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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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1850</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=73">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=70">70</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=71">71</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=72">72</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=73">73</a></li><li class="page-item active"><a remote="false" class="page-link">74</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=75">75</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=76">76</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=77">77</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=78">78</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=75">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB00104">Octreotide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>5-hydoxyindoacetate</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Octreotide <em>decreases</em> the level of <em>5-hydoxyindoacetate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25755" data-original-title="Al-Efraij K, Aljama MA, Kennecke HF: Association of dose escalation of octreotide long-acting release on clinical symptoms and tumor markers and response among patients with neuroendocrine tumors. Cancer Med. 2015 Jun;4(6):864-70. doi: 10.1002/cam4.435. Epub 2015 Feb 26.">A25755</a></li></ul></td></tr><tr><td><a href="/drugs/DB00635">Prednisone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00289">Uric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Prednisone <em>decreases</em> the level of <em>Uric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25756" data-original-title="Meng H, Liu G, Zhai J, Zhen Y, Zhao Q, Zheng M, Ma G, Wang L, Tian L, Ji L, Duan L, Li L, Liu K, Liu C: Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study. J Rheumatol. 2015 May;42(5):866-9. doi: 10.3899/jrheum.141037. Epub 2015 Mar 15.">A25756</a></li></ul></td></tr><tr><td><a href="/drugs/DB00731">Nateglinide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>Triglycerides</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Nateglinide <em>decreases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25757" data-original-title="Zhou J, Deng Z, Lu J, Li H, Zhang X, Peng Y, Mo Y, Bao Y, Jia W: Differential therapeutic effects of nateglinide and acarbose on fasting and postprandial lipid profiles: a randomized trial. Diabetes Technol Ther. 2015 Apr;17(4):229-34. doi: 10.1089/dia.2014.0299.">A25757</a></li></ul></td></tr><tr><td><a href="/drugs/DB00169">Cholecalciferol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Nutraceutical</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01903">1,25-dihydroxyvitamin D</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Cholecalciferol <em>increases</em> the level of <em>1,25-dihydroxyvitamin D</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25758" data-original-title="Curiel-Lewandrowski C, Tang JY, Einspahr JG, Bermudez Y, Hsu CH, Rezaee M, Lee AH, Tangrea J, Parnes HL, Alberts DS, Chow HH: Pilot study on the bioactivity of vitamin d in the skin after oral supplementation. Cancer Prev Res (Phila). 2015 Jun;8(6):563-9. doi: 10.1158/1940-6207.CAPR-14-0280. Epub 2015 Apr 2.">A25758</a></li></ul></td></tr><tr><td><a href="/drugs/DB01012">Cinacalcet</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01429">Phosphate</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
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</div> decreased</span></td><td>Cinacalcet <em>decreases</em> the level of <em>Phosphate</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25759" data-original-title="Yamada S, Tokumoto M, Taniguchi M, Toyonaga J, Suehiro T, Eriguchi R, Fujimi S, Ooboshi H, Kitazono T, Tsuruya K: Two Years of Cinacalcet Hydrochloride Treatment Decreased Parathyroid Gland Volume and Serum Parathyroid Hormone Level in Hemodialysis Patients With Advanced Secondary Hyperparathyroidism. Ther Apher Dial. 2015 Aug;19(4):367-77. doi: 10.1111/1744-9987.12292. Epub 2015 Apr 7.">A25759</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB07008">Diacylglycerol 14:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
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</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Diacylglycerol 14:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB07098">Diacylglycerol 16:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Diacylglycerol 16:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB0056036">Diacylglycerol 18:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Diacylglycerol 18:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB0056062">Diacylglycerol 20:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Diacylglycerol 20:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB0046381">Triglycerides 22:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Triglycerides 22:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB06725">Cholesterol ester 14:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 14:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00885">Cholesterol ester 16:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 16:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB10368">Cholesterol ester 18:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 18:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB06740">Cholesterol ester 20:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 20:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB06727">Cholesterol ester 22:0</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 22:0</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB10367">Cholesterol ester 14:1n5</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 14:1n5</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00658">Cholesterol ester 16:1n7</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 16:1n7</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB05189">Cholesterol ester 18:1n7</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 18:1n7</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00918">Cholesterol ester 18:1n9</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 18:1n9</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB10373">Cholesterol ester 20:3n9</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 20:3n9</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00610">Cholesterol ester 18:2n6</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 18:2n6</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB10369">Cholesterol ester 18:3n6</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 18:3n6</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Cholesterol ester 20:2n6</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 20:2n6</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB06736">Cholesterol ester 20:3n6</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 20:3n6</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB06726">Cholesterol ester 20:4n6</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
<use xlink:href="/assets/icons-b5e582577bf5da72d1df8a7d1b81629eea1cc7deaae8c957adf46f1fbe736051.svg#arrow-down"></use>
</svg>
</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>Cholesterol ester 20:4n6</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25760" data-original-title="Kaddurah-Daouk R, Weinshilboum R: Metabolomic Signatures for Drug Response Phenotypes: Pharmacometabolomics Enables Precision Medicine. Clin Pharmacol Ther. 2015 Jul;98(1):71-5. doi: 10.1002/cpt.134. Epub 2015 Jun 4.">A25760</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>1826 - 1850</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=73">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=70">70</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=71">71</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=72">72</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=73">73</a></li><li class="page-item active"><a remote="false" class="page-link">74</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=75">75</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=76">76</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=77">77</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=78">78</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=75">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial"><img style="width: 130px; 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