')
+  })
+})
+
 describe.concurrent('search method', async () => {
   beforeEach(() => {
     // we make `DottyClient.toSpdi` return null / fail every time
@@ -142,6 +170,39 @@ describe.concurrent('search method', async () => {
     })
   })
 
+  it('should return "variant" route location for Variant queries with commas in position', async () => {
+    const result = await search('chr37:12,345:A:G', 'ghcr37')
+    expect(result).toEqual({
+      name: 'variant',
+      params: {
+        searchTerm: 'chr37:12345:A:G',
+        genomeRelease: 'ghcr37'
+      }
+    })
+  })
+
+  it('should return "cnv" route location for SV quries', async () => {
+    const result = await search('DEL:chr37:12345:123456', 'ghcr37')
+    expect(result).toEqual({
+      name: 'cnv',
+      params: {
+        searchTerm: 'DEL:chr37:12345:123456',
+        genomeRelease: 'ghcr37'
+      }
+    })
+  })
+
+  it('should return "cnv" route location for SV quries with commas in start and end', async () => {
+    const result = await search('DEL:chr37:12,345:123,456', 'ghcr37')
+    expect(result).toEqual({
+      name: 'cnv',
+      params: {
+        searchTerm: 'DEL:chr37:12345:123456',
+        genomeRelease: 'ghcr37'
+      }
+    })
+  })
+
   it('should return "genes" route location for general queries', async () => {
     const result = await search('TP53', 'ghcr37')
     expect(result).toEqual({
diff --git a/frontend/src/lib/utils.ts b/frontend/src/lib/utils.ts
index cca70c79..1fba0f78 100644
--- a/frontend/src/lib/utils.ts
+++ b/frontend/src/lib/utils.ts
@@ -82,6 +82,17 @@ export const isVariantMtHomopolymer = (smallVar: any): boolean => {
   }
 }
 
+/**
+ * Removes commas from numbers within a string without affecting words.
+ * For example, it'll convert "chr17:41,197,708:T:G" to "chr17:41197708:T:G".
+ *
+ * @param str Input string possibly containing numbers with commas.
+ * @returns Sanitized string with commas removed from numbers.
+ */
+export function removeCommasFromNumbers(str: string): string {
+  return str.replace(/(\d),(?=\d)/g, '$1')
+}
+
 /**
  * Take a `searchTerm` and return a route location that can be used to navigate to
  * the correct page.
@@ -164,6 +175,7 @@ export const search = async (searchTerm: string, genomeRelease: string) => {
     ]
   ]
 
+  searchTerm = removeCommasFromNumbers(searchTerm)
   for (const [regexp, getRoute] of SEARCH_REGEXPS) {
     if (regexp.test(searchTerm)) {
       const routeLocation = getRoute()