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</div></div></div></nav></header><main role="main"><div class="content-container"><div class="content-header d-sm-flex align-items-center"><h1 class="align-self-center mr-auto">Pharmaco-metabolomics<small>Metabolite changes due to the metabolism of pharmaceutical compounds</small></h1><div class="page-actions ml-auto justify-content-sm-end mt-2 mt-sm-0"><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/genomics">Pharmaco-genomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1 disabled" href="/pharmaco/metabolomics">Pharmaco-metabolomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/transcriptomics">Pharmaco-transcriptomics</a><a class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/proteomics">Pharmaco-proteomics</a><a data-no-turbolink="true" class="btn btn-sm btn-blue ml-sm-3 mr-2 mr-sm-0 mt-1 mb-1" href="/pharmaco/search">Search</a></div></div><form class="metabolite_regulation_search" id="metabolite_regulation_search" action="/pharmaco/metabolomics" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓"><div class="container-fluid"><div class="filter-bar row justify-content-start d-flex flex-wrap flex-column flex-sm-row"><div class="advanced-toggle d-flex d-sm-none justify-content-between align-items-center"><h3>Advanced Filter</h3><div class="toggle"><div class="drugbank-icon icon-add"><svg class="icon" role="img" title="add">
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2475</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=98">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=95">95</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=96">96</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=97">97</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=98">98</a></li><li class="page-item active"><a remote="false" class="page-link">99</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=100">100</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=101">101</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=102">102</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=103">103</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=100">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div><table class="table-metabolite-regulations table table-bordered"><thead><tr><th>Drug</th><th>Drug Groups</th><th>Metabolite</th><th>Change</th><th>Description</th><th>Reference</th></tr><tr class="table-search-row"><th><input class=" form-control input-md input-tbl-search" type="text" name="q[drug_precise_names_name_cont]" id="q_drug_precise_names_name_cont"></th><th></th><th><input class=" form-control input-md input-tbl-search" type="text" name="q[metabolite_cont]" id="q_metabolite_cont"></th><th><select class=" form-control input-sm input-tbl-search select2-standard" name="q[change_eq]" id="q_change_eq"><option value=""></option>
<option value="increased">increased</option>
<option value="decreased">decreased</option></select></th><th></th><th class="table-search-submit"><div class="btn-group"><button name="button" type="submit" class="table-search-submit btn btn-sm btn-light"><div class="drugbank-icon icon-search-big"><svg class="icon" role="img" title="search-big">
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</div></button> <a id="table-search-reset" class="btn btn-light btn-sm" href="/pharmaco/metabolomics">Clear</a></div></th></tr></thead><tbody><tr><td><a href="/drugs/DB00717">Norethisterone</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Triglycerides</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Norethisterone <em>increases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26073" data-original-title="Wynn V: [Influence of progestins on adverse effects of oral contraceptives]. Contracept Fertil Sex (Paris). 1985 Jan;13(1 Suppl):425-30.">A26073</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25097" data-original-title="Paterson ME, Sturdee DW, Moore B, Whitehead TP: The effect of various regimens of hormone therapy on serum cholesterol and triglyceride concentrations in postmenopausal women. Br J Obstet Gynaecol. 1980 Jul;87(7):552-60.">A25097</a></li></ul></td></tr><tr><td><a href="/drugs/DB01197">Captopril</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00037">Aldosterone</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Captopril <em>decreases</em> the level of <em>Aldosterone</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25152" data-original-title="Lijnen P, Staessen J, Fagard R, Amery A: Increase in plasma aldosterone during prolonged captopril treatment. Am J Cardiol. 