forked from arinbasu/brca-study
-
Notifications
You must be signed in to change notification settings - Fork 0
/
Copy pathAnnBrCaPaper.html
259 lines (217 loc) · 10.6 KB
/
AnnBrCaPaper.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
<!DOCTYPE html>
<html>
<head>
<meta charset="utf-8"/>
<title>AnnBrCaPaper</title>
<meta name="author" content="Arindam Bose"/>
</head>
<body>
<p>Title: AnnBrCaPaper
Author: Arindam Bose
Base Header Level: 1</p>
<h2 id="theworksofarpreliminaryanalyses">The Work so Far (Preliminary Analyses)</h2>
<p>Data from the spreadsheet was abstracted and a new data table was created that contained the following information:</p>
<ol>
<li>The name of the country where the screening for breast cancer,</li>
<li>The percentage reduction in the usage of HRT between peak use and the last reported use</li>
<li>The percentage reduction in the reported incidence for the corresponding years for the relevant age groups (50–64+)</li>
<li>The Age Range at which Screening for Breast Cancer using Mammograms begin. If the age range was 50–64 years, it was given a code of 1, else if the age at which mammogram began was earlier (that is for younger age), the Age range variable was assigned a code of 2.</li>
</ol>
<p>In addition to this, data from the papers by Verkooijen et al
\cite{Verkooijen 2009} and Zbuk et al \cite{Zbuk 2012} were extracted. For each of these data, the following information were abstracted from each paper</p>
<ol>
<li>The name of the country where the study was conducted</li>
<li>The percentage of reduction from peak HRT usage till the date when it was reported</li>
<li>The reduction in percentage in the corresponding breast cancer incidence as reported in the paper.</li>
</ol>
<p>These were presented in a corresponding table abstracted from the papers (see Figures 1 and 2). For each of the three data, a linear regression model was run to study the extent to which reduction in the HRT usage might explain the reduction in the incidence of Breast Cancer. For the current dataset, in addition, the relationship between the reduction in Breast Cancer and the HRT usage was further adjusted for by including the age at which screening begins. </p>
<h2 id="results">Results</h2>
<p>Table 1 shows the data abstracted from the current dataset.</p>
<table>
<colgroup>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
</colgroup>
<thead>
<tr>
<th style="text-align:left;">Country</th>
<th style="text-align:left;">Reduction in HRT Usage (pct)</th>
<th style="text-align:left;">Reduction in Br Ca (percent)</th>
<th style="text-align:left;">Age Category of Screening</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align:left;">Australia</td>
<td style="text-align:left;">43</td>
<td style="text-align:left;">6.7</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Canada</td>
<td style="text-align:left;">70</td>
<td style="text-align:left;">8</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">Denmark</td>
<td style="text-align:left;">19</td>
<td style="text-align:left;">5.63</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">France</td>
<td style="text-align:left;">66</td>
<td style="text-align:left;">6.3</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">Italy</td>
<td style="text-align:left;">42</td>
<td style="text-align:left;">6.18</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">United States</td>
<td style="text-align:left;">33</td>
<td style="text-align:left;">6.7</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Germany</td>
<td style="text-align:left;">50</td>
<td style="text-align:left;">8.8</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Belgium</td>
<td style="text-align:left;">60</td>
<td style="text-align:left;">9.5</td>
<td style="text-align:left;">50–69</td>
</tr>
</tbody>
</table>
<p><img src="ourdata.jpg" alt="Graph from our Data" />
Figure 1 shows the graph from the regression model of the relationship between reduction in HRT usage and reduction in breast cancer incidence from the studies included in this paper</p>
<p>Exhibit 1 shows the results of the regression model from the data abstracted for this analysis.
<img src="ourfigure.png" alt="Regression Output" /></p>
<h2 id="comparisonwithtwootherstudieszbukandanandandverkooijenetal">Comparison with Two Other Studies (Zbuk and Anand and Verkooijen et al)</h2>
<p>For comparison, we present two other datasets and two other analyses, one from the paper by Zbuk and Anand and the other by a paper by Verkooijen. </p>
<p>Figure 2. Data from the paper by Zbuk
<img src="zbuk.jpg" alt="Table from Zbuk Paper" /></p>
<p>Figure 3 presents the results of data analyses and regression model constructed from the zbuk data.
