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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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2975</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=118">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=115">115</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=116">116</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=117">117</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=118">118</a></li><li class="page-item active"><a remote="false" class="page-link">119</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=120">120</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=121">121</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=122">122</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=123">123</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=120">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB12319">Benzbromarone</a></td><td><span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Withdrawn</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00289">Uric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Benzbromarone <em>decreases</em> the level of <em>Uric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25979" data-original-title="Burns CM, Wortmann RL: Latest evidence on gout management: what the clinician needs to know. Ther Adv Chronic Dis. 2012 Nov;3(6):271-86. doi: 10.1177/2040622312462056.">A25979</a></li></ul></td></tr><tr><td><a href="/drugs/DB05262">Oxypurinol</a></td><td><span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00289">uric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Oxypurinol <em>decreases</em> the level of <em>uric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25979" data-original-title="Burns CM, Wortmann RL: Latest evidence on gout management: what the clinician needs to know. Ther Adv Chronic Dis. 2012 Nov;3(6):271-86. doi: 10.1177/2040622312462056.">A25979</a></li></ul></td></tr><tr><td><a href="/drugs/DB09208">Pegloticase</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00289">uric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Pegloticase <em>decreases</em> the level of <em>uric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25979" data-original-title="Burns CM, Wortmann RL: Latest evidence on gout management: what the clinician needs to know. Ther Adv Chronic Dis. 2012 Nov;3(6):271-86. doi: 10.1177/2040622312462056.">A25979</a></li></ul></td></tr><tr><td><a href="/drugs/DB09208">Pegloticase</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>allantoin</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Pegloticase <em>increases</em> the level of <em>allantoin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25979" data-original-title="Burns CM, Wortmann RL: Latest evidence on gout management: what the clinician needs to know. Ther Adv Chronic Dis. 2012 Nov;3(6):271-86. doi: 10.1177/2040622312462056.">A25979</a></li></ul></td></tr><tr><td><a href="/drugs/DB00049">Rasburicase</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>allantoin</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Rasburicase <em>increases</em> the level of <em>allantoin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25979" data-original-title="Burns CM, Wortmann RL: Latest evidence on gout management: what the clinician needs to know. Ther Adv Chronic Dis. 2012 Nov;3(6):271-86. doi: 10.1177/2040622312462056.">A25979</a></li></ul></td></tr><tr><td><a href="/drugs/DB00252">Phenytoin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Phenytoin <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00564">Carbamazepine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Carbamazepine <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00675">Tamoxifen</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Tamoxifen <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00257">Clotrimazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Clotrimazole <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01045">Rifampicin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Rifampicin <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01234">Dexamethasone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Dexamethasone <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01115">Nifedipine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Nifedipine <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00421">Spironolactone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Spironolactone <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01232">Saquinavir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Saquinavir <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB04839">Cyproterone acetate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Cyproterone acetate <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01892">Hyperforin</a></td><td><span class="badge badge-secondary badge-pill">Nutraceutical</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Hyperforin <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00794">Primidone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01438">25-hydroxyvitamin D</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Primidone <em>decreases</em> the level of <em>25-hydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00252">Phenytoin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Phenytoin <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00564">Carbamazepine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Carbamazepine <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00675">Tamoxifen</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Tamoxifen <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00257">Clotrimazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Clotrimazole <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01045">Rifampicin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Rifampicin <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01234">Dexamethasone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Dexamethasone <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB01115">Nifedipine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Nifedipine <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr><tr><td><a href="/drugs/DB00421">Spironolactone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D3</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Spironolactone <em>decreases</em> the level of <em>1,25-dihydroxyvitamin D3</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26328" data-original-title="Grober U, Kisters K: Influence of drugs on vitamin D and calcium metabolism. Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.">A26328</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>2951 - 2975</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=118">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=115">115</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=116">116</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=117">117</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=118">118</a></li><li class="page-item active"><a remote="false" class="page-link">119</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=120">120</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=121">121</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=122">122</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=123">123</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=120">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial hidden"><img style="width: 130px; 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