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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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2625</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=104">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=101">101</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=102">102</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=103">103</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=104">104</a></li><li class="page-item active"><a remote="false" class="page-link">105</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=106">106</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=107">107</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=108">108</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=109">109</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=106">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB01228">Encainide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Withdrawn</span></td><td>Quinidine sulphate</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Encainide <em>increases</em> the level of <em>Quinidine sulphate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26168" data-original-title="Halawa B: [Interactions of quinidine and propranolol with mexiletine, encainide, flecainide and tocainide]. Pol Tyg Lek. 1990 Mar 5-12;45(10-11):222-4.">A26168</a></li></ul></td></tr><tr><td><a href="/drugs/DB00379">Mexiletine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>Quinidine sulphate</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Mexiletine <em>increases</em> the level of <em>Quinidine sulphate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26168" data-original-title="Halawa B: [Interactions of quinidine and propranolol with mexiletine, encainide, flecainide and tocainide]. Pol Tyg Lek. 1990 Mar 5-12;45(10-11):222-4.">A26168</a></li></ul></td></tr><tr><td><a href="/drugs/DB01544">Flunitrazepam</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span></td><td>7-acetamidoFlunitrazepam</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Flunitrazepam <em>increases</em> the level of <em>7-acetamidoFlunitrazepam</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26169" data-original-title="Namera A, Makita R, Saruwatari T, Hatano A, Shiraishi H, Nagao M: Acute intoxication caused by overdose of flunitrazepam and triazolam: high concentration of metabolites detected at autopsy examination. Am J Forensic Med Pathol. 2012 Dec;33(4):293-6. doi: 10.1097/PAF.0b013e31820f1514.">A26169</a></li></ul></td></tr><tr><td><a href="/drugs/DB01544">Flunitrazepam</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span></td><td>7-acetamidodesmethylFlunitrazepam</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Flunitrazepam <em>increases</em> the level of <em>7-acetamidodesmethylFlunitrazepam</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26169" data-original-title="Namera A, Makita R, Saruwatari T, Hatano A, Shiraishi H, Nagao M: Acute intoxication caused by overdose of flunitrazepam and triazolam: high concentration of metabolites detected at autopsy examination. Am J Forensic Med Pathol. 2012 Dec;33(4):293-6. doi: 10.1097/PAF.0b013e31820f1514.">A26169</a></li></ul></td></tr><tr><td><a href="/drugs/DB01544">Flunitrazepam</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span></td><td>7-aminodesmethylFlunitrazepam</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Flunitrazepam <em>increases</em> the level of <em>7-aminodesmethylFlunitrazepam</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26169" data-original-title="Namera A, Makita R, Saruwatari T, Hatano A, Shiraishi H, Nagao M: Acute intoxication caused by overdose of flunitrazepam and triazolam: high concentration of metabolites detected at autopsy examination. Am J Forensic Med Pathol. 2012 Dec;33(4):293-6. doi: 10.1097/PAF.0b013e31820f1514.">A26169</a></li></ul></td></tr><tr><td><a href="/drugs/DB00492">Fosinopril</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Fosinoprilat</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Fosinopril <em>increases</em> the level of <em>Fosinoprilat</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A24910" data-original-title="Duchin KL, Waclawski AP, Tu JI, Manning J, Frantz M, Willard DA: Pharmacokinetics, safety, and pharmacologic effects of fosinopril sodium, an angiotensin-converting enzyme inhibitor in healthy subjects. J Clin Pharmacol. 1991 Jan;31(1):58-64.">A24910</a></li></ul></td></tr><tr><td><a href="/drugs/DB08981">Fenbufen</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Gamma-hydroxy(1,1'-biphenyl)-4-butanoic acid</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Fenbufen <em>increases</em> the level of <em>Gamma-hydroxy(1,1'-biphenyl)-4-butanoic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26170" data-original-title="Chiccarelli FS, Eisner HJ, Van Lear GE: Metabolic and pharmacokinetic studies with fenbufen in man. Arzneimittelforschung. 1980;30(4A):728-35.">A26170</a></li></ul></td></tr><tr><td><a href="/drugs/DB08981">Fenbufen</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>(1,1'-biphenyl)-4-acetic acid</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Fenbufen <em>increases</em> the level of <em>(1,1'-biphenyl)-4-acetic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26170" data-original-title="Chiccarelli FS, Eisner HJ, Van Lear GE: Metabolic and pharmacokinetic studies with fenbufen in man. Arzneimittelforschung. 