diff --git a/src/main/webapp/app/components/SimpleTable.tsx b/src/main/webapp/app/components/SimpleTable.tsx
index a419cbe56..dd5afd49f 100644
--- a/src/main/webapp/app/components/SimpleTable.tsx
+++ b/src/main/webapp/app/components/SimpleTable.tsx
@@ -2,7 +2,10 @@ import * as React from 'react';
 import { Table } from 'react-bootstrap';
 
 export type ElementType = JSX.Element | string;
-export type SimpleTableCell = { key: string; content: ElementType };
+export type SimpleTableCell = {
+  key: string;
+  content: ElementType | ElementType[];
+};
 export type SimpleTableRow = { key: string; content: SimpleTableCell[] };
 export type SimpleTableRows = SimpleTableRow[];
 export type SimpleTableColumn = {
@@ -21,8 +24,8 @@ export type SimpleTableProps = {
 export const SimpleTable = (props: SimpleTableProps) => {
   const getRow = (row: SimpleTableRow) => {
     return row.content
-      ? row.content.map(cell => {
-          return <td key={cell.key}>{cell.content}</td>;
+      ? row.content.map(({ key, content }) => {
+          return <td key={key}>{content}</td>;
         })
       : null;
   };
@@ -44,9 +47,41 @@ export const SimpleTable = (props: SimpleTableProps) => {
           </thead>
         )}
         <tbody className={props.tbodyClassName}>
-          {props.rows.map(row => (
-            <tr key={row.key}>{getRow(row)}</tr>
-          ))}
+          {props.rows.flatMap(({ key, content }) => {
+            let maxContentSize = 1;
+            for (const cur of content) {
+              maxContentSize = Array.isArray(cur.content)
+                ? Math.max(cur.content.length, maxContentSize)
+                : maxContentSize;
+            }
+            const elements: JSX.Element[] = [];
+            for (let i = 0; i < maxContentSize; i++) {
+              const element = (
+                <tr key={`${key}_${i}`}>
+                  {content.map(({ content: innerContent, key: innerKey }) => {
+                    if (Array.isArray(innerContent)) {
+                      return <td key={innerKey}>{innerContent[i]}</td>;
+                    } else if (i === 0) {
+                      return (
+                        <td
+                          key={innerKey}
+                          rowSpan={
+                            maxContentSize > 1 ? maxContentSize : undefined
+                          }
+                        >
+                          {innerContent}
+                        </td>
+                      );
+                    } else {
+                      return <></>;
+                    }
+                  })}
+                </tr>
+              );
+              elements.push(element);
+            }
+            return elements;
+          })}
         </tbody>
       </Table>
     </div>
diff --git a/src/main/webapp/app/config/constants.tsx b/src/main/webapp/app/config/constants.tsx
index 9bf39edae..cc4c89eb8 100644
--- a/src/main/webapp/app/config/constants.tsx
+++ b/src/main/webapp/app/config/constants.tsx
@@ -821,6 +821,7 @@ export type DataRelease = {
 };
 
 export const DATA_RELEASES: DataRelease[] = [
+  { date: '10232024', version: 'v4.22' },
   { date: '09252024', version: 'v4.21' },
   { date: '08152024', version: 'v4.20' },
   { date: '07042024', version: 'v4.19' },
diff --git a/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx b/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
index 31a76afd1..ad17819b2 100644
--- a/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
+++ b/src/main/webapp/app/pages/newsPage/ChangedAnnotationListItem.tsx
@@ -117,7 +117,7 @@ export const ChangedAnnotationListItem = (props: {
     case AnnotationColumnHeaderType.UPDATED_SAME_LEVEL_DRUG:
       annotationColumnHeader = CHANGED_ANNOTATION_UPDATED_DRUG_SAME_HIGHEST_LEVEL_COLUMNS;
       defaultTitle =
-        "Addition of drug(s) associated with a tumor type-specific leveled alteration(s) currently in OncoKB™ (without changing the alteration's highest level of evidence)";
+        "Updated therapeutic implications - Addition of drug(s) associated with a tumor type-specific leveled alteration(s) currently in OncoKB™ (without changing the alteration's highest level of evidence)";
       useOneLineRowClass = true;
       break;
     case AnnotationColumnHeaderType.LEVEL:
diff --git a/src/main/webapp/app/pages/newsPage/NewsPage.tsx b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
index c172f5ba5..560f57819 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPage.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
@@ -87,6 +87,7 @@ export default class NewsPage extends React.Component<{
           <CitationText />
         </div>
         <div className="mt-2">
+          <NewsList date={'10232024'} />
           <NewsList date={'09252024'} />
           <NewsList date={'08152024'} />
           <NewsList date={'07042024'} />
diff --git a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
index 4465b1546..ea5985cc7 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
@@ -46,7 +46,7 @@ import { AnnotationColumnHeaderType } from './ChangedAnnotationListItem';
 import { linkableMutationName, convertGeneInputToLinks } from './Util';
 
 export type ChangedAnnotation = {
-  content: ElementType[][];
+  content: (ElementType | ElementType[])[][];
   title?: string;
   columnHeaderType?: AnnotationColumnHeaderType;
   headers?: { name: string }[];
@@ -300,6 +300,270 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
 // https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
 
 export const NEWS_BY_DATE: { [date: string]: NewsData } = {
+  '10232024': {
+    priorityNews: [
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.CDX}>
+          FDA Cleared or Approved Companion Diagnostic Devices
+        </Link>{' '}
+        (CDx) page
+      </span>,
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.ONCOLOGY_TX}>FDA-Approved Oncology Therapies</Link>{' '}
+        page
+      </span>,
+    ],
+    changedAnnotations: [
+      {
+        columnHeaderType: AnnotationColumnHeaderType.NEW_ALTERATION_WITH_LEVEL,
+        content: [
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'G2032R')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+
+            ['Taletrectinib', 'Crizotinib, Lorlatinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="38822758, 31399568" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink
+                  wrapText
+                  pmids="33685866, 29333528, 23724914, 36135089, 36135089, 32918045"
+                />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'L2086F')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+            ['Cabozantinib', 'Lorlatinib, Repotrectinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="33685866, 37291202, 39117775, 39091594" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="37291202, 33685866, 39091594" />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            '3A',
+            'SMARCA4',
+            'Oncogenic Mutations',
+            'Non-Small Cell Lung Cancer, Esophageal Adenocarcinoma',
+            'PRT3789',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Guo, R. et al., Abstract# 603O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02189-6/fulltext"
+              />
+              <AbstractLink
+                abstract="Hulse, M. et al., Abstract# 3263, AACR 2022"
+                link="https://aacrjournals.org/cancerres/article/82/12_Supplement/3263/703325/Abstract-3263-Preclinical-characterization-of"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        useOneLineRowClass: false,
+        title:
+          'Updated therapeutic implications - Promotion of tumor type-specific level of evidence for an alteration(s)',
+        headers: CHANGED_ANNOTATION_LEVEL_WITH_EVIDENCE_COLUMNS,
+        content: [
+          [
+            'PIK3CA',
+            <>
+              <AlterationPageLink
+                hugoSymbol="PIK3CA"
+                alteration="Oncogenic Mutations"
+              />{' '}
+              <span>
+                (excluding R88Q, N345K, C420R, E542K, E545A/D/G/K/Q,
+                Q546E/K/R/P, M1043V/I, H1047Y/R/L, G1049R which are already
+                Level 1)
+              </span>
+            </>,
+            'Breast Cancer',
+            <div>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_CURRENTLY_IN_ONCOKB}:
+              </div>
+              <div>
+                Alpelisib + Fulvestrant, Capivasertib + Fulvestrant (Level 2)
+              </div>
+              <br></br>
+              <div>Inavolisib + Palbociclib + Fulvestrant (Level 3A)</div>
+              <br></br>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_PROMOTED_IN_ONCOKB}:
+              </div>
+              <div>Inavolisib + Palbociclib + Fulvestrant (Level 1)</div>
+            </div>,
+            '2',
+            '1',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib + Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        columnHeaderType: AnnotationColumnHeaderType.UPDATED_SAME_LEVEL_DRUG,
+        content: [
+          [
+            '1',
+            'EGFR',
+            <>
+              <AlterationPageLink
+                hugoSymbol="EGFR"
+                alteration={'Exon 19 in-frame deletions'}
+              />
+              , <AlterationPageLink hugoSymbol="EGFR" alteration={'L858R'} />
+            </>,
+            'Non-Small Cell Lung Cancer',
+            <>
+              <div>
+                Afatinib, Dacomitinib, Erlotinib, Erlotinib + Ramucirumab,
+                Gefitinib, Osimertinib, Osimertinib + Chemotherapy, Amivantamab
+                + Lazertinib (Level 1)
+              </div>
+              <br></br>
+              <div>Amivantamab + Chemotherapy (Level 2)</div>
+              <br></br>
+              <div>Patritumab Deruxtecan (Level 3A)</div>
+            </>,
+
+            'Amivantamab + Chemotherapy (Level 1)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Amivantamab with Chemotherapy"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-amivantamab-vmjw-carboplatin-and-pemetrexed-non-small-cell-lung-cancer-egfr-exon-19"
+              />
+              <PMIDLink pmids="37879444" />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'PIK3CA',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('PIK3CA', 'R88Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'N345K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'C420R')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E542K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E545A/D/G/K/Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'Q546E/K/R/P')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'M1043V/I')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'H1047Y/R/L')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'G1049R')}
+            </WithSeparator>,
+            'Breast Cancer',
+            <>
+              <div>Capivasertib + Fulvestrant (Level 1)</div>
+              <br></br>
+              <div>
+                Alpelisib + Fulvestrant (Level 1 for PIK3CA C420R, E542K,
+                E545A/D/G/K, H1047Y/R/L, Q546E/R only)'
+              </div>
+            </>,
+            'Inavolisib + Palbociclib + Fulvestrant (Level 1; Promoted from Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib with Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ALK',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            'Alectinib, Brigatinib, Certinib, Crizotinib, Lorlatinib (Level 1) ',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024 "
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ROS1',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            <>
+              <div>Crizotinib, Entrectinib, Repotrectinib (Level 1)</div>
+              <br></br>
+              <div>Ceritinib, Lorlatinib (Level 2)</div>
+            </>,
+            'Taletrectinib (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="38822758, 36877099, 31399568" />
+            </WithSeparator>,
+          ],
+          [
+            '2',
+            'ALK',
+            'G1202R',
+            'Non-Small Cell Lung Cancer',
+            'Lorlatinib (Level 2)',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '3A',
+            'KRAS',
+            'G12D',
+            'Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma',
+            'RMC-6236 (Level 3A)',
+            'ASP3082 (Level 3A; Promoted from Level 4)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Park, W. et al., Abstract# 608O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02194-X/fulltext"
+              />
+              <AbstractLink
+                abstract="Nagashima, T. et al., Abstract# 5735, AACR 2023"
+                link="https://aacrjournals.org/cancerres/article/83/7_Supplement/5735/722276"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+    ],
+    newlyAddedGenes: ['ADARB2', 'BUB1B', 'CCN6', 'CDKN1C', 'EGR2'],
+  },
   '09252024': {
     changedAnnotations: [
       {
diff --git a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
index 26572e33e..af1bfbffd 100644
--- a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
+++ b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
@@ -486,7 +486,7 @@ const OncologyTherapiesPage: React.FunctionComponent<{}> = props => {
                 'https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications'
               }
             >
-              Content current as of 8/5/2024
+              Content current as of 10/21/2024
             </Linkout>
           </div>
           <div>
diff --git a/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json b/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
index f053cd053..1348f36b3 100644
--- a/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
+++ b/src/main/webapp/content/files/companionDiagnosticDevices/companion_diagnostic_devices.json
@@ -5,7 +5,7 @@
     "manufacturer": "Abbott Molecular, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:37.809127Z",
+    "lastUpdated": "2024-04-06T01:03:37.565709Z",
     "fdaSubmissions": [
       {
         "id": 1,
@@ -19,29 +19,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 1,
+            "id": 119,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
                 "id": 1,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "entity": "DRUG",
+                "rule": "30",
+                "name": null
+              },
+              {
+                "id": 2,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -50,13 +49,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -64,12 +63,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -78,13 +76,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -92,12 +90,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -106,13 +103,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -120,12 +117,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -134,13 +130,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -148,12 +144,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -162,13 +157,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -176,34 +171,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 1,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 29,
-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 2,
@@ -217,29 +211,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 2,
+            "id": 120,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 2,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 411,
-                  "code": "MDS",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Myelodysplastic Syndromes",
-                  "subtype": "Myelodysplastic Syndromes",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 3,
+                "entity": "DRUG",
+                "rule": "30",
+                "name": null
+              },
+              {
+                "id": 4,
+                "entity": "CANCER_TYPE",
+                "rule": "411",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -248,13 +241,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -262,12 +255,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -276,13 +268,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -290,12 +282,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -304,13 +295,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -318,12 +309,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -332,13 +322,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -346,12 +336,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -360,13 +349,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -374,34 +363,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 2,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 29,
-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 411,
+                "code": "MDS",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Myelodysplastic Syndromes",
+                "subtype": "Myelodysplastic Syndromes",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 3,
@@ -415,29 +403,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 3,
+            "id": 121,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 3,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 5,
+                "entity": "DRUG",
+                "rule": "32",
+                "name": null
+              },
+              {
+                "id": 6,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9271,
+                "id": 9374,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132C",
                 "alteration": "R132C",
@@ -446,13 +433,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -460,12 +447,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9272,
+                "id": 9375,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132H",
                 "alteration": "R132H",
@@ -474,13 +460,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -488,12 +474,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9273,
+                "id": 9376,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132G",
                 "alteration": "R132G",
@@ -502,13 +487,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -516,12 +501,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9274,
+                "id": 9377,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132S",
                 "alteration": "R132S",
@@ -530,13 +514,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -544,12 +528,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9275,
+                "id": 9378,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132L",
                 "alteration": "R132L",
@@ -558,13 +541,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -572,34 +555,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 3,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 31,
-                    "uuid": "6a19e843-8b1f-45bc-9203-5ba8b25e3246",
-                    "name": "Olutasidenib"
-                  }
-                ]
+                "id": 476,
+                "code": "AML",
+                "color": "LightSalmon",
+                "level": 3,
+                "mainType": "Leukemia",
+                "subtype": "Acute Myeloid Leukemia",
+                "tissue": "Myeloid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 32,
+                "uuid": "6a19e843-8b1f-45bc-9203-5ba8b25e3246",
+                "name": "Olutasidenib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -621,7 +603,7 @@
     "manufacturer": "Abbott Molecular, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:38.544484Z",
+    "lastUpdated": "2024-04-06T01:03:38.248210Z",
     "fdaSubmissions": [
       {
         "id": 4,
@@ -635,44 +617,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 4,
+            "id": 122,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 4,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 476,
-                  "code": "AML",
-                  "color": "LightSalmon",
-                  "level": 3,
-                  "mainType": "Leukemia",
-                  "subtype": "Acute Myeloid Leukemia",
-                  "tissue": "Myeloid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 7,
+                "entity": "DRUG",
+                "rule": "147",
+                "name": null
+              },
+              {
+                "id": 8,
+                "entity": "CANCER_TYPE",
+                "rule": "476",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9304,
+                "id": 9408,
                 "type": "PROTEIN_CHANGE",
-                "name": "R140Q",
-                "alteration": "R140Q",
-                "proteinChange": "R140Q",
-                "start": 140,
-                "end": 140,
+                "name": "R172G",
+                "alteration": "R172G",
+                "proteinChange": "R172G",
+                "start": 172,
+                "end": 172,
                 "refResidues": "R",
-                "variantResidues": "Q",
+                "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -680,27 +661,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9305,
+                "id": 9407,
                 "type": "PROTEIN_CHANGE",
-                "name": "R172G",
-                "alteration": "R172G",
-                "proteinChange": "R172G",
-                "start": 172,
-                "end": 172,
+                "name": "R140Q",
+                "alteration": "R140Q",
+                "proteinChange": "R140Q",
+                "start": 140,
+                "end": 140,
                 "refResidues": "R",
-                "variantResidues": "G",
+                "variantResidues": "Q",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -708,12 +688,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9306,
+                "id": 9409,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172K",
                 "alteration": "R172K",
@@ -722,13 +701,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -736,12 +715,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9307,
+                "id": 9410,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172M",
                 "alteration": "R172M",
@@ -750,13 +728,13 @@
                 "end": 172,
                 "refResidues": "R",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23188,
+                    "id": 23172,
                     "entrezGeneId": 3418,
                     "hugoSymbol": "IDH2",
-                    "hgncId": "5383",
-                    "evidences": null
+                    "hgncId": "5383"
                   }
                 ],
                 "consequence": {
@@ -764,12 +742,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 9308,
+                "id": 9411,
                 "type": "PROTEIN_CHANGE",
                 "name": "R172S",
                 "alteration": "R172S",
@@ -778,13 +755,13 @@
                 "end": 172,
                 "refResidues": "R",
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@@ -792,12 +769,11 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
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                 "alteration": "R140L",
@@ -806,13 +782,13 @@
                 "end": 140,
                 "refResidues": "R",
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+                    "hgncId": "5383"
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@@ -820,12 +796,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "alteration": "R140G",
@@ -834,13 +809,13 @@
                 "end": 140,
                 "refResidues": "R",
                 "variantResidues": "G",
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@@ -848,12 +823,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
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                 "alteration": "R140W",
@@ -862,13 +836,13 @@
                 "end": 140,
                 "refResidues": "R",
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@@ -876,12 +850,11 @@
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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                 "alteration": "R172W",
@@ -890,13 +863,13 @@
                 "end": 172,
                 "refResidues": "R",
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@@ -904,34 +877,33 @@
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@@ -953,7 +925,7 @@
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@@ -967,29 +939,28 @@
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@@ -998,13 +969,13 @@
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@@ -1012,34 +983,33 @@
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@@ -1056,7 +1026,7 @@
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@@ -1070,199 +1040,185 @@
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@@ -1276,199 +1232,185 @@
         "curated": true,
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                 "alteration": "Oncogenic Mutations",
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                   {
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                     "hugoSymbol": "BRCA2",
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                   }
                 ],
                 "consequence": {
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-                  "term": "UNKNOWN",
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                   "isGenerallyTruncating": false,
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                 }
               }
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             ]
