diff --git a/pkg/controllers/provisioning/scheduling/queue.go b/pkg/controllers/provisioning/scheduling/queue.go
index d2a98a822f..c1a506211c 100644
--- a/pkg/controllers/provisioning/scheduling/queue.go
+++ b/pkg/controllers/provisioning/scheduling/queue.go
@@ -22,6 +22,7 @@ import (
 	v1 "k8s.io/api/core/v1"
 	"k8s.io/apimachinery/pkg/types"
 
+	"sigs.k8s.io/karpenter/pkg/utils/pod"
 	"sigs.k8s.io/karpenter/pkg/utils/resources"
 )
 
@@ -96,6 +97,15 @@ func byCPUAndMemoryDescending(pods []*v1.Pod) func(i int, j int) bool {
 			return true
 		}
 
+		// anti-affinity pods should be sorted before normal pods
+		if affinityCmp := pod.PodAffinityCmp(lhsPod, rhsPod); affinityCmp != 0 {
+			return affinityCmp > 0
+		}
+
+		if len(lhsPod.Spec.TopologySpreadConstraints) != len(rhsPod.Spec.TopologySpreadConstraints) {
+			return len(lhsPod.Spec.TopologySpreadConstraints) > len(rhsPod.Spec.TopologySpreadConstraints)
+		}
+
 		// If all else is equal, give a consistent ordering. This reduces the number of NominatePod events as we
 		// de-duplicate those based on identical content.
 
diff --git a/pkg/utils/pod/scheduling.go b/pkg/utils/pod/scheduling.go
index 139df8e634..3daf108282 100644
--- a/pkg/utils/pod/scheduling.go
+++ b/pkg/utils/pod/scheduling.go
@@ -198,3 +198,38 @@ func HasPodAntiAffinity(pod *corev1.Pod) bool {
 		(len(pod.Spec.Affinity.PodAntiAffinity.RequiredDuringSchedulingIgnoredDuringExecution) != 0 ||
 			len(pod.Spec.Affinity.PodAntiAffinity.PreferredDuringSchedulingIgnoredDuringExecution) != 0)
 }
+
+// PodAffinityCmp compares two pods based on their affinity
+func PodAffinityCmp(lhsPod *corev1.Pod, rhsPod *corev1.Pod) int {
+	if lhsPod.Spec.Affinity != nil && rhsPod.Spec.Affinity != nil {
+		if HasRequiredPodAntiAffinity(lhsPod) && !HasRequiredPodAntiAffinity(rhsPod) {
+			return 1
+		} else if !HasRequiredPodAntiAffinity(lhsPod) && HasRequiredPodAntiAffinity(rhsPod) {
+			return -1
+		} else if HasRequiredPodAntiAffinity(lhsPod) && HasRequiredPodAntiAffinity(rhsPod) {
+			return PodAntiAffinityCmp(lhsPod, rhsPod)
+		}
+	}
+
+	return 0
+}
+
+// PodAntiAffinityCmp compares two pods based on their the size of their anti-affinity constraints
+func PodAntiAffinityCmp(lhsPod *corev1.Pod, rhsPod *corev1.Pod) int {
+	lPodAntiAffinity := lhsPod.Spec.Affinity.PodAntiAffinity
+	rPodAntiAffinity := rhsPod.Spec.Affinity.PodAntiAffinity
+	if len(lPodAntiAffinity.RequiredDuringSchedulingIgnoredDuringExecution) > len(rPodAntiAffinity.RequiredDuringSchedulingIgnoredDuringExecution) {
+		return 1
+	} else if len(lPodAntiAffinity.RequiredDuringSchedulingIgnoredDuringExecution) <
+		len(rPodAntiAffinity.RequiredDuringSchedulingIgnoredDuringExecution) {
+		return -1
+	}
+
+	if len(lPodAntiAffinity.PreferredDuringSchedulingIgnoredDuringExecution) > len(rPodAntiAffinity.PreferredDuringSchedulingIgnoredDuringExecution) {
+		return 1
+	} else if len(lPodAntiAffinity.PreferredDuringSchedulingIgnoredDuringExecution) < len(rPodAntiAffinity.PreferredDuringSchedulingIgnoredDuringExecution) {
+		return -1
+	}
+
+	return 0
+}