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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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2725</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=108">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=105">105</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=106">106</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=107">107</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=108">108</a></li><li class="page-item active"><a remote="false" class="page-link">109</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=110">110</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=111">111</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=112">112</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=113">113</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=110">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Simvastatin <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25674" data-original-title="Trupp M, Zhu H, Wikoff WR, Baillie RA, Zeng ZB, Karp PD, Fiehn O, Krauss RM, Kaddurah-Daouk R: Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One. 2012;7(7):e38386. doi: 10.1371/journal.pone.0038386. Epub 2012 Jul 9.">A25674</a></li></ul></td></tr><tr><td><a href="/drugs/DB00415">Ampicillin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB10335">Estriol-glucuronide</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Ampicillin <em>decreases</em> the level of <em>Estriol-glucuronide</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2f4c571b-a27e-40ef-b0cd-e6e44ac9a15e">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00334">Olanzapine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Olanzapine <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26209" data-original-title="Chen VC, Wang TN, Lu ML, Chou JY, Ju PC, Wu JY, Lin ZR, Ji TT, Chou CE, Lee CT, Lai TJ: Weight gain and ghrelin level after olanzapine monotherapy. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):632-5. doi: 10.1016/j.pnpbp.2011.01.010. Epub 2011 Jan 20.">A26209</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26210" data-original-title="Moteshafi H, Zhornitsky S, Brunelle S, Stip E: Comparing tolerability of olanzapine in schizophrenia and affective disorders: a meta-analysis. Drug Saf. 2012 Oct 1;35(10):819-36. doi: 10.2165/11631510-000000000-00000.">A26210</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25526" data-original-title="Tohen M, Kryzhanovskaya L, Carlson G, Delbello M, Wozniak J, Kowatch R, Wagner K, Findling R, Lin D, Robertson-Plouch C, Xu W, Dittmann RW, Biederman J: Olanzapine versus placebo in the treatment of adolescents with bipolar mania. Am J Psychiatry. 2007 Oct;164(10):1547-56.">A25526</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26211" data-original-title="Von Hayek D, Huttl V, Reiss J, Schweiger HD, Fuessl HS: [Hyperglycemia and ketoacidosis associated with olanzapine]. Nervenarzt. 1999 Sep;70(9):836-7.">A26211</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25696" data-original-title="Hu S, Yao M, Peterson BS, Xu D, Hu J, Tang J, Fan B, Liao Z, Yuan T, Li Y, Yue W, Wei N, Zhou W, Huang M, Xu Y: A randomized, 12-week study of the effects of extended-release paliperidone (paliperidone ER) and olanzapine on metabolic profile, weight, insulin resistance, and beta-cell function in schizophrenic patients. Psychopharmacology (Berl). 2013 Nov;230(1):3-13. doi: 10.1007/s00213-013-3073-1. Epub 2013 Apr 5.">A25696</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25752" data-original-title="Zhang S, Lan G: Prospective 8-week trial on the effect of olanzapine, quetiapine, and aripiprazole on blood glucose and lipids among individuals with first-onset schizophrenia. Shanghai Arch Psychiatry. 2014 Dec;26(6):339-46. doi: 10.11919/j.issn.1002-0829.214037.">A25752</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25541" data-original-title="van Winkel R, De Hert M, Wampers M, Van Eyck D, Hanssens L, Scheen A, Peuskens J: Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry. 2008 Mar;69(3):472-9.">A25541</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26212" data-original-title="Komossa K, Rummel-Kluge C, Hunger H, Schmid F, Schwarz S, Duggan L, Kissling W, Leucht S: Olanzapine versus other atypical antipsychotics for schizophrenia. Cochrane Database Syst Rev. 2010 Mar 17;(3):CD006654. doi: 10.1002/14651858.CD006654.pub2.">A26212</a></li></ul><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9a57a63e-f856-aafa-037a-c08f2fea6496">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB01224">Quetiapine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Quetiapine <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25541" data-original-title="van Winkel R, De Hert M, Wampers M, Van Eyck D, Hanssens L, Scheen A, Peuskens J: Major changes in glucose metabolism, including new-onset diabetes, within 3 months after initiation of or switch to atypical antipsychotic medication in patients with schizophrenia and schizoaffective disorder. J Clin Psychiatry. 