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-        }
+        ]
       },
       {
         "id": 8,
@@ -1482,171 +1424,165 @@
         "curated": true,
         "genetic": true,
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-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
-                }
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-                  "mainType": "Prostate Cancer",
-                  "subtype": null,
-                  "tissue": "Prostate",
-                  "tumorForm": "SOLID"
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             "alterations": [
               {
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-                "type": "PROTEIN_CHANGE",
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                 "name": "Oncogenic Mutations",
                 "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
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                 "end": null,
                 "refResidues": null,
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                   {
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                     "hugoSymbol": "BRCA1",
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                   }
                 ],
                 "consequence": {
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-                  "term": "UNKNOWN",
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                 }
               }
             ],
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+                "id": 935,
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             ],
             "alterations": [
               {
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                 "alteration": "Oncogenic Mutations",
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                 ],
                 "consequence": {
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               }
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           }
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-        }
+        ]
       }
     ],
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@@ -1663,7 +1599,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
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     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:42.457238Z",
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     "fdaSubmissions": [
       {
         "id": 9,
@@ -1677,29 +1613,28 @@
         "curated": true,
         "genetic": true,
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           {
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-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
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+              },
+              {
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               }
             ],
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               {
-                "id": 1388,
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                 "name": "V600E",
                 "alteration": "V600E",
@@ -1708,13 +1643,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
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                 "genes": [
                   {
-                    "id": 41259,
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                     "hugoSymbol": "BRAF",
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+                    "hgncId": "1097"
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                 ],
                 "consequence": {
@@ -1722,34 +1657,33 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
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-                    "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
-                    "name": "Vemurafenib"
-                  }
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+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
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+            ],
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-        }
+        ]
       },
       {
         "id": 10,
@@ -1763,29 +1697,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
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             ],
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                 "alteration": "V600E",
@@ -1794,13 +1727,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
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                 "genes": [
                   {
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                     "hugoSymbol": "BRAF",
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                 ],
                 "consequence": {
@@ -1808,12 +1741,11 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
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                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -1822,13 +1754,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
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                     "hugoSymbol": "BRAF",
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+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -1836,39 +1768,39 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
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-                    "name": "Cobimetinib"
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-                ]
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+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
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+                "uuid": "4e91da20-6cf0-4e07-995f-7f7db4c7c077",
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+              },
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-        }
+        ]
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     ],
     "specimenTypes": [
@@ -1885,7 +1817,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
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     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:42.770910Z",
+    "lastUpdated": "2024-04-06T01:03:42.011315Z",
     "fdaSubmissions": [
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@@ -1899,29 +1831,28 @@
         "curated": true,
         "genetic": true,
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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             ],
             "alterations": [
               {
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -1930,13 +1861,13 @@
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                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -1944,62 +1875,60 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 14,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
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-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -2016,7 +1945,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:49.091757Z",
+    "lastUpdated": "2024-04-06T01:03:45.151008Z",
     "fdaSubmissions": [
       {
         "id": 12,
@@ -2030,29 +1959,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 15,
+            "id": 133,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 25,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 29,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 30,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -2061,13 +1989,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2075,34 +2003,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 15,
-                "name": null,
-                "drugs": [
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-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 13,
@@ -2116,29 +2043,28 @@
         "curated": true,
         "genetic": true,
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+        "articles": null,
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           {
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             "name": null,
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               {
-                "id": 26,
-                "relation": "INCLUSION",
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 31,
+                "entity": "DRUG",
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+              },
+              {
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               }
             ],
             "alterations": [
               {
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -2147,13 +2073,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
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                   {
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                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2161,62 +2087,60 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 16,
-                "name": null,
-                "drugs": [
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-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
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               }
             ]
           }
-        ],
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-        }
+        ]
       },
       {
         "id": 14,
@@ -2230,29 +2154,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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           {
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             "name": null,
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-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
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                 "alteration": "L858R",
@@ -2261,13 +2184,13 @@
                 "end": 858,
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                 "variantResidues": "R",
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                 "genes": [
                   {
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                     "hugoSymbol": "EGFR",
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+                    "hgncId": "3236"
                   }
                 ],
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@@ -2275,62 +2198,60 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                "id": 17,
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-                "drugs": [
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-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
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             ]
           }
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-          "type": "PMA",
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-        }
+        ]
       },
       {
         "id": 15,
@@ -2344,29 +2265,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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         "associations": [
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
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             ],
             "alterations": [
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -2375,13 +2295,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
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                 "genes": [
                   {
-                    "id": 24498,
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                     "hugoSymbol": "EGFR",
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+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2389,62 +2309,60 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
-                "id": 18,
-                "name": null,
-                "drugs": [
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-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
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             ]
           }
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-        "type": {
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-          "type": "PMA",
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-        }
+        ]
       },
       {
         "id": 16,
@@ -2458,29 +2376,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
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+            "id": 137,
             "name": null,
-            "associationCancerTypes": [
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-                "relation": "INCLUSION",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
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+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
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             ],
             "alterations": [
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -2489,13 +2406,13 @@
                 "end": 858,
                 "refResidues": "L",
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                 "genes": [
                   {
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+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2503,76 +2420,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
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-                "name": null,
-                "drugs": [
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-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
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               }
             ]
           },
           {
-            "id": 20,
+            "id": 138,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 30,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 39,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 40,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2581,13 +2501,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2595,76 +2515,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 20,
-                "name": null,
-                "drugs": [
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-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
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               }
             ]
           },
           {
-            "id": 21,
+            "id": 139,
             "name": null,
-            "associationCancerTypes": [
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               {
-                "id": 31,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 41,
+                "entity": "DRUG",
+                "rule": "59",
+                "name": null
+              },
+              {
+                "id": 42,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2673,13 +2596,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2687,76 +2610,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
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                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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-                "end": 761,
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+                "end": null,
                 "refResidues": null,
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                   {
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                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
-                "id": 21,
-                "name": null,
-                "drugs": [
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-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
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-                ]
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+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
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+            ],
+            "drugs": [
+              {
+                "id": 59,
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             ]
           },
           {
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 43,
+                "entity": "DRUG",
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+                "name": null
+              },
+              {
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               }
             ],
             "alterations": [
               {
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -2765,13 +2691,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
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                 "genes": [
                   {
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                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2779,62 +2705,60 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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-                "end": 761,
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
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-            "treatments": [
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-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
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-                ]
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+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
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               }
             ]
           }
-        ],
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-        }
+        ]
       },
       {
         "id": 17,
@@ -2848,29 +2772,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 23,
+            "id": 141,
             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 45,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 46,
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+                "rule": "64",
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               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -2879,13 +2802,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2893,34 +2816,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
-                "id": 23,
-                "name": null,
-                "drugs": [
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-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
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               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
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-        }
+        ]
       },
       {
         "id": 18,
@@ -2934,29 +2856,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 24,
+            "id": 142,
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               {
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-                "relation": "INCLUSION",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 47,
+                "entity": "DRUG",
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+              },
+              {
+                "id": 48,
+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -2965,13 +2886,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
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                 "genes": [
                   {
-                    "id": 24498,
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                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -2979,62 +2900,60 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
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                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
-                "id": 24,
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-                "drugs": [
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-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
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+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
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           }
-        ],
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-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -3051,7 +2970,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:49.431272Z",
+    "lastUpdated": "2024-04-06T01:03:45.593844Z",
     "fdaSubmissions": [
       {
         "id": 19,
@@ -3065,29 +2984,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 25,
+            "id": 143,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 35,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 774,
-                  "code": "FL",
-                  "color": "LimeGreen",
-                  "level": 5,
-                  "mainType": "Mature B-Cell Neoplasms",
-                  "subtype": "Follicular Lymphoma",
-                  "tissue": "Lymphoid",
-                  "tumorForm": "LIQUID"
-                }
+                "id": 49,
+                "entity": "DRUG",
+                "rule": "110",
+                "name": null
+              },
+              {
+                "id": 50,
+                "entity": "CANCER_TYPE",
+                "rule": "774",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 7685,
+                "id": 7788,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646H",
                 "alteration": "Y646H",
@@ -3096,13 +3014,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "H",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3110,12 +3028,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7686,
+                "id": 7789,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646S",
                 "alteration": "Y646S",
@@ -3124,13 +3041,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "S",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3138,12 +3055,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7687,
+                "id": 7790,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646C",
                 "alteration": "Y646C",
@@ -3152,13 +3068,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3166,12 +3082,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7688,
+                "id": 7791,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646F",
                 "alteration": "Y646F",
@@ -3180,13 +3095,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "F",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3194,12 +3109,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7689,
+                "id": 7792,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y646N",
                 "alteration": "Y646N",
@@ -3208,13 +3122,13 @@
                 "end": 646,
                 "refResidues": "Y",
                 "variantResidues": "N",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3222,12 +3136,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7690,
+                "id": 7793,
                 "type": "PROTEIN_CHANGE",
                 "name": "A682G",
                 "alteration": "A682G",
@@ -3236,13 +3149,13 @@
                 "end": 682,
                 "refResidues": "A",
                 "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3250,12 +3163,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 7697,
+                "id": 7800,
                 "type": "PROTEIN_CHANGE",
                 "name": "A692V",
                 "alteration": "A692V",
@@ -3264,13 +3176,13 @@
                 "end": 692,
                 "refResidues": "A",
                 "variantResidues": "V",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 29916,
+                    "id": 29867,
                     "entrezGeneId": 2146,
                     "hugoSymbol": "EZH2",
-                    "hgncId": "3527",
-                    "evidences": null
+                    "hgncId": "3527"
                   }
                 ],
                 "consequence": {
@@ -3278,34 +3190,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 25,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 109,
-                    "uuid": "49e07d49-ee64-4049-c09d-37c6ce612cad",
-                    "name": "Tazemetostat"
-                  }
-                ]
+                "id": 774,
+                "code": "FL",
+                "color": "LimeGreen",
+                "level": 5,
+                "mainType": "Mature B-Cell Neoplasms",
+                "subtype": "Follicular Lymphoma",
+                "tissue": "Lymphoid",
+                "tumorForm": "LIQUID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 110,
+                "uuid": "49e07d49-ee64-4049-c09d-37c6ce612cad",
+                "name": "Tazemetostat",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -3322,7 +3233,7 @@
     "manufacturer": "Roche Molecular Systems, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:50.367695Z",
+    "lastUpdated": "2024-04-06T01:03:45.998378Z",
     "fdaSubmissions": [
       {
         "id": 20,
@@ -3336,29 +3247,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 26,
+            "id": 144,
             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 51,
+                "entity": "DRUG",
+                "rule": "124,124+104",
+                "name": null
+              },
+              {
+                "id": 52,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3367,13 +3277,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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                     "hugoSymbol": "KRAS",
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-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3381,64 +3291,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                "drugs": [
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-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
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-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
