diff --git a/requirements/main.in b/requirements/main.in
index 5e2b8613f0ba..3e7cd1509695 100644
--- a/requirements/main.in
+++ b/requirements/main.in
@@ -51,7 +51,7 @@ redis>=2.8.0,<5.0.0
 rfc3986
 sentry-sdk
 setuptools
-sqlalchemy[asyncio]>=0.9,<1.5.0  # https://github.com/pypa/warehouse/pull/9228
+sqlalchemy[asyncio]>=0.9,<2.1.0  # https://github.com/pypa/warehouse/pull/9228
 sqlalchemy-citext
 sqlalchemy-utils
 stdlib-list
diff --git a/requirements/main.txt b/requirements/main.txt
index 64ec7df99c12..470df27031ee 100644
--- a/requirements/main.txt
+++ b/requirements/main.txt
@@ -1089,43 +1089,47 @@ six==1.16.0 \
     #   python-dateutil
     #   requests-aws4auth
     #   sqlalchemy-utils
-sqlalchemy[asyncio]==1.4.31 \
-    --hash=sha256:05fa14f279d43df68964ad066f653193187909950aa0163320b728edfc400167 \
-    --hash=sha256:0ddc5e5ccc0160e7ad190e5c61eb57560f38559e22586955f205e537cda26034 \
-    --hash=sha256:15a03261aa1e68f208e71ae3cd845b00063d242cbf8c87348a0c2c0fc6e1f2ac \
-    --hash=sha256:289465162b1fa1e7a982f8abe59d26a8331211cad4942e8031d2b7db1f75e649 \
-    --hash=sha256:2e216c13ecc7fcdcbb86bb3225425b3ed338e43a8810c7089ddb472676124b9b \
-    --hash=sha256:2fd4d3ca64c41dae31228b80556ab55b6489275fb204827f6560b65f95692cf3 \
-    --hash=sha256:330eb45395874cc7787214fdd4489e2afb931bc49e0a7a8f9cd56d6e9c5b1639 \
-    --hash=sha256:3c7ed6c69debaf6198fadb1c16ae1253a29a7670bbf0646f92582eb465a0b999 \
-    --hash=sha256:4ad31cec8b49fd718470328ad9711f4dc703507d434fd45461096da0a7135ee0 \
-    --hash=sha256:57205844f246bab9b666a32f59b046add8995c665d9ecb2b7b837b087df90639 \
-    --hash=sha256:582b59d1e5780a447aada22b461e50b404a9dc05768da1d87368ad8190468418 \
-    --hash=sha256:5e9c7b3567edbc2183607f7d9f3e7e89355b8f8984eec4d2cd1e1513c8f7b43f \
-    --hash=sha256:6a01ec49ca54ce03bc14e10de55dfc64187a2194b3b0e5ac0fdbe9b24767e79e \
-    --hash=sha256:6f22c040d196f841168b1456e77c30a18a3dc16b336ddbc5a24ce01ab4e95ae0 \
-    --hash=sha256:81f2dd355b57770fdf292b54f3e0a9823ec27a543f947fa2eb4ec0df44f35f0d \
-    --hash=sha256:85e4c244e1de056d48dae466e9baf9437980c19fcde493e0db1a0a986e6d75b4 \
-    --hash=sha256:8d0949b11681380b4a50ac3cd075e4816afe9fa4a8c8ae006c1ca26f0fa40ad8 \
-    --hash=sha256:975f5c0793892c634c4920057da0de3a48bbbbd0a5c86f5fcf2f2fedf41b76da \
-    --hash=sha256:9e4fb2895b83993831ba2401b6404de953fdbfa9d7d4fa6a4756294a83bbc94f \
-    --hash=sha256:b35dca159c1c9fa8a5f9005e42133eed82705bf8e243da371a5e5826440e65ca \
-    --hash=sha256:b7b20c88873675903d6438d8b33fba027997193e274b9367421e610d9da76c08 \
-    --hash=sha256:bb4b15fb1f0aafa65cbdc62d3c2078bea1ceecbfccc9a1f23a2113c9ac1191fa \
-    --hash=sha256:c0c7171aa5a57e522a04a31b84798b6c926234cb559c0939840c3235cf068813 \