2008 Mar;69(3):472-9.">A25541</a></li></ul></td></tr><tr><td><a href="/drugs/DB01072">Atazanavir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00054">Bilirubin</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Atazanavir <em>increases</em> the level of <em>Bilirubin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26213" data-original-title="Rodriguez-Novoa S, Morello J, Gonzalez M, Vispo E, Barreiro P, Gonzalez-Pardo G, Jimenez-Nacher I, Gonzalez-Lahoz J, Soriano V: Increase in serum bilirubin in HIV/hepatitis-C virus-coinfected patients on atazanavir therapy following initiation of pegylated-interferon and ribavirin. AIDS. 2008 Nov 30;22(18):2535-7. doi: 10.1097/QAD.0b013e3283177f38.">A26213</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26016" data-original-title="Rotger M, Taffe P, Bleiber G, Gunthard HF, Furrer H, Vernazza P, Drechsler H, Bernasconi E, Rickenbach M, Telenti A: Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia. J Infect Dis. 2005 Oct 15;192(8):1381-6. Epub 2005 Sep 9.">A26016</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25787" data-original-title="Crutchley RD, Guduru RC, Cheng AM: Evaluating the role of atazanavir/cobicistat and darunavir/cobicistat fixed-dose combinations for the treatment of HIV-1 infection. HIV AIDS (Auckl). 2016 Mar 9;8:47-65. doi: 10.2147/HIV.S99063. eCollection 2016.">A25787</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26214" data-original-title="Krishna R, East L, Larson P, Valiathan C, Deschamps K, Luk JA, Bethel-Brown C, Manthos H, Brejda J, Gartner M: Atazanavir increases the plasma concentrations of 1200 mg raltegravir dose. Biopharm Drug Dispos. 2016 Dec;37(9):533-541. doi: 10.1002/bdd.2043. Epub 2016 Nov 4.">A26214</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00696">Methionine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Sertraline <em>increases</em> the level of <em>Methionine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr><tr><td><a href="/drugs/DB00196">Fluconazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Fluconazole <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dd975843-c3e4-44f4-bb0d-33b294c1f6fb">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00999">Hydrochlorothiazide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td>Triglycerides</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Hydrochlorothiazide <em>increases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26215" data-original-title="Beyer KH Jr, Ward TD, Vary JE, Gelarden RT, Knutson DW, Vesell ES: Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. J Clin Pharmacol. 1993 Jun;33(6):554-61.">A26215</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25149" data-original-title="Leary WP, Reyes AJ: Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride. S Afr Med J. 1981 Sep 5;60(10):381-4.">A25149</a></li></ul><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e4fb5cd8-1928-437f-8dad-498740d5bc0a">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00248">Cabergoline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00742">Homocysteine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Cabergoline <em>decreases</em> the level of <em>Homocysteine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25739" data-original-title="Krysiak R, Okopien B: Different effects of cabergoline and bromocriptine on metabolic and cardiovascular risk factors in patients with elevated prolactin levels. Basic Clin Pharmacol Toxicol. 2015 Mar;116(3):251-6. doi: 10.1111/bcpt.12307. Epub 2014 Sep 11.">A25739</a></li></ul></td></tr><tr><td><a href="/drugs/DB11738">Rilmenidine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Rilmenidine <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26010" data-original-title="Anichkov DA, Shostak NA, Schastnaya OV: Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome. Curr Med Res Opin. 2005 Jan;21(1):113-9.">A26010</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26216" data-original-title="Konrady AO, Kasherininov YR, Shavarov AA, Shavarova EK, Vachrameeva NV, Krutikov AN, Smirnova EV, Shlyakhto EV: How can we block sympathetic overactivity? Effects of rilmenidine and atenolol in overweight hypertensive patients. J Hum Hypertens. 