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-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
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             ]
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             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
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-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 53,
+                "entity": "DRUG",
+                "rule": "66,66+104",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
+                "rule": "874",
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               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3447,13 +3351,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
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                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
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-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3461,50 +3365,39 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
-                "id": 28,
-                "name": null,
-                "drugs": [
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-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
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               {
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-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
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-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -3521,7 +3414,7 @@
     "manufacturer": "EntroGen, Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:00:51.350125Z",
+    "lastUpdated": "2024-04-06T01:03:46.438126Z",
     "fdaSubmissions": [
       {
         "id": 21,
@@ -3535,29 +3428,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 28,
+            "id": 146,
             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 55,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 56,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3566,13 +3458,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -3580,64 +3472,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
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-                "drugs": [
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-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
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-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
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-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
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               }
             ]
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           {
-            "id": 29,
+            "id": 147,
             "name": null,
-            "associationCancerTypes": [
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               {
-                "id": 39,
-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 57,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 58,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
+                "id": 12919,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -3646,13 +3532,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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+                    "id": 17611,
                     "entrezGeneId": 4893,
                     "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "hgncId": "7989"
                   }
                 ],
                 "consequence": {
@@ -3660,50 +3546,39 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                "drugs": [
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-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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@@ -3720,7 +3595,7 @@
     "manufacturer": "Foundation Medicine, Inc.",
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@@ -3734,199 +3609,185 @@
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@@ -3943,144 +3804,249 @@
     "manufacturer": "Foundation Medicine, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:02.995848Z",
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         "number": "P170019",
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         "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
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-        "description": "Approval order for extending the label claim to include an indication for PEMAZYRE(pemigatinib)in cholangiocarcinoma patients with FGFR2 fusions and select rearrangements. ",
+        "dateReceived": "2018-09-24T00:00:00Z",
+        "decisionDate": "2019-07-01T00:00:00Z",
+        "description": "Approval order for extending the label claim to include an indication for LYNPARZA (olaparib) in ovarian cancer patients with BRCA1/2 alterations.",
         "curated": true,
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-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
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-        "supplementNumber": "",
-        "deviceName": "FoundationOne CDx",
-        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
-        "dateReceived": "2017-06-02T00:00:00Z",
-        "decisionDate": "2017-11-30T00:00:00Z",
-        "description": "Approval for the FoundationOne CDx (F1CDx). This device is a next generation sequencing based in vitro diagnostic device for detection of substitutions, insertion and deletion alterations (indels), and copy number alterations (CNAs) in 324 genes and select gene rearrangements, as well as genomic signatures including microsatellite instability (MSI) and tumor mutational burden (TMB) using DNA isolated from formalin-fixed paraffin embedded (FFPE) tumor tissue specimens. The test is intended as a companion diagnostic to identify patients who may benefit from treatment with the targeted therapies listed in Table 1 in accordance with the approved therapeutic product labeling. Additionally, F1CDx is intended to provide tumor mutation profiling to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms. The F1CDx assay is a single-site assay performed at Foundation Medicine, Inc.Table 1: Companion diagnostic indicationsIndication: Non-small cell lung cancer (NSCLC). - Biomarker: EGFR exon 19 deletions and EGFR exon 21 L858R alterations. Therapy: Gilotrif® (afatinib), Iressa® (gefitinib), or Tarceva® (erlotinib). - Biomarker: EGFR exon 20 T790M alterations. Therapy: Tagrisso® (osimertinib). - Biomarker: ALK rearrangements. Therapy: Alecensa® (alectinib), Xalkori® (crizotinib), or Zykadia® (ceritinib). - Biomarker: BRAF V600E. Therapy: Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib).Indication: Melanoma. - Biomarker: BRAF V600E. Therapy: Tafinlar® (dabrafenib) or Zelboraf® (vemurafenib) - Biomarker: BRAF V600E and V600K. Therapy: Mekinist® (trametinib) or Cotellic® (cobimetinib) in combination with Zelboraf® (vemurafenib).Indication: Breast cancer. Biomarker: ERBB2 (HER2) amplification. Therapy: Herceptin® (trastuzumab), Kadcyla® (ado-trastuzumab-emtansine), orPerjeta® (pertuzumab).Indication: Colorectal cancer. - Biomarker: KRAS wild-type (absence of mutations in codons 12 and 13). Therapy: Erbitux® (cetuximab) - Biomarker: KRAS wild-type (absence of mutations in exons 2, 3, and 4) and NRAS wild type (absence of mutations in exons 2, 3, and 4). Therapy: Vectibix® (panitumumab)Indication: Ovarian cancer. Biomarker: BRCA1/2 alterations. Therapy: Rubraca® (rucaparib)",
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+        "dateReceived": "2017-06-02T00:00:00Z",
+        "decisionDate": "2017-11-30T00:00:00Z",
+        "description": "Approval for the FoundationOne CDx (F1CDx). This device is a next generation sequencing based in vitro diagnostic device for detection of substitutions, insertion and deletion alterations (indels), and copy number alterations (CNAs) in 324 genes and select gene rearrangements, as well as genomic signatures including microsatellite instability (MSI) and tumor mutational burden (TMB) using DNA isolated from formalin-fixed paraffin embedded (FFPE) tumor tissue specimens. The test is intended as a companion diagnostic to identify patients who may benefit from treatment with the targeted therapies listed in Table 1 in accordance with the approved therapeutic product labeling. Additionally, F1CDx is intended to provide tumor mutation profiling to be used by qualified health care professionals in accordance with professional guidelines in oncology for patients with solid malignant neoplasms. The F1CDx assay is a single-site assay performed at Foundation Medicine, Inc.Table 1: Companion diagnostic indicationsIndication: Non-small cell lung cancer (NSCLC). - Biomarker: EGFR exon 19 deletions and EGFR exon 21 L858R alterations. Therapy: Gilotrif® (afatinib), Iressa® (gefitinib), or Tarceva® (erlotinib). - Biomarker: EGFR exon 20 T790M alterations. Therapy: Tagrisso® (osimertinib). - Biomarker: ALK rearrangements. Therapy: Alecensa® (alectinib), Xalkori® (crizotinib), or Zykadia® (ceritinib). - Biomarker: BRAF V600E. Therapy: Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib).Indication: Melanoma. - Biomarker: BRAF V600E. Therapy: Tafinlar® (dabrafenib) or Zelboraf® (vemurafenib) - Biomarker: BRAF V600E and V600K. Therapy: Mekinist® (trametinib) or Cotellic® (cobimetinib) in combination with Zelboraf® (vemurafenib).Indication: Breast cancer. Biomarker: ERBB2 (HER2) amplification. Therapy: Herceptin® (trastuzumab), Kadcyla® (ado-trastuzumab-emtansine), orPerjeta® (pertuzumab).Indication: Colorectal cancer. - Biomarker: KRAS wild-type (absence of mutations in codons 12 and 13). Therapy: Erbitux® (cetuximab) - Biomarker: KRAS wild-type (absence of mutations in exons 2, 3, and 4) and NRAS wild type (absence of mutations in exons 2, 3, and 4). Therapy: Vectibix® (panitumumab)Indication: Ovarian cancer. Biomarker: BRCA1/2 alterations. Therapy: Rubraca® (rucaparib)",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 151,
+            "name": null,
+            "rules": [
+              {
+                "id": 65,
+                "entity": "DRUG",
+                "rule": "34",
+                "name": null
+              },
+              {
+                "id": 66,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 5126,
+                "type": "PROTEIN_CHANGE",
+                "name": "L858R",
+                "alteration": "L858R",
+                "proteinChange": "L858R",
+                "start": 858,
+                "end": 858,
+                "refResidues": "L",
+                "variantResidues": "R",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 24469,
+                    "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4088,76 +4054,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 36,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 33,
+            "id": 150,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 47,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 63,
+                "entity": "DRUG",
+                "rule": "59",
+                "name": null
+              },
+              {
+                "id": 64,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -4166,13 +4135,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4180,76 +4149,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 37,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 33,
-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 34,
+            "id": 152,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 48,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 67,
+                "entity": "DRUG",
+                "rule": "115",
+                "name": null
+              },
+              {
+                "id": 68,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -4258,13 +4230,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4272,76 +4244,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 38,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 114,
-                    "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
-                    "name": "Erlotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 115,
+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
+                "name": "Erlotinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 35,
+            "id": 153,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 49,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 69,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 70,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -4350,13 +4325,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -4364,48 +4339,52 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 39,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 73,
+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 36,
+            "id": 154,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 50,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 71,
+                "entity": "DRUG",
+                "rule": "99",
+                "name": null
+              },
+              {
+                "id": 72,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 559,
+                "id": 662,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -4414,62 +4393,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 21832,
+                    "id": 21829,
                     "entrezGeneId": 238,
                     "hugoSymbol": "ALK",
-                    "hgncId": "427",
-                    "evidences": null
+                    "hgncId": "427"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 40,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 98,
-                    "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
-                    "name": "Alectinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 99,
+                "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
+                "name": "Alectinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 45,
+            "id": 162,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 59,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 874,
-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 87,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
+                "id": 88,
+                "entity": "CANCER_TYPE",
+                "rule": "874",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 12816,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -4478,13 +4461,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 17596,
-                    "entrezGeneId": 4893,
-                    "hugoSymbol": "NRAS",
-                    "hgncId": "7989",
-                    "evidences": null
+                    "id": 30432,
+                    "entrezGeneId": 3845,
+                    "hugoSymbol": "KRAS",
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -4492,64 +4475,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 52,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
-                "id": 53,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 46,
+            "id": 164,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 60,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 91,
+                "entity": "DRUG",
+                "rule": "123",
+                "name": null
+              },
+              {
+                "id": 92,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
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               }
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@@ -4558,13 +4535,13 @@
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@@ -4572,12 +4549,11 @@
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@@ -4600,48 +4576,52 @@
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             "alterations": [
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-                "type": "NA",
-                "name": "Wildtype",
-                "alteration": "Wildtype",
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@@ -5095,64 +5070,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
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               }
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-                    "name": "Cetuximab"
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+                "color": "HotPink",
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                 "alteration": "Amplification",
@@ -5161,333 +5130,136 @@
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-                "end": 420,
-                "refResidues": "C",
-                "variantResidues": "R",
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                     "hugoSymbol": "PIK3CA",
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@@ -5495,12 +5267,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "alteration": "E542K",
@@ -5509,13 +5280,13 @@
                 "end": 542,
                 "refResidues": "E",
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                     "hugoSymbol": "PIK3CA",
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@@ -5523,12 +5294,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "alteration": "E545A",
@@ -5537,13 +5307,13 @@
                 "end": 545,
                 "refResidues": "E",
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                     "hugoSymbol": "PIK3CA",
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                 "consequence": {
@@ -5551,27 +5321,26 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545G",
+                "alteration": "E545G",
+                "proteinChange": "E545G",
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                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "G",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "PIK3CA",
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                 "consequence": {
@@ -5579,27 +5348,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545G",
-                "alteration": "E545G",
-                "proteinChange": "E545G",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
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                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "G",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -5607,12 +5375,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
                 "name": "Q546E",
                 "alteration": "Q546E",
@@ -5621,13 +5388,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "E",
+                "flags": null,
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -5635,12 +5402,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "type": "PROTEIN_CHANGE",
                 "name": "Q546R",
                 "alteration": "Q546R",
@@ -5649,13 +5415,13 @@
                 "end": 546,
                 "refResidues": "Q",
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -5663,27 +5429,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "Y",
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -5691,12 +5456,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "name": "H1047R",
                 "alteration": "H1047R",
@@ -5705,13 +5469,13 @@
                 "end": 1047,
                 "refResidues": "H",
                 "variantResidues": "R",
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 "consequence": {
@@ -5719,27 +5483,26 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
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                 "end": 1047,
                 "refResidues": "H",
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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@@ -5747,39 +5510,39 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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+                "tissue": "Breast",
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+        ]
       },
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@@ -5793,29 +5556,28 @@
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@@ -5824,13 +5586,13 @@
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@@ -5838,379 +5600,562 @@
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-                  "term": "INFRAME_DELETION",
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@@ -7131,341 +7189,427 @@
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             ]
-          }
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+              },
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             ],
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                 ],
                 "consequence": {
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-                  "term": "MISSENSE_VARIANT",
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-                  "categoricalAlterations": null
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               }
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               }
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           }
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-        }
+        ]
       },
       {
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+        "dateReceived": "2021-04-19T00:00:00Z",
+        "decisionDate": "2022-02-18T00:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne®CDx (F1CDx) to include a companion diagnostic (CDx) indication for the detection of microsatellite instability High (MSI-H) status in patients with solid tumors who may benefit from treatment with KEYTRUDA® (pembrolizumab).",
         "curated": true,
-        "genetic": true,
+        "genetic": false,
         "note": null,
+        "articles": null,
         "associations": [
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-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 113,
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+              },
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               }
             ],
             "alterations": [
               {
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-                "type": "PROTEIN_CHANGE",
-                "name": "Oncogenic Mutations",
-                "alteration": "Oncogenic Mutations",
-                "proteinChange": "Oncogenic Mutations",
+                "id": 22640,
+                "type": "NA",
+                "name": "Microsatellite Instability-High",
+                "alteration": "Microsatellite Instability-High",
+                "proteinChange": "Microsatellite Instability-High",
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                 "refResidues": null,
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-                    "entrezGeneId": 5290,
-                    "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
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+                    "hugoSymbol": "Other Biomarkers",
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                   }
                 ],
                 "consequence": {
@@ -7473,39 +7617,33 @@
                   "term": "UNKNOWN",
                   "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                ]
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+                "color": "MIXED",
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+                "mainType": "All Solid Tumors",
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+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
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+            "drugs": [
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+                "uuid": "0746dd92-8f4d-4bf7-9161-57a223cb67d5",
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             ]
           }
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-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -7522,7 +7660,7 @@
     "manufacturer": "Foundation Medicine, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
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+    "lastUpdated": "2024-04-06T01:04:01.518821Z",
     "fdaSubmissions": [
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         "id": 37,
@@ -7536,107 +7674,77 @@
         "curated": true,
         "genetic": true,
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 133,
+                "entity": "DRUG",
+                "rule": "67",
+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
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-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5244,
+                "id": 22641,
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-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
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-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
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               }
             ],
             "articles": null,
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-                    "name": "Mobocertinib"
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+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
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+                "uuid": "3de4c502-6c5e-4c10-93b6-f67976c56213",
+                "name": "Mobocertinib",
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               }
             ]
           }
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-        }
+        ]
       },
       {
         "id": 38,
@@ -7650,29 +7758,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 68,
+            "id": 186,
