From e04a58c3b521a2b78945c29e5acd605533c3b072 Mon Sep 17 00:00:00 2001
From: John Konecny <24961694+jfkonecn@users.noreply.github.com>
Date: Fri, 18 Oct 2024 14:17:57 -0400
Subject: [PATCH] Update news 4.22

---
 .../webapp/app/components/SimpleTable.tsx     |  47 +++-
 src/main/webapp/app/config/constants.tsx      |   1 +
 .../webapp/app/pages/newsPage/NewsPage.tsx    |   1 +
 .../app/pages/newsPage/NewsPageContent.tsx    | 246 +++++++++++++++++-
 .../oncologyTherapiesPage.tsx                 |   2 +-
 .../fda_approved_oncology_therapies.json      |  40 +++
 .../fda_approved_oncology_therapies.xlsx      | Bin 27189 -> 32281 bytes
 7 files changed, 329 insertions(+), 8 deletions(-)

diff --git a/src/main/webapp/app/components/SimpleTable.tsx b/src/main/webapp/app/components/SimpleTable.tsx
index a419cbe56..dd5afd49f 100644
--- a/src/main/webapp/app/components/SimpleTable.tsx
+++ b/src/main/webapp/app/components/SimpleTable.tsx
@@ -2,7 +2,10 @@ import * as React from 'react';
 import { Table } from 'react-bootstrap';
 
 export type ElementType = JSX.Element | string;
-export type SimpleTableCell = { key: string; content: ElementType };
+export type SimpleTableCell = {
+  key: string;
+  content: ElementType | ElementType[];
+};
 export type SimpleTableRow = { key: string; content: SimpleTableCell[] };
 export type SimpleTableRows = SimpleTableRow[];
 export type SimpleTableColumn = {
@@ -21,8 +24,8 @@ export type SimpleTableProps = {
 export const SimpleTable = (props: SimpleTableProps) => {
   const getRow = (row: SimpleTableRow) => {
     return row.content
-      ? row.content.map(cell => {
-          return <td key={cell.key}>{cell.content}</td>;
+      ? row.content.map(({ key, content }) => {
+          return <td key={key}>{content}</td>;
         })
       : null;
   };
@@ -44,9 +47,41 @@ export const SimpleTable = (props: SimpleTableProps) => {
           </thead>
         )}
         <tbody className={props.tbodyClassName}>
-          {props.rows.map(row => (
-            <tr key={row.key}>{getRow(row)}</tr>
-          ))}
+          {props.rows.flatMap(({ key, content }) => {
+            let maxContentSize = 1;
+            for (const cur of content) {
+              maxContentSize = Array.isArray(cur.content)
+                ? Math.max(cur.content.length, maxContentSize)
+                : maxContentSize;
+            }
+            const elements: JSX.Element[] = [];
+            for (let i = 0; i < maxContentSize; i++) {
+              const element = (
+                <tr key={`${key}_${i}`}>
+                  {content.map(({ content: innerContent, key: innerKey }) => {
+                    if (Array.isArray(innerContent)) {
+                      return <td key={innerKey}>{innerContent[i]}</td>;
+                    } else if (i === 0) {
+                      return (
+                        <td
+                          key={innerKey}
+                          rowSpan={
+                            maxContentSize > 1 ? maxContentSize : undefined
+                          }
+                        >
+                          {innerContent}
+                        </td>
+                      );
+                    } else {
+                      return <></>;
+                    }
+                  })}
+                </tr>
+              );
+              elements.push(element);
+            }
+            return elements;
+          })}
         </tbody>
       </Table>
     </div>
diff --git a/src/main/webapp/app/config/constants.tsx b/src/main/webapp/app/config/constants.tsx
index 9bf39edae..cc4c89eb8 100644
--- a/src/main/webapp/app/config/constants.tsx
+++ b/src/main/webapp/app/config/constants.tsx
@@ -821,6 +821,7 @@ export type DataRelease = {
 };
 
 export const DATA_RELEASES: DataRelease[] = [
+  { date: '10232024', version: 'v4.22' },
   { date: '09252024', version: 'v4.21' },
   { date: '08152024', version: 'v4.20' },
   { date: '07042024', version: 'v4.19' },
diff --git a/src/main/webapp/app/pages/newsPage/NewsPage.tsx b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
index c172f5ba5..560f57819 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPage.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPage.tsx
@@ -87,6 +87,7 @@ export default class NewsPage extends React.Component<{
           <CitationText />
         </div>
         <div className="mt-2">
+          <NewsList date={'10232024'} />
           <NewsList date={'09252024'} />
           <NewsList date={'08152024'} />
           <NewsList date={'07042024'} />
diff --git a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
index 4465b1546..956a7383e 100644
--- a/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
+++ b/src/main/webapp/app/pages/newsPage/NewsPageContent.tsx
@@ -46,7 +46,7 @@ import { AnnotationColumnHeaderType } from './ChangedAnnotationListItem';
 import { linkableMutationName, convertGeneInputToLinks } from './Util';
 
