diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 4902da3e9..7728182a2 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -16,6 +16,7 @@ Since last release
 * Link against ``libxml++`` imported target in CMake instead of ``LIBXMLXX_LIBRARIES`` (#608)
 * Cleaned up ``using`` declarations throughout archetypes (#610)
 * Update archetype definitions to use cyclus constants instead of arbitrary hardcoded values (#606)
+* Use ``CyclusBuildSetup`` macros to replace CMake boilerplate (#627)
 
 **Fixed:**
 
diff --git a/CMakeLists.txt b/CMakeLists.txt
index eb41dd393..f29e8af70 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -1,26 +1,19 @@
-CMAKE_MINIMUM_REQUIRED(VERSION 3.16)
-#taken from http://geant4.cern.ch/support/source/geant4/CMakeLists.txt
-IF(${CMAKE_SOURCE_DIR} STREQUAL ${CMAKE_BINARY_DIR})
-    message(STATUS "Cycamore requires an out-of-source build.")
-    message(STATUS "Please remove these files from ${CMAKE_BINARY_DIR} first:")
-    message(STATUS "CMakeCache.txt")
-    message(STATUS "CMakeFiles")
-    message(STATUS "Once these files are removed, create a separate directory")
-    message(STATUS "and run CMake from there")
-    message(FATAL_ERROR "in-source build detected")
-ENDIF()
+SET(CYCAMORE_SOURCE_DIR ${CMAKE_SOURCE_DIR})
+# Tell CMake where the modules are
+LIST(APPEND CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} "${CMAKE_INSTALL_PREFIX}/share/cyclus/cmake" ${CYCAMORE_SOURCE_DIR}/cmake)
+MESSAGE("--CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH}")
+
+INCLUDE(CyclusBuildSetup)
+
+cyclus_minimum_cmake_version(MINIMUM_CMAKE_VERSION)
+CMAKE_MINIMUM_REQUIRED(VERSION ${MINIMUM_CMAKE_VERSION})
+
+cyclus_require_out_of_source_build()
 
 # This project name is cycamore.
 PROJECT(CYCAMORE VERSION 1.6.0)
 
-# check for and enable c++11 support (required for cyclus)
-INCLUDE(CheckCXXCompilerFlag)
-CHECK_CXX_COMPILER_FLAG("-std=c++17" COMPILER_SUPPORTS_CXX17)
-IF(COMPILER_SUPPORTS_CXX17)
-    SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -std=c++17")
-ELSE()
-    MESSAGE(STATUS "The compiler ${CMAKE_CXX_COMPILER} has no C++17 support. Please use a different C++ compiler.")
-ENDIF()
+cyclus_require_cxx_support()
 
 # quiets fortify_source warnings when not compiling with optimizations
 # in linux distros where compilers were compiled with fortify_source enabled by
@@ -33,9 +26,6 @@ ENDIF()
 # no overflow warnings because of silly coin-ness
 SET(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -Wno-overflow")
 
-# Direct any out-of-source builds to this directory
-SET(CYCAMORE_SOURCE_DIR ${CMAKE_SOURCE_DIR})
-
 IF(NOT CYCLUS_DOC_ONLY)
     # Direct any binary installation paths to this directory
     SET(CYCAMORE_BINARY_DIR ${CMAKE_BINARY_DIR})
@@ -44,48 +34,11 @@ IF(NOT CYCLUS_DOC_ONLY)
     SET(BUILD_SHARED_LIBS true)
 
     # Setup build locations.
-    IF(NOT CMAKE_RUNTIME_OUTPUT_DIRECTORY)
-        SET(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${CYCAMORE_BINARY_DIR}/bin)
-    endif()
-    IF(NOT CMAKE_LIBRARY_OUTPUT_DIRECTORY)
-        SET(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${CYCAMORE_BINARY_DIR}/lib)
-    endif()
-    IF(NOT CMAKE_ARCHIVE_OUTPUT_DIRECTORY)
-        SET(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${CYCAMORE_BINARY_DIR}/lib)
-    ENDIF()
+    cyclus_setup_build_locations(${CYCAMORE_BINARY_DIR})
 
     SET(CYCAMORE_EXECUTABLE_DIR ${CMAKE_RUNTIME_OUTPUT_DIRECTORY})
 
-    # use, i.e. don't skip the full RPATH for the build tree
-    SET(CMAKE_SKIP_BUILD_RPATH  FALSE)
-
-    # when building, don't use the install RPATH already
-    # (but later on when installing)
-    SET(CMAKE_BUILD_WITH_INSTALL_RPATH FALSE)
-
-    SET(CMAKE_INSTALL_RPATH "${CMAKE_INSTALL_PREFIX}/lib:${CMAKE_INSTALL_PREFIX}/lib/cyclus")
-
-    # add the automatically determined parts of the RPATH
-    # which point to directories outside the build tree to the install RPATH
-    SET(CMAKE_INSTALL_RPATH_USE_LINK_PATH TRUE)
-
-    # the RPATH to be used when installing, but only if it's not a system directory
-    LIST(FIND CMAKE_PLATFORM_IMPLICIT_LINK_DIRECTORIES "${CMAKE_INSTALL_PREFIX}/lib" isSystemDir)
-    IF("${isSystemDir}" STREQUAL "-1")
-        SET(CMAKE_INSTALL_RPATH "${CMAKE_INSTALL_PREFIX}/lib:${CMAKE_INSTALL_PREFIX}/lib/cyclus")
-        GET_FILENAME_COMPONENT(cxxCompilerRoot ${CMAKE_CXX_COMPILER} DIRECTORY)
-        GET_FILENAME_COMPONENT(cxxCompilerRoot ${cxxCompilerRoot} DIRECTORY)
-        IF (NOT "${CMAKE_INSTALL_RPATH}" STREQUAL "${cxxCompilerRoot}")
-            SET(CMAKE_INSTALL_RPATH "${CMAKE_INSTALL_RPATH}:${cxxCompilerRoot}/lib:${cxxCompilerRoot}/lib/cyclus")
-        ENDIF (NOT "${CMAKE_INSTALL_RPATH}" STREQUAL "${cxxCompilerRoot}")
-        SET(CMAKE_BUILD_RPATH "${CMAKE_INSTALL_RPATH}")
-    ENDIF("${isSystemDir}" STREQUAL "-1")
-    MESSAGE("-- CMAKE_INSTALL_RPATH: ${CMAKE_INSTALL_RPATH}")
-
-    # Tell CMake where the modules are
-    SET(CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} "${CMAKE_INSTALL_PREFIX}/share/cyclus/cmake")
-    SET(CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH} ${CYCAMORE_SOURCE_DIR}/cmake)
-    MESSAGE("--CMAKE_MODULE_PATH ${CMAKE_MODULE_PATH}")
+    cyclus_set_rpath()
 
     # get dependency hints
     if (NOT DEPS_ROOT_DIR)