diff --git a/.github/workflows/screenshot-test.yml b/.github/workflows/screenshot-test.yml
index 5748c1037..5c0b19669 100644
--- a/.github/workflows/screenshot-test.yml
+++ b/.github/workflows/screenshot-test.yml
@@ -18,13 +18,13 @@ jobs:
     - name: Run the test
       run: yarn run screenshot-test-in-docker
     - name: Archive screenshots
-      uses: actions/upload-artifact@v2
+      uses: actions/upload-artifact@v4
       if: failure()
       with:
         name: visual-regression-screenshots
         path: /home/runner/work/oncokb-public/oncokb-public/screenshot-test/__latest_snapshots__/
     - name: Archive visual regression failures
-      uses: actions/upload-artifact@v2
+      uses: actions/upload-artifact@v4
       if: failure()
       with:
         name: visual-regression-diff-report
diff --git a/src/main/webapp/app/config/constants.tsx b/src/main/webapp/app/config/constants.tsx
index 0017ff88d..a7f1ca567 100644
--- a/src/main/webapp/app/config/constants.tsx
+++ b/src/main/webapp/app/config/constants.tsx
@@ -800,6 +800,7 @@ export type DataRelease = {
 };
 
 export const DATA_RELEASES: DataRelease[] = [
+  { date: '09192024', version: 'v4.21' },
   { date: '08152024', version: 'v4.20' },
   { date: '07042024', version: 'v4.19' },
   { date: '07022024', version: 'v4.18' },
diff --git a/src/main/webapp/app/pages/newsPage/NewsPage.tsx b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
index 1a34720d7..ff93d2764 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPage.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
@@ -84,6 +84,7 @@ export default class NewsPage extends React.Component<{
             <CitationText />
           </div>
           <div className="mt-2">
+            <NewsList date={'09192024'} />
             <NewsList date={'08152024'} />
             <NewsList date={'07042024'} />
             <NewsList date={'07022024'} />
diff --git a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
index f1ac9de8d..b8de43c44 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
@@ -289,6 +289,51 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
 // https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
 
 export const NEWS_BY_DATE: { [date: string]: NewsData } = {
+  '09192024': {
+    changedAnnotations: [
+      {
+        columnHeaderType: AnnotationColumnHeaderType.NEW_ALTERATION_WITH_LEVEL,
+        content: [
+          [
+            '3A',
+            'ALK',
+            'F1174L/C, F1245Y/V, R1275Q/L',
+            'Neuroblastoma',
+            'Lorlatinib',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="38410486" />
+              <PMIDLink pmids="37012551" />
+              <PMIDLink pmids="26554404" />
+              <PMIDLink pmids="38032104" />
+              <PMIDLink pmids="27483357" />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        columnHeaderType:
+          AnnotationColumnHeaderType.DRUG_UPDATE_SAME_HIGHEST_LEVEL,
+        content: [
+          [
+            '1',
+            'EGFR',
+            'Exon 19 in-frame deletions, L858R',
+            'Non-Small Cell Lung Cancer',
+            'Afatinib, Dacomitinib, Erlotinib, Erlotinib + Ramucirumab, Gefitinib, Osimertinib, Osimertinib + Chemotherapy (Level 1); Amivantamab + Chemotherapy (Level 2); Amivantamab + Lazertinib, Patritumab Deruxtecan (Level 3A',
+            'Amivantamab + Lazertinib (Level 1)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Amivantamab + Lazertinib"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lazertinib-amivantamab-vmjw-non-small-lung-cancer"
+              />
+              <PMIDLink pmids="38924756" />
+            </WithSeparator>,
+          ],
+        ],
+      },
+    ],
+    newlyAddedGenes: ['ABCB1', 'ADGRA2', 'ELL2', 'XPA'],
+  },
   '08152024': {
     changedAnnotations: [
       {
diff --git a/src/main/webapp/index.html b/src/main/webapp/index.html
index e77f402ee..5da1199ae 100644
--- a/src/main/webapp/index.html
+++ b/src/main/webapp/index.html
@@ -15,7 +15,7 @@
     <meta name="twitter:site" content="@oncokb">
     <meta name="twitter:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
     <meta name="twitter:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
-    <meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240815">
+    <meta name="twitter:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240919">
     <meta name="twitter:url" content="https://www.oncokb.org/">
 
     <meta property="og:site_name" content="OncoKB™">
@@ -23,7 +23,7 @@
     <meta property="og:url" content="https://www.oncokb.org/">
     <meta property="og:title" content="OncoKB™ - MSK's Precision Oncology Knowledge Base">
     <meta property="og:description" content="OncoKB™ is a precision oncology knowledge base developed at Memorial Sloan Kettering Cancer Center that contains biological and clinical information about genomic alterations in cancer.">
-    <meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240815">
+    <meta property="og:image" content="https://www.oncokb.org/content/images/oncokb_summary.png?20240919">
 
     <link rel="mask-icon" href="content/images/favicon/safari-pinned-tab.svg" color="#0968c3">
     <!-- Preload the customized fonts, so the html knows how to pain the page  -->