             "name": null,
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-                "relation": "INCLUSION",
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
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+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
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                 "name": "L858R",
                 "alteration": "L858R",
@@ -7681,13 +7788,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "EGFR",
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+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -7695,76 +7802,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
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-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 76,
-                "name": null,
-                "drugs": [
-                  {
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-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 34,
+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
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+            "id": 187,
             "name": null,
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 137,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 138,
+                "entity": "CANCER_TYPE",
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+                "name": null
               }
             ],
             "alterations": [
               {
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+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -7773,13 +7883,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "EGFR",
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+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -7787,76 +7897,79 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
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                 "genes": [
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                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
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-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
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@@ -7865,13 +7978,13 @@
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@@ -7879,218 +7992,216 @@
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-        }
+        ]
       },
       {
         "id": 39,
@@ -8104,29 +8215,28 @@
         "curated": true,
         "genetic": true,
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                 "alteration": "L858R",
@@ -8135,13 +8245,13 @@
                 "end": 858,
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@@ -8149,76 +8259,79 @@
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                 ],
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-                  "term": "INFRAME_DELETION",
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-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
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-                  "tissue": "Lung",
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@@ -8227,13 +8340,13 @@
                 "end": 858,
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@@ -8241,76 +8354,79 @@
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                 ],
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-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
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-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
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@@ -8319,13 +8435,13 @@
                 "end": 858,
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@@ -8333,62 +8449,60 @@
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-                "proteinChange": "729_761del",
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-                "end": 761,
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                 ],
                 "consequence": {
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-                  "term": "INFRAME_DELETION",
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-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
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+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
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+              }
+            ],
+            "drugs": [
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+                "uuid": "83754311-3f3b-4782-bfbf-08e71c790b9a",
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               }
             ]
           }
-        ],
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-          "type": "PMA",
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-        }
+        ]
       },
       {
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@@ -8402,29 +8516,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
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+            "id": 189,
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-            "associationCancerTypes": [
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
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+                "entity": "DRUG",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
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-                "id": 1388,
+                "id": 1491,
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                 "name": "V600E",
                 "alteration": "V600E",
@@ -8433,13 +8546,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
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                     "hugoSymbol": "BRAF",
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                 "consequence": {
@@ -8447,39 +8560,39 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
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-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
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-                    "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
-                    "name": "Binimetinib"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
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+                "mainType": "Non-Small Cell Lung Cancer",
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+                "tissue": "Lung",
+                "tumorForm": "SOLID"
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+            ],
+            "drugs": [
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+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
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+              },
+              {
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+                "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
+                "name": "Binimetinib",
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             ]
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-        }
+        ]
       },
       {
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@@ -8493,29 +8606,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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         "associations": [
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
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+              },
+              {
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             ],
             "alterations": [
               {
-                "id": 15858,
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                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8524,62 +8636,66 @@
                 "end": null,
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                 "variantResidues": null,
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                     "hugoSymbol": "ROS1",
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                 ],
                 "consequence": {
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-                  "term": "UNKNOWN",
-                  "name": "Unknown",
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                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
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               }
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+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
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+            ],
+            "drugs": [
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-                  "mainType": "All Solid Tumors",
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-                  "tissue": "MIXED",
-                  "tumorForm": "SOLID"
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                 "alteration": "Fusions",
@@ -8588,62 +8704,66 @@
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                 "consequence": {
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-                  "name": "Unknown",
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-                  "tissue": "MIXED",
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                 "alteration": "Fusions",
@@ -8652,62 +8772,66 @@
                 "end": null,
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                 "consequence": {
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-                  "description": "Unknown status",
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+                  "description": "Any variant"
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+                "mainType": "All Solid Tumors",
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+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
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+            ],
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+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
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-                  "mainType": "All Solid Tumors",
-                  "subtype": null,
-                  "tissue": "MIXED",
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+              },
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               }
             ],
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                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8716,48 +8840,47 @@
                 "end": null,
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                     "hugoSymbol": "NTRK3",
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                 "consequence": {
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-                  "categoricalAlterations": null
+                  "description": "Any variant"
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-                    "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
-                    "name": "Entrectinib"
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+                "mainType": "All Solid Tumors",
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+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
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+            ],
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+                "uuid": "2371f7f5-6407-4a4b-b951-a0f786355455",
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           }
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-        }
+        ]
       },
       {
         "id": 42,
@@ -8771,29 +8894,28 @@
         "curated": true,
         "genetic": true,
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-                  "mainType": "Non-Small Cell Lung Cancer",
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-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
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+              },
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             ],
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                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -8802,77 +8924,81 @@
                 "end": null,
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                 ],
                 "consequence": {
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-                  "term": "UNKNOWN",
-                  "name": "Unknown",
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+                  "term": "ANY",
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-                  "description": "Unknown status",
-                  "categoricalAlterations": null
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               }
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-                    "uuid": "ef2bee25-4fa3-40c4-a79f-4f885377afa7",
-                    "name": "Alectinib"
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-                ]
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+                "code": "NSCLC",
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+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
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             ]
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-                "relation": "INCLUSION",
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-                  "code": null,
-                  "color": "HotPink",
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-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 157,
+                "entity": "DRUG",
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+                "name": null
+              },
+              {
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             ],
             "alterations": [
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+                "id": 13532,
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-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
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                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
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                     "hugoSymbol": "PIK3CA",
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                 "consequence": {
@@ -8880,12 +9006,11 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13529,
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                 "name": "C420R",
                 "alteration": "C420R",
@@ -8894,13 +9019,13 @@
                 "end": 420,
                 "refResidues": "C",
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -8908,12 +9033,11 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13530,
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                 "alteration": "E542K",
@@ -8922,13 +9046,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -8936,12 +9060,11 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "name": "E545A",
                 "alteration": "E545A",
@@ -8950,13 +9073,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "A",
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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@@ -8964,27 +9087,26 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545G",
+                "alteration": "E545G",
+                "proteinChange": "E545G",
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                 "end": 545,
                 "refResidues": "E",
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                 "genes": [
                   {
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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@@ -8992,27 +9114,26 @@
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                   "name": "Missense Variant",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
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+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545G",
-                "alteration": "E545G",
-                "proteinChange": "E545G",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
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                 "end": 545,
                 "refResidues": "E",
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                 "genes": [
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                     "hugoSymbol": "PIK3CA",
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@@ -9020,12 +9141,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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                 "alteration": "Q546E",
@@ -9034,13 +9154,13 @@
                 "end": 546,
                 "refResidues": "Q",
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                     "hugoSymbol": "PIK3CA",
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@@ -9048,12 +9168,11 @@
                   "term": "MISSENSE_VARIANT",
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "type": "PROTEIN_CHANGE",
                 "name": "Q546R",
                 "alteration": "Q546R",
@@ -9062,13 +9181,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "R",
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                     "hugoSymbol": "PIK3CA",
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@@ -9076,27 +9195,26 @@
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
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                 "end": 1047,
                 "refResidues": "H",
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                     "hugoSymbol": "PIK3CA",
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@@ -9104,12 +9222,11 @@
                   "term": "MISSENSE_VARIANT",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "alteration": "H1047R",
@@ -9118,13 +9235,13 @@
                 "end": 1047,
                 "refResidues": "H",
                 "variantResidues": "R",
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                     "hugoSymbol": "PIK3CA",
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@@ -9132,27 +9249,26 @@
                   "term": "MISSENSE_VARIANT",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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               },
               {
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                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
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@@ -9160,273 +9276,273 @@
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-        }
+        ]
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@@ -9440,29 +9556,28 @@
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-                  "tissue": "Bowel",
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@@ -9471,13 +9586,13 @@
                 "end": 600,
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@@ -9485,39 +9600,328 @@
                   "term": "MISSENSE_VARIANT",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
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+                "id": 118,
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+              },
+              {
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
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+              }
+            ]
+          }
+        ]
+      },
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+        "number": "P190032",
+        "supplementNumber": "S001",
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+        "genericName": "Next generation sequencing oncology panel, somatic or germline variant detection system",
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+        "description": "Approval to include a companion diagnostic indication for detection of MET single nucleotide variants (SNVs) and indels that lead to MET exon 14 skipping in non-small cell lung cancer patients who may benefit from treatment with TABRECTA (capmatinib)",
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+        "genetic": true,
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+            "id": 269,
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+            "rules": [],
+            "alterations": [
+              {
+                "id": 11231,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010splice",
+                "alteration": "963_1010splice",
+                "proteinChange": "963_1010splice",
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+                "refResidues": "D",
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-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
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+                    "hugoSymbol": "MET",
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+                  }
+                ],
+                "consequence": {
+                  "id": 27,
+                  "term": "SPLICE_REGION_VARIANT",
+                  "name": "Splice Region Variant",
+                  "isGenerallyTruncating": true,
+                  "description": "A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron"
+                }
+              },
+              {
+                "id": 11238,
+                "type": "PROTEIN_CHANGE",
+                "name": "963_1010del",
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+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
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+                  }
+                ],
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+                  "term": "INFRAME_DELETION",
+                  "name": "Inframe Deletion",
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+                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence"
+                }
+              },
+              {
+                "id": 11240,
+                "type": "PROTEIN_CHANGE",
+                "name": "D1010",
+                "alteration": "D1010",
+                "proteinChange": "D1010",
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+                "end": 1010,
+                "refResidues": "D",
+                "variantResidues": "",
+                "flags": null,
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+                  {
+                    "id": 22683,
+                    "entrezGeneId": 4233,
+                    "hugoSymbol": "MET",
+                    "hgncId": "7029"
+                  }
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
+                }
+              }
+            ],
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+                "tissue": "Lung",
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+            ],
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+              }
+            ]
+          }
+        ]
+      },
+      {
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+        "decisionDate": "2024-06-27T04:00:00Z",
+        "description": "Approval order to expand the intended use of FoundationOne Liquid CDx (F1LCDx) to include a companion diagnostic indication for identifying patients with Prostate Cancer harboring a BRCA1 or BRCA2 alteration who may benefit from treatment with AKEEGA® (niraparib + abiraterone acetate). ",
+        "curated": true,
+        "genetic": true,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 275,
+            "name": null,
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+              }
+            ],
+            "alterations": [
+              {
+                "id": 2677,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 32458,
+                    "entrezGeneId": 675,
+                    "hugoSymbol": "BRCA2",
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+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 987,
+                "code": null,
+                "color": "Cyan",
+                "level": 0,
+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 27,
+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
+                "fdaDrugs": null
+              },
+              {
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+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
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+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 276,
+            "name": null,
+            "rules": [
+              {
+                "id": 292,
+                "entity": "DRUG",
+                "rule": "38+40+27",
+                "name": null
+              }
+            ],
+            "alterations": [
+              {
+                "id": 2054,
+                "type": "ANY",
+                "name": "Oncogenic Mutations",
+                "alteration": "Oncogenic Mutations",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 123,
-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
+                    "id": 41134,
+                    "entrezGeneId": 672,
+                    "hugoSymbol": "BRCA1",
+                    "hgncId": "1100"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
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+                "code": null,
+                "color": "Cyan",
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+                "mainType": "Prostate Cancer",
+                "subtype": null,
+                "tissue": "Prostate",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "992573c5-802e-4748-8ae4-5aa3cf0834ff",
+                "name": "Prednisone",
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+              },
+              {
+                "id": 38,