1982 Apr 21;49(6):1561-3.">A25152</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26074" data-original-title="Ohman KP, Karlberg BE, Nilsson OR, Wettre S: Captopril, aldosterone and urinary kallikrein in primary hypertension. Clin Exp Hypertens A. 1983;5(4):523-9.">A26074</a></li></ul></td></tr><tr><td><a href="/drugs/DB06410">Doxercalciferol</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01315">Phosphorus</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Doxercalciferol <em>increases</em> the level of <em>Phosphorus</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25582" data-original-title="Palmer SC, McGregor DO, Craig JC, Elder G, Macaskill P, Strippoli GF: Vitamin D compounds for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD008175. doi: 10.1002/14651858.CD008175.">A25582</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26075" data-original-title="Andress DL, Coyne DW, Kalantar-Zadeh K, Molitch ME, Zangeneh F, Sprague SM: Management of secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease. Endocr Pract. 2008 Jan-Feb;14(1):18-27.">A26075</a></li></ul></td></tr><tr><td><a href="/drugs/DB00641">Simvastatin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB01863">2-hydroxyvaleric acid</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Simvastatin <em>decreases</em> the level of <em>2-hydroxyvaleric acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25674" data-original-title="Trupp M, Zhu H, Wikoff WR, Baillie RA, Zeng ZB, Karp PD, Fiehn O, Krauss RM, Kaddurah-Daouk R: Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment. PLoS One. 2012;7(7):e38386. doi: 10.1371/journal.pone.0038386. Epub 2012 Jul 9.">A25674</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25710" data-original-title="Krauss RM, Zhu H, Kaddurah-Daouk R: Pharmacometabolomics of statin response. Clin Pharmacol Ther. 2013 Nov;94(5):562-5. doi: 10.1038/clpt.2013.164. Epub 2013 Aug 14.">A25710</a></li></ul></td></tr><tr><td><a href="/drugs/DB00722">Lisinopril</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td>HDL cholesterol</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Lisinopril <em>increases</em> the level of <em>HDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26010" data-original-title="Anichkov DA, Shostak NA, Schastnaya OV: Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome. Curr Med Res Opin. 2005 Jan;21(1):113-9.">A26010</a></li></ul></td></tr><tr><td><a href="/drugs/DB01221">Ketamine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB29581">Hexadienoic acid</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Ketamine <em>increases</em> the level of <em>Hexadienoic acid</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25724" data-original-title="Villasenor A, Ramamoorthy A, Silva dos Santos M, Lorenzo MP, Laje G, Zarate C Jr, Barbas C, Wainer IW: A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks. Br J Pharmacol. 2014 Apr;171(8):2230-42. doi: 10.1111/bph.12494.">A25724</a></li></ul></td></tr><tr><td><a href="/drugs/DB00982">Isotretinoin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>Triglycerides</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Isotretinoin <em>increases</em> the level of <em>Triglycerides</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26076" data-original-title="Stoll D, Binnert C, Mooser V, Tappy L: Short-term administration of isotretinoin elevates plasma triglyceride concentrations without affecting insulin sensitivity in healthy humans. Metabolism. 2004 Jan;53(1):4-10.">A26076</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25025" data-original-title="Marsden JR, Shuster S, Dennis JD: Antipyrine clearance and alpha 1-acid glycoprotein levels after isotretinoin. Hum Toxicol. 