1980;30(4A):728-35.">A26170</a></li></ul></td></tr><tr><td><a href="/drugs/DB00327">Hydromorphone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB60824">Hydromorphone-3-glucuronide</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Hydromorphone <em>increases</em> the level of <em>Hydromorphone-3-glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26171" data-original-title="Vandenbossche J, Richards H, Francke S, Van Den Bergh A, Lu CC, Franc MA: The effect of UGT2B7*2 polymorphism on the pharmacokinetics of OROS(R) hydromorphone in Taiwanese subjects. J Clin Pharmacol. 2014 Oct;54(10):1170-9. doi: 10.1002/jcph.305. Epub 2014 Apr 15.">A26171</a></li></ul></td></tr><tr><td><a href="/drugs/DB00502">Haloperidol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB60903">Reduced Haloperidol</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Haloperidol <em>increases</em> the level of <em>Reduced Haloperidol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26172" data-original-title="Lane HY, Lin HN, Hwu HG, Jann M, Hu WH, Chang WH: Haloperidol plasma concentrations in Taiwanese psychiatric patients. J Formos Med Assoc. 1995 Nov;94(11):671-8.">A26172</a></li></ul></td></tr><tr><td><a href="/drugs/DB01452">Diamorphine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB41812">6-Acetylmorphine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-up"></use>
</svg>
</div> increased</span></td><td>Diamorphine <em>increases</em> the level of <em>6-Acetylmorphine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26173" data-original-title="Jenkins AJ, Keenan RM, Henningfield JE, Cone EJ: Pharmacokinetics and pharmacodynamics of smoked heroin. J Anal Toxicol. 1994 Oct;18(6):317-30.">A26173</a></li></ul></td></tr><tr><td><a href="/drugs/DB00531">Cyclophosphamide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB14672">Cyclophosphamide</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</svg>
</div> decreased</span></td><td>Cyclophosphamide <em>decreases</em> the level of <em>Cyclophosphamide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25546" data-original-title="Ekhart C, Rodenhuis S, Beijnen JH, Huitema AD: Carbamazepine induces bioactivation of cyclophosphamide and thiotepa. Cancer Chemother Pharmacol. 2009 Feb;63(3):543-7. doi: 10.1007/s00280-008-0758-y. Epub 2008 Apr 24.">A25546</a></li></ul></td></tr><tr><td><a href="/drugs/DB00531">Cyclophosphamide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB15576">Thiotepa</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Cyclophosphamide <em>decreases</em> the level of <em>Thiotepa</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25546" data-original-title="Ekhart C, Rodenhuis S, Beijnen JH, Huitema AD: Carbamazepine induces bioactivation of cyclophosphamide and thiotepa. Cancer Chemother Pharmacol. 2009 Feb;63(3):543-7. doi: 10.1007/s00280-008-0758-y. Epub 2008 Apr 24.">A25546</a></li></ul></td></tr><tr><td><a href="/drugs/DB00801">Halazepam</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Illicit</span> <span class="badge badge-secondary badge-pill">Withdrawn</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB60538">Desmethyldiazepam</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-up"></use>
</svg>
</div> increased</span></td><td>Halazepam <em>increases</em> the level of <em>Desmethyldiazepam</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26174" data-original-title="Greenblatt DJ, Locniskar A, Shader RI: Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography. Psychopharmacology (Berl). 1983;80(2):178-80.">A26174</a></li></ul></td></tr><tr><td><a href="/drugs/DB01026">Ketoconazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB60546">Norbuprenorphine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-up"></use>
</svg>
</div> increased</span></td><td>Ketoconazole <em>increases</em> the level of <em>Norbuprenorphine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26175" data-original-title="Kapil RP, Cipriano A, Michels GH, Perrino P, O'Keefe SA, Shet MS, Colucci SV, Noveck RJ, Harris SC: Effect of ketoconazole on the pharmacokinetic profile of buprenorphine following administration of a once-weekly buprenorphine transdermal system. Clin Drug Investig. 2012 Sep 1;32(9):583-92. doi: 10.2165/11633060-000000000-00000.">A26175</a></li></ul></td></tr><tr><td><a href="/drugs/DB01026">Ketoconazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>Norbuprenorphine-3beta-glucuronide</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Ketoconazole <em>increases</em> the level of <em>Norbuprenorphine-3beta-glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26175" data-original-title="Kapil RP, Cipriano A, Michels GH, Perrino P, O'Keefe SA, Shet MS, Colucci SV, Noveck RJ, Harris SC: Effect of ketoconazole on the pharmacokinetic profile of buprenorphine following administration of a once-weekly buprenorphine transdermal system. Clin Drug Investig. 2012 Sep 1;32(9):583-92. doi: 10.2165/11633060-000000000-00000.">A26175</a></li></ul></td></tr><tr><td><a href="/drugs/DB00186">Lorazepam</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB41917">Lorazepam glucuronide</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Lorazepam <em>increases</em> the level of <em>Lorazepam glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26176" data-original-title="Greenblatt DJ, Comer WH, Elliott HW, Shader RI, Knowles JA, Ruelius HW: Clinical pharmacokinetics of lorazepam. III. Intravenous injection. Preliminary results. J Clin Pharmacol. 