diff --git a/anvio/docs/programs/anvi-draw-kegg-pathways.md b/anvio/docs/programs/anvi-draw-kegg-pathways.md index a9d2cd48c..ff3effee0 100644 --- a/anvio/docs/programs/anvi-draw-kegg-pathways.md +++ b/anvio/docs/programs/anvi-draw-kegg-pathways.md @@ -198,7 +198,7 @@ Below is the `Global metabolism` map using the same species groups with threshol ![Global metabolism group maps using two group thresholds](../../images/anvi-draw-kegg-pathways/kos_db_groups_global.png) -Exploring the `Folate biosynthesis` map given the observation regarding cofactors in the global map, all *faecalis* genomes have a full set of enzymes required for folate biosynthesis, whereas all *faecium* genomes appear to be missing a big chunk of the pathway in the center of the map, from `7,8-Dihydroneopterin 3'-3P` to `7,8-Dihydropteroate`. The implication of folate auxotropy in *faecium* is confirmed by Ramsey, Hartke, and Huycke in ["The Physiology and Metabolism of Enterococci"](https://www.ncbi.nlm.nih.gov/books/NBK190432/): "Characteristically, *E. faecium* requires folate while *E. faecalis* does not." +Exploring the `Folate biosynthesis` map given the observation regarding cofactors in the global map, all *faecalis* genomes have a full set of enzymes required for folate biosynthesis, whereas all *faecium* genomes appear to be missing a big chunk of the pathway in the center of the map, from `7,8-Dihydroneopterin 3'-3P` to `7,8-Dihydropteroate`. The implication of folate auxotropy in *faecium* is confirmed by Ramsey, Hartke, and Huycke in [The Physiology and Metabolism of Enterococci](https://www.ncbi.nlm.nih.gov/books/NBK190432/): "Characteristically, *E. faecium* requires folate while *E. faecalis* does not." ![Folate metabolism group maps using two group thresholds](../../images/anvi-draw-kegg-pathways/kos_db_groups_folate.png)