1985 May;4(3):335-8.">A25025</a></li></ul></td></tr><tr><td><a href="/drugs/DB00999">Hydrochlorothiazide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00547">Magnesium</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Hydrochlorothiazide <em>decreases</em> the level of <em>Magnesium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25149" data-original-title="Leary WP, Reyes AJ: Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride. S Afr Med J. 1981 Sep 5;60(10):381-4.">A25149</a></li></ul></td></tr><tr><td><a href="/drugs/DB00796">Candesartan cilexetil</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Candesartan cilexetil <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26077" data-original-title="Nakamura T, Kanno Y, Takenaka T, Suzuki H: An angiotensin receptor blocker reduces the risk of congestive heart failure in elderly hypertensive patients with renal insufficiency. Hypertens Res. 2005 May;28(5):415-23.">A26077</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25644" data-original-title="Okumi M, Kawada N, Ichimaru N, Kitamura H, Abe T, Imamura R, Kojima Y, Kokado Y, Isaka Y, Rakugi H, Nonomura N, Moriyama T, Takahara S: Safety and efficacy of administering the maximal dose of candesartan in renal transplant recipients. Clin Exp Nephrol. 2011 Dec;15(6):907-15. doi: 10.1007/s10157-011-0503-4. Epub 2011 Aug 5.">A25644</a></li></ul></td></tr><tr><td><a href="/drugs/DB00879">Emtricitabine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Emtricitabine <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26078" data-original-title="Jin S, Kim MH, Park JH, Jung HJ, Lee HJ, Kim SW, Lee JM, Kim S, Chang HH: The Incidence and Clinical Characteristics of Acute Serum Creatinine Elevation more than 1.5 mg/dL among the Patients Treated with Tenofovir/Emtricitabine-containing HAART Regimens. Infect Chemother. 2015 Dec;47(4):239-46. doi: 10.3947/ic.2015.47.4.239. Epub 2015 Dec 30.">A26078</a></li></ul></td></tr><tr><td><a href="/drugs/DB00503">Ritonavir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00067">Total cholesterol</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Ritonavir <em>increases</em> the level of <em>Total cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26079" data-original-title="Orkin C, DeJesus E, Khanlou H, Stoehr A, Supparatpinyo K, Lathouwers E, Lefebvre E, Opsomer M, Van de Casteele T, Tomaka F: Final 192-week efficacy and safety of once-daily darunavir/ritonavir compared with lopinavir/ritonavir in HIV-1-infected treatment-naive patients in the ARTEMIS trial. HIV Med. 2013 Jan;14(1):49-59. doi: 10.1111/j.1468-1293.2012.01060.x. Epub 2012 Oct 23.">A26079</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25653" data-original-title="Rao MN, Lee GA, Grunfeld C: Metabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase Inhibitors. Am J Infect Dis. 2006 Sep 30;2(3):159-166.">A25653</a></li></ul></td></tr><tr><td><a href="/drugs/DB01221">Ketamine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td>Hydroxy-hexadienal</td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Ketamine <em>increases</em> the level of <em>Hydroxy-hexadienal</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25724" data-original-title="Villasenor A, Ramamoorthy A, Silva dos Santos M, Lorenzo MP, Laje G, Zarate C Jr, Barbas C, Wainer IW: A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks. Br J Pharmacol. 2014 Apr;171(8):2230-42. doi: 10.1111/bph.12494.">A25724</a></li></ul></td></tr><tr><td><a href="/drugs/DB00900">Didanosine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Didanosine <em>increases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26039" data-original-title="Riyaten P, Salvadori N, Traisathit P, Ngo-Giang-Huong N, Cressey TR, Leenasirimakul P, Techapornroong M, Bowonwatanuwong C, Kantipong P, Nilmanat A, Yutthakasemsunt N, Chutanunta A, Thongpaen S, Klinbuayaem V, Decker L, Le Coeur S, Lallemant M, Capeau J, Mary JY, Jourdain G: New-Onset Diabetes and Antiretroviral Treatments in HIV-Infected Adults in Thailand. J Acquir Immune Defic Syndr. 2015 Aug 1;69(4):453-9. doi: 10.1097/QAI.0000000000000647.">A26039</a></li></ul></td></tr><tr><td><a href="/drugs/DB00284">Acarbose</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Acarbose <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26080" data-original-title="Wachters-Hagedoorn RE, Priebe MG, Heimweg JA, Heiner AM, Elzinga H, Stellaard F, Vonk RJ: Low-dose acarbose does not delay digestion of starch but reduces its bioavailability. Diabet Med. 2007 Jun;24(6):600-6. Epub 2007 Mar 22.">A26080</a></li></ul></td></tr><tr><td><a href="/drugs/DB00468">Quinine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Quinine <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26081" data-original-title="Okitolonda W, Delacollette C, Malengreau M, Henquin JC: High incidence of hypoglycaemia in African patients treated with intravenous quinine for severe malaria. Br Med J (Clin Res Ed). 