diff --git a/.github/workflows/macos-install.sh b/.github/workflows/macos-install.sh
index 4e54f49922f..0c3e55eae3c 100755
--- a/.github/workflows/macos-install.sh
+++ b/.github/workflows/macos-install.sh
@@ -8,8 +8,8 @@ fi
 brew install \
     freetype \
     ghostscript \
+    jpeg-turbo \
     libimagequant \
-    libjpeg \
     libtiff \
     little-cms2 \
     openjpeg \
diff --git a/.github/workflows/wheels-dependencies.sh b/.github/workflows/wheels-dependencies.sh
index 0efda07eac6..01f6768bb44 100755
--- a/.github/workflows/wheels-dependencies.sh
+++ b/.github/workflows/wheels-dependencies.sh
@@ -50,11 +50,7 @@ if [[ -n "$IS_MACOS" ]]; then
 else
     GIFLIB_VERSION=5.2.1
 fi
-if [[ -n "$IS_MACOS" ]] || [[ "$MB_ML_VER" != 2014 ]]; then
-    ZLIB_VERSION=1.3.1
-else
-    ZLIB_VERSION=1.2.8
-fi
+ZLIB_NG_VERSION=2.2.2
 LIBWEBP_VERSION=1.4.0
 BZIP2_VERSION=1.0.8
 LIBXCB_VERSION=1.17.0
@@ -76,6 +72,16 @@ function build_pkg_config {
     touch pkg-config-stamp
 }
 
+function build_zlib_ng {
+    if [ -e zlib-stamp ]; then return; fi
+    fetch_unpack https://github.com/zlib-ng/zlib-ng/archive/$ZLIB_NG_VERSION.tar.gz zlib-ng-$ZLIB_NG_VERSION.tar.gz
+    (cd zlib-ng-$ZLIB_NG_VERSION \
+        && ./configure --prefix=$BUILD_PREFIX --zlib-compat \
+        && make -j4 \
+        && make install)
+    touch zlib-stamp
+}
+
 function build_brotli {
     if [ -e brotli-stamp ]; then return; fi
     local out_dir=$(fetch_unpack https://github.com/google/brotli/archive/v$BROTLI_VERSION.tar.gz brotli-$BROTLI_VERSION.tar.gz)
@@ -167,14 +173,14 @@ function build {
     if [ -z "$IS_ALPINE" ] && [ -z "$IS_MACOS" ]; then
         yum remove -y zlib-devel
     fi
-    build_new_zlib
+    build_zlib_ng
 
     build_libavif
 
     build_simple xcb-proto 1.17.0 https://xorg.freedesktop.org/archive/individual/proto
     if [ -n "$IS_MACOS" ]; then
         build_simple xorgproto 2024.1 https://www.x.org/pub/individual/proto
-        build_simple libXau 1.0.11 https://www.x.org/pub/individual/lib
+        build_simple libXau 1.0.12 https://www.x.org/pub/individual/lib
         build_simple libpthread-stubs 0.5 https://xcb.freedesktop.org/dist
     else
         sed s/\${pc_sysrootdir\}// $BUILD_PREFIX/share/pkgconfig/xcb-proto.pc > $BUILD_PREFIX/lib/pkgconfig/xcb-proto.pc
diff --git a/Tests/check_wheel.py b/Tests/check_wheel.py
index 4c3f634a6c3..ed5f860ea1a 100644
--- a/Tests/check_wheel.py
+++ b/Tests/check_wheel.py
@@ -41,6 +41,7 @@ def test_wheel_features() -> None:
         "fribidi",
         "harfbuzz",
         "libjpeg_turbo",
+        "zlib_ng",
         "xcb",
     }
 
diff --git a/Tests/test_features.py b/Tests/test_features.py
index ed792997376..f8f7f6eec59 100644
--- a/Tests/test_features.py
+++ b/Tests/test_features.py
@@ -36,10 +36,11 @@ def test(name: str, function: Callable[[str], str | None]) -> None:
         else:
             assert function(name) == version
             if name != "PIL":
-                if name == "zlib" and version is not None:
-                    version = re.sub(".zlib-ng$", "", version)
-                elif name == "libtiff" and version is not None:
-                    version = re.sub("t$", "", version)
+                if version is not None:
+                    if name == "zlib" and features.check_feature("zlib_ng"):
+                        version = re.sub(".zlib-ng$", "", version)
+                    elif name == "libtiff":
+                        version = re.sub("t$", "", version)
                 assert version is None or re.search(r"\d+(\.\d+)*$", version)
 
     for module in features.modules:
diff --git a/docs/reference/features.rst b/docs/reference/features.rst
index d1e4f7470eb..72f29874443 100644
--- a/docs/reference/features.rst
+++ b/docs/reference/features.rst
@@ -55,6 +55,7 @@ Feature version numbers are available only where stated.
 Support for the following features can be checked:
 
 * ``libjpeg_turbo``: (compile time) Whether Pillow was compiled against the libjpeg-turbo version of libjpeg. Compile-time version number is available.
+* ``zlib_ng``: (compile time) Whether Pillow was compiled against the zlib-ng version of zlib. Compile-time version number is available.
 * ``raqm``: Raqm library, required for ``ImageFont.Layout.RAQM`` in :py:func:`PIL.ImageFont.truetype`. Run-time version number is available for Raqm 0.7.0 or newer.
 * ``libimagequant``: (compile time) ImageQuant quantization support in :py:func:`PIL.Image.Image.quantize`. Run-time version number is available.
 * ``xcb``: (compile time) Support for X11 in :py:func:`PIL.ImageGrab.grab` via the XCB library.
diff --git a/pyproject.toml b/pyproject.toml
index aaaba0032e7..2c6c7bcd077 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -104,6 +104,7 @@ test-extras = "tests"
 