+                "uuid": "d6cdce1b-5d80-4c71-8e5a-d1a9d3c81e17",
+                "name": "Niraparib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 40,
+                "uuid": "4294d397-9397-4e22-961b-0aad9cb22298",
+                "name": "Abiraterone Acetate",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -9534,7 +9938,7 @@
     "manufacturer": "Guardant Health, Inc.",
     "indicationDetails": null,
     "platformType": "NGS",
-    "lastUpdated": "2024-01-11T17:01:10.899676Z",
+    "lastUpdated": "2024-04-06T01:04:04.474379Z",
     "fdaSubmissions": [
       {
         "id": 44,
@@ -9548,29 +9952,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 84,
+            "id": 202,
             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 167,
+                "entity": "DRUG",
+                "rule": "73",
+                "name": null
+              },
+              {
+                "id": 168,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -9579,13 +9982,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -9593,12 +9996,11 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5025,
+                "id": 5128,
                 "type": "PROTEIN_CHANGE",
                 "name": "T790M",
                 "alteration": "T790M",
@@ -9607,13 +10009,13 @@
                 "end": 790,
                 "refResidues": "T",
                 "variantResidues": "M",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -9621,62 +10023,60 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 92,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 72,
-                    "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
-                    "name": "Osimertinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
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+                "uuid": "4c2c1261-bfc3-4180-8113-127194366320",
+                "name": "Osimertinib",
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               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
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-        }
+        ]
       },
       {
         "id": 45,
@@ -9690,107 +10090,77 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
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+            "id": 203,
             "name": null,
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-                "relation": "INCLUSION",
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
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+                "entity": "DRUG",
+                "rule": "54",
+                "name": null
+              },
+              {
+                "id": 170,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
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-                "type": "PROTEIN_CHANGE",
-                "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
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-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
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-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
-                }
-              },
-              {
-                "id": 5244,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
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+                "end": null,
                 "refResidues": null,
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+                "flags": null,
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                   {
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                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 93,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 53,
-                    "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
-                    "name": "Amivantamab"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 54,
+                "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
+                "name": "Amivantamab",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 46,
@@ -9804,29 +10174,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 86,
+            "id": 204,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 114,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 171,
+                "entity": "DRUG",
+                "rule": "17",
+                "name": null
+              },
+              {
+                "id": 172,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -9835,13 +10204,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -9849,34 +10218,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 94,
-                "name": null,
-                "drugs": [
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@@ -9890,79 +10258,77 @@
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@@ -9976,29 +10342,28 @@
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@@ -10007,13 +10372,13 @@
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@@ -10021,12 +10386,11 @@
                   "term": "MISSENSE_VARIANT",
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@@ -10035,13 +10399,13 @@
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@@ -10049,12 +10413,11 @@
                   "term": "MISSENSE_VARIANT",
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@@ -10063,13 +10426,13 @@
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@@ -10077,12 +10440,11 @@
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@@ -10091,13 +10453,13 @@
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@@ -10105,12 +10467,11 @@
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@@ -10119,13 +10480,13 @@
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@@ -10133,12 +10494,11 @@
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@@ -10147,13 +10507,13 @@
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@@ -10161,34 +10521,33 @@
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@@ -10205,7 +10564,7 @@
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@@ -10219,29 +10578,28 @@
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@@ -10250,64 +10608,53 @@
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@@ -10324,7 +10671,7 @@
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@@ -10338,29 +10685,28 @@
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@@ -10369,64 +10715,53 @@
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+        ]
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@@ -10440,29 +10775,28 @@
         "curated": true,
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                 "alteration": "Amplification",
@@ -10471,74 +10805,59 @@
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@@ -10552,29 +10871,28 @@
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@@ -10583,58 +10901,59 @@
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@@ -10648,29 +10967,28 @@
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@@ -10679,48 +10997,47 @@
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@@ -10737,7 +11054,7 @@
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@@ -10751,29 +11068,28 @@
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@@ -10782,64 +11098,53 @@
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@@ -10856,7 +11161,7 @@
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@@ -10870,29 +11175,28 @@
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@@ -10901,64 +11205,53 @@
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@@ -10972,29 +11265,28 @@
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@@ -11003,48 +11295,47 @@
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@@ -11061,7 +11352,7 @@
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@@ -11075,29 +11366,28 @@
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@@ -11106,64 +11396,53 @@
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@@ -11194,29 +11473,28 @@
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@@ -11225,13 +11503,13 @@
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@@ -11239,34 +11517,33 @@
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@@ -11283,7 +11560,7 @@
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@@ -11297,57 +11574,28 @@
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@@ -11444,57 +11718,28 @@
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@@ -11503,13 +11748,13 @@
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@@ -11517,12 +11762,11 @@
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@@ -11531,13 +11775,13 @@
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@@ -11545,34 +11789,60 @@
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@@ -11586,57 +11856,28 @@
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@@ -11645,13 +11886,13 @@
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@@ -11659,12 +11900,11 @@
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@@ -11673,13 +11913,13 @@
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@@ -11687,34 +11927,60 @@
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-        }
+        ]
       }
     ],
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@@ -11736,7 +12002,7 @@
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     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:17.504051Z",
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     "fdaSubmissions": [
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@@ -11750,29 +12016,28 @@
         "curated": true,
         "genetic": false,
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-                  "tissue": "Myeloid",
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-                }
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                 "alteration": "BCR-ABL1 Fusion",
@@ -11781,13 +12046,19 @@
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                 "refResidues": null,
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@@ -11795,34 +12066,33 @@
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-        }
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@@ -11839,7 +12109,7 @@
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@@ -11853,135 +12123,124 @@
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@@ -11998,7 +12257,7 @@
     "manufacturer": "Pillar Biosciences, Inc.",
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@@ -12012,29 +12271,28 @@
         "curated": true,
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@@ -12043,13 +12301,13 @@
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@@ -12057,64 +12315,58 @@
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                 "alteration": "Wildtype",
@@ -12123,13 +12375,13 @@
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@@ -12137,50 +12389,39 @@
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@@ -12197,7 +12438,7 @@
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@@ -12211,29 +12452,28 @@
         "curated": true,
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@@ -12242,13 +12482,13 @@
                 "end": 600,
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@@ -12256,53 +12496,58 @@
                   "term": "MISSENSE_VARIANT",
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               {
-                "id": 137,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 213,
+                "entity": "DRUG",
+                "rule": "3",
+                "name": null
+              },
+              {
+                "id": 214,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 15858,
+                "id": 15961,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -12311,62 +12556,66 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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+                    "id": 6704,
                     "entrezGeneId": 6098,
                     "hugoSymbol": "ROS1",
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-                    "evidences": null
+                    "hgncId": "10261"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 123,
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-                "drugs": [
-                  {
-                    "id": 3,
-                    "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
-                    "name": "Crizotinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 3,
+                "uuid": "f05d12ab-6204-4a1c-803f-f3a7f6e30af2",
+                "name": "Crizotinib",
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               }
             ]
           },
           {
-            "id": 108,
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             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 215,
+                "entity": "DRUG",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
+                "rule": "64",
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               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -12375,13 +12624,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
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                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -12389,62 +12638,60 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
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-                    "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
-                    "name": "Gefitinib"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "b76d7b2b-b5fb-4561-892f-6b00bfaf0dfa",
+                "name": "Gefitinib",
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             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
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-        }
+        ]
       },
       {
         "id": 66,
@@ -12458,29 +12705,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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         "associations": [
           {
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               {
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 217,
+                "entity": "DRUG",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
               {
-                "id": 15637,
+                "id": 15740,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -12489,48 +12735,47 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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+                    "id": 5121,
                     "entrezGeneId": 5979,
                     "hugoSymbol": "RET",
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-                    "evidences": null
+                    "hgncId": "9967"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
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-                "drugs": [
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-                    "id": 36,
-                    "uuid": "7f9be086-3520-4c28-a414-8d4f3682f920",
-                    "name": "Pralsetinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "7f9be086-3520-4c28-a414-8d4f3682f920",
+                "name": "Pralsetinib",
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               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 67,
@@ -12544,107 +12789,77 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
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-                  "code": "NSCLC",
-                  "color": "Gainsboro",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 219,
+                "entity": "DRUG",
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+              },
+              {
+                "id": 220,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5243,
+                "id": 22641,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 20 in-frame insertions",
-                "alteration": "762_823ins",
-                "proteinChange": "762_823ins",
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-                ],
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-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
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-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
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-              },
-              {
-                "id": 5244,
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-                "alteration": "762_823ins {excluding A763_Y764insFQEA}",
-                "proteinChange": "762_823ins",
-                "start": 762,
-                "end": 823,
+                "alteration": "Exon 20 in-frame insertions",
+                "proteinChange": "Exon 20 in-frame insertions",
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+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
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                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
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+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
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               }
             ],
             "articles": null,
-            "treatments": [
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-                    "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
-                    "name": "Amivantamab"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
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+                "uuid": "5079a0fa-8b3a-41c5-9b03-9216f0044057",
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             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 68,
@@ -12658,43 +12873,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 111,
+            "id": 229,
             "name": null,
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+            "rules": [
               {
-                "id": 141,
-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": "IHCH",
-                  "color": "Green",
-                  "level": 3,
-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Intrahepatic Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 221,
+                "entity": "DRUG",
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+                "name": null
               },
               {
-                "id": 142,
-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": "CHOL",
-                  "color": "Green",
-                  "level": 2,
-                  "mainType": "Hepatobiliary Cancer",
-                  "subtype": "Cholangiocarcinoma",
-                  "tissue": "Biliary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 222,
+                "entity": "CANCER_TYPE",
+                "rule": "400,115",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 9277,
+                "id": 9380,
                 "type": "PROTEIN_CHANGE",
                 "name": "R132",
                 "alteration": "R132",
@@ -12703,13 +12903,13 @@
                 "end": 132,
                 "refResidues": "R",
                 "variantResidues": "",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 23182,
+                    "id": 23166,
                     "entrezGeneId": 3417,
                     "hugoSymbol": "IDH1",
-                    "hgncId": "5382",
-                    "evidences": null
+                    "hgncId": "5382"
                   }
                 ],
                 "consequence": {
@@ -12717,34 +12917,43 @@
                   "term": "NA",
                   "name": "NA",
                   "isGenerallyTruncating": false,
-                  "description": "NA",
-                  "categoricalAlterations": null
+                  "description": "NA"
                 }
               }
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-                "drugs": [
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-                    "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
-                    "name": "Ivosidenib"
-                  }
-                ]
+                "id": 115,
+                "code": "CHOL",
+                "color": "Green",
+                "level": 2,
+                "mainType": "Hepatobiliary Cancer",
+                "subtype": "Cholangiocarcinoma",
+                "tissue": "Biliary Tract",
+                "tumorForm": "SOLID"
+              },
+              {
+                "id": 400,
+                "code": "IHCH",
+                "color": "Green",
+                "level": 3,
+                "mainType": "Hepatobiliary Cancer",
+                "subtype": "Intrahepatic Cholangiocarcinoma",
+                "tissue": "Biliary Tract",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 30,
+                "uuid": "6e09176b-e044-4190-8bbd-767c907577eb",
+                "name": "Ivosidenib",
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             ]
           }
-        ],
-        "type": {
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-        }
+        ]
       },
       {
         "id": 69,
@@ -12758,107 +12967,77 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 223,
+                "entity": "DRUG",
+                "rule": "67",
+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
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             ],
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-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
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-              },
-              {
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-                "proteinChange": "762_823ins",
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+                "alteration": "Exon 20 in-frame insertions",
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                     "hugoSymbol": "EGFR",
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                   }
                 ],
                 "consequence": {
-                  "id": 12,
-                  "term": "INFRAME_INSERTION",
-                  "name": "Inframe Insertion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
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+            ],
+            "drugs": [
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             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
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@@ -12872,79 +13051,77 @@
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                 "alteration": "Oncogenic Mutations",
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@@ -12958,29 +13135,28 @@
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                 "alteration": "Fusions",
@@ -12989,112 +13165,115 @@
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@@ -13108,29 +13287,28 @@
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@@ -13139,13 +13317,13 @@
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@@ -13153,39 +13331,39 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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@@ -13202,7 +13380,7 @@
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@@ -13216,29 +13394,28 @@
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@@ -13247,64 +13424,53 @@
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@@ -13321,7 +13487,7 @@
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@@ -13335,29 +13501,28 @@
         "curated": true,
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@@ -13366,64 +13531,53 @@
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@@ -13440,7 +13594,7 @@
     "manufacturer": "Abbott Molecular Inc.",
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@@ -13454,29 +13608,28 @@
         "curated": true,
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-                }
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                 "alteration": "Fusions",
@@ -13485,48 +13638,47 @@
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                 "genes": [
                   {
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                     "hugoSymbol": "ALK",
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                   }
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                 "consequence": {
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+                "code": "NSCLC",
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+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
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+            ],
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-        }
+        ]
       },
       {
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@@ -13540,29 +13692,28 @@
         "curated": true,
         "genetic": true,
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                 "alteration": "Fusions",
@@ -13571,48 +13722,47 @@
                 "end": null,
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                 "consequence": {
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+        ]
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@@ -13629,7 +13779,7 @@
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     "platformType": "NGS",
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@@ -13643,29 +13793,28 @@
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-                  "tissue": "Bowel",
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                 "alteration": "Wildtype",
@@ -13674,13 +13823,13 @@
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@@ -13688,64 +13837,58 @@
                   "term": "ANY",
