diff --git a/docs/source/supported-types.rst b/docs/source/supported-types.rst
index 0f0fe9de..1eb6b93f 100644
--- a/docs/source/supported-types.rst
+++ b/docs/source/supported-types.rst
@@ -487,10 +487,9 @@ as total seconds. See :ref:`strict-vs-lax` for more information.
 ``uuid``
 --------
 
-`uuid.UUID` values are serialized as RFC4122_ encoded strings in all protocols.
-Subclasses of `uuid.UUID` are also supported for encoding only.
-
-When decoding, both hyphenated and unhyphenated forms are supported.
+`uuid.UUID` values are serialized as RFC4122_ encoded canonical strings in all
+protocols by default. Subclasses of `uuid.UUID` are also supported for encoding
+only.
 
 .. code-block:: python
 
@@ -504,14 +503,60 @@ When decoding, both hyphenated and unhyphenated forms are supported.
     >>> msgspec.json.decode(b'"c4524ac0-e81e-4aa8-a595-0aec605a659a"', type=uuid.UUID)
     UUID('c4524ac0-e81e-4aa8-a595-0aec605a659a')
 
-    >>> msgspec.json.decode(b'"c4524ac0e81e4aa8a5950aec605a659a"', type=uuid.UUID)
-    UUID('c4524ac0-e81e-4aa8-a595-0aec605a659a')
-
     >>> msgspec.json.decode(b'"oops"', type=uuid.UUID)
     Traceback (most recent call last):
         File "<stdin>", line 1, in <module>
     msgspec.ValidationError: Invalid UUID
 
+Alternative formats are also supported by the JSON and MessagePack encoders.
+The format may be selected by passing it to ``uuid_format`` when creating an
+``Encoder``. The following options are supported:
+
+- ``canonical``: UUIDs are encoded as RFC4122_ canonical strings (same as
+  ``str(uuid)``). This is the default.
+- ``hex``: UUIDs are encoded as RFC4122_ hex strings (same as ``uuid.hex``).
+- ``bytes``: UUIDs are encoded as binary values of the uuid's big-endian
+  128-bit integer representation (same as ``uuid.bytes``). This is only supported
+  by the MessagePack encoder.
+
+When decoding, both ``canonical`` and ``hex`` formats are supported by all
+protocols.
+
+.. code-block:: python
+
+    >>> enc = msgspec.json.Encoder(uuid_format="hex")
+
+    >>> enc.encode(u)
+    b'"c4524ac0e81e4aa8a5950aec605a659a"'
+
+    >>> u.hex
+    "c4524ac0e81e4aa8a5950aec605a659a"
+
+    >>> msgspec.json.decode(b'"c4524ac0e81e4aa8a5950aec605a659a"', type=uuid.UUID)
+    UUID('c4524ac0-e81e-4aa8-a595-0aec605a659a')
+
+Additionally, if ``strict=False`` is specified, the ``bytes`` format may be
+decoded by the MessagePack decoder. See :ref:`strict-vs-lax` for more
+information.
+
+.. code-block:: python
+
+    >>> enc = msgspec.msgpack.Encoder(uuid_format="bytes")
+
+    >>> msg = enc.encode(u)
+
+    >>> msg
+    b'\xc4\x10\xc4RJ\xc0\xe8\x1eJ\xa8\xa5\x95\n\xec`Ze\x9a'
+
+    >>> msgspec.msgpack.decode(msg, type=uuid.UUID)
+    Traceback (most recent call last):
+      File "<stdin>", line 1, in <module>
+    msgspec.ValidationError: Expected `uuid`, got `bytes`
+
+    >>> msgspec.msgpack.decode(msg, type=uuid.UUID, strict=False)
+    UUID('c4524ac0-e81e-4aa8-a595-0aec605a659a')
+
+
 ``decimal``
 -----------