diff --git a/src/ontology/mp-edit.owl b/src/ontology/mp-edit.owl
index bb897610..73ed6705 100644
--- a/src/ontology/mp-edit.owl
+++ b/src/ontology/mp-edit.owl
@@ -11840,6 +11840,11 @@ Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014526>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014527>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014528>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014529>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014530>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014531>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014532>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014533>))
+Declaration(Class(<http://purl.obolibrary.org/obo/MP_0014534>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0020000>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0020001>))
 Declaration(Class(<http://purl.obolibrary.org/obo/MP_0020002>))
@@ -52952,6 +52957,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0003977> "abnormal circulating carnitine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0003977> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17126> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0003977> <http://purl.obolibrary.org/obo/MP_0005311>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0003977> <http://purl.obolibrary.org/obo/MP_0021132>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0003978> (decreased circulating carnitine level)
 
@@ -52962,6 +52968,8 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0003978> "decreased circulating carnitine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0003978> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17126> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0003978> <http://purl.obolibrary.org/obo/MP_0003977>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0003978> <http://purl.obolibrary.org/obo/MP_0014531>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0003978> <http://purl.obolibrary.org/obo/MP_0021134>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0003979> (increased circulating carnitine level)
 
@@ -52971,6 +52979,8 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0003979> "increased circulating carnitine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0003979> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17126> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0003979> <http://purl.obolibrary.org/obo/MP_0003977>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0003979> <http://purl.obolibrary.org/obo/MP_0014530>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0003979> <http://purl.obolibrary.org/obo/MP_0021133>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0003980> (increased circulating phospholipid level)
 
@@ -69487,6 +69497,7 @@ AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0005553> "incr
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0005553> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16737> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0005553> <http://purl.obolibrary.org/obo/MP_0005328>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0005553> <http://purl.obolibrary.org/obo/MP_0009644>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0005553> <http://purl.obolibrary.org/obo/MP_0014530>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0005554> (decreased circulating creatinine level)
 
@@ -69501,6 +69512,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#inSubset> <htt
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0005554> "decreased circulating creatinine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0005554> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16737> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0005554> <http://purl.obolibrary.org/obo/MP_0005328>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0005554> <http://purl.obolibrary.org/obo/MP_0014531>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0005556> (abnormal renal filtration rate)
 
@@ -99990,7 +100002,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0010060> "MP:0010060")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0010060> "abnormal creatine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0010060> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> <http://purl.obolibrary.org/obo/CHEBI_16919>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
-SubClassOf(<http://purl.obolibrary.org/obo/MP_0010060> <http://purl.obolibrary.org/obo/MP_0005332>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0010060> <http://purl.obolibrary.org/obo/MP_0021145>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0010061> (increased creatine level)
 
@@ -100006,7 +100018,6 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0010061> "increased creatine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0010061> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> <http://purl.obolibrary.org/obo/CHEBI_16919>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0010061> <http://purl.obolibrary.org/obo/MP_0010060>)
-SubClassOf(<http://purl.obolibrary.org/obo/MP_0010061> <http://purl.obolibrary.org/obo/MP_0014527>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0010062> (decreased creatine level)
 
@@ -100025,7 +100036,6 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0010062> "decreased creatine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0010062> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> <http://purl.obolibrary.org/obo/CHEBI_16919>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0010062> <http://purl.obolibrary.org/obo/MP_0010060>)
-SubClassOf(<http://purl.obolibrary.org/obo/MP_0010062> <http://purl.obolibrary.org/obo/MP_0014528>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0010063> (abnormal circulating creatine level)
 
@@ -100039,7 +100049,6 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0010063> "MP:0010063")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0010063> "abnormal circulating creatine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0010063> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16919> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
-SubClassOf(<http://purl.obolibrary.org/obo/MP_0010063> <http://purl.obolibrary.org/obo/MP_0005311>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0010063> <http://purl.obolibrary.org/obo/MP_0010060>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0010064> (increased circulating creatine level)
@@ -116890,6 +116899,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0011230> "abnormal folic acid level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0011230> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> <http://purl.obolibrary.org/obo/CHEBI_27470>) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0011230> <http://purl.obolibrary.org/obo/MP_0005400>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0011230> <http://purl.obolibrary.org/obo/MP_0021145>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0011231> (abnormal vitamin E level)
 
@@ -123074,6 +123084,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0011652> "increased circulating histidine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0011652> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_27570> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0011652> <http://purl.obolibrary.org/obo/MP_0011651>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0011652> <http://purl.obolibrary.org/obo/MP_0014530>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0011653> (decreased circulating histidine level)
 