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                   "isGenerallyTruncating": false,
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+                  "description": "Any variant"
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@@ -13754,13 +13897,13 @@
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@@ -13768,64 +13911,58 @@
                   "term": "ANY",
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+                  "description": "Any variant"
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@@ -13834,13 +13971,13 @@
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@@ -13848,50 +13985,39 @@
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@@ -13918,7 +14044,7 @@
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@@ -13932,29 +14058,28 @@
         "curated": true,
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@@ -13963,48 +14088,47 @@
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-          "description": "Searchable listing of Humanitarian Device Exemption (HDE) Class III medical devices."
-        }
+        ]
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@@ -14021,7 +14145,7 @@
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@@ -14035,29 +14159,28 @@
         "curated": true,
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@@ -14066,13 +14189,13 @@
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@@ -14080,64 +14203,58 @@
                   "term": "ANY",
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+              {
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                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -14146,13 +14263,13 @@
                 "end": null,
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                     "hugoSymbol": "NRAS",
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+                    "hgncId": "7989"
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@@ -14160,50 +14277,39 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                    "name": "Panitumumab"
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+                "color": "SaddleBrown",
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+                "mainType": "Colorectal Cancer",
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+                "tissue": "Bowel",
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+              }
+            ],
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+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
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-        }
+        ]
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     ],
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@@ -14220,7 +14326,7 @@
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-    "lastUpdated": "2024-01-11T17:01:29.049550Z",
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     "fdaSubmissions": [
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@@ -14234,29 +14340,28 @@
         "curated": true,
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-                  "mainType": "Breast Cancer",
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-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
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                 "alteration": "Amplification",
@@ -14265,64 +14370,53 @@
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                     "hugoSymbol": "ERBB2",
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                 ],
                 "consequence": {
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-                  "term": "UNKNOWN",
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                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
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-                    "name": "Trastuzumab"
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-        }
+        ]
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     "specimenTypes": [
@@ -14339,7 +14433,7 @@
     "manufacturer": "QIAGEN GmbH",
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     "platformType": "PCR",
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     "fdaSubmissions": [
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@@ -14353,29 +14447,28 @@
         "curated": true,
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-                  "mainType": "Colorectal Cancer",
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-                  "tissue": "Bowel",
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                 "alteration": "V600E",
@@ -14384,13 +14477,13 @@
                 "end": 600,
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@@ -14398,39 +14491,39 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
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+                "tissue": "Bowel",
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-        }
+        ]
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@@ -14447,7 +14540,7 @@
     "manufacturer": "Qiagen Manchester, Ltd.",
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-    "lastUpdated": "2024-01-11T17:01:32.262924Z",
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@@ -14461,29 +14554,28 @@
         "curated": true,
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-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
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                 "alteration": "L858R",
@@ -14492,13 +14584,13 @@
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@@ -14506,62 +14598,60 @@
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-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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+                "alteration": "Exon 19 in-frame deletions",
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                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
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                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
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+                "color": "Gainsboro",
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+                "mainType": "Non-Small Cell Lung Cancer",
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-        }
+        ]
       },
       {
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@@ -14575,29 +14665,28 @@
         "curated": true,
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-                  "tissue": "Lung",
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                 "alteration": "L858R",
@@ -14606,13 +14695,13 @@
                 "end": 858,
                 "refResidues": "L",
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@@ -14620,62 +14709,60 @@
                   "term": "MISSENSE_VARIANT",
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                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
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+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
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-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
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                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
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                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
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               }
             ],
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-            "treatments": [
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-        }
+        ]
       },
       {
         "id": 84,
@@ -14689,29 +14776,69 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 131,
+            "id": 270,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [],
+            "alterations": [
               {
-                "id": 162,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
+                "id": 5127,
+                "type": "PROTEIN_CHANGE",
+                "name": "G719",
+                "alteration": "G719",
+                "proteinChange": "G719",
+                "start": 719,
+                "end": 719,
+                "refResidues": "G",
+                "variantResidues": "",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
+                  }
+                ],
+                "consequence": {
+                  "id": 17,
+                  "term": "NA",
+                  "name": "NA",
+                  "isGenerallyTruncating": false,
+                  "description": "NA"
                 }
-              }
-            ],
-            "alterations": [
+              },
+              {
+                "id": 5142,
+                "type": "PROTEIN_CHANGE",
+                "name": "S768I",
+                "alteration": "S768I",
+                "proteinChange": "S768I",
+                "start": 768,
+                "end": 768,
+                "refResidues": "S",
+                "variantResidues": "I",
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 24469,
+                    "entrezGeneId": 1956,
+                    "hugoSymbol": "EGFR",
+                    "hgncId": "3236"
+                  }
+                ],
+                "consequence": {
+                  "id": 16,
+                  "term": "MISSENSE_VARIANT",
+                  "name": "Missense Variant",
+                  "isGenerallyTruncating": false,
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
+                }
+              },
               {
-                "id": 5041,
+                "id": 5144,
                 "type": "PROTEIN_CHANGE",
                 "name": "L861Q",
                 "alteration": "L861Q",
@@ -14720,13 +14847,13 @@
                 "end": 861,
                 "refResidues": "L",
                 "variantResidues": "Q",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14734,34 +14861,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 155,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 58,
-                    "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
-                    "name": "Afatinib"
-                  }
-                ]
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 59,
+                "uuid": "e1f45ae7-33ae-428c-9e77-da4a9b7270b6",
+                "name": "Afatinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 85,
@@ -14775,29 +14901,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 132,
+            "id": 250,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 163,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 263,
+                "entity": "DRUG",
+                "rule": "88",
+                "name": null
+              },
+              {
+                "id": 264,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 5023,
+                "id": 5126,
                 "type": "PROTEIN_CHANGE",
                 "name": "L858R",
                 "alteration": "L858R",
@@ -14806,13 +14931,13 @@
                 "end": 858,
                 "refResidues": "L",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
@@ -14820,62 +14945,60 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 5027,
+                "id": 22638,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 19 in-frame deletions",
-                "alteration": "729_761del",
-                "proteinChange": "729_761del",
-                "start": 729,
-                "end": 761,
+                "alteration": "Exon 19 in-frame deletions",
+                "proteinChange": "Exon 19 in-frame deletions",
+                "start": null,
+                "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
-                    "id": 24498,
+                    "id": 24469,
                     "entrezGeneId": 1956,
                     "hugoSymbol": "EGFR",
-                    "hgncId": "3236",
-                    "evidences": null
+                    "hgncId": "3236"
                   }
                 ],
                 "consequence": {
-                  "id": 11,
-                  "term": "INFRAME_DELETION",
-                  "name": "Inframe Deletion",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "An inframe non synonymous variant that deletes bases from the coding sequence",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 156,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 87,
-                    "uuid": "ee16e91a-38a2-4433-97d2-9b9ae9d2a497",
-                    "name": "Dacomitinib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 88,
+                "uuid": "ee16e91a-38a2-4433-97d2-9b9ae9d2a497",
+                "name": "Dacomitinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -14892,7 +15015,7 @@
     "manufacturer": "QIAGEN Manchester Ltd.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:32.693221Z",
+    "lastUpdated": "2024-04-06T01:04:23.342470Z",
     "fdaSubmissions": [
       {
         "id": 86,
@@ -14906,29 +15029,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 133,
+            "id": 251,
             "name": null,
-            "associationCancerTypes": [
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               {
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": null,
-                  "color": "Yellow",
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-                  "mainType": "Bladder Cancer",
-                  "subtype": null,
-                  "tissue": "Bladder/Urinary Tract",
-                  "tumorForm": "SOLID"
-                }
+                "id": 265,
+                "entity": "DRUG",
+                "rule": "94",
+                "name": null
+              },
+              {
+                "id": 266,
+                "entity": "CANCER_TYPE",
+                "rule": "977",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 8245,
+                "id": 8348,
                 "type": "PROTEIN_CHANGE",
                 "name": "R248C",
                 "alteration": "R248C",
@@ -14937,13 +15059,13 @@
                 "end": 248,
                 "refResidues": "R",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
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                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -14951,12 +15073,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8246,
+                "id": 8349,
                 "type": "PROTEIN_CHANGE",
                 "name": "S249C",
                 "alteration": "S249C",
@@ -14965,13 +15086,13 @@
                 "end": 249,
                 "refResidues": "S",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
+                    "id": 20762,
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                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -14979,12 +15100,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8247,
+                "id": 8350,
                 "type": "PROTEIN_CHANGE",
                 "name": "Y373C",
                 "alteration": "Y373C",
@@ -14993,13 +15113,13 @@
                 "end": 373,
                 "refResidues": "Y",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
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                     "hugoSymbol": "FGFR3",
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-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -15007,12 +15127,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8282,
+                "id": 8385,
                 "type": "PROTEIN_CHANGE",
                 "name": "G370C",
                 "alteration": "G370C",
@@ -15021,13 +15140,13 @@
                 "end": 370,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 20766,
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                     "entrezGeneId": 2261,
                     "hugoSymbol": "FGFR3",
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-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
@@ -15035,12 +15154,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 8287,
+                "id": 8390,
                 "type": "STRUCTURAL_VARIANT",
                 "name": "Fusions",
                 "alteration": "Fusions",
@@ -15049,48 +15167,47 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
                   {
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                     "hugoSymbol": "FGFR3",
-                    "hgncId": "3690",
-                    "evidences": null
+                    "hgncId": "3690"
                   }
                 ],
                 "consequence": {
-                  "id": 39,
-                  "term": "UNKNOWN",
-                  "name": "Unknown",
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Unknown status",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
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-                "id": 157,
-                "name": null,
-                "drugs": [
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-                    "uuid": "f2e41d69-c383-4e33-ba25-0bf5f837db11",
-                    "name": "Erdafitinib"
-                  }
-                ]
+                "id": 977,
+                "code": null,
+                "color": "Yellow",
+                "level": 0,
+                "mainType": "Bladder Cancer",
+                "subtype": null,
+                "tissue": "Bladder/Urinary Tract",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 94,
+                "uuid": "f2e41d69-c383-4e33-ba25-0bf5f837db11",
+                "name": "Erdafitinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -15107,7 +15224,7 @@
     "manufacturer": "Qiagen Manchester, Ltd.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:34.466152Z",
+    "lastUpdated": "2024-04-06T01:04:24.395416Z",
     "fdaSubmissions": [
       {
         "id": 87,
@@ -15121,29 +15238,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 134,
+            "id": 252,
             "name": null,
-            "associationCancerTypes": [
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-                "relation": "INCLUSION",
-                "cancerType": {
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-                  "code": null,
-                  "color": "SaddleBrown",
-                  "level": 0,
-                  "mainType": "Colorectal Cancer",
-                  "subtype": null,
-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 267,
+                "entity": "DRUG",
+                "rule": "66,66+104",
+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
+                "rule": "874",
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               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15152,13 +15268,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "KRAS",
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-                    "evidences": null
+                    "hgncId": "6407"
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                 ],
                 "consequence": {
@@ -15166,50 +15282,39 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
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-                "name": null,
-                "drugs": [
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-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  }
-                ]
+                "id": 874,
+                "code": null,
+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 66,
+                "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
+                "name": "Panitumumab",
+                "fdaDrugs": null
               },
               {
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-                "name": null,
-                "drugs": [
-                  {
-                    "id": 65,
-                    "uuid": "d7b1d12a-e942-4801-bb64-916c9bdfaaf3",
-                    "name": "Panitumumab"
-                  },
-                  {
-                    "id": 103,
-                    "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
-                    "name": "Chemotherapy"
-                  }
-                ]
+                "id": 104,
+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
+                "name": "Chemotherapy",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 88,
@@ -15223,29 +15328,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 135,
+            "id": 253,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 166,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 64,
-                  "code": "NSCLC",
-                  "color": "Gainsboro",
-                  "level": 2,
-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 269,
+                "entity": "DRUG",
+                "rule": "17",
+                "name": null
+              },
+              {
+                "id": 270,
+                "entity": "CANCER_TYPE",
+                "rule": "64",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 10208,
+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -15254,13 +15358,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 30480,
+                    "id": 30432,
                     "entrezGeneId": 3845,
                     "hugoSymbol": "KRAS",
-                    "hgncId": "6407",
-                    "evidences": null
+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15268,34 +15372,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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               {
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-                    "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
-                    "name": "Sotorasib"
-                  }
-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "7d507726-ed2e-4f65-a35a-0e1e88984278",
+                "name": "Sotorasib",
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               }
             ]
           }
-        ],
-        "type": {
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-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 89,
@@ -15309,29 +15412,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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               {
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-                  "mainType": "Colorectal Cancer",
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-                  "tissue": "Bowel",
-                  "tumorForm": "SOLID"
-                }
+                "id": 271,
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+              },
+              {
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               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15340,13 +15442,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
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                 "genes": [
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                     "hugoSymbol": "KRAS",
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+                    "hgncId": "6407"
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                 ],
                 "consequence": {
@@ -15354,50 +15456,39 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                ]
+                "id": 874,
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+                "color": "SaddleBrown",
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+                "mainType": "Colorectal Cancer",
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+                "tissue": "Bowel",
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+              }
+            ],
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-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
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               }
             ]
           }
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-        }
+        ]
       },
       {
         "id": 90,
@@ -15411,29 +15502,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
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         "associations": [
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-                  "subtype": null,
-                  "tissue": "Bowel",
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-                }
+                "id": 273,
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
               {
-                "id": 10204,
+                "id": 10307,
                 "type": "NA",
                 "name": "Wildtype",
                 "alteration": "Wildtype",
@@ -15442,13 +15532,13 @@
                 "end": null,
                 "refResidues": null,
                 "variantResidues": null,
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                     "hugoSymbol": "KRAS",
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+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15456,64 +15546,58 @@
                   "term": "ANY",
                   "name": "Any",
                   "isGenerallyTruncating": false,
-                  "description": "Any variant",
-                  "categoricalAlterations": null
+                  "description": "Any variant"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
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-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 874,
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+                "color": "SaddleBrown",
+                "level": 0,