 export type ChangedAnnotation = {
-  content: ElementType[][];
+  content: (ElementType | ElementType[])[][];
   title?: string;
   columnHeaderType?: AnnotationColumnHeaderType;
   headers?: { name: string }[];
@@ -300,6 +300,250 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
 // https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
 
 export const NEWS_BY_DATE: { [date: string]: NewsData } = {
+  '10232024': {
+    priorityNews: [
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.CDX}>
+          "FDA Cleared or Approved Companion Diagnostic Devices"
+        </Link>{' '}
+        (CDx) page
+      </span>,
+      <span>
+        Update to our{' '}
+        <Link to={PAGE_ROUTE.ONCOLOGY_TX}>
+          "FDA-Approved Oncology Therapies"
+        </Link>{' '}
+        page
+      </span>,
+    ],
+    changedAnnotations: [
+      {
+        columnHeaderType: AnnotationColumnHeaderType.NEW_ALTERATION_WITH_LEVEL,
+        content: [
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'G2032R')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+
+            ['Taletrectinib', 'Crizotinib, Lorlatinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="38822758, 31399568" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink
+                  wrapText
+                  pmids="33685866, 29333528, 23724914, 36135089, 36135089, 32918045"
+                />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            ['3A', 'R2'],
+            'ROS1',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('ROS1', 'L2086F')}
+            </WithSeparator>,
+            'Non-Small Cell Lung Cancer',
+            ['Cabozantinib', 'Lorlatinib, Repotrectinib'],
+            [
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="33685866, 37291202, 39117775, 39091594" />
+              </WithSeparator>,
+              <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+                <PMIDLink pmids="37291202, 33685866, 39091594" />
+              </WithSeparator>,
+            ],
+          ],
+          [
+            '3A',
+            'SMARCA4',
+            'Oncogenic Mutations',
+            'Non-Small Cell Lung Cancer, Esophageal Adenocarcinoma',
+            'PRT3789',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Guo, R. et al., Abstract# 603O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02189-6/fulltext"
+              />
+              <AbstractLink
+                abstract="Hulse, M. et al., Abstract# 3263, AACR 2022"
+                link="https://aacrjournals.org/cancerres/article/82/12_Supplement/3263/703325/Abstract-3263-Preclinical-characterization-of"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        useOneLineRowClass: false,
+        title:
+          'Updated therapeutic implications - Promotion of tumor type-specific level of evidence for an alteration(s)',
+        headers: CHANGED_ANNOTATION_LEVEL_WITH_EVIDENCE_COLUMNS,
+        content: [
+          [
+            'PIK3CA',
+            <>
+              <AlterationPageLink
+                hugoSymbol="PIK3CA"
+                alteration="Oncogenic Mutations"
+              />{' '}
+              <span>
+                (excluding R88Q, N345K, C420R, E542K, E545A/D/G/K/Q,
+                Q546E/K/R/P, M1043V/I, H1047Y/R/L, G1049R which are already
+                Level 1)
+              </span>
+            </>,
+            'Breast Cancer',
+            <div>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_CURRENTLY_IN_ONCOKB}:
+              </div>
+              <div>
+                Alpelisib + Fulvestrant, Capivasertib + Fulvestrant (Level 2);
+                Inavolisib + Palbociclib + Fulvestrant
+              </div>
+              <br></br>
+              <div>(Level 3A)</div>
+              <div style={{ fontStyle: 'italic' }}>
+                {DRUGS_PROMOTED_IN_ONCOKB}:
+              </div>
+              <div>Inavolisib + Palbociclib + Fulvestrant (Level 1)</div>
+            </div>,
+            '2',
+            '1',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib with Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+      {
+        columnHeaderType: AnnotationColumnHeaderType.UPDATED_SAME_LEVEL_DRUG,
+        content: [
+          [
+            '1',
+            'EGFR',
+            <>
+              <AlterationPageLink
+                hugoSymbol="EGFR"
+                alteration={'Exon 19 in-frame deletions'}
+              />
+              , <AlterationPageLink hugoSymbol="EGFR" alteration={'L858R'} />
+            </>,
+            'Non-Small Cell Lung Cancer',
+            'Afatinib, Dacomitinib, Erlotinib, Erlotinib + Ramucirumab, Gefitinib, Osimertinib, Osimertinib + Chemotherapy, Amivantamab + Lazertinib (Level 1); Amivantamab + Chemotherapy (Level 2); Patritumab Deruxtecan (Level 3A)',
+            'Amivantamab + Chemotherapy (Level 1)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Amivantamab with Chemotherapy"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-amivantamab-vmjw-carboplatin-and-pemetrexed-non-small-cell-lung-cancer-egfr-exon-19"
+              />
+              <PMIDLink pmids="37879444" />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'PIK3CA',
+            <WithSeparator separator={', '}>
+              {getAlternativeAllelesPageLinks('PIK3CA', 'R88Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'N345K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'C420R')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E542K')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'E545A/D/G/K/Q')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'Q546E/K/R/P')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'M1043V/I')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'H1047Y/R/L')}