@@ -123087,6 +123098,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0011653> "decreased circulating histidine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0011653> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_27570> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0011653> <http://purl.obolibrary.org/obo/MP_0011651>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0011653> <http://purl.obolibrary.org/obo/MP_0014531>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0011654> (histidinuria)
 
@@ -132395,6 +132407,7 @@ AnnotationAssertion(rdfs:comment <http://purl.obolibrary.org/obo/MP_0012334> "A
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0012334> "decreased circulating homocysteine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0012334> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17230> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0012334> <http://purl.obolibrary.org/obo/MP_0006076>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0012334> <http://purl.obolibrary.org/obo/MP_0014531>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0012335> (increased circulating homocysteine level)
 
@@ -132410,6 +132423,7 @@ AnnotationAssertion(rdfs:comment <http://purl.obolibrary.org/obo/MP_0012335> "A
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0012335> "increased circulating homocysteine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0012335> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17230> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0012335> <http://purl.obolibrary.org/obo/MP_0006076>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0012335> <http://purl.obolibrary.org/obo/MP_0014530>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0012336> (decreased vitamin D level)
 
@@ -146578,6 +146592,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0013723> "increased circulating tyrosine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0013723> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18186> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0013723> <http://purl.obolibrary.org/obo/MP_0013722>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0013723> <http://purl.obolibrary.org/obo/MP_0014530>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0013724> (decreased circulating tyrosine level)
 
@@ -146587,6 +146602,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0013724> "decreased circulating tyrosine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0013724> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18186> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0013724> <http://purl.obolibrary.org/obo/MP_0013722>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0013724> <http://purl.obolibrary.org/obo/MP_0014531>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0013725> (abnormal mammary gland cord morphology)
 
@@ -154587,6 +154603,64 @@ EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0014529> ObjectSomeValuesFr
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0014529> <http://purl.obolibrary.org/obo/MP_0014528>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0014529> <http://purl.obolibrary.org/obo/MP_0030729>)
 
+# Class: <http://purl.obolibrary.org/obo/MP_0014530> (increased circulating amino acid level)
+
+AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "CHEBI:33709") <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0014530> "increase in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/MP_0014530> <https://orcid.org/0000-0003-4606-0597>)
+AnnotationAssertion(<http://purl.org/dc/terms/date> <http://purl.obolibrary.org/obo/MP_0014530> "2024-08-08T14:40:52Z"^^xsd:dateTime)
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/MP_0014530> "elevated circulating amino acid level")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0014530> "MP:0014530")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0014530> "increased circulating amino acid level")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0014530> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014530> <http://purl.obolibrary.org/obo/MP_0005311>)
+
+# Class: <http://purl.obolibrary.org/obo/MP_0014531> (decreased circulating amino acid level)
+
+AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "CHEBI:33709") <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0014531> "reduction in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/MP_0014531> <https://orcid.org/0000-0003-4606-0597>)
+AnnotationAssertion(<http://purl.org/dc/terms/date> <http://purl.obolibrary.org/obo/MP_0014531> "2024-08-08T14:41:10Z"^^xsd:dateTime)
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/MP_0014531> "reduced circulating amino acid level")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0014531> "MP:0014531")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0014531> "decreased circulating amino acid level")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0014531> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_33709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014531> <http://purl.obolibrary.org/obo/MP_0005311>)
+
+# Class: <http://purl.obolibrary.org/obo/MP_0014532> (decreased circulating glutathione level)
+
+AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "CHEBI:16856") <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0014532> "reduction in the amount per unit of blood of glutathione, a tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/MP_0014532> <https://orcid.org/0000-0003-4606-0597>)
+AnnotationAssertion(<http://purl.org/dc/terms/date> <http://purl.obolibrary.org/obo/MP_0014532> "2024-08-08T14:50:42Z"^^xsd:dateTime)
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/MP_0014532> "reduced circulating glutathione level")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0014532> "MP:0014532")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0014532> "decreased circulating glutathione level")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0014532> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16856> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014532> <http://purl.obolibrary.org/obo/MP_0014531>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014532> <http://purl.obolibrary.org/obo/MP_0030652>)
+
+# Class: <http://purl.obolibrary.org/obo/MP_0014533> (decreased circulating homocitrulline level)
+
+AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> <https://en.wikipedia.org/wiki/Homocitrulline>) <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0014533> "reduction in the amount per unit of blood of homocitrulline, an amino acid and a metabolite of ornithine in mammalian metabolism")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/MP_0014533> <https://orcid.org/0000-0003-4606-0597>)
+AnnotationAssertion(<http://purl.org/dc/terms/date> <http://purl.obolibrary.org/obo/MP_0014533> "2024-08-08T14:54:47Z"^^xsd:dateTime)
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/MP_0014533> "reduced circulating homocitrulline level")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0014533> "MP:0014533")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0014533> "decreased circulating homocitrulline level")
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014533> <http://purl.obolibrary.org/obo/MP_0014531>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014533> <http://purl.obolibrary.org/obo/MP_0030744>)
+
+# Class: <http://purl.obolibrary.org/obo/MP_0014534> (decreased circulating hydroxyprolne level)
+
+AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "CHEBI:24741") <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0014534> "reduction in the amount per unit of blood of hydroxyproline, a non-proteinogenic alpha-amino acid that is a major component of collagen and plays a key role in the stability of the collagen triple helix")
+AnnotationAssertion(<http://purl.org/dc/terms/contributor> <http://purl.obolibrary.org/obo/MP_0014534> <https://orcid.org/0000-0003-4606-0597>)
+AnnotationAssertion(<http://purl.org/dc/terms/date> <http://purl.obolibrary.org/obo/MP_0014534> "2024-08-08T15:03:54Z"^^xsd:dateTime)
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynonym> <http://purl.obolibrary.org/obo/MP_0014534> "reduced circulating hydroxyproline level")
+AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0014534> "MP:0014534")
+AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0014534> "decreased circulating hydroxyprolne level")
+EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0014534> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_24741> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014534> <http://purl.obolibrary.org/obo/MP_0014531>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014534> <http://purl.obolibrary.org/obo/MP_0030679>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0014534> <http://purl.obolibrary.org/obo/MP_0030680>)
+
 # Class: <http://purl.obolibrary.org/obo/MP_0020000> (abnormal response to antigen)
 
 AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> <https://orcid.org/0000-0001-5208-3432>) <http://purl.obolibrary.org/obo/IAO_0000115> <http://purl.obolibrary.org/obo/MP_0020000> "anomaly in the immune response after exposure to an antigen")
@@ -164034,6 +164108,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasNarrowSynon
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0020836> "MP:0020836")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0020836> "increased circulating citrulline level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0020836> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18211> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0020836> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0020836> <http://purl.obolibrary.org/obo/MP_0020835>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0020837> (decreased circulating citrulline level)
@@ -164046,6 +164121,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasNarrowSynon
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0020837> "MP:0020837")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0020837> "decreased circulating citrulline level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0020837> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18211> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0020837> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0020837> <http://purl.obolibrary.org/obo/MP_0020835>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0020838> (increased acute myeloid leukemia incidence)
@@ -176876,6 +176952,7 @@ AnnotationAssertion(<http://purl.org/dc/elements/1.1/date> <http://purl.obolibra
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace> <http://purl.obolibrary.org/obo/MP_0030625> "MPheno.ontology")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030625> "MP:0030625")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030625> "increased circulating cysteine level")
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030625> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030625> <http://purl.obolibrary.org/obo/MP_0030622>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030625> <http://purl.obolibrary.org/obo/MP_0030624>)
 
@@ -176888,6 +176965,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace> <http://purl.obolibrary.org/obo/MP_0030626> "MPheno.ontology")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030626> "MP:0030626")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030626> "decreased circulating cysteine level")
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030626> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030626> <http://purl.obolibrary.org/obo/MP_0030623>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030626> <http://purl.obolibrary.org/obo/MP_0030624>)
 
@@ -176948,7 +177026,6 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030631> "abnormal urine creatine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030631> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000070> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16919> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0001088>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030631> <http://purl.obolibrary.org/obo/MP_0010060>)
-SubClassOf(<http://purl.obolibrary.org/obo/MP_0030631> <http://purl.obolibrary.org/obo/MP_0011468>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0030632> (increased urine creatine level)
 
@@ -177034,6 +177111,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030638> "MP:0030638")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030638> "increased circulating taurine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030638> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_15891> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030638> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030638> <http://purl.obolibrary.org/obo/MP_0030635>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030638> <http://purl.obolibrary.org/obo/MP_0030637>)
 
@@ -177047,6 +177125,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030639> "MP:0030639")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030639> "decreased circulating taurine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030639> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_15891> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030639> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030639> <http://purl.obolibrary.org/obo/MP_0030636>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030639> <http://purl.obolibrary.org/obo/MP_0030637>)
 