+                "mainType": "Colorectal Cancer",
+                "subtype": null,
+                "tissue": "Bowel",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "3bbe37b1-edc8-4c54-93f8-5360d9a83d69",
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-                    "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
-                    "name": "Cetuximab"
-                  }
-                ]
+                "id": 124,
+                "uuid": "5fce3074-e420-4c36-9603-2423daf20118",
+                "name": "Cetuximab",
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               }
             ]
           },
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-                  "code": "NSCLC",
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-                  "mainType": "Non-Small Cell Lung Cancer",
-                  "subtype": "Non-Small Cell Lung Cancer",
-                  "tissue": "Lung",
-                  "tumorForm": "SOLID"
-                }
+                "id": 275,
+                "entity": "DRUG",
+                "rule": "121",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
               {
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+                "id": 10311,
                 "type": "PROTEIN_CHANGE",
                 "name": "G12C",
                 "alteration": "G12C",
@@ -15522,13 +15606,13 @@
                 "end": 12,
                 "refResidues": "G",
                 "variantResidues": "C",
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                 "genes": [
                   {
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                     "hugoSymbol": "KRAS",
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+                    "hgncId": "6407"
                   }
                 ],
                 "consequence": {
@@ -15536,34 +15620,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
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-                    "name": "Adagrasib"
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-                ]
+                "id": 64,
+                "code": "NSCLC",
+                "color": "Gainsboro",
+                "level": 2,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": "Non-Small Cell Lung Cancer",
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
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+                "uuid": "0a7b3eb1-d1f0-4511-aaac-9a696955bf57",
+                "name": "Adagrasib",
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             ]
           }
-        ],
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-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -15580,7 +15663,7 @@
     "manufacturer": "QIAGEN GmbH",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:35.144681Z",
+    "lastUpdated": "2024-04-06T01:04:24.862345Z",
     "fdaSubmissions": [
       {
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@@ -15594,79 +15677,77 @@
         "curated": true,
         "genetic": true,
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-                  "code": "GIST",
-                  "color": "LightYellow",
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-                  "mainType": "Gastrointestinal Stromal Tumor",
-                  "subtype": "Gastrointestinal Stromal Tumor",
-                  "tissue": "Soft Tissue",
-                  "tumorForm": "SOLID"
-                }
+                "id": 277,
+                "entity": "DRUG",
+                "rule": "74",
+                "name": null
+              },
+              {
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+                "entity": "CANCER_TYPE",
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               }
             ],
             "alterations": [
               {
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+                "id": 22644,
                 "type": "PROTEIN_CHANGE",
                 "name": "Exon 18 missense mutations",
-                "alteration": "814_852mis",
-                "proteinChange": "814_852mis",
-                "start": 814,
-                "end": 852,
+                "alteration": "Exon 18 missense mutations",
+                "proteinChange": "Exon 18 missense mutations",
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                     "hugoSymbol": "PDGFRA",
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                 ],
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-                  "term": "MISSENSE_VARIANT",
-                  "name": "Missense Variant",
+                  "id": 39,
+                  "term": "UNKNOWN",
+                  "name": "Unknown",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "Unknown status"
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               }
             ],
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-                    "name": "Avapritinib"
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+                "id": 219,
+                "code": "GIST",
+                "color": "LightYellow",
+                "level": 2,
+                "mainType": "Gastrointestinal Stromal Tumor",
+                "subtype": "Gastrointestinal Stromal Tumor",
+                "tissue": "Soft Tissue",
+                "tumorForm": "SOLID"
+              }
+            ],
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+                "uuid": "3d49e386-0cc4-401e-9acd-d2d33b2923a3",
+                "name": "Avapritinib",
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             ]
           }
-        ],
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-        }
+        ]
       }
     ],
     "specimenTypes": [
@@ -15683,7 +15764,7 @@
     "manufacturer": "QIAGEN GmbH",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:35.815793Z",
+    "lastUpdated": "2024-09-24T16:40:32.380917Z",
     "fdaSubmissions": [
       {
         "id": 92,
@@ -15697,44 +15778,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
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         "associations": [
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+            "id": 258,
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-                "relation": "INCLUSION",
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-                  "code": null,
-                  "color": "HotPink",
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-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 279,
+                "entity": "DRUG",
+                "rule": "84+33",
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+              },
+              {
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+                "entity": "CANCER_TYPE",
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             ],
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+                "id": 13532,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
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                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -15742,12 +15822,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -15756,13 +15835,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -15770,12 +15849,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -15784,13 +15862,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -15798,12 +15876,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545A",
                 "alteration": "E545A",
@@ -15812,13 +15889,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "A",
+                "flags": null,
                 "genes": [
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                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -15826,27 +15903,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
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+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545G",
+                "alteration": "E545G",
+                "proteinChange": "E545G",
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                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "G",
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                 "genes": [
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                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
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+                    "hgncId": "8975"
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                 ],
                 "consequence": {
@@ -15854,27 +15930,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545G",
-                "alteration": "E545G",
-                "proteinChange": "E545G",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "G",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15882,12 +15957,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
                 "name": "Q546E",
                 "alteration": "Q546E",
@@ -15896,13 +15970,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15910,12 +15984,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
                 "name": "Q546R",
                 "alteration": "Q546R",
@@ -15924,13 +15997,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15938,27 +16011,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15966,12 +16038,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
                 "name": "H1047R",
                 "alteration": "H1047R",
@@ -15980,13 +16051,13 @@
                 "end": 1047,
                 "refResidues": "H",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -15994,27 +16065,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16022,39 +16092,39 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 167,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 93,
@@ -16068,44 +16138,43 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 140,
+            "id": 258,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 171,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 978,
-                  "code": null,
-                  "color": "HotPink",
-                  "level": 0,
-                  "mainType": "Breast Cancer",
-                  "subtype": null,
-                  "tissue": "Breast",
-                  "tumorForm": "SOLID"
-                }
+                "id": 279,
+                "entity": "DRUG",
+                "rule": "84+33",
+                "name": null
+              },
+              {
+                "id": 280,
+                "entity": "CANCER_TYPE",
+                "rule": "978",
+                "name": null
               }
             ],
             "alterations": [
-              {
-                "id": 13431,
-                "type": "PROTEIN_CHANGE",
-                "name": "E545K",
-                "alteration": "E545K",
-                "proteinChange": "E545K",
+              {
+                "id": 13532,
+                "type": "PROTEIN_CHANGE",
+                "name": "E545D",
+                "alteration": "E545D",
+                "proteinChange": "E545D",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "K",
+                "variantResidues": "D",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16113,12 +16182,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13426,
+                "id": 13529,
                 "type": "PROTEIN_CHANGE",
                 "name": "C420R",
                 "alteration": "C420R",
@@ -16127,13 +16195,13 @@
                 "end": 420,
                 "refResidues": "C",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16141,12 +16209,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13427,
+                "id": 13530,
                 "type": "PROTEIN_CHANGE",
                 "name": "E542K",
                 "alteration": "E542K",
@@ -16155,13 +16222,13 @@
                 "end": 542,
                 "refResidues": "E",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16169,12 +16236,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13428,
+                "id": 13531,
                 "type": "PROTEIN_CHANGE",
                 "name": "E545A",
                 "alteration": "E545A",
@@ -16183,13 +16249,13 @@
                 "end": 545,
                 "refResidues": "E",
                 "variantResidues": "A",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16197,27 +16263,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13429,
+                "id": 13533,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545D",
-                "alteration": "E545D",
-                "proteinChange": "E545D",
+                "name": "E545G",
+                "alteration": "E545G",
+                "proteinChange": "E545G",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "D",
+                "variantResidues": "G",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16225,27 +16290,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13430,
+                "id": 13534,
                 "type": "PROTEIN_CHANGE",
-                "name": "E545G",
-                "alteration": "E545G",
-                "proteinChange": "E545G",
+                "name": "E545K",
+                "alteration": "E545K",
+                "proteinChange": "E545K",
                 "start": 545,
                 "end": 545,
                 "refResidues": "E",
-                "variantResidues": "G",
+                "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16253,12 +16317,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13432,
+                "id": 13535,
                 "type": "PROTEIN_CHANGE",
                 "name": "Q546E",
                 "alteration": "Q546E",
@@ -16267,13 +16330,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16281,12 +16344,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13433,
+                "id": 13536,
                 "type": "PROTEIN_CHANGE",
                 "name": "Q546R",
                 "alteration": "Q546R",
@@ -16295,13 +16357,13 @@
                 "end": 546,
                 "refResidues": "Q",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16309,27 +16371,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13434,
+                "id": 13539,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047L",
-                "alteration": "H1047L",
-                "proteinChange": "H1047L",
+                "name": "H1047Y",
+                "alteration": "H1047Y",
+                "proteinChange": "H1047Y",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "L",
+                "variantResidues": "Y",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16337,12 +16398,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13435,
+                "id": 13538,
                 "type": "PROTEIN_CHANGE",
                 "name": "H1047R",
                 "alteration": "H1047R",
@@ -16351,13 +16411,13 @@
                 "end": 1047,
                 "refResidues": "H",
                 "variantResidues": "R",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16365,27 +16425,26 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 13436,
+                "id": 13537,
                 "type": "PROTEIN_CHANGE",
-                "name": "H1047Y",
-                "alteration": "H1047Y",
-                "proteinChange": "H1047Y",
+                "name": "H1047L",
+                "alteration": "H1047L",
+                "proteinChange": "H1047L",
                 "start": 1047,
                 "end": 1047,
                 "refResidues": "H",
-                "variantResidues": "Y",
+                "variantResidues": "L",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 39934,
+                    "id": 39811,
                     "entrezGeneId": 5290,
                     "hugoSymbol": "PIK3CA",
-                    "hgncId": "8975",
-                    "evidences": null
+                    "hgncId": "8975"
                   }
                 ],
                 "consequence": {
@@ -16393,42 +16452,47 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 167,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 32,
-                    "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
-                    "name": "Fulvestrant"
-                  },
-                  {
-                    "id": 83,
-                    "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
-                    "name": "Alpelisib"
-                  }
-                ]
+                "id": 978,
+                "code": null,
+                "color": "HotPink",
+                "level": 0,
+                "mainType": "Breast Cancer",
+                "subtype": null,
+                "tissue": "Breast",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 33,
+                "uuid": "b25af9e9-2195-4f16-90ea-7c21fcf3882d",
+                "name": "Fulvestrant",
+                "fdaDrugs": null
+              },
+              {
+                "id": 84,
+                "uuid": "d76cc0eb-d098-4133-95a5-5f59fad65f80",
+                "name": "Alpelisib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
+      {
+        "id": 1,
+        "type": "CFDNA",
+        "name": "cfDNA from plasma"
+      },
       {
         "id": 3,
         "type": "FFPE",
@@ -16442,7 +16506,7 @@
     "manufacturer": "bioMérieux Inc.",
     "indicationDetails": null,
     "platformType": "PCR",
-    "lastUpdated": "2024-01-11T17:01:36.986892Z",
+    "lastUpdated": "2024-04-06T01:04:27.506321Z",
     "fdaSubmissions": [
       {
         "id": 94,
@@ -16456,29 +16520,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 141,
+            "id": 259,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 172,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 281,
+                "entity": "DRUG",
+                "rule": "123",
+                "name": null
+              },
+              {
+                "id": 282,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16487,13 +16550,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16501,12 +16564,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -16515,13 +16577,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16529,48 +16591,52 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 168,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 122,
-                    "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
-                    "name": "Trametinib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 123,
+                "uuid": "fb2bb01c-c0ec-4641-abf7-87f486075022",
+                "name": "Trametinib",
+                "fdaDrugs": null
               }
             ]
           },
           {
-            "id": 142,
+            "id": 260,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 173,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 283,
+                "entity": "DRUG",
+                "rule": "15",
+                "name": null
+              },
+              {
+                "id": 284,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16579,13 +16645,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16593,34 +16659,33 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 169,
-                "name": null,
-                "drugs": [
-                  {
-                    "id": 15,
-                    "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
-                    "name": "Dabrafenib"
-                  }
-                ]
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 15,
+                "uuid": "939cd40b-b515-499d-b099-fd29027c0d17",
+                "name": "Dabrafenib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       },
       {
         "id": 95,
@@ -16634,29 +16699,28 @@
         "curated": true,
         "genetic": true,
         "note": null,
+        "articles": null,
         "associations": [
           {
-            "id": 143,
+            "id": 261,
             "name": null,
-            "associationCancerTypes": [
+            "rules": [
               {
-                "id": 174,
-                "relation": "INCLUSION",
-                "cancerType": {
-                  "id": 172,
-                  "code": "MEL",
-                  "color": "Black",
-                  "level": 2,
-                  "mainType": "Melanoma",
-                  "subtype": "Melanoma",
-                  "tissue": "Skin",
-                  "tumorForm": "SOLID"
-                }
+                "id": 285,
+                "entity": "DRUG",
+                "rule": "118+120",
+                "name": null
+              },
+              {
+                "id": 286,
+                "entity": "CANCER_TYPE",
+                "rule": "172",
+                "name": null
               }
             ],
             "alterations": [
               {
-                "id": 1388,
+                "id": 1491,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600E",
                 "alteration": "V600E",
@@ -16665,13 +16729,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "E",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16679,12 +16743,11 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               },
               {
-                "id": 1392,
+                "id": 1495,
                 "type": "PROTEIN_CHANGE",
                 "name": "V600K",
                 "alteration": "V600K",
@@ -16693,13 +16756,13 @@
                 "end": 600,
                 "refResidues": "V",
                 "variantResidues": "K",
+                "flags": null,
                 "genes": [
                   {
-                    "id": 41259,
+                    "id": 41135,
                     "entrezGeneId": 673,
                     "hugoSymbol": "BRAF",
-                    "hgncId": "1097",
-                    "evidences": null
+                    "hgncId": "1097"
                   }
                 ],
                 "consequence": {
@@ -16707,39 +16770,292 @@
                   "term": "MISSENSE_VARIANT",
                   "name": "Missense Variant",
                   "isGenerallyTruncating": false,
-                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
-                  "categoricalAlterations": null
+                  "description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved"
                 }
               }
             ],
             "articles": null,
-            "treatments": [
+            "cancerTypes": [
               {
-                "id": 170,
-                "name": null,
-                "drugs": [
+                "id": 172,
+                "code": "MEL",
+                "color": "Black",
+                "level": 2,
+                "mainType": "Melanoma",
+                "subtype": "Melanoma",
+                "tissue": "Skin",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 118,
+                "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
+                "name": "Encorafenib",
+                "fdaDrugs": null
+              },
+              {
+                "id": 120,
+                "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
+                "name": "Binimetinib",
+                "fdaDrugs": null
+              }
+            ]
+          }
+        ]
+      }
+    ],
+    "specimenTypes": [
+      {
+        "id": 3,
+        "type": "FFPE",
+        "name": "FFPE"
+      }
+    ]
+  },
+  {
+    "id": 40,
+    "name": "TruSight Oncology Comprehensive",
+    "manufacturer": "Illumina, Inc.",
+    "indicationDetails": "",
+    "platformType": "NGS",
+    "lastUpdated": "2024-10-22T15:11:21.096078Z",
+    "fdaSubmissions": [
+      {
+        "id": 98,
+        "number": "P230011",
+        "supplementNumber": "",
+        "deviceName": "TruSight Oncology Comprehensive",
+        "genericName": "",
+        "dateReceived": "2024-10-22T04:00:00Z",
+        "decisionDate": "2024-10-22T04:00:00Z",
+        "description": "",
+        "curated": false,
+        "genetic": false,
+        "note": null,
+        "articles": null,
+        "associations": [
+          {
+            "id": 265,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 15740,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 117,
-                    "uuid": "001e534f-3e63-432f-90a6-d1af1759e4e2",
-                    "name": "Encorafenib"
-                  },
+                    "id": 5121,
+                    "entrezGeneId": 5979,
+                    "hugoSymbol": "RET",
+                    "hgncId": "9967"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 878,
+                "code": null,
+                "color": "Gainsboro",
+                "level": 0,
+                "mainType": "Non-Small Cell Lung Cancer",
+                "subtype": null,
+                "tissue": "Lung",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 266,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13094,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20523,
+                    "entrezGeneId": 4914,
+                    "hugoSymbol": "NTRK1",
+                    "hgncId": "8031"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 267,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13153,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
+                  {
+                    "id": 20524,
+                    "entrezGeneId": 4915,
+                    "hugoSymbol": "NTRK2",
+                    "hgncId": "8032"
+                  }
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 44,
+                "uuid": "b0b3d8ee-86a5-4421-b4a9-053d3c1ff544",
