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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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1275</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=50">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=47">47</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=48">48</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=49">49</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=50">50</a></li><li class="page-item active"><a remote="false" class="page-link">51</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=52">52</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=53">53</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=54">54</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=55">55</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=52">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB00621">Oxandrolone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00357">3-hydroxybutyrate</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Oxandrolone <em>increases</em> the level of <em>3-hydroxybutyrate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25560" data-original-title="Vega GL, Clarenbach JJ, Dunn F, Grundy SM: Oxandrolone enhances hepatic ketogenesis in adult men. J Investig Med. 2008 Oct;56(7):920-4. doi: 10.2310/JIM.0b013e318189153d.">A25560</a></li></ul></td></tr><tr><td><a href="/drugs/DB01006">Letrozole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00151">Estradiol</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Letrozole <em>decreases</em> the level of <em>Estradiol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25561" data-original-title="Geisler J, Helle H, Ekse D, Duong NK, Evans DB, Nordbo Y, Aas T, Lonning PE: Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels. Clin Cancer Res. 2008 Oct 1;14(19):6330-5. doi: 10.1158/1078-0432.CCR-07-5221.">A25561</a></li></ul></td></tr><tr><td><a href="/drugs/DB01006">Letrozole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00145">Estrone</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Letrozole <em>decreases</em> the level of <em>Estrone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25561" data-original-title="Geisler J, Helle H, Ekse D, Duong NK, Evans DB, Nordbo Y, Aas T, Lonning PE: Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels. Clin Cancer Res. 2008 Oct 1;14(19):6330-5. doi: 10.1158/1078-0432.CCR-07-5221.">A25561</a></li></ul></td></tr><tr><td><a href="/drugs/DB01006">Letrozole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01425">Estrone sulfate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Letrozole <em>decreases</em> the level of <em>Estrone sulfate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25561" data-original-title="Geisler J, Helle H, Ekse D, Duong NK, Evans DB, Nordbo Y, Aas T, Lonning PE: Letrozole is superior to anastrozole in suppressing breast cancer tissue and plasma estrogen levels. Clin Cancer Res. 2008 Oct 1;14(19):6330-5. doi: 10.1158/1078-0432.CCR-07-5221.">A25561</a></li></ul></td></tr><tr><td><a href="/drugs/DB00619">Imatinib</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00588">Sodium</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Imatinib <em>decreases</em> the level of <em>Sodium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25562" data-original-title="Liapis K, Apostolidis J, Charitaki E, Panitsas F, Harhalakis N, Nikiforakis E: Syndrome of inappropriate secretion of antidiuretic hormone associated with imatinib. Ann Pharmacother. 2008 Dec;42(12):1882-6. doi: 10.1345/aph.1L410. Epub 2008 Nov 18.">A25562</a></li></ul></td></tr><tr><td><a href="/drugs/DB00307">Bexarotene</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00067">Total cholesterol</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Bexarotene <em>increases</em> the level of <em>Total cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25563" data-original-title="de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC: Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein. Endocrinology. 2009 May;150(5):2368-75. doi: 10.1210/en.2008-1540. Epub 2009 Jan 15.">A25563</a></li></ul></td></tr><tr><td><a href="/drugs/DB00307">Bexarotene</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>VLDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Bexarotene <em>increases</em> the level of <em>VLDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25563" data-original-title="de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC: Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein. Endocrinology. 2009 May;150(5):2368-75. doi: 10.1210/en.2008-1540. Epub 2009 Jan 15.">A25563</a></li></ul></td></tr><tr><td><a href="/drugs/DB00307">Bexarotene</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>LDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Bexarotene <em>increases</em> the level of <em>LDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25563" data-original-title="de Vries-van der Weij J, de Haan W, Hu L, Kuif M, Oei HL, van der Hoorn JW, Havekes LM, Princen HM, Romijn JA, Smit JW, Rensen PC: Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein. Endocrinology. 