@@ -177115,6 +177194,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030644> "MP:0030644")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030644> "increased circulating methionine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030644> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16811> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030644> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030644> <http://purl.obolibrary.org/obo/MP_0030641>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030644> <http://purl.obolibrary.org/obo/MP_0030643>)
 
@@ -177132,6 +177212,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030645> "MP:0030645")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030645> "decreased circulating methionine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030645> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16811> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030645> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030645> <http://purl.obolibrary.org/obo/MP_0030642>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030645> <http://purl.obolibrary.org/obo/MP_0030643>)
 
@@ -177200,6 +177281,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030650> "MP:0030650")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030650> "increased circulating ornithine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030650> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18257> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030650> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030650> <http://purl.obolibrary.org/obo/MP_0030647>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030650> <http://purl.obolibrary.org/obo/MP_0030649>)
 
@@ -177217,6 +177299,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030651> "MP:0030651")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030651> "decreased circulating ornithine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030651> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18257> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030651> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030651> <http://purl.obolibrary.org/obo/MP_0030648>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030651> <http://purl.obolibrary.org/obo/MP_0030649>)
 
@@ -177254,6 +177337,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030653> "increased circulating glutathione level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030653> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16856> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030653> <http://purl.obolibrary.org/obo/MP_0012606>)
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030653> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030653> <http://purl.obolibrary.org/obo/MP_0030652>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0030654> (abnormal circulating glycine level)
@@ -177285,6 +177369,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030655> "MP:0030655")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030655> "increased circulating glycine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030655> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_15428> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030655> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030655> <http://purl.obolibrary.org/obo/MP_0030654>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030655> <http://purl.obolibrary.org/obo/MP_0030658>)
 
@@ -177302,6 +177387,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030656> "MP:0030656")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030656> "decreased circulating glycine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030656> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_15428> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030656> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030656> <http://purl.obolibrary.org/obo/MP_0030654>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030656> <http://purl.obolibrary.org/obo/MP_0030659>)
 
@@ -177370,6 +177456,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030661> "MP:0030661")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030661> "increased circulating arginine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030661> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_29016> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030661> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030661> <http://purl.obolibrary.org/obo/MP_0030660>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030661> <http://purl.obolibrary.org/obo/MP_0030664>)
 
@@ -177387,6 +177474,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030662> "MP:0030662")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030662> "decreased circulating arginine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030662> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_29016> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030662> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030662> <http://purl.obolibrary.org/obo/MP_0030660>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030662> <http://purl.obolibrary.org/obo/MP_0030665>)
 
@@ -177455,6 +177543,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030667> "MP:0030667")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030667> "increased circulating proline level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030667> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_26271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030667> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030667> <http://purl.obolibrary.org/obo/MP_0020237>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030667> <http://purl.obolibrary.org/obo/MP_0030666>)
 
@@ -177472,6 +177561,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030668> "MP:0030668")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030668> "decreased circulating proline level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030668> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_26271> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030668> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030668> <http://purl.obolibrary.org/obo/MP_0020238>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030668> <http://purl.obolibrary.org/obo/MP_0030666>)
 
@@ -177504,6 +177594,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030670> "MP:0030670")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030670> "increased circulating phenylalanine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030670> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_28044> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030670> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030670> <http://purl.obolibrary.org/obo/MP_0030669>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030670> <http://purl.obolibrary.org/obo/MP_0030697>)
 
@@ -177521,6 +177612,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030671> "MP:0030671")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030671> "decreased circulating phenylalanine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030671> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_28044> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030671> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030671> <http://purl.obolibrary.org/obo/MP_0030669>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030671> <http://purl.obolibrary.org/obo/MP_0030698>)
 
@@ -177553,6 +177645,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030673> "MP:0030673")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030673> "increased circulating alanine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030673> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16449> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030673> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030673> <http://purl.obolibrary.org/obo/MP_0030672>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030673> <http://purl.obolibrary.org/obo/MP_0031640>)
 
@@ -177570,6 +177663,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030674> "MP:0030674")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030674> "decreased circulating alanine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030674> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_16449> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030674> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030674> <http://purl.obolibrary.org/obo/MP_0030672>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030674> <http://purl.obolibrary.org/obo/MP_0031639>)
 
@@ -177661,6 +177755,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030681> "MP:0030681")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030681> "increased circulating hydroxyproline level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030681> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_24741> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030681> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030681> <http://purl.obolibrary.org/obo/MP_0030678>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030681> <http://purl.obolibrary.org/obo/MP_0030680>)
 
