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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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1800</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=71">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=68">68</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=69">69</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=70">70</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=71">71</a></li><li class="page-item active"><a remote="false" class="page-link">72</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=73">73</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=74">74</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=75">75</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=76">76</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=73">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB01136">Carvedilol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01895">Salicylate</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Carvedilol <em>increases</em> the level of <em>Salicylate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25728" data-original-title="Altmaier E, Fobo G, Heier M, Thorand B, Meisinger C, Romisch-Margl W, Waldenberger M, Gieger C, Illig T, Adamski J, Suhre K, Kastenmuller G: Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol. 2014 May;29(5):325-36. doi: 10.1007/s10654-014-9910-7. Epub 2014 May 10.">A25728</a></li></ul></td></tr><tr><td><a href="/drugs/DB01136">Carvedilol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB0006461">Acylcarnitins</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Carvedilol <em>increases</em> the level of <em>Acylcarnitins</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25728" data-original-title="Altmaier E, Fobo G, Heier M, Thorand B, Meisinger C, Romisch-Margl W, Waldenberger M, Gieger C, Illig T, Adamski J, Suhre K, Kastenmuller G: Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol. 2014 May;29(5):325-36. doi: 10.1007/s10654-014-9910-7. Epub 2014 May 10.">A25728</a></li></ul></td></tr><tr><td><a href="/drugs/DB01136">Carvedilol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00378">2-Methylbutyroylcarnitine C4-M</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Carvedilol <em>increases</em> the level of <em>2-Methylbutyroylcarnitine C4-M</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25728" data-original-title="Altmaier E, Fobo G, Heier M, Thorand B, Meisinger C, Romisch-Margl W, Waldenberger M, Gieger C, Illig T, Adamski J, Suhre K, Kastenmuller G: Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism. Eur J Epidemiol. 2014 May;29(5):325-36. doi: 10.1007/s10654-014-9910-7. Epub 2014 May 10.">A25728</a></li></ul></td></tr><tr><td><a href="/drugs/DB09303">Evolocumab</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>LDL cholesterol</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Evolocumab <em>decreases</em> the level of <em>LDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25729" data-original-title="Robinson JG, Nedergaard BS, Rogers WJ, Fialkow J, Neutel JM, Ramstad D, Somaratne R, Legg JC, Nelson P, Scott R, Wasserman SM, Weiss R: Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA. 2014 May 14;311(18):1870-82. doi: 10.1001/jama.2014.4030.">A25729</a></li></ul></td></tr><tr><td><a href="/drugs/DB00746">Deferoxamine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Deferoxamine <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25730" data-original-title="Meerpohl JJ, Schell LK, Rucker G, Motschall E, Fleeman N, Niemeyer CM, Bassler D: Deferasirox for managing transfusional iron overload in people with sickle cell disease. Cochrane Database Syst Rev. 2014 May 27;5:CD007477.">A25730</a></li></ul></td></tr><tr><td><a href="/drugs/DB01257">Eculizumab</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Eculizumab <em>decreases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25731" data-original-title="Rosenblad T, Rebetz J, Johansson M, Bekassy Z, Sartz L, Karpman D: Eculizumab treatment for rescue of renal function in IgA nephropathy. Pediatr Nephrol. 2014 Nov;29(11):2225-8. doi: 10.1007/s00467-014-2863-y. Epub 2014 Jun 13.">A25731</a></li></ul></td></tr><tr><td><a href="/drugs/DB01393">Bezafibrate</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>HDL2 cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Bezafibrate <em>increases</em> the level of <em>HDL2 cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25732" data-original-title="Sakuma N, Ikeuchi R, Hibino T, Yoshida T, Mukai S, Akita S, Yajima K, Miyabe H, Goto T, Takada N, Ohte N, Kunimatu M, Kimura G: Increased serum triglyceride clearance and elevated high-density lipoprotein 2 and 3 cholesterol during treatment of primary hypertriglyceridemia with bezafibrate. Curr Ther Res Clin Exp. 2003 Nov;64(9):697-706. doi: 10.1016/j.curtheres.2003.10.002.">A25732</a></li></ul></td></tr><tr><td><a href="/drugs/DB00007">Leuprolide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00234">Total testosterone</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Leuprolide <em>decreases</em> the level of <em>Total testosterone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25733" data-original-title="Yu EY, Getzenberg RH, Coss CC, Gittelman MM, Keane T, Tutrone R, Belkoff L, Given R, Bass J, Chu F, Gambla M, Gaylis F, Bailen J, Hancock ML, Smith J, Dalton JT, Steiner MS: Selective estrogen receptor alpha agonist GTx-758 decreases testosterone with reduced side effects of androgen deprivation therapy in men with advanced prostate cancer. Eur Urol. 2015 Feb;67(2):334-41. doi: 10.1016/j.eururo.2014.06.011. Epub 2014 Jun 24.">A25733</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB11733">Glycylglycine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Glycylglycine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00148">L-glutamic acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-glutamic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00687">L-Leucine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Leucine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00159">L-Phenylalanine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Phenylalanine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00187">L-Serine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Serine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00149">Ethanolamine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Ethanolamine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00168">L-Asparagine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Asparagine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00883">L-Valine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Valine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00056">Beta-alanine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>Beta-alanine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00182">L-Lysine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Lysine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00177">L-Histidine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Histidine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00158">L-Tyrosine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Tyrosine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00641">L-Glutamine</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acetylsalicylic acid <em>decreases</em> the level of <em>L-Glutamine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB00945">Acetylsalicylic acid</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00224">O-Phosphoethanolamine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Acetylsalicylic acid <em>increases</em> the level of <em>O-Phosphoethanolamine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25734" data-original-title="Ellero-Simatos S, Lewis JP, Georgiades A, Yerges-Armstrong LM, Beitelshees AL, Horenstein RB, Dane A, Harms AC, Ramaker R, Vreeken RJ, Perry CG, Zhu H, Sanchez CL, Kuhn C, Ortel TL, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R: Pharmacometabolomics reveals that serotonin is implicated in aspirin response variability. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 16;3:e125. doi: 10.1038/psp.2014.22.">A25734</a></li></ul></td></tr><tr><td><a href="/drugs/DB06016">Cariprazine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Cariprazine <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25735" data-original-title="Durgam S, Starace A, Li D, Migliore R, Ruth A, Nemeth G, Laszlovszky I: The efficacy and tolerability of cariprazine in acute mania associated with bipolar I disorder: a phase II trial. Bipolar Disord. 2015 Feb;17(1):63-75. doi: 10.1111/bdi.12238. Epub 2014 Jul 24.">A25735</a></li></ul></td></tr><tr><td><a href="/drugs/DB00642">Pemetrexed</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00742">Homocysteine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Pemetrexed <em>increases</em> the level of <em>Homocysteine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25736" data-original-title="Singh N, Aggarwal AN, Kaur J, Behera D: Association of Graded Folic Acid Supplementation and Total Plasma Homocysteine Levels With Hematological Toxicity During First-line Treatment of Nonsquamous NSCLC Patients With Pemetrexed-based Chemotherapy. Am J Clin Oncol. 2017 Feb;40(1):75-82. doi: 10.1097/COC.0000000000000111.">A25736</a></li></ul></td></tr><tr><td><a href="/drugs/DB00871">Terbutaline</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00190">Lactate</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Terbutaline <em>increases</em> the level of <em>Lactate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25737" data-original-title="Hostrup M, Kalsen A, Bangsbo J, Hemmersbach P, Karlsson S, Backer V: High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men. Eur J Appl Physiol. 2014 Dec;114(12):2499-508. doi: 10.1007/s00421-014-2970-2. Epub 2014 Aug 12.">A25737</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>1776 - 1800</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=71">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=68">68</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=69">69</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=70">70</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=71">71</a></li><li class="page-item active"><a remote="false" class="page-link">72</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=73">73</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=74">74</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=75">75</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=76">76</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=73">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial"><img style="width: 130px; 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