2009 May;150(5):2368-75. doi: 10.1210/en.2008-1540. Epub 2009 Jan 15.">A25563</a></li></ul></td></tr><tr><td><a href="/drugs/DB04841">Flunarizine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03339">Glutamate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Flunarizine <em>decreases</em> the level of <em>Glutamate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25564" data-original-title="Ferrari A, Spaccapelo L, Pinetti D, Tacchi R, Bertolini A: Effective prophylactic treatments of migraine lower plasma glutamate levels. Cephalalgia. 2009 Apr;29(4):423-9. doi: 10.1111/j.1468-2982.2008.01749.x. Epub 2008 Dec 11.">A25564</a></li></ul></td></tr><tr><td><a href="/drugs/DB00273">Topiramate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03339">Glutamate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Topiramate <em>decreases</em> the level of <em>Glutamate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25564" data-original-title="Ferrari A, Spaccapelo L, Pinetti D, Tacchi R, Bertolini A: Effective prophylactic treatments of migraine lower plasma glutamate levels. Cephalalgia. 2009 Apr;29(4):423-9. doi: 10.1111/j.1468-2982.2008.01749.x. Epub 2008 Dec 11.">A25564</a></li></ul></td></tr><tr><td><a href="/drugs/DB00321">Amitriptyline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03339">Glutamate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Amitriptyline <em>decreases</em> the level of <em>Glutamate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25564" data-original-title="Ferrari A, Spaccapelo L, Pinetti D, Tacchi R, Bertolini A: Effective prophylactic treatments of migraine lower plasma glutamate levels. Cephalalgia. 2009 Apr;29(4):423-9. doi: 10.1111/j.1468-2982.2008.01749.x. Epub 2008 Dec 11.">A25564</a></li></ul></td></tr><tr><td><a href="/drugs/DB00571">Propranolol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03339">Glutamate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Propranolol <em>decreases</em> the level of <em>Glutamate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25564" data-original-title="Ferrari A, Spaccapelo L, Pinetti D, Tacchi R, Bertolini A: Effective prophylactic treatments of migraine lower plasma glutamate levels. Cephalalgia. 2009 Apr;29(4):423-9. doi: 10.1111/j.1468-2982.2008.01749.x. Epub 2008 Dec 11.">A25564</a></li></ul></td></tr><tr><td><a href="/drugs/DB00343">Diltiazem</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00742">Homocysteine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Diltiazem <em>decreases</em> the level of <em>Homocysteine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25565" data-original-title="Demir M, Ozaydin M, Varol E, Dogan A, Altinbas A: Effects of metoprolol and diltiazem on plasma homocysteine levels in patients with isolated coronary artery ectasia. Anadolu Kardiyol Derg. 2009 Feb;9(1):69-70.">A25565</a></li></ul></td></tr><tr><td><a href="/drugs/DB00834">Mifepristone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00586">Potassium</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Mifepristone <em>decreases</em> the level of <em>Potassium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25566" data-original-title="Castinetti F, Fassnacht M, Johanssen S, Terzolo M, Bouchard P, Chanson P, Do Cao C, Morange I, Pico A, Ouzounian S, Young J, Hahner S, Brue T, Allolio B, Conte-Devolx B: Merits and pitfalls of mifepristone in Cushing's syndrome. Eur J Endocrinol. 2009 Jun;160(6):1003-10. doi: 10.1530/EJE-09-0098. Epub 2009 Mar 16.">A25566</a></li></ul></td></tr><tr><td><a href="/drugs/DB01399">Salsalate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Salsalate <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25567" data-original-title="Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE: Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May;1(1):36-43. doi: 10.1111/j.1752-8062.2008.00026.x.">A25567</a></li></ul></td></tr><tr><td><a href="/drugs/DB01399">Salsalate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Free fatty acids</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Salsalate <em>decreases</em> the level of <em>Free fatty acids</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25567" data-original-title="Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE: Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May;1(1):36-43. doi: 10.1111/j.1752-8062.2008.00026.x.">A25567</a></li></ul></td></tr><tr><td><a href="/drugs/DB00243">Ranolazine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Ranolazine <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25568" data-original-title="Morrow DA, Scirica BM, Chaitman BR, McGuire DK, Murphy SA, Karwatowska-Prokopczuk E, McCabe CH, Braunwald E: Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial. Circulation. 