diff --git a/Dockerfile b/Dockerfile
index 6b2f7d8..6f3d32b 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,61 +1,99 @@
 # Dockerfile for uWSGI wrapped Giftless Git LFS Server
+# Shared build ARGs among stages
+ARG WORKDIR=/app
+ARG VENV="$WORKDIR/.venv"
+ARG UV_VERSION=0.5.16
 
-### --- Build Depdendencies ---
-
-FROM python:3.12 as builder
-MAINTAINER "Shahar Evron <shahar.evron@datopian.com>"
-
-# Build wheels for uWSGI and all requirements
-RUN DEBIAN_FRONTEND=noninteractive apt-get update \
-    && apt-get install -y build-essential libpcre3 libpcre3-dev git
-RUN pip install -U pip
-RUN mkdir /wheels
+### Distroless uv version layer to be copied from (because COPY --from does not interpolate variables)
+FROM ghcr.io/astral-sh/uv:$UV_VERSION AS uv
 
+### --- Build Depdendencies ---
+FROM python:3.12 AS builder
 ARG UWSGI_VERSION=2.0.23
-RUN pip wheel -w /wheels uwsgi==$UWSGI_VERSION
-
-COPY requirements/main.txt /requirements.txt
-RUN pip wheel -w /wheels -r /requirements.txt
+# Common WSGI middleware modules to be pip-installed
+# These are not required in every Giftless installation but are common enough
+ARG EXTRA_PACKAGES="wsgi_cors_middleware"
+# expose shared ARGs
+ARG WORKDIR
+ARG VENV
+
+# Set WORKDIR (also creates the dir)
+WORKDIR $WORKDIR
+
+# Install packages to build wheels for uWSGI and other requirements
+RUN set -eux ;\
+    export DEBIAN_FRONTEND=noninteractive ;\
+    apt-get update ;\
+    apt-get install -y --no-install-recommends build-essential libpcre3 libpcre3-dev git ;\
+    rm -rf /var/lib/apt/lists/*
+
+# Install uv to replace pip & friends
+COPY --from=uv /uv /uvx /bin/
+
+# Set a couple uv-related settings
+# Wait a bit longer for slow connections
+ENV UV_HTTP_TIMEOUT=100
+# Don't cache packages
+ENV UV_NO_CACHE=1
+
+# Create virtual env to store dependencies, "activate" it
+RUN uv venv "$VENV"
+ENV VIRTUAL_ENV="$VENV" PATH="$VENV/bin:$PATH"
+
+# Install runtime dependencies
+RUN --mount=target=/build-ctx \
+    uv pip install -r /build-ctx/requirements/main.txt
+RUN uv pip install uwsgi==$UWSGI_VERSION
+# Install extra packages into the virtual env
+RUN uv pip install ${EXTRA_PACKAGES}
+
+# Copy project contents necessary for an editable install
+COPY .git .git/
+COPY giftless giftless/
+COPY pyproject.toml .
+# Editable-install the giftless package (add a kind of a project path reference in site-packages)
+# To detect the package version dynamically, setuptools-scm needs the git binary
+RUN uv pip install -e .
 
 ### --- Build Final Image ---
-
-FROM python:3.12-slim
-
-RUN DEBIAN_FRONTEND=noninteractive apt-get update \
-    && apt-get install -y libpcre3 libxml2 tini git \
-    && apt-get clean \
-    && apt -y autoremove
-
-RUN mkdir /app
-
-# Install dependencies
-COPY --from=builder /wheels /wheels
-RUN pip install /wheels/*.whl
-
-# Copy project code
-COPY . /app
-RUN pip install -e /app
+FROM python:3.12-slim AS final
+LABEL org.opencontainers.image.authors="Shahar Evron <shahar.evron@datopian.com>"
 
 ARG USER_NAME=giftless
+# Writable path for local LFS storage
 ARG STORAGE_DIR=/lfs-storage
-ENV GIFTLESS_TRANSFER_ADAPTERS_basic_options_storage_options_path $STORAGE_DIR
-
-RUN useradd -d /app $USER_NAME
-RUN mkdir $STORAGE_DIR
-RUN chown $USER_NAME $STORAGE_DIR
-
-# Pip-install some common WSGI middleware modules
-# These are not required in every Giftless installation but are common enough
-ARG EXTRA_PACKAGES="wsgi_cors_middleware"
-RUN pip install ${EXTRA_PACKAGES}
-
+# expose shared ARGs
+ARG WORKDIR
+ARG VENV
+
+# Set WORKDIR (also creates the dir)
+WORKDIR $WORKDIR
+
+# Create a user and set local storage write permissions
+RUN set -eux ;\
+    useradd -d "$WORKDIR" "$USER_NAME" ;\
+    mkdir "$STORAGE_DIR" ;\
+    chown "$USER_NAME" "$STORAGE_DIR"
+
+# Install runtime dependencies
+RUN set -eux ;\
+    export DEBIAN_FRONTEND=noninteractive ;\
+    apt-get update ;\
+    apt-get install -y libpcre3 libxml2 tini ;\
+    rm -rf /var/lib/apt/lists/*
+
+# Use the virtual env with dependencies from builder stage
+COPY --from=builder "$VENV" "$VENV"
+ENV VIRTUAL_ENV="$VENV" PATH="$VENV/bin:$PATH"
+# Copy project source back into the same path referenced by the editable install
+COPY --from=builder "$WORKDIR/giftless" "giftless"
+
+# Set runtime properties
 USER $USER_NAME
+ENV GIFTLESS_TRANSFER_ADAPTERS_basic_options_storage_options_path="$STORAGE_DIR"
+ENV UWSGI_MODULE="giftless.wsgi_entrypoint"
 
-WORKDIR /app
-
-ENV UWSGI_MODULE "giftless.wsgi_entrypoint"
-
-ENTRYPOINT ["tini", "uwsgi", "--"]
+ENTRYPOINT ["tini", "--", "uwsgi"]
 CMD ["-s", "127.0.0.1:5000", "-M", "-T", "--threads", "2", "-p", "2", \
      "--manage-script-name", "--callable", "app"]
 
diff --git a/requirements/dev.txt b/requirements/dev.txt
index 76454ae..7fb7f99 100644
--- a/requirements/dev.txt
+++ b/requirements/dev.txt
@@ -248,9 +248,7 @@ urllib3==2.0.7
     #   responses
     #   types-requests
 uv==0.5.8
-    # via
-    #   -c requirements/main.txt
-    #   -r requirements/dev.in
+    # via -r requirements/dev.in
 vcrpy==6.0.1
     # via pytest-vcr
 virtualenv==20.25.1
diff --git a/requirements/main.in b/requirements/main.in
index 611cda2..20dbb4e 100644
--- a/requirements/main.in
+++ b/requirements/main.in
@@ -22,7 +22,4 @@ boto3~=1.34
 # GitHub AA Provider
 cachetools~=5.3
 
-# uv: fast pip replacement
-uv
-
 importlib-metadata; python_version < '3.13'
diff --git a/requirements/main.txt b/requirements/main.txt
index 7b5fdec..490e194 100644
--- a/requirements/main.txt
+++ b/requirements/main.txt
@@ -132,8 +132,6 @@ urllib3==2.0.7
     # via
     #   botocore
     #   requests
-uv==0.5.8
-    # via -r requirements/main.in
 webargs==8.4.0
     # via -r requirements/main.in
 werkzeug==3.0.3