+                "name": "Larotrectinib",
+                "fdaDrugs": null
+              }
+            ]
+          },
+          {
+            "id": 268,
+            "name": null,
+            "rules": [],
+            "alterations": [
+              {
+                "id": 13173,
+                "type": "STRUCTURAL_VARIANT",
+                "name": "Fusions",
+                "alteration": "Fusions",
+                "proteinChange": "",
+                "start": null,
+                "end": null,
+                "refResidues": null,
+                "variantResidues": null,
+                "flags": null,
+                "genes": [
                   {
-                    "id": 119,
-                    "uuid": "feb9f4a3-e374-4c75-8a3b-0f1fbcdbf677",
-                    "name": "Binimetinib"
+                    "id": 38985,
+                    "entrezGeneId": 4916,
+                    "hugoSymbol": "NTRK3",
+                    "hgncId": "8033"
                   }
-                ]
+                ],
+                "consequence": {
+                  "id": 3,
+                  "term": "ANY",
+                  "name": "Any",
+                  "isGenerallyTruncating": false,
+                  "description": "Any variant"
+                }
+              }
+            ],
+            "articles": null,
+            "cancerTypes": [
+              {
+                "id": 3,
+                "code": "",
+                "color": "MIXED",
+                "level": -1,
+                "mainType": "All Solid Tumors",
+                "subtype": null,
+                "tissue": "MIXED",
+                "tumorForm": "SOLID"
+              }
+            ],
+            "drugs": [
+              {
+                "id": 5,
+                "uuid": "f495e1be-c45d-4858-99bd-eac4a7eead23",
+                "name": "Selpercatinib",
+                "fdaDrugs": null
               }
             ]
           }
-        ],
-        "type": {
-          "id": 1,
-          "type": "PMA",
-          "name": "Premarket Approval",
-          "shortName": "PMA",
-          "description": "Premarket approval by FDA is the required process of scientific review to ensure the safety and effectiveness of all devices classified as Class III devices. An approved Premarket Approval Application (PMA) is, in effect, a private license granted to the applicant for marketing a particular medical device. This database may be searched by a variety of fields and is updated once a week."
-        }
+        ]
       }
     ],
     "specimenTypes": [
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
index 4bac79214..cd46d6640 100644
--- a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
+++ b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
@@ -90,11 +90,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "1998-2001*",
-    "tx": "Imatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)\nKIT+\nPDGFRA, PDGFRB Fusions\nPDGFB Fusions\nFIP1L1-PDGFRA Fusion",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include BCR-ABL, KIT, PDGFRA)",
+    "year": "2018",
+    "tx": "Lorlatinib",
+    "biomarker": "ALK+ (ALK Fusions)",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include ALK and ROS1 among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -211,9 +211,9 @@
   },
   {
     "year": "2003",
-    "tx": "Tositumomab and Iodine I 131 Tositumomab*",
+    "tx": "Tositumomab and Iodine I 131 Tositumomab",
     "biomarker": "CD20+",
-    "agentClass": "Hematopoietic protein binding antibody, ADC* or cytotoxin",
+    "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "Anti-CD20 antibody",
     "targetedTx": "Y",
     "pxTx": "Y",
@@ -290,24 +290,24 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2005",
-    "tx": "Sorafenib",
-    "biomarker": "",
+    "year": "1998-2001*",
+    "tx": "Imatinib",
+    "biomarker": "*Ph+ (BCR-ABL1 Fusion)\n*KIT+\n*PDGFRA, PDGFRB Fusions\n*PDGFB Fusions\n*FIP1L1-PDGFRA fusion",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, BRAF, KIT, FLT3 and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include BCR-ABL, KIT, PDGFRA)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
-    "year": "2006",
-    "tx": "Dasatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
+    "year": "2019",
+    "tx": "Pexidartinib",
+    "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include SRC, BCR-ABL1, KIT and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include CSF1R, KIT and FLT3)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2006",
@@ -340,11 +340,11 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2006",
-    "tx": "Sunitinib",
-    "biomarker": "KIT+",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, KIT, FLT3, CSF1R and PDGFRɑ/β among others)",
+    "year": "2019",
+    "tx": "Erdafitinib",
+    "biomarker": "FGFR3-TACC3 Fusion, FGFR3-BAIAP2L1 Fusion, FGFR3 S249C, R248C, G370C, Y373C",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include FGFR1/2/3/4 among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -380,11 +380,11 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2007",
-    "tx": "Nilotinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
+    "year": "2017",
+    "tx": "Midostaurin",
+    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, PDGFR and KIT among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include FLT3, VEGFR2, KIT and PDGFR)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -422,7 +422,7 @@
   {
     "year": "2009",
     "tx": "Everolimus",
-    "biomarker": "TSC1, TSC2 Oncogenic Mutations",
+    "biomarker": "TSC1, TSC2 Oncogenic Mutations",
     "agentClass": "Large molecule inhibitor",
     "drugTarget": "mTOR inhibitor",
     "targetedTx": "Y",
@@ -440,11 +440,11 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2009",
-    "tx": "Pazopanib",
+    "year": "2019",
+    "tx": "Fedratinib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include VEGFR1/2/3, PDGFRɑ/β, KIT, FGFR1/3 among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include JAK2 and FLT3)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
@@ -530,11 +530,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "2011",
-    "tx": "Crizotinib",
-    "biomarker": "ALK+ (ALK Fusions)\nROS1+ (ROS1 Fusions)",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include ALK, ROS1 and MET)",
+    "year": "2020",
+    "tx": "Avapritinib",
+    "biomarker": "*PDGFRA Exon 18 Mutations\n*KIT D816",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include KIT D816V, PDGFRA, PDGFRA D842, KIT exon 11, 11/17 and 17 mutants)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -570,14 +570,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2011",
-    "tx": "Vandetanib",
-    "biomarker": "",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR, EGFR and RET)",
+    "year": "2019",
+    "tx": "Entrectinib",
+    "biomarker": "*NTRK1, NTRK2, NTRK3 Fusions\n*ROS1 Fusions",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include NTRK1/2/3, ROS1 and ALK among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2011",
@@ -610,25 +610,25 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2012",
-    "tx": "Bosutinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1 and SRC family kinases)",
-    "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
-  },
-  {
-    "year": "2012",
-    "tx": "Cabozantinib",
+    "year": "2021",
+    "tx": "Umbralisib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, AXL, KIT, RET and ROS1 among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include PI3Kδ and CK1ε among others)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
+  {
+    "year": "2023",
+    "tx": "Repotrectinib",
+    "biomarker": "*ROS1 Fusions \n*NTRK Fusions",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include ROS1 and NTRK1/2/3)",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
   {
     "year": "2012",
     "tx": "Carfilzomib",
@@ -670,24 +670,24 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2012",
-    "tx": "Ponatinib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion) or ABL1 T315I",
+    "year": "2006",
+    "tx": "Dasatinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, VEGFR, PDGFR, FGFR and SRC family members among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include SRC, BCR-ABL1, KIT and PDGFRβ among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
-    "year": "2012",
-    "tx": "Regorafenib",
-    "biomarker": "KIT+",
+    "year": "2005",
+    "tx": "Sorafenib",
+    "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include KIT, RET, VEGFR1/2/3, FGFR1/2, PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, BRAF, KIT, FLT3 and PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2012",
@@ -743,7 +743,7 @@
     "year": "2013",
     "tx": "Obinutuzumab",
     "biomarker": "",
-    "agentClass": "Hematopoietic protein binding antibody, ADC* or cytotoxin",
+    "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "Anti-CD20 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
@@ -862,7 +862,7 @@
   {
     "year": "2014",
     "tx": "Olaparib",
-    "biomarker": "BRCA1, BRCA2 Oncogenic Mutations\nATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1/2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54 Oncogenic Mutations",
+    "biomarker": "*BRCA1, BRCA2 Oncogenic Mutations  *ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54 Oncogenic Mutations",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "PARP inhibitor",
     "targetedTx": "Y",
@@ -872,7 +872,7 @@
   {
     "year": "2014",
     "tx": "Pembrolizumab",
-    "biomarker": "MSI-H or dMMR\nTMB-H\nPD-L1-expression\npMMR",
+    "biomarker": "*MSI-H or dMMR\n*TMB-H\n*PD-L1-expressing\n*pMMR",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-PD-1 antibody",
     "targetedTx": "Y",
@@ -911,10 +911,10 @@
   },
   {
     "year": "2015",
-    "tx": "Cobimetinib + Vemurafenib",
+    "tx": "Vemurafenib + Cobimetinib ",
     "biomarker": "BRAF V600E/K",
-    "agentClass": "Small molecule inhibitor combination",
-    "drugTarget": "MEK1/2 inhibitor + BRAF inhibitor",
+    "agentClass": "Small molecule kinase inhibitor combination",
+    "drugTarget": "BRAF inhibitor + MEK1/2 inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -952,7 +952,7 @@
   {
     "year": "2015",
     "tx": "Ipilimumab + Nivolumab",
-    "biomarker": "MSI-H or dMMR\nPD-L1-expressing",
+    "biomarker": "*MSI-H or dMMR\n*PD-L1-expressing",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-CTLA-4 antibody + Anti-PD1 antibody",
     "targetedTx": "Y",
@@ -970,11 +970,11 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2015",
-    "tx": "Lenvatinib",
+    "year": "2021",
+    "tx": "Tivozanib",
     "biomarker": "",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, FGFR1/2/3/4, KIT, RET and PDGFRβ among others)",
+    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, KIT and PDGFRβ)",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
@@ -1011,7 +1011,7 @@
   },
   {
     "year": "2015",
-    "tx": "Panobinostat*",
+    "tx": "Panobinostat",
     "biomarker": "",
     "agentClass": "HDAC inhibitor",
     "drugTarget": "Histone deacetylase (HDAC) inhibitor",
@@ -1071,7 +1071,7 @@
   },
   {
     "year": "2016",
-    "tx": "Olaratumab*",
+    "tx": "Olaratumab",
     "biomarker": "",
     "agentClass": "Monoclonal antibody",
     "drugTarget": "Anti-PDGFRɑ antibody",
@@ -1172,12 +1172,12 @@
   {
     "year": "2017",
     "tx": "Durvalumab",
-    "biomarker": "",
+    "biomarker": "dMMR",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti-PDL-1 antibody",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "N"
   },
   {
     "year": "2017",
@@ -1192,7 +1192,7 @@
   {
     "year": "2017",
     "tx": "Inotuzumab Ozogamicin",
-    "biomarker": "CD22",
+    "biomarker": "CD22+",
     "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "CD22-directed antibody-drug conjugate",
     "targetedTx": "Y",
@@ -1200,11 +1200,11 @@
     "ngsTest": "N"
   },
   {
-    "year": "2017",
-    "tx": "Midostaurin",
-    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
+    "year": "2011",
+    "tx": "Crizotinib",
+    "biomarker": "*ALK+ (ALK Fusions)\n*ROS1+ (ROS1 Fusions)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include FLT3, VEGFR2, KIT and PDGFR)",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include ALK, ROS1 and MET)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1214,7 +1214,7 @@
     "tx": "Neratinib",
     "biomarker": "HER2+ (ERBB2 Amplification)",
     "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "EGFR/HER2 (ERBB2)/HER4 (ERBB4) inhibitor",
+    "drugTarget": "EGFR//HER2 (ERBB2)/HER4 (ERBB4) inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1261,10 +1261,10 @@
   },
   {
     "year": "2018",
-    "tx": "Binimetinib + Encorafenib",
+    "tx": "Encorafenib + Binimetinib",
     "biomarker": "BRAF V600E/K",
-    "agentClass": "Small molecule inhibitor combination",
-    "drugTarget": "MEK1/2 inhibitor + BRAF inhibitor",
+    "agentClass": "Small molecule kinase inhibitor combination",
+    "drugTarget": "BRAF inhibitor + MEK1/2 inhibitor",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1310,14 +1310,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2018",
-    "tx": "Gilteritinib",
-    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include mutant and WT FLT3, AXL and ALK)",
+    "year": "2011",
+    "tx": "Vandetanib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR, EGFR and RET)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2018",
@@ -1360,14 +1360,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2018",
-    "tx": "Lorlatinib",
-    "biomarker": "ALK+ (ALK Fusions)",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include ALK and ROS1 among others)",
+    "year": "2012",
+    "tx": "Cabozantinib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, AXL, KIT, RET and ROS1 among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2018",
@@ -1412,7 +1412,7 @@
   {
     "year": "2018",
     "tx": "Talazoparib",
-    "biomarker": "BRCA1, BRCA2 Oncogenic Mutations\nATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11, NBN, PALB2, RAD51C Oncogenic Mutations",
+    "biomarker": "*BRCA1, BRCA2 Oncogenic Mutations\n*ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11, NBN, PALB2, RAD51C\nOncogenic Mutations",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "PARP inhibitor",
     "targetedTx": "Y",
@@ -1450,44 +1450,44 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2019",
-    "tx": "Entrectinib",
-    "biomarker": "NTRK1, NTRK2, NTRK3 Fusions\nROS1 Fusions",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include NTRK1/2/3, ROS1 and ALK among others)",
+    "year": "2015",
+    "tx": "Lenvatinib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, FGFR1/2/3/4, KIT, RET and PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
-    "year": "2019",
-    "tx": "Erdafitinib",
-    "biomarker": "FGFR3-TACC3 Fusion, FGFR3-BAIAP2L1 Fusion, FGFR3 S249C, R248C, G370C, Y373C",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include FGFR1/2/3/4 among others)",
+    "year": "2006",
+    "tx": "Sunitinib",
+    "biomarker": "KIT+",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted receptor tyrosine kinase inhibitor (targets include VEGFR1/2/3, KIT, FLT3, CSF1R and PDGFRɑ/β among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
-    "year": "2019",
-    "tx": "Fedratinib",
-    "biomarker": "",
+    "year": "2012",
+    "tx": "Bosutinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include JAK2 and FLT3)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1 and SRC family kinases)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
-    "year": "2019",
-    "tx": "Pexidartinib",
-    "biomarker": "",
+    "year": "2007",
+    "tx": "Nilotinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include CSF1R, KIT and FLT3)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, PDGFR and KIT among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2019",
@@ -1512,7 +1512,7 @@
   {
     "year": "2019",
     "tx": "Trastuzumab deruxtecan",
-    "biomarker": "HER2+ (ERBB2 Amplification)\nHER2-low\nERBB2 Oncogenic Mutations",
+    "biomarker": "*HER2+ (ERBB2 Amplification)\n*HER2-low\n*ERBB2 Oncogenic Mutations",
     "agentClass": "Antibody drug conjugate",
     "drugTarget": "HER2 (ERBB2)-directed antibody and topoisomerase inhibitor conjugate",
     "targetedTx": "Y",
@@ -1540,18 +1540,18 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2020",
-    "tx": "Avapritinib",
-    "biomarker": "PDGFRA Exon 18 Mutations\nKIT D816",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include KIT D816V, PDGFRA, PDGFRA D842, KIT exon 11, 11/17 and 17 mutants)",
+    "year": "2012",
+    "tx": "Ponatinib",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion) or\nABL1 T315I",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include BCR-ABL1, VEGFR, PDGFR, FGFR and SRC family members among others)",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
   },
   {
     "year": "2020",
-    "tx": "Belantamab mafodotin*",
+    "tx": "Belantamab mafodotin",
     "biomarker": "",
     "agentClass": "Hematopoietic protein binding antibody, ADC or cytotoxin",
     "drugTarget": "BCMA-directed antibody-drug conjugate",
@@ -1594,7 +1594,7 @@
     "tx": "Encorafenib + Cetuximab",
     "biomarker": "BRAF V600E",
     "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
-    "drugTarget": "BRAF inhibitor + Anti-EGFR monoclonal antibody",
+    "drugTarget": "BRAF inhibitor + Anti-EGFR antibody",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1637,12 +1637,12 @@
     "drugTarget": "Anti-GD2 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
-    "ngsTest": "NA"
+    "ngsTest": ""
   },
   {
     "year": "2020",
     "tx": "Pemigatinib",
-    "biomarker": "FGFR2 Fusions\nFGFR1 Fusions",
+    "biomarker": "*FGFR2 Fusions\n*FGFR1 Fusions",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "FGFR1/2/3 inhibitor",
     "targetedTx": "Y",
@@ -1672,9 +1672,9 @@
   {
     "year": "2020",
     "tx": "Ripretinib",
-    "biomarker": "KIT+",
+    "biomarker": "KIT/PDGFRA inhibitor",
     "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "KIT/PDGFRA inhibitor",
+    "drugTarget": "KIT/PDGFRA D816",
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
@@ -1722,7 +1722,7 @@
   {
     "year": "2020",
     "tx": "Tazemetostat",
-    "biomarker": "EZH2 Y646F, A692V, Y646C, Y646S, Y646N, Y646H, A682G\nSMARCB1 Deletion",
+    "biomarker": "*EZH2 Y646F, A692V, Y646C, Y646S, Y646N, Y646H, A682G\n*SMARCB1 Deletion",
     "agentClass": "Small molecule inhibitor",
     "drugTarget": "EZH2 inhibitor (methyltransferase inhibitor)",
     "targetedTx": "Y",
@@ -1732,7 +1732,7 @@
   {
     "year": "2020",
     "tx": "Tucatinib + Trastuzumab",
-    "biomarker": "HER2+ (ERBB2 Amplifiaction)\nKRAS and NRAS  Wildtype, and HER2+ (ERBB2 Amplifiaction)",
+    "biomarker": "*HER2+ (ERBB2 Amplifiaction)\n*KRAS and NRAS Wildtype and HER2+ (ERBB2 Amplification)",
     "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
     "drugTarget": "HER2 (ERBB2) inhibitor + Anti-HER2 (ERBB2) antibody",
     "targetedTx": "Y",
@@ -1742,7 +1742,7 @@
   {
     "year": "2021",
     "tx": "Amivantamab",
-    "biomarker": "EGFR Exon 20 Insertions",
+    "biomarker": "*EGFR Exon 20 Insertions \n*EGFR Exon 19 Deletions, L858R",
     "agentClass": "Monoclonal antibody",
     "drugTarget": "EGFR-MET bispecific antibody",
     "targetedTx": "Y",
@@ -1752,7 +1752,7 @@
   {
     "year": "2021",
     "tx": "Asciminib",
-    "biomarker": "Ph+ (BCR-ABL1 Fusion) or ABL1 T315I",
+    "biomarker": "Ph+ (BCR-ABL1 Fusion)\nor ABL1 T315I",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "ABL/BCR-ABL1 tyrosine kinase inhibitor",
     "targetedTx": "Y",
@@ -1772,7 +1772,7 @@
   {
     "year": "2021",
     "tx": "Dostarlimab",
-    "biomarker": "dMMR\ndMMR or MSI-H",
+    "biomarker": "*dMMR                                                     *dMMR or MSI-H",
     "agentClass": "Immune checkpoint inhibitor",
     "drugTarget": "Anti PD-1 antibody",
     "targetedTx": "Y",
@@ -1791,7 +1791,7 @@
   },
   {
     "year": "2021",
-    "tx": "Infigratinib*",
+    "tx": "Infigratinib",
     "biomarker": "FGFR2 Fusions",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "FGFR1/2/3 inhibitor",
@@ -1880,14 +1880,14 @@
     "ngsTest": "NA"
   },
   {
-    "year": "2021",
-    "tx": "Tivozanib",
-    "biomarker": "",
+    "year": "2012",
+    "tx": "Regorafenib",
+    "biomarker": "KIT+",
     "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include VEGFR1/2/3, KIT and PDGFRβ)",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include KIT, RET, VEGFR1/2/3, FGFR1/2, PDGFRβ among others)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2021",
@@ -1900,14 +1900,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2021",
-    "tx": "Umbralisib*",
-    "biomarker": "",
-    "agentClass": "Multikinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include PI3Kδ and CK1ε among others)",
+    "year": "2018",
+    "tx": "Gilteritinib",
+    "biomarker": "FLT3 ITD Mutations, TKD Mutations I836 and D835",
+    "agentClass": "Small molecule kinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include mutant and WT FLT3, AXL and ALK)",
     "targetedTx": "Y",
-    "pxTx": "N",
-    "ngsTest": "NA"
+    "pxTx": "Y",
+    "ngsTest": "Y"
   },
   {
     "year": "2022",
@@ -1965,7 +1965,7 @@
     "biomarker": "",
     "agentClass": "Gene therapy",
     "drugTarget": "Adenoviral vector-based gene therapy carrying IFNɑ2b",
-    "targetedTx": "N",
+    "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
@@ -2042,7 +2042,7 @@
   {
     "year": "2023",
     "tx": "Elacestrant",
-    "biomarker": "ESR1 Ligand-binding domain missense mutations and ER+/HER2-",
+    "biomarker": "ESR1 Ligand-binding domain missense mutations and\nER+/HER2-",
     "agentClass": "Hormone therapy",
     "drugTarget": "Selective estrogen receptor degrader (SERD)",
     "targetedTx": "Y",
@@ -2063,7 +2063,7 @@
     "year": "2023",
     "tx": "Enfortumab vedotin + Pembrolizumab",
     "biomarker": "",
-    "agentClass": "Antibody drug conjugate and immune checkpoint inhibitor combination",
+    "agentClass": "Antibody drug conjugate and immune checkpoint inhibitor combination ",
     "drugTarget": "Nectin-4-directed antibody and microtubule inhibitor conjugate + Anti-PD-1 antibody",
     "targetedTx": "Y",
     "pxTx": "N",
@@ -2071,7 +2071,7 @@
   },
   {
     "year": "2023",
-    "tx": "Epcoritamab",
+    "tx": "Epcoritamab ",
     "biomarker": "",
     "agentClass": "Bispecific T-cell engager",
     "drugTarget": "Bispecific CD20-directed CD3 T-cell engager",
@@ -2120,14 +2120,14 @@
     "ngsTest": "Y"
   },
   {
-    "year": "2023",
-    "tx": "Repotrectinib",
-    "biomarker": "ROS1 Fusions",
-    "agentClass": "Small molecule kinase inhibitor",
-    "drugTarget": "Multi-targeted kinase inhibitor (targets include ROS1 and NTRK1/2/3)",
+    "year": "2009",
+    "tx": "Pazopanib",
+    "biomarker": "",
+    "agentClass": "Multikinase inhibitor",
+    "drugTarget": "Multi-targeted tyrosine kinase inhibitor (targets include VEGFR1/2/3, PDGFRɑ/β, KIT, FGFR1/3 among others)",
     "targetedTx": "Y",
-    "pxTx": "Y",
-    "ngsTest": "Y"
+    "pxTx": "N",
+    "ngsTest": "NA"
   },
   {
     "year": "2023",
@@ -2164,14 +2164,14 @@
     "tx": "Eflornithine",
     "biomarker": "",
     "agentClass": "Small molecule inhibitor",
-    "drugTarget": "Ornithine decarboxylase inhibitor",
+    "drugTarget": "Ornithine decarboxylase inhibitor ",
     "targetedTx": "Y",
     "pxTx": "N",
     "ngsTest": "NA"
   },
   {
     "year": "2024",
-    "tx": "Lifileucel",
+    "tx": "Lifileucel ",
     "biomarker": "",
     "agentClass": "Other Immunotherapy",
     "drugTarget": "Tumor-infiltrating lymphocyte therapy",
@@ -2192,7 +2192,7 @@
   {
     "year": "2024",
     "tx": "Tovorafenib",
-    "biomarker": "BRAF Fusions, BRAF Rearrangement, BRAF V600",
+    "biomarker": "BRAF Fusions, BRAF Rearrangement, BRAF V600 ",
     "agentClass": "Small molecule kinase inhibitor",
     "drugTarget": "RAF inhibitor",
     "targetedTx": "Y",
@@ -2238,5 +2238,45 @@
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Lazertinib + Amivantamab",
+    "biomarker": "EGFR L858R, Exon 19 Deletions",
+    "agentClass": "Small molecule kinase inhibitor and monoclonal antibody combination",
+    "drugTarget": "EGFR tyrosine kinase inhibitor + EGFR-MET bispecific antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Inavolisib + Fulvestrant + Palbociclib",
+    "biomarker": "PIK3CA Oncogenic Mutations, HR+/HER2-",
+    "agentClass": "Small molecule inhibitor and hormone therapy combination",
+    "drugTarget": "α-specific PI3K inhibitor + selective estrogen receptor degrader + CDK4/6 inhibitor",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Adagrasib + Cetuximab",
+    "biomarker": "KRAS G12C",
+    "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
+    "drugTarget": "KRAS G12C inhibitor + Anti-EGFR antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Zolbetuximab",
+    "biomarker": "HER2- and CLDN18.2+",
+    "agentClass": "Monoclonal antibody",
+    "drugTarget": "CDLN18.2-directed cytolytic antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "N"
   }
 ]
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx
index ef19144ab..80cfeced0 100644
Binary files a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx and b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx differ