2009 Apr 21;119(15):2032-9. doi: 10.1161/CIRCULATIONAHA.107.763912. Epub 2009 Apr 6.">A25568</a></li></ul></td></tr><tr><td><a href="/drugs/DB00472">Fluoxetine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03339">Glutamate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Fluoxetine <em>decreases</em> the level of <em>Glutamate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25569" data-original-title="Kucukibrahimoglu E, Saygin MZ, Caliskan M, Kaplan OK, Unsal C, Goren MZ: The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression. Eur J Clin Pharmacol. 2009 Jun;65(6):571-7. doi: 10.1007/s00228-009-0650-7. Epub 2009 Apr 17.">A25569</a></li></ul></td></tr><tr><td><a href="/drugs/DB00472">Fluoxetine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00641">Glutamine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Fluoxetine <em>decreases</em> the level of <em>Glutamine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25569" data-original-title="Kucukibrahimoglu E, Saygin MZ, Caliskan M, Kaplan OK, Unsal C, Goren MZ: The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression. Eur J Clin Pharmacol. 2009 Jun;65(6):571-7. doi: 10.1007/s00228-009-0650-7. Epub 2009 Apr 17.">A25569</a></li></ul></td></tr><tr><td><a href="/drugs/DB00472">Fluoxetine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00112">GABA</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Fluoxetine <em>increases</em> the level of <em>GABA</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25569" data-original-title="Kucukibrahimoglu E, Saygin MZ, Caliskan M, Kaplan OK, Unsal C, Goren MZ: The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression. Eur J Clin Pharmacol. 2009 Jun;65(6):571-7. doi: 10.1007/s00228-009-0650-7. Epub 2009 Apr 17.">A25569</a></li></ul></td></tr><tr><td><a href="/drugs/DB06155">Rimonabant</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>Triglycerides</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Rimonabant <em>decreases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25570" data-original-title="Loh KY, Kew ST: Endocannabinoid system and cardio-metabolic risk. Med J Malaysia. 2008 Oct;63(4):348-50; quiz 351.">A25570</a></li></ul></td></tr><tr><td><a href="/drugs/DB06155">Rimonabant</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>HDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Rimonabant <em>increases</em> the level of <em>HDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25570" data-original-title="Loh KY, Kew ST: Endocannabinoid system and cardio-metabolic risk. Med J Malaysia. 2008 Oct;63(4):348-50; quiz 351.">A25570</a></li></ul></td></tr><tr><td><a href="/drugs/DB00599">Thiopental</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00586">Potassium</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Thiopental <em>decreases</em> the level of <em>Potassium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25571" data-original-title="Neil MJ, Dale MC: Hypokalaemia with severe rebound hyperkalaemia after therapeutic barbiturate coma. Anesth Analg. 2009 Jun;108(6):1867-8. doi: 10.1213/ane.0b013e3181a16418.">A25571</a></li></ul></td></tr><tr><td><a href="/drugs/DB01132">Pioglitazone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>HDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Pioglitazone <em>increases</em> the level of <em>HDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25572" data-original-title="Hanefeld M: The role of pioglitazone in modifying the atherogenic lipoprotein profile. Diabetes Obes Metab. 2009 Aug;11(8):742-56. doi: 10.1111/j.1463-1326.2009.01048.x. Epub 2009 Jun 10.">A25572</a></li></ul></td></tr><tr><td><a href="/drugs/DB01132">Pioglitazone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>Triglycerides</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Pioglitazone <em>decreases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25572" data-original-title="Hanefeld M: The role of pioglitazone in modifying the atherogenic lipoprotein profile. Diabetes Obes Metab. 2009 Aug;11(8):742-56. doi: 10.1111/j.1463-1326.2009.01048.x. Epub 2009 Jun 10.">A25572</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>1251 - 1275</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=50">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=47">47</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=48">48</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=49">49</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=50">50</a></li><li class="page-item active"><a remote="false" class="page-link">51</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=52">52</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=53">53</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=54">54</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=55">55</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=52">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial"><img style="width: 130px; 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