diff --git a/UefiCpuPkg/CpuS3DataDxe/CpuS3Data.c b/UefiCpuPkg/CpuS3DataDxe/CpuS3Data.c
index 86ce5303cab4..c87f82bc22ba 100644
--- a/UefiCpuPkg/CpuS3DataDxe/CpuS3Data.c
+++ b/UefiCpuPkg/CpuS3DataDxe/CpuS3Data.c
@@ -9,7 +9,7 @@ number of CPUs reported by the MP Services Protocol, so this module does not
 support hot plug CPUs.  This module can be copied into a CPU specific package
 and customized if these additional features are required.
 
-Copyright (c) 2013 - 2021, Intel Corporation. All rights reserved.<BR>
+Copyright (c) 2013 - 2024, Intel Corporation. All rights reserved.<BR>
 Copyright (c) 2015, Red Hat, Inc.
 
 SPDX-License-Identifier: BSD-2-Clause-Patent
@@ -26,6 +26,7 @@ SPDX-License-Identifier: BSD-2-Clause-Patent
 #include <Library/DebugLib.h>
 #include <Library/MtrrLib.h>
 #include <Library/MemoryAllocationLib.h>
+#include <Library/LockBoxLib.h>
 
 #include <Protocol/MpService.h>
 #include <Guid/EventGroup.h>
@@ -130,6 +131,16 @@ CpuS3DataOnEndOfDxe (
   DEBUG ((DEBUG_VERBOSE, "%a\n", __func__));
   MtrrGetAllMtrrs (&AcpiCpuDataEx->MtrrTable);
 
+  //
+  // Save MTRR in lockbox
+  //
+  Status = SaveLockBox (
+             &gEdkiiS3MtrrSettingGuid,
+             &AcpiCpuDataEx->MtrrTable,
+             sizeof (MTRR_SETTINGS)
+             );
+  ASSERT_EFI_ERROR (Status);
+
   //
   // Close event, so it will not be invoked again.
   //
diff --git a/UefiCpuPkg/CpuS3DataDxe/CpuS3DataDxe.inf b/UefiCpuPkg/CpuS3DataDxe/CpuS3DataDxe.inf
index 510133a614ba..c690f7df5be1 100644
--- a/UefiCpuPkg/CpuS3DataDxe/CpuS3DataDxe.inf
+++ b/UefiCpuPkg/CpuS3DataDxe/CpuS3DataDxe.inf
@@ -9,7 +9,7 @@
 #  support hot plug CPUs.  This module can be copied into a CPU specific package
 #  and customized if these additional features are required.
 #
-#  Copyright (c) 2013-2016, Intel Corporation. All rights reserved.<BR>
+#  Copyright (c) 2013-2024, Intel Corporation. All rights reserved.<BR>
 #  Copyright (c) 2015, Red Hat, Inc.
 #
 #  SPDX-License-Identifier: BSD-2-Clause-Patent
@@ -46,9 +46,11 @@
   BaseLib
   MtrrLib
   MemoryAllocationLib
+  LockBoxLib
 
 [Guids]
   gEfiEndOfDxeEventGroupGuid         ## CONSUMES   ## Event
+  gEdkiiS3MtrrSettingGuid
 
 [Protocols]
   gEfiMpServiceProtocolGuid          ## CONSUMES