-    --hash=sha256:c317ddd7c586af350a6aef22b891e84b16bff1a27886ed5b30f15c1ed59caeaa \
-    --hash=sha256:c3abc34fed19fdeaead0ced8cf56dd121f08198008c033596aa6aae7cc58f59f \
-    --hash=sha256:ca68c52e3cae491ace2bf39b35fef4ce26c192fd70b4cd90f040d419f70893b5 \
-    --hash=sha256:cf2cd387409b12d0a8b801610d6336ee7d24043b6dd965950eaec09b73e7262f \
-    --hash=sha256:d046a9aeba9bc53e88a41e58beb72b6205abb9a20f6c136161adf9128e589db5 \
-    --hash=sha256:d5c20c8415173b119762b6110af64448adccd4d11f273fb9f718a9865b88a99c \
-    --hash=sha256:d86132922531f0dc5a4f424c7580a472a924dd737602638e704841c9cb24aea2 \
-    --hash=sha256:dccff41478050e823271642837b904d5f9bda3f5cf7d371ce163f00a694118d6 \
-    --hash=sha256:de85c26a5a1c72e695ab0454e92f60213b4459b8d7c502e0be7a6369690eeb1a \
-    --hash=sha256:e3a86b59b6227ef72ffc10d4b23f0fe994bef64d4667eab4fb8cd43de4223bec \
-    --hash=sha256:e79e73d5ee24196d3057340e356e6254af4d10e1fc22d3207ea8342fc5ffb977 \
-    --hash=sha256:ea8210090a816d48a4291a47462bac750e3bc5c2442e6d64f7b8137a7c3f9ac5 \
-    --hash=sha256:f3b7ec97e68b68cb1f9ddb82eda17b418f19a034fa8380a0ac04e8fe01532875
+sqlalchemy[asyncio]==2.0.5.post1 \
+    --hash=sha256:03cd5709839fc376538f102c58f632d48bd0b92715bd290c3b2c066e0dd0f214 \
+    --hash=sha256:0433abeb650c72c872e31010bff8536907fb05f6fa29a9b880046570c03383ca \
+    --hash=sha256:059ddd4ddbfb8f1c872d601b168273dfaab0eae458736c7c754187b9a8e92ad5 \
+    --hash=sha256:1012c0440108c360b94f43667525365c43516e8c7f1f7de8dfb73471181055df \
+    --hash=sha256:13eb2a5882cfd9f4eedaaec14a5603a096f0125f7c3cb48611b3bfa3c253f25d \
+    --hash=sha256:15c92107437770087ad4fece6ed9553ab97474f3b92d15eb62cea9686228f252 \
+    --hash=sha256:1edb6621782f9a3e80750ba1859580b778a424242d4e6b9bcd46fa6beca75c12 \
+    --hash=sha256:22f60d214899b573edc8aeb9ba84f7e832505511ce68974636e6da4a27c957a3 \
+    --hash=sha256:2bffc27ec0386ef4af7c8923f0f809f88671859b907c9e11f000c39b97195e99 \
+    --hash=sha256:2c3869a7bdd5bb76fb50976abe339e30cce8e9f7c778a50811d310ec82cdf51a \
+    --hash=sha256:3c4e673da09af37b7a5c13b947fdb387c3800d43dcd86c1d553e3c70369e4749 \
+    --hash=sha256:4756878d0ceb6e0e9c6cfcfaa9df81adbfcca8cc4b9ec37934918008c0f20507 \
+    --hash=sha256:50b15fce441b8eb13bfd06df1088aa52c9a3d72d4894e3456040857d48a622da \
+    --hash=sha256:56d38c3638965df5257ac4648ba2887aaf1e3409397192dd85ddfe7b96dc7680 \
+    --hash=sha256:5c00d2b3607f9ae5c0827ebb2d01020c26cfce4064aa664db21d1fd6a47f8f60 \
+    --hash=sha256:621e92ace804e19da2e472e349736d7ba5e2e4a14d41c4de9e2474e5f40a11ed \
+    --hash=sha256:68c4c5ab13997fa7af37d5780da11ddc184d4e88fb2d8a26525044c233f03bc7 \
+    --hash=sha256:6df48bb7af217fd086617aae1f9606ff91cfab9a29c3e77dd80e4bab8aaf29fc \
+    --hash=sha256:72e8d65b20147df71297d863981d8e56e429a8ae2bb835bd5e89efd7ef849866 \