1987 Sep 19;295(6600):716-8.">A26081</a></li></ul></td></tr><tr><td><a href="/drugs/DB00752">Tranylcypromine</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00259">Serotonin</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Tranylcypromine <em>increases</em> the level of <em>Serotonin</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A24898" data-original-title="Hyland K, Surtees RA, Rodeck C, Clayton PT: Aromatic L-amino acid decarboxylase deficiency: clinical features, diagnosis, and treatment of a new inborn error of neurotransmitter amine synthesis. Neurology. 1992 Oct;42(10):1980-8.">A24898</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26082" data-original-title="Kremer HP, Goekoop JG, Van Kempen GM: Clinical use of the determination of serotonin in whole blood. J Clin Psychopharmacol. 1990 Apr;10(2):83-7.">A26082</a></li></ul></td></tr><tr><td><a href="/drugs/DB00658">Sevelamer</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td>LDL cholesterol</td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Sevelamer <em>decreases</em> the level of <em>LDL cholesterol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25590" data-original-title="Gulati A, Sridhar V, Bose T, Hari P, Bagga A: Short-term efficacy of sevelamer versus calcium acetate in patients with chronic kidney disease stage 3-4. Int Urol Nephrol. 2010 Dec;42(4):1055-62. doi: 10.1007/s11255-009-9688-9. Epub 2009 Dec 18.">A25590</a></li></ul></td></tr><tr><td><a href="/drugs/DB06335">Saxagliptin</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Saxagliptin <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25584" data-original-title="Hollander P, Li J, Allen E, Chen R: Saxagliptin added to a thiazolidinedione improves glycemic control in patients with type 2 diabetes and inadequate control on thiazolidinedione alone. J Clin Endocrinol Metab. 2009 Dec;94(12):4810-9. doi: 10.1210/jc.2009-0550. Epub 2009 Oct 28.">A25584</a></li></ul></td></tr><tr><td><a href="/drugs/DB00999">Hydrochlorothiazide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Vet Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Hydrochlorothiazide <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25406" data-original-title="Westphal S, Rading A, Luley C, Dierkes J: Antihypertensive treatment and homocysteine concentrations. Metabolism. 2003 Mar;52(3):261-3.">A25406</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26083" data-original-title="Franklin SS, Smith RD: A comparison of enalapril plus hydrochlorothiazide with standard triple therapy in renovascular hypertension. Nephron. 1986;44 Suppl 1:73-82.">A26083</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25149" data-original-title="Leary WP, Reyes AJ: Antihypertensive and metabolic effects of a combination of hydrochlorothiazide and amiloride. S Afr Med J. 1981 Sep 5;60(10):381-4.">A25149</a></li></ul><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6f3d7045-a4ee-4426-844a-411c79f87179">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00280">Disopyramide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Disopyramide <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A25324" data-original-title="Hasegawa J, Mori A, Yamamoto R, Kinugawa T, Morisawa T, Kishimoto Y: Disopyramide decreases the fasting serum glucose level in man. Cardiovasc Drugs Ther. 1999 Jul;13(4):325-7.">A25324</a></li></ul></td></tr><tr><td><a href="/drugs/DB01171">Moclobemide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00318">3,4-dihydroxyphenylglycol</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Moclobemide <em>decreases</em> the level of <em>3,4-dihydroxyphenylglycol</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A24973" data-original-title="Koulu M, Scheinin M, Kaarttinen A, Kallio J, Pyykko K, Vuorinen J, Zimmer RH: Inhibition of monoamine oxidase by moclobemide: effects on monoamine metabolism and secretion of anterior pituitary hormones and cortisol in healthy volunteers. Br J Clin Pharmacol. 1989 Feb;27(2):243-55.">A24973</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A25258" data-original-title="Radat F, Berlin I, Spreux-Varoquaux O, Elatki S, Ferreri M, Puech AJ: Initial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression. A double blind, randomized study. Psychopharmacology (Berl). 1996 Oct;127(4):370-6.">A25258</a></li></ul></td></tr><tr><td><a href="/drugs/DB00104">Octreotide</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00122">Glucose</a></td><td><span class="text-danger"><div class="drugbank-icon icon-arrow-down"><svg class="icon" role="img" title="arrow-down">
