diff --git a/internal/dash0/startup/auto_operator_configuration_handler.go b/internal/dash0/startup/auto_operator_configuration_handler.go
index cc929c0..f30af51 100644
--- a/internal/dash0/startup/auto_operator_configuration_handler.go
+++ b/internal/dash0/startup/auto_operator_configuration_handler.go
@@ -211,6 +211,17 @@ func (r *AutoOperatorConfigurationResourceHandler) createOperatorConfigurationRe
 	operatorConfigurationResource := dash0v1alpha1.Dash0OperatorConfiguration{
 		ObjectMeta: metav1.ObjectMeta{
 			Name: operatorConfigurationAutoResourceName,
+			Annotations: map[string]string{
+				// For clusters managed by ArgoCD, we need to prevent ArgoCD to prune resources that are not created
+				// directly via the Helm chart and that have no owner reference. These are all cluster-scoped resources
+				// not created via Helm, like cluster roles & cluster role bindings. See also:
+				// * https://github.com/argoproj/argo-cd/issues/4764#issuecomment-722661940 -- this is where they say
+				//   that only top level resources are pruned (that is basically the same as resources without an owner
+				//   reference).
+				// * The docs for preventing this on a resource level are here:
+				//   https://argo-cd.readthedocs.io/en/stable/user-guide/sync-options/#no-prune-resources
+				"argocd.argoproj.io/sync-options": "Prune=false",
+			},
 		},
 		Spec: dash0v1alpha1.Dash0OperatorConfigurationSpec{
 			SelfMonitoring: dash0v1alpha1.SelfMonitoring{
diff --git a/internal/dash0/startup/auto_operator_configuration_handler_test.go b/internal/dash0/startup/auto_operator_configuration_handler_test.go
index e85d1b5..eb26b41 100644
--- a/internal/dash0/startup/auto_operator_configuration_handler_test.go
+++ b/internal/dash0/startup/auto_operator_configuration_handler_test.go
@@ -104,8 +104,11 @@ var _ = Describe("Create an operator configuration resource at startup", Ordered
 			err := k8sClient.Get(ctx, types.NamespacedName{
 				Name: operatorConfigurationAutoResourceName,
 			}, &operatorConfiguration)
-
 			g.Expect(err).ToNot(HaveOccurred())
+
+			g.Expect(operatorConfiguration.Annotations).To(HaveLen(1))
+			g.Expect(operatorConfiguration.Annotations["argocd.argoproj.io/sync-options"]).To(Equal("Prune=false"))
+
 			export := operatorConfiguration.Spec.Export
 			g.Expect(export).ToNot(BeNil())
 			dash0Export := export.Dash0
@@ -129,8 +132,11 @@ var _ = Describe("Create an operator configuration resource at startup", Ordered
 			err := k8sClient.Get(ctx, types.NamespacedName{
 				Name: operatorConfigurationAutoResourceName,
 			}, &operatorConfiguration)
-
 			g.Expect(err).ToNot(HaveOccurred())
+
+			g.Expect(operatorConfiguration.Annotations).To(HaveLen(1))
+			g.Expect(operatorConfiguration.Annotations["argocd.argoproj.io/sync-options"]).To(Equal("Prune=false"))
+
 			export := operatorConfiguration.Spec.Export
 			g.Expect(export).ToNot(BeNil())
 			dash0Export := export.Dash0