+    --hash=sha256:744b01fcdfef66b7373262bf75d714a4339f85c05b74b1732749f25ed65f33f6 \
+    --hash=sha256:7e33867e09820c98630f7faec535a8cc4116fd362787404b41883d373437290b \
+    --hash=sha256:7fab3d4062472e1e6002bfcd53cc7446189941be083a5465760aa794092004ee \
+    --hash=sha256:7fe933831e17f93947b4e3db4e4a7470dae24340f269baf06cdfcc0538c8d1cb \
+    --hash=sha256:869ca02661f6d4cece5823997a364dfa97601de11151fca3ebc3429eb9ffa2e0 \
+    --hash=sha256:8e7d5766fb99743eb70126daaff45f43bee3f4b79ba6047a0749912e8538f0ff \
+    --hash=sha256:9a4d9a7e9b344bf8ce2ed699baa8a43d9fbdad3aecff259f1d0daf6bb2e7e0c0 \
+    --hash=sha256:9bb63e22ddf01cbbb290e61f31471480d2e40283e558cdd924b94dc4fc2e186b \
+    --hash=sha256:a7e55659740e768a1bf1257275b565137a3d28839789c85193dd6a1e642b3cc9 \
+    --hash=sha256:ac12d8bef707d02ef179f0586c848db2954668dca2b72c69df950e08dc8cddb4 \
+    --hash=sha256:b21694c8543becc2bc4f05f8d07970860e6ad005024712b7195abb1f4e0daf47 \
+    --hash=sha256:b52be78c5e86ade646c82a10b2be4b6ed8f623052b4405b26681880df1a15d5a \
+    --hash=sha256:c12f0455f30d637644f4d6df2bda1475c61398483edb58d55c670be31a31d549 \
+    --hash=sha256:c2c41bf05b4cf4ffead35896affa3b457c17755d0fd83b1ba72f7f55abb3a3f1 \
+    --hash=sha256:d6cb241c5c1af422c0fa742bd09a8eaf158da1433617ded1ffcbb56de6ff8047 \
+    --hash=sha256:d811b97f58d99e5948752087903cb414fd77a60a5e09293be16c924219178c3b \
+    --hash=sha256:d81b2fa605939c437f8b0b8522ec2c19508f3036d6043cb70a15dd56760ab710 \
+    --hash=sha256:e13cea675937125417953fd011138f13cf979051567f48074fffb3bb0b64b917 \
+    --hash=sha256:e40c39cfcbe416a7722a226ecd98fad0e08f8ae33e8f94b0858afe094583bfbc \
+    --hash=sha256:f53542654124d30a3c3ebff9f99e5749add75e4cf28895a2ca6cd1458039bd8f \
+    --hash=sha256:ffda70373ddfe8ec733d518e4e41eb5599480d48e8496c44bb0cac0e37b281c0
     # via
     #   -r requirements/main.in
     #   alembic
@@ -1177,10 +1181,12 @@ typeguard==2.13.3 \
     --hash=sha256:00edaa8da3a133674796cf5ea87d9f4b4c367d77476e185e80251cc13dfbb8c4 \
     --hash=sha256:5e3e3be01e887e7eafae5af63d1f36c849aaa94e3a0112097312aabfa16284f1
     # via -r requirements/main.in
-typing-extensions==4.1.1 \
-    --hash=sha256:1a9462dcc3347a79b1f1c0271fbe79e844580bb598bafa1ed208b94da3cdcd42 \
-    --hash=sha256:21c85e0fe4b9a155d0799430b0ad741cdce7e359660ccbd8b530613e8df88ce2
-    # via pydantic
+typing-extensions==4.5.0 \
+    --hash=sha256:5cb5f4a79139d699607b3ef622a1dedafa84e115ab0024e0d9c044a9479ca7cb \
+    --hash=sha256:fb33085c39dd998ac16d1431ebc293a8b3eedd00fd4a32de0ff79002c19511b4
+    # via
+    #   pydantic
+    #   sqlalchemy
 urllib3==1.26.8 \
     --hash=sha256:000ca7f471a233c2251c6c7023ee85305721bfdf18621ebff4fd17a8653427ed \
     --hash=sha256:0e7c33d9a63e7ddfcb86780aac87befc2fbddf46c58dbb487e0855f7ceec283c