2006 Jun;20(6):398-406.">A26216</a></li></ul></td></tr><tr><td><a href="/drugs/DB00014">Goserelin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00234">Testosterone</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Goserelin <em>decreases</em> the level of <em>Testosterone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A1784" data-original-title="Kirby RS, Fitzpatrick JM, Clarke N: Abarelix and other gonadotrophin-releasing hormone antagonists in prostate cancer. BJU Int. 2009 Dec;104(11):1580-4. doi: 10.1111/j.1464-410X.2009.08924.x.">A1784</a></li></ul></td></tr><tr><td><a href="/drugs/DB00136">Calcitriol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Nutraceutical</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00464">Calcium</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Calcitriol <em>increases</em> the level of <em>Calcium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26217" data-original-title="Malberti F, Surian M, Cosci P: Effect of chronic intravenous calcitriol on parathyroid function and set point of calcium in dialysis patients with refractory secondary hyperparathyroidism. Nephrol Dial Transplant. 1992;7(8):822-8.">A26217</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26014" data-original-title="Cozzolino M, Galassi A, Gallieni M, Brancaccio D: Pathogenesis and treatment of secondary hyperparathyroidism in dialysis patients: the role of paricalcitol. Curr Vasc Pharmacol. 2008 Apr;6(2):148-53.">A26014</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26218" data-original-title="Wesseling-Perry K, Pereira RC, Sahney S, Gales B, Wang HJ, Elashoff R, Juppner H, Salusky IB: Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism. Kidney Int. 2011 Jan;79(1):112-9. doi: 10.1038/ki.2010.352. Epub 2010 Sep 22.">A26218</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26219" data-original-title="Kallas M, Green F, Hewison M, White C, Kline G: Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review. J Clin Endocrinol Metab. 2010 Jul;95(7):3111-7. doi: 10.1210/jc.2009-2673. Epub 2010 Apr 28.">A26219</a></li></ul></td></tr><tr><td><a href="/drugs/DB08930">Dolutegravir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Dolutegravir <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26220" data-original-title="Rivero A, Domingo P: [Safety profile of dolutegravir]. Enferm Infecc Microbiol Clin. 2015 Mar;33 Suppl 1:9-13. doi: 10.1016/S0213-005X(15)30003-3.">A26220</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26221" data-original-title="Maggi P, Montinaro V, Rusconi S, Di Biagio A, Bellagamba R, Bonfanti P, Calza L, Corsi P, Montella F, Mussini C: The problem of renal function monitoring in patients treated with the novel antiretroviral drugs. HIV Clin Trials. 2014 May-Jun;15(3):87-91. doi: 10.1310/hct1503-87.">A26221</a></li></ul></td></tr><tr><td><a href="/drugs/DB00973">Ezetimibe</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00852">Sitosterol</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Ezetimibe <em>decreases</em> the level of <em>Sitosterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26208" data-original-title="Sudhop T, Lutjohann D, Kodal A, Igel M, Tribble DL, Shah S, Perevozskaya I, von Bergmann K: Inhibition of intestinal cholesterol absorption by ezetimibe in humans. Circulation. 2002 Oct 8;106(15):1943-8.">A26208</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25592" data-original-title="Hiramitsu S, Ishiguro Y, Matsuyama H, Yamada K, Kato K, Noba M, Uemura A, Yoshida S, Matsubara Y, Kani A, Hasegawa K, Hishida H, Ozaki Y: The effects of ezetimibe on surrogate markers of cholesterol absorption and synthesis in Japanese patients with dyslipidemia. J Atheroscler Thromb. 2010 Feb;17(1):106-14. Epub 2010 Jan 14.">A25592</a></li></ul></td></tr><tr><td><a href="/drugs/DB00718">Adefovir dipivoxil</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Adefovir dipivoxil <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26222" data-original-title="Wai CT, Prabhakaran K, Wee A, Lee YM, Dan YY, Sutedja DS, Mak K, Isaac J, Lee KH, Lee HL, Da Costa M, Lim SG: Adefovir dipivoxil as the rescue therapy for lamivudine-resistant hepatitis B post liver transplant. Transplant Proc. 2004 Oct;36(8):2313-4.">A26222</a></li></ul><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e047f3b2-feae-4c5e-9d07-1fefb4c0ec25#adv-sec-6.2">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00999">Hydrochlorothiazide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Hydrochlorothiazide <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25269" data-original-title="Middeke M, Richter WO, Schwandt P, Holzgreve H: The effects of antihypertensive combination therapy on lipid and glucose metabolism: hydrochlorothiazide plus sotalol vs. hydrochlorothiazide plus captopril. Int J Clin Pharmacol Ther. 1997 Jun;35(6):231-4.">A25269</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26215" data-original-title="Beyer KH Jr, Ward TD, Vary JE, Gelarden RT, Knutson DW, Vesell ES: Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. J Clin Pharmacol. 