diff --git a/src/webgpu/api/validation/encoding/cmds/copyTextureToTexture.spec.ts b/src/webgpu/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
index f1c3d91e2940..af91534943b1 100644
--- a/src/webgpu/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
+++ b/src/webgpu/api/validation/encoding/cmds/copyTextureToTexture.spec.ts
@@ -255,6 +255,12 @@ Test that textures in copyTextureToTexture must have the same sample count.
       .combine('srcSampleCount', [1, 4])
       .combine('dstSampleCount', [1, 4])
   )
+  .beforeAllSubcases(t => {
+    t.skipIf(
+      t.isCompatibility && (t.params.srcSampleCount !== 1 || t.params.dstSampleCount !== 1),
+      'multisample textures are not copyable in compatibility mode'
+    );
+  })
   .fn(t => {
     const { srcSampleCount, dstSampleCount } = t.params;
 
@@ -307,6 +313,9 @@ TODO: Check the source and destination constraints separately.
       .expand('copyWidth', p => [32 - Math.max(p.srcCopyOrigin.x, p.dstCopyOrigin.x), 16])
       .expand('copyHeight', p => [16 - Math.max(p.srcCopyOrigin.y, p.dstCopyOrigin.y), 8])
   )
+  .beforeAllSubcases(t => {
+    t.skipIf(t.isCompatibility, 'multisample textures are not copyable in compatibility mode');
+  })
   .fn(t => {
     const { srcCopyOrigin, dstCopyOrigin, copyWidth, copyHeight } = t.params;