1977 Aug-Sep;17(8-9):490-4.">A26176</a></li></ul></td></tr><tr><td><a href="/drugs/DB00295">Morphine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB14440">Morphine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Morphine <em>increases</em> the level of <em>Morphine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26177" data-original-title="Kalman S, Metcalf K, Eintrei C: Morphine, morphine-6-glucuronide, and morphine-3-glucuronide in cerebrospinal fluid and plasma after epidural administration of morphine. Reg Anesth. 1997 Mar-Apr;22(2):131-6.">A26177</a></li></ul></td></tr><tr><td><a href="/drugs/DB00295">Morphine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB41937">Morphine-6-glucuronide</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Morphine <em>increases</em> the level of <em>Morphine-6-glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26177" data-original-title="Kalman S, Metcalf K, Eintrei C: Morphine, morphine-6-glucuronide, and morphine-3-glucuronide in cerebrospinal fluid and plasma after epidural administration of morphine. Reg Anesth. 1997 Mar-Apr;22(2):131-6.">A26177</a></li></ul></td></tr><tr><td><a href="/drugs/DB00295">Morphine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB41936">Morphine-3-glucuronide</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Morphine <em>increases</em> the level of <em>Morphine-3-glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26177" data-original-title="Kalman S, Metcalf K, Eintrei C: Morphine, morphine-6-glucuronide, and morphine-3-glucuronide in cerebrospinal fluid and plasma after epidural administration of morphine. Reg Anesth. 1997 Mar-Apr;22(2):131-6.">A26177</a></li></ul></td></tr><tr><td><a href="/drugs/DB01149">Nefazodone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Withdrawn</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB61040">HydroxyNefazodone</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Nefazodone <em>increases</em> the level of <em>HydroxyNefazodone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26178" data-original-title="Kaul S, Shukla UA, Barbhaiya RH: Nonlinear pharmacokinetics of nefazodone after escalating single and multiple oral doses. J Clin Pharmacol. 1995 Aug;35(8):830-9.">A26178</a></li></ul></td></tr><tr><td><a href="/drugs/DB00461">Nabumetone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB60787">6-methoxy-2-naphthylacetic acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Nabumetone <em>increases</em> the level of <em>6-methoxy-2-naphthylacetic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26179" data-original-title="Hyneck ML: An overview of the clinical pharmacokinetics of nabumetone. J Rheumatol Suppl. 1992 Nov;36:20-4.">A26179</a></li></ul></td></tr><tr><td><a href="/drugs/DB00881">Quinapril</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB42005">Quinaprilat</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Quinapril <em>increases</em> the level of <em>Quinaprilat</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26180" data-original-title="Cetnarowski-Cropp AB: Quinapril: a new second-generation ACE inhibitor. DICP. 1991 May;25(5):499-504.">A26180</a></li></ul></td></tr><tr><td><a href="/drugs/DB00468">Quinine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01091">3-hydroxyquinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Quinine <em>increases</em> the level of <em>3-hydroxyquinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26181" data-original-title="Pukrittayakamee S, Pitisuttithum P, Zhang H, Jantra A, Wanwimolruk S, White NJ: Effects of cigarette smoking on quinine pharmacokinetics in malaria. Eur J Clin Pharmacol. 2002 Aug;58(5):315-9. Epub 2002 Jun 20.">A26181</a></li></ul></td></tr><tr><td><a href="/drugs/DB01348">Spirapril</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Spiraprilat</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</svg>
</div> increased</span></td><td>Spirapril <em>increases</em> the level of <em>Spiraprilat</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26160" data-original-title="Grass P, Gerbeau C, Kutz K: Spirapril: pharmacokinetic properties and drug interactions. Blood Press Suppl. 1994;2:7-13.">A26160</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>2601 - 2625</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=104">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=101">101</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=102">102</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=103">103</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=104">104</a></li><li class="page-item active"><a remote="false" class="page-link">105</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=106">106</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=107">107</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=108">108</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=109">109</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=106">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial"><img style="width: 130px; 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