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</div> decreased</span></td><td>Octreotide <em>decreases</em> the level of <em>Glucose</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26084" data-original-title="Lunetta M, Di Mauro M, Le Moli R: [Effect of octreotide on blood glucose levels in poorly compensated insulin-dependent diabetics on insulin treatment]. Minerva Endocrinol. 1992 Jan-Mar;17(1):7-12.">A26084</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A26085" data-original-title="Hirose T, Kuroda T, Otsuki M, Takagi M, Yamamoto H, Motomura T, Kurebayashi S, Miyashita Y, Koga M, Arita N, Hayakawa T, Kishimoto T, Kasayama S: A patient with acromegaly who showed remarkable improvement of hyperglycemia after treatment with octreotide. Intern Med. 1997 May;36(5):345-50.">A26085</a></li></ul></td></tr><tr><td><a href="/drugs/DB01048">Abacavir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span> <span class="badge badge-secondary badge-pill">Investigational</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Abacavir <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=01e46f58-8bda-4ff3-ab21-57d5b540d440">DailyMed</a></li></ul></td></tr><tr><td><a href="/drugs/DB00369">Cidofovir</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00562">Creatinine</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Cidofovir <em>increases</em> the level of <em>Creatinine</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26086" data-original-title="Lachiewicz AM, Cianciolo R, Miller MB, Derebail VK: Adenovirus causing fever, upper respiratory infection, and allograft nephritis complicated by persistent asymptomatic viremia. Transpl Infect Dis. 2014 Aug;16(4):648-52. doi: 10.1111/tid.12248. Epub 2014 Jun 26.">A26086</a></li></ul></td></tr><tr><td><a href="/drugs/DB00594">Amiloride</a></td><td><span class="badge badge-secondary badge-pill">Approved</span></td><td><a target="_blank" rel="noopener" href="http://www.hmdb.ca/metabolites/HMDB00586">Potassium</a></td><td><span class="text-success"><div class="drugbank-icon icon-arrow-up"><svg class="icon" role="img" title="arrow-up">
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</div> increased</span></td><td>Amiloride <em>increases</em> the level of <em>Potassium</em> in the blood</td><td><ul class="list-unstyled table-list"><li><a target="_blank" title="" class="tips" href="/articles/A26031" data-original-title="Ramsay LE, Hettiarachchi J, Fraser R, Morton JJ: Amiloride, spironolactone, and potassium chloride in thiazide-treated hypertensive patients. Clin Pharmacol Ther. 1980 Apr;27(4):533-43.">A26031</a></li>
<li><a target="_blank" title="" class="tips" href="/articles/A24875" data-original-title="Kremer D, Boddy K, Brown JJ, Davies DL, Fraser R, Lever AF, Morton JJ, Robertson JI: Amiloride in the treatment of primary hyperaldosteronism and essential hypertension. Clin Endocrinol (Oxf). 1977 Aug;7(2):151-7.">A24875</a></li></ul></td></tr></tbody></table><div class="pagination-holder"><div class="page_info">Displaying entries <b>2451 - 2475</b> of <b>3084</b> in total</div><nav><ul class="pagination pagination-sm"><li class="page-item first"><a class="page-link" href="/pharmaco/metabolomics">«</a></li><li class="page-item previous"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=98">‹</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=95">95</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=96">96</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=97">97</a></li><li class="page-item"><a rel="prev" class="page-link" href="/pharmaco/metabolomics?page=98">98</a></li><li class="page-item active"><a remote="false" class="page-link">99</a></li><li class="page-item"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=100">100</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=101">101</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=102">102</a></li><li class="page-item"><a class="page-link" href="/pharmaco/metabolomics?page=103">103</a></li><li class="page-item disabled"><a class="page-link" href="#">…</a></li><li class="page-item next"><a rel="next" class="page-link" href="/pharmaco/metabolomics?page=100">›</a></li><li class="page-item last"><a class="page-link" href="/pharmaco/metabolomics?page=124">»</a></li></ul></nav></div></div></form></div></main><footer><div class="row p-3 p-sm-4 m-0"><div class="col-md-5 footer-content"><div class="footer-item footer-commercial hidden"><img style="width: 130px; 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