 [tool.cibuildwheel.macos.environment]
 PATH = "$(pwd)/build/deps/darwin/bin:$(dirname $(which python3)):/usr/bin:/bin:/usr/sbin:/sbin:/Library/Apple/usr/bin"
+DYLD_LIBRARY_PATH = "$(pwd)/build/deps/darwin/lib"
 
 [tool.black]
 exclude = "wheels/multibuild"
diff --git a/src/PIL/features.py b/src/PIL/features.py
index 3429d3f7e46..6ccb7867b1f 100644
--- a/src/PIL/features.py
+++ b/src/PIL/features.py
@@ -128,6 +128,7 @@ def get_supported_codecs() -> list[str]:
     "fribidi": ("PIL._imagingft", "HAVE_FRIBIDI", "fribidi_version"),
     "harfbuzz": ("PIL._imagingft", "HAVE_HARFBUZZ", "harfbuzz_version"),
     "libjpeg_turbo": ("PIL._imaging", "HAVE_LIBJPEGTURBO", "libjpeg_turbo_version"),
+    "zlib_ng": ("PIL._imaging", "HAVE_ZLIBNG", "zlib_ng_version"),
     "libimagequant": ("PIL._imaging", "HAVE_LIBIMAGEQUANT", "imagequant_version"),
     "xcb": ("PIL._imaging", "HAVE_XCB", None),
 }
@@ -310,7 +311,11 @@ def pilinfo(out: IO[str] | None = None, supported_formats: bool = True) -> None:
                     # this check is also in src/_imagingcms.c:setup_module()
                     version_static = tuple(int(x) for x in v.split(".")) < (2, 7)
                 t = "compiled for" if version_static else "loaded"
-                if name == "raqm":
+                if name == "zlib":
+                    zlib_ng_version = version_feature("zlib_ng")
+                    if zlib_ng_version is not None:
+                        v += ", compiled for zlib-ng " + zlib_ng_version
+                elif name == "raqm":
                     for f in ("fribidi", "harfbuzz"):
                         v2 = version_feature(f)
                         if v2 is not None:
diff --git a/src/_imaging.c b/src/_imaging.c
index 2db4486b23e..5d6d97bedab 100644
--- a/src/_imaging.c
+++ b/src/_imaging.c
@@ -4397,6 +4397,20 @@ setup_module(PyObject *m) {
     }
 #endif
 
+    PyObject *have_zlibng;
+#ifdef ZLIBNG_VERSION
+    have_zlibng = Py_True;
+    {
+        PyObject *v = PyUnicode_FromString(ZLIBNG_VERSION);
+        PyDict_SetItemString(d, "zlib_ng_version", v ? v : Py_None);
+        Py_XDECREF(v);
+    }
+#else
+    have_zlibng = Py_False;
+#endif
+    Py_INCREF(have_zlibng);
+    PyModule_AddObject(m, "HAVE_ZLIBNG", have_zlibng);
+
 #ifdef HAVE_LIBTIFF
     {
         extern const char *ImagingTiffVersion(void);
diff --git a/winbuild/build_prepare.py b/winbuild/build_prepare.py
index 82488628c6f..39bd4afb6fc 100644
--- a/winbuild/build_prepare.py
+++ b/winbuild/build_prepare.py
@@ -121,12 +121,11 @@ def cmd_msbuild(
     "OPENJPEG": "2.5.3",
     "TIFF": "4.6.0",
     "XZ": "5.6.3",
-    "ZLIB": "1.3.1",
+    "ZLIBNG": "2.2.2",
     "LIBAVIF": "1.1.1",
 }
 V["LIBPNG_DOTLESS"] = V["LIBPNG"].replace(".", "")
 V["LIBPNG_XY"] = "".join(V["LIBPNG"].split(".")[:2])
-V["ZLIB_DOTLESS"] = V["ZLIB"].replace(".", "")
 
 
 # dependencies, listed in order of compilation
@@ -162,18 +161,22 @@ def cmd_msbuild(
         "bins": ["cjpeg.exe", "djpeg.exe"],
     },
     "zlib": {
-        "url": "https://zlib.net/FILENAME",
-        "filename": f"zlib{V['ZLIB_DOTLESS']}.zip",
-        "dir": f"zlib-{V['ZLIB']}",
-        "license": "README",
-        "license_pattern": "Copyright notice:\n\n(.+)$",
+        "url": f"https://github.com/zlib-ng/zlib-ng/archive/refs/tags/{V['ZLIBNG']}.zip",
+        "filename": f"zlib-ng-{V['ZLIBNG']}.zip",
+        "dir": f"zlib-ng-{V['ZLIBNG']}",
+        "license": "LICENSE.md",
+        "patch": {
+            r"CMakeLists.txt": {
+                "set_target_properties(zlib PROPERTIES OUTPUT_NAME zlibstatic${{SUFFIX}})": "set_target_properties(zlib PROPERTIES OUTPUT_NAME zlib)",  # noqa: E501
+            },
+        },
         "build": [
-            cmd_nmake(r"win32\Makefile.msc", "clean"),
-            cmd_nmake(r"win32\Makefile.msc", "zlib.lib"),
-            cmd_copy("zlib.lib", "z.lib"),
+            *cmds_cmake(
+                "zlib", "-DBUILD_SHARED_LIBS:BOOL=OFF", "-DZLIB_COMPAT:BOOL=ON"
+            ),
         ],
         "headers": [r"z*.h"],
-        "libs": [r"*.lib"],
+        "libs": [r"zlib.lib"],
     },
     "xz": {
         "url": f"https://github.com/tukaani-project/xz/releases/download/v{V['XZ']}/FILENAME",