1993 Jun;33(6):554-61.">A26215</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26223" data-original-title="Lindholm LH, Persson M, Alaupovic P, Carlberg B, Svensson A, Samuelsson O: Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). J Hypertens. 2003 Aug;21(8):1563-74.">A26223</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25204" data-original-title="Pelttari L, Rauhala E, Kantola I: Effects of antihypertensive medication on hypertension in patients with sleep apnoea. Blood Press Suppl. 1994;2:88-91.">A25204</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26224" data-original-title="Jansen RW, Van Lier HJ, Hoefnagels WH: Nitrendipine versus hydrochlorothiazide in hypertensive patients over 70 years of age. Clin Pharmacol Ther. 1989 Mar;45(3):291-8.">A26224</a></li></ul></td></tr><tr><td><a href="/drugs/DB00158">Folic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Nutraceutical</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00742">Homocysteine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Folic acid <em>decreases</em> the level of <em>Homocysteine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26225" data-original-title="McKinley MC, McNulty H, McPartlin J, Strain JJ, Scott JM: Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. Eur J Clin Nutr. 2002 Sep;56(9):850-6.">A26225</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25854" data-original-title="Dierkes J, Luley C, Westphal S: Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels. Vasc Health Risk Manag. 2007;3(1):99-108.">A25854</a></li></ul></td></tr><tr><td><a href="/drugs/DB00175">Pravastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>LDL cholesterol</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Pravastatin <em>decreases</em> the level of <em>LDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25178" data-original-title="Pitt B, Mancini GB, Ellis SG, Rosman HS, Park JS, McGovern ME: Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC I): reduction in atherosclerosis progression and clinical events. PLAC I investigation. J Am Coll Cardiol. 1995 Nov 1;26(5):1133-9.">A25178</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26129" data-original-title="Lea AP, McTavish D: Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47.">A26129</a></li></ul></td></tr><tr><td><a href="/drugs/DB01407">Clenbuterol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Clenbuterol <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A24955" data-original-title="Edwards DJ, Virji MA: Hypoaminoacidemia caused by imipramine but not by clenbuterol is dissociable from hyperglycemia and hyperinsulinemia. Life Sci. 1990;47(6):PL13-8.">A24955</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25037" data-original-title="Eisemann JH, Huntington GB, Ferrell CL: Effects of dietary clenbuterol on metabolism of the hindquarters in steers. J Anim Sci. 1988 Feb;66(2):342-53.">A25037</a></li></ul></td></tr><tr><td><a href="/drugs/DB00357">Aminoglutethimide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00145">Estrone</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Aminoglutethimide <em>decreases</em> the level of <em>Estrone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25279" data-original-title="Geisler J, Lien EA, Ekse D, Lonning PE: Influence of aminoglutethimide on plasma levels of estrone sulphate and dehydroepiandrosterone sulphate in postmenopausal breast cancer patients. J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):53-8.">A25279</a></li></ul></td></tr><tr><td><a href="/drugs/DB00720">Clodronic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01429">Phosphate</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Clodronic acid <em>increases</em> the level of <em>Phosphate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A24996" data-original-title="McCloskey EV, Yates AJ, Beneton MN, Galloway J, Harris S, Kanis JA: Comparative effects of intravenous diphosphonates on calcium and skeletal metabolism in man. Bone. 1987;8 Suppl 1:S35-41.">A24996</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26226" data-original-title="McCloskey EV, Yates AJ, Gray RE, Hamdy NA, Galloway J, Kanis JA: Diphosphonates and phosphate homoeostasis in man. Clin Sci (Lond). 