<img src="zbukgraph.jpg" alt="Graph from the Zbuk Study" /></p>
<p>Figure 4 presents the regression outputs from the Zbuk data abstracted from the paper
<img src="zbukoutput.png" alt="Regression Table from Zbuk Paper" /></p>
<p>Figure 5 presents the tables from Verkooijen study
<img src="verkooijen.jpg" alt="Table from Verkooijen Study" /></p>
<p>Figure 6 presents the figure of the data analyses from regression model constructed from Verkooijen study
<img src="verkgraph.jpg" alt="Graph from Verkooijen Study" /></p>
<p>Figure 7 presents the figure of the regression table from Verkooijen study
<img src="verkoutput.png" alt="Regression Table from Verkooijen Study" /></p>
<h2 id="theworksofarpreliminaryanalyses">The Work so Far (Preliminary Analyses)</h2>
<p>Data from the spreadsheet was abstracted and a new data table was created that contained the following information:</p>
<ol>
<li>The name of the country where the screening for breast cancer,</li>
<li>The percentage reduction in the usage of HRT between peak use and the last reported use</li>
<li>The percentage reduction in the reported incidence for the corresponding years for the relevant age groups (50–64+)</li>
<li>The Age Range at which Screening for Breast Cancer using Mammograms begin. If the age range was 50–64 years, it was given a code of 1, else if the age at which mammogram began was earlier (that is for younger age), the Age range variable was assigned a code of 2.</li>
</ol>
<p>In addition to this, data from the papers by Verkooijen et al
\cite{Verkooijen 2009} and Zbuk et al \cite{Zbuk 2012} were extracted. For each of these data, the following information were abstracted from each paper</p>
<ol>
<li>The name of the country where the study was conducted</li>
<li>The percentage of reduction from peak HRT usage till the date when it was reported</li>
<li>The reduction in percentage in the corresponding breast cancer incidence as reported in the paper.</li>
</ol>
<p>These were presented in a corresponding table abstracted from the papers (see Figures 1 and 2). For each of the three data, a linear regression model was run to study the extent to which reduction in the HRT usage might explain the reduction in the incidence of Breast Cancer. For the current dataset, in addition, the relationship between the reduction in Breast Cancer and the HRT usage was further adjusted for by including the age at which screening begins. </p>
<h2 id="results">Results</h2>
<p>Table 1 shows the data abstracted from the current dataset.</p>
<table>
<colgroup>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
<col style="text-align:left;"/>
</colgroup>
<thead>
<tr>
<th style="text-align:left;">Country</th>
<th style="text-align:left;">Reduction in HRT Usage (pct)</th>
<th style="text-align:left;">Reduction in Br Ca (percent)</th>
<th style="text-align:left;">Age Category of Screening</th>
</tr>
</thead>
<tbody>
<tr>
<td style="text-align:left;">Australia</td>
<td style="text-align:left;">43</td>
<td style="text-align:left;">6.7</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Canada</td>
<td style="text-align:left;">70</td>
<td style="text-align:left;">8</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">Denmark</td>
<td style="text-align:left;">19</td>
<td style="text-align:left;">5.63</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">France</td>
<td style="text-align:left;">66</td>
<td style="text-align:left;">6.3</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">Italy</td>
<td style="text-align:left;">42</td>
<td style="text-align:left;">6.18</td>
<td style="text-align:left;">50–69</td>
</tr>
<tr>
<td style="text-align:left;">United States</td>
<td style="text-align:left;">33</td>
<td style="text-align:left;">6.7</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Germany</td>
<td style="text-align:left;">50</td>
<td style="text-align:left;">8.8</td>
<td style="text-align:left;">40–75</td>
</tr>
<tr>
<td style="text-align:left;">Belgium</td>
<td style="text-align:left;">60</td>
<td style="text-align:left;">9.5</td>
<td style="text-align:left;">50–69</td>
</tr>
</tbody>
</table>
<p><img src="ourdata.jpg" alt="Graph from our Data" />
Figure 1 shows the graph from the regression model of the relationship between reduction in HRT usage and reduction in breast cancer incidence from the studies included in this paper</p>
<p>Exhibit 1 shows the results of the regression model from the data abstracted for this analysis.
<img src="ourfigure.png" alt="Regression Output" /></p>
<h2 id="comparisonwithtwootherstudieszbukandanandandverkooijenetal">Comparison with Two Other Studies (Zbuk and Anand and Verkooijen et al)</h2>
<p>For comparison, we present two other datasets and two other analyses, one from the paper by Zbuk and Anand and the other by a paper by Verkooijen. </p>
<p>Figure 2. Data from the paper by Zbuk
<img src="zbuk.jpg" alt="Table from Zbuk Paper" /></p>
<p>Figure 3 presents the results of data analyses and regression model constructed from the zbuk data.
<img src="zbukgraph.jpg" alt="Graph from the Zbuk Study" /></p>
<p>Figure 4 presents the regression outputs from the Zbuk data abstracted from the paper
<img src="zbukoutput.png" alt="Regression Table from Zbuk Paper" /></p>
<p>Figure 5 presents the tables from Verkooijen study
<img src="verkooijen.jpg" alt="Table from Verkooijen Study" /></p>
<p>Figure 6 presents the figure of the data analyses from regression model constructed from Verkooijen study
<img src="verkgraph.jpg" alt="Graph from Verkooijen Study" /></p>
<p>Figure 7 presents the figure of the regression table from Verkooijen study
<img src="verkoutput.png" alt="Regression Table from Verkooijen Study" /></p>
</body>
</html>