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pharmaco-metabolomics-page64_markup.html
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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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1600</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=63">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=60">60</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=61">61</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=62">62</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=63">63</a></li><li class="page-item active"><a remote="false" class="page-link">64</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=65">65</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=66">66</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=67">67</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=68">68</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=65">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB00338">Omeprazole</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01375">Hydroxymethylglutaryl coenzyme A</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Omeprazole <em>increases</em> the level of <em>Hydroxymethylglutaryl coenzyme A</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25701" data-original-title="Elazzazy S, Eziada SS, Zaidan M: Rhabdomyolysis secondary to drug interaction between atorvastatin, omeprazole, and dexamethasone. Int Med Case Rep J. 2012 Sep 4;5:59-61. doi: 10.2147/IMCRJ.S34919. Print 2012.">A25701</a></li></ul></td></tr><tr><td><a href="/drugs/DB00503">Ritonavir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Ritonavir <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25702" data-original-title="Cao Y, Han Y, Xie J, Cui Q, Zhang L, Li Y, Li Y, Song X, Zhu T, Li T: Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted protease inhibitor-based regimen on renal function in HIV-infected individuals: a prospective, multicenter study. BMC Infect Dis. 2013 Jul 1;13:301. doi: 10.1186/1471-2334-13-301.">A25702</a></li></ul></td></tr><tr><td><a href="/drugs/DB01399">Salsalate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00289">Uric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Salsalate <em>decreases</em> the level of <em>Uric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25703" data-original-title="Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE: Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2013 Jul 2;159(1):1-12. doi: 10.7326/0003-4819-159-1-201307020-00003.">A25703</a></li></ul></td></tr><tr><td><a href="/drugs/DB01399">Salsalate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>LDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Salsalate <em>increases</em> the level of <em>LDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25703" data-original-title="Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE: Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2013 Jul 2;159(1):1-12. doi: 10.7326/0003-4819-159-1-201307020-00003.">A25703</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00784">Azelaic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Azelaic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00283">D-Ribose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>D-Ribose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00207">Oleic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Oleic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03229">Palmitoleic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Palmitoleic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00673">Linoleic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Linoleic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00157">Hypoxanthine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Hypoxanthine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB03070">Shikimic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Shikimic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00292">Xanthine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Xanthine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00807">3-Phosphoglyceric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>3-Phosphoglyceric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB04812">2,5-Furandicarboxylic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>2,5-Furandicarboxylic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01895">Salicylic acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>Salicylic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00840">SalicylUric acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>SalicylUric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00195">Inosine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>Inosine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00133">Guanosine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>Guanosine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00045">Adenosine-5-monophosphate</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>Adenosine-5-monophosphate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00050">Adenosine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>Adenosine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25704" data-original-title="Yerges-Armstrong LM, Ellero-Simatos S, Georgiades A, Zhu H, Lewis JP, Horenstein RB, Beitelshees AL, Dane A, Reijmers T, Hankemeier T, Fiehn O, Shuldiner AR, Kaddurah-Daouk R: Purine pathway implicated in mechanism of resistance to aspirin therapy: pharmacometabolomics-informed pharmacogenomics. Clin Pharmacol Ther. 2013 Oct;94(4):525-32. doi: 10.1038/clpt.2013.119. Epub 2013 Jun 11.">A25704</a></li></ul></td></tr><tr><td><a href="/drugs/DB06203">Alogliptin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB02712">1,5-anhydroglucitol</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Alogliptin <em>increases</em> the level of <em>1,5-anhydroglucitol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25705" data-original-title="Sakata K, Hayakawa M, Yano Y, Tamaki N, Yokota N, Eto T, Watanabe R, Hirayama N, Matsuo T, Kuroki K, Sagara S, Mishima O, Koga M, Nagata N, Nishino Y, Kitamura K, Kario K, Takeuchi M, Yamagishi S: Efficacy of alogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end product (AGE) - receptor for AGE (RAGE) axis and albuminuria in Japanese type 2 diabetes. Diabetes Metab Res Rev. 2013 Nov;29(8):624-30. doi: 10.1002/dmrr.2437.">A25705</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00763">5-hydroxyindoleacetic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Sertraline <em>decreases</em> the level of <em>5-hydroxyindoleacetic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01389">Melatonin</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Sertraline <em>increases</em> the level of <em>Melatonin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00020">4-Hydroxyphenylacetic Acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Sertraline <em>increases</em> the level of <em>4-Hydroxyphenylacetic Acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr><tr><td><a href="/drugs/DB01104">Sertraline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01866">3,4-Dihydroxymandelic Acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Sertraline <em>increases</em> the level of <em>3,4-Dihydroxymandelic Acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25706" data-original-title="Zhu H, Bogdanov MB, Boyle SH, Matson W, Sharma S, Matson S, Churchill E, Fiehn O, Rush JA, Krishnan RR, Pickering E, Delnomdedieu M, Kaddurah-Daouk R: Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. doi: 10.1371/journal.pone.0068283. Print 2013.">A25706</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>1576 - 1600</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=63">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=60">60</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=61">61</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=62">62</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=63">63</a></li><li class="page-item active"><a remote="false" class="page-link">64</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=65">65</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=66">66</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=67">67</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=68">68</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=65">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial hidden"><img style="width: 130px; 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