+              {getAlternativeAllelesPageLinks('PIK3CA', 'G1049R')}
+            </WithSeparator>,
+            'Breast Cancer',
+            'Capivasertib + Fulvestrant (Level 1); Alpelisib + Fulvestrant (Level 1 for PIK3CA C420R, E542K, E545A/D/G/K, H1047Y/R/L, Q546E/R only)',
+            'Inavolisib + Palbociclib + Fulvestrant (Level 1; Promoted from Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <FdaApprovalLink
+                approval="Inavolisib with Palbociclib + Fulvestrant"
+                link="https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-inavolisib-palbociclib-and-fulvestrant-endocrine-resistant-pik3ca-mutated-hr-positive"
+              />
+              <AbstractLink
+                abstract="Jhaveri, K. et al., Abstract# GS03-13, SABCS 2023"
+                link="https://medically.gene.com/global/en/unrestricted/oncology/SABCS-2023/sabcs-2023-presentation-jhaveri-inavolisib-or-placebo-i.html"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ALK',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            'Alectinib, Brigatinib, Certinib, Crizotinib, Lorlatinib (Level 1) ',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024 "
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '1',
+            'ROS1',
+            'Fusions',
+            'Non-Small Cell Lung Cancer',
+            'Crizotinib, Entrectinib, Repotrectinib (Level 1); Ceritinib, Lorlatinib (Level 2)',
+            'Taletrectinib (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="38822758, 36877099, 31399568" />
+            </WithSeparator>,
+          ],
+          [
+            '2',
+            'ALK',
+            'G1202R',
+            'Non-Small Cell Lung Cancer',
+            'Lorlatinib (Level 2)',
+            'NVL-655 (Level 3A)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <PMIDLink pmids="39269178" />
+              <AbstractLink
+                abstract="Drilon, A. et al., Abstract# 1253O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02829-1/fulltext"
+              />
+            </WithSeparator>,
+          ],
+          [
+            '3A',
+            'KRAS',
+            'G12D',
+            'Non-Small Cell Lung Cancer, Pancreatic Adenocarcinoma',
+            'RMC-6236 (Level 3A)',
+            'ASP3082 (Level 3A; Promoted from Level 4)',
+            <WithSeparator separator={EVIDENCE_COLUMN_SEPARATOR}>
+              <AbstractLink
+                abstract="Park, W. et al., Abstract# 608O, ESMO 2024"
+                link="https://www.annalsofoncology.org/article/S0923-7534(24)02194-X/fulltext"
+              />
+              <AbstractLink
+                abstract="Nagashima, T. et al., Abstract# 5735, AACR 2023"
+                link="https://aacrjournals.org/cancerres/article/83/7_Supplement/5735/722276"
+              />
+            </WithSeparator>,
+          ],
+        ],
+      },
+    ],
+    newlyAddedGenes: ['ADARB2', 'BUB1B', 'CCN6', 'CDKN1C', 'EGR2'],
+  },
   '09252024': {
     changedAnnotations: [
       {
diff --git a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
index 26572e33e..af1bfbffd 100644
--- a/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
+++ b/src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx
@@ -486,7 +486,7 @@ const OncologyTherapiesPage: React.FunctionComponent<{}> = props => {
                 'https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications'
               }
             >
-              Content current as of 8/5/2024
+              Content current as of 10/21/2024
             </Linkout>
           </div>
           <div>
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
index 4bac79214..1e1f288d0 100644
--- a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
+++ b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json
@@ -2238,5 +2238,45 @@
     "targetedTx": "Y",
     "pxTx": "Y",
     "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Lazertinib + Amivantamab",
+    "biomarker": "EGFR L858R, Exon 19 Deletions",
+    "agentClass": "Small molecule kinase inhibitor and monoclonal antibody combination",
+    "drugTarget": "EGFR tyrosine kinase inhibitor + EGFR-MET bispecific antibody ",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Inavolisib + Fulvestrant + Palbociclib",
+    "biomarker": "PIK3CA Oncogenic Mutations, HR+/HER2-",
+    "agentClass": "Small molecule inhibitor and hormone therapy combination",
+    "drugTarget": "α-specific PI3K inhibitor + selective estrogen receptor degrader + CDK4/6 inhibitor ",
+    "targetedTx": "Y",
+    "pxTx": "Y ",
+    "ngsTest": "Y "
+  },
+  {
+    "year": "2024",
+    "tx": "Adagrasib + Cetuximab",
+    "biomarker": "KRAS G12C",
+    "agentClass": "Small molecule inhibitor and monoclonal antibody combination",
+    "drugTarget": "KRAS G12C inhibitor + Anti-EGFR antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "Y"
+  },
+  {
+    "year": "2024",
+    "tx": "Zolbetuximab",
+    "biomarker": "HER2- and CLDN18.2+",
+    "agentClass": "Monoclonal antibody",
+    "drugTarget": "CDLN18.2-directed cytolytic antibody",
+    "targetedTx": "Y",
+    "pxTx": "Y",
+    "ngsTest": "N"
   }
 ]
diff --git a/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx b/src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx
index ef19144ab340abd129819d1e79510b610173d3cd..f702095f505fe18d3a213be73111bd4ed1f9a1ab 100644
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