1988 Jun;74(6):607-12.">A26226</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00259">Serotonin</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Sertraline <em>decreases</em> the level of <em>Serotonin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01310">Alanine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Simvastatin <em>increases</em> the level of <em>Alanine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25674" data-original-title="Trupp M, Zhu H, Wikoff WR, Baillie RA, Zeng ZB, Karp PD, Fiehn O, Krauss RM, Kaddurah-Daouk R: Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One. 2012;7(7):e38386. doi: 10.1371/journal.pone.0038386. Epub 2012 Jul 9.">A25674</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00067">Total cholesterol</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Total cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26227" data-original-title="Panichi V, Mantuano E, Paoletti S, Santi S, Manca Rizza G, Cutrupi S, Pizzini P, Spoto B, Tripepi G, Zoccali C: Effect of simvastatin on plasma asymmetric dimethylarginine concentration in patients with chronic kidney disease. J Nephrol. 2008 Jan-Feb;21(1):38-44.">A26227</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A24944" data-original-title="Nakandakare E, Garcia RC, Rocha JC, Sperotto G, Oliveira HC, Quintao EC: Effects of simvastatin, bezafibrate and gemfibrozil on the quantity and composition of plasma lipoproteins. Atherosclerosis. 1990 Dec;85(2-3):211-7.">A24944</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25870" data-original-title="Bruckert E, De Gennes JL, Malbecq W, Baigts F: Comparison of the efficacy of simvastatin and standard fibrate therapy in the treatment of primary hypercholesterolemia and combined hyperlipidemia. Clin Cardiol. 1995 Nov;18(11):621-9.">A25870</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26228" data-original-title="Ballantyne CM, Olsson AG, Cook TJ, Mercuri MF, Pedersen TR, Kjekshus J: Influence of low high-density lipoprotein cholesterol and elevated triglyceride on coronary heart disease events and response to simvastatin therapy in 4S. Circulation. 2001 Dec 18;104(25):3046-51.">A26228</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26229" data-original-title="Stewart MW, Dyer RG, Alberti KG, Laker MF: The effects of lipid lowering drugs on metabolic control and lipoprotein composition in type 2 diabetic patients with mild hyperlipidaemia. Diabet Med. 1995 Mar;12(3):250-7.">A26229</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26230" data-original-title="Gavish D, Leibovitz E, Shapira I, Rubinstein A: Bezafibrate and simvastatin combination therapy for diabetic dyslipidaemia: efficacy and safety. J Intern Med. 2000 May;247(5):563-9.">A26230</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26129" data-original-title="Lea AP, McTavish D: Atorvastatin. A review of its pharmacology and therapeutic potential in the management of hyperlipidaemias. Drugs. 1997 May;53(5):828-47.">A26129</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25438" data-original-title="Skrha J, Stulc T, Hilgertova J, Weiserova H, Kvasnicka J, Ceska R: Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes. Eur J Pharmacol. 2004 Jun 16;493(1-3):183-9.">A25438</a></li></ul></td></tr><tr><td><a href="/drugs/DB00328">Indomethacin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03252">Thromboxane B2</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Indomethacin <em>decreases</em> the level of <em>Thromboxane B2</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A10546" data-original-title="van Kraaij DJ, Hovestad-Witterland AH, de Metz M, Vollaard EJ: A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers. Br J Clin Pharmacol. 2002 Jun;53(6):644-7.">A10546</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26231" data-original-title="Salvetti A, Abdel-Haq B, Magagna A, Pedrinelli R: Indomethacin reduces the antihypertensive action of enalapril. Clin Exp Hypertens A. 1987;9(2-3):559-67.">A26231</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>2701 - 2725</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=108">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=105">105</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=106">106</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=107">107</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=108">108</a></li><li class="page-item active"><a remote="false" class="page-link">109</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=110">110</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=111">111</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=112">112</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=113">113</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=110">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial hidden"><img style="width: 130px; 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