@@ -177745,6 +177840,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://pu
 AnnotationAssertion(Annotation(<http://www.geneontology.org/formats/oboInOwl#hasDbXref> "HP:0003286") rdfs:comment <http://purl.obolibrary.org/obo/MP_0030687> "cystathionine can be directly interconverted to cysteine; cystathionine is not normally detectable in plasma")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030687> "increased circulating cystathionine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030687> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17755> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030687> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030687> <http://purl.obolibrary.org/obo/MP_0030684>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030687> <http://purl.obolibrary.org/obo/MP_0030686>)
 
@@ -177760,6 +177856,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030688> "MP:0030688")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030688> "decreased circulating cystathionine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030688> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17755> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030688> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030688> <http://purl.obolibrary.org/obo/MP_0030685>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030688> <http://purl.obolibrary.org/obo/MP_0030686>)
 
@@ -177840,6 +177937,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030694> "MP:0030694")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030694> "increased circulating serine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030694> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17822> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030694> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030694> <http://purl.obolibrary.org/obo/MP_0030691>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030694> <http://purl.obolibrary.org/obo/MP_0030693>)
 
@@ -177857,6 +177955,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030695> "MP:0030695")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030695> "decreased circulating serine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030695> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_17822> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030695> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030695> <http://purl.obolibrary.org/obo/MP_0030692>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030695> <http://purl.obolibrary.org/obo/MP_0030693>)
 
@@ -177959,6 +178058,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030703> "MP:0030703")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030703> "increased circulating threonine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030703> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_26986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030703> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030703> <http://purl.obolibrary.org/obo/MP_0030700>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030703> <http://purl.obolibrary.org/obo/MP_0030702>)
 
@@ -177974,6 +178074,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030704> "MP:0030704")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030704> "decreased circulating threonine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030704> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_26986> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030704> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030704> <http://purl.obolibrary.org/obo/MP_0030701>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030704> <http://purl.obolibrary.org/obo/MP_0030702>)
 
@@ -178040,6 +178141,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030709> "MP:0030709")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030709> "increased circulating glutamine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030709> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_28300> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030709> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030709> <http://purl.obolibrary.org/obo/MP_0030706>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030709> <http://purl.obolibrary.org/obo/MP_0030708>)
 
@@ -178057,6 +178159,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030710> "MP:0030710")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030710> "decreased circulating glutamine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030710> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_28300> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030710> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030710> <http://purl.obolibrary.org/obo/MP_0030707>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030710> <http://purl.obolibrary.org/obo/MP_0030708>)
 
@@ -178123,6 +178226,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030715> "MP:0030715")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030715> "increased circulating isoleucine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030715> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_24898> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030715> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030715> <http://purl.obolibrary.org/obo/MP_0030712>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030715> <http://purl.obolibrary.org/obo/MP_0030714>)
 
@@ -178140,6 +178244,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030716> "MP:0030716")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030716> "decreased circulating isoleucine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030716> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_24898> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030716> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030716> <http://purl.obolibrary.org/obo/MP_0030713>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030716> <http://purl.obolibrary.org/obo/MP_0030714>)
 
@@ -178172,6 +178277,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030718> "MP:0030718")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030718> "increased circulating lysine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030718> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_25094> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030718> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030718> <http://purl.obolibrary.org/obo/MP_0030717>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030718> <http://purl.obolibrary.org/obo/MP_0030721>)
 
@@ -178189,6 +178295,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030719> "MP:0030719")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030719> "decreased circulating lysine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030719> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_25094> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030719> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030719> <http://purl.obolibrary.org/obo/MP_0030717>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030719> <http://purl.obolibrary.org/obo/MP_0030722>)
 
@@ -178293,6 +178400,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030727> "MP:0030727")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030727> "increased circulating valine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030727> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_27266> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030727> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030727> <http://purl.obolibrary.org/obo/MP_0030724>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030727> <http://purl.obolibrary.org/obo/MP_0030726>)
 
@@ -178310,6 +178418,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030728> "MP:0030728")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030728> "decreased circulating valine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030728> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_27266> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030728> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030728> <http://purl.obolibrary.org/obo/MP_0030725>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030728> <http://purl.obolibrary.org/obo/MP_0030726>)
 
@@ -178466,6 +178575,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030739> "MP:0030739")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030739> "increased circulating glutamic acid level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030739> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030739> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030739> <http://purl.obolibrary.org/obo/MP_0030736>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030739> <http://purl.obolibrary.org/obo/MP_0030738>)
 
@@ -178483,6 +178593,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030740> "MP:0030740")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030740> "decreased circulating glutamic acid level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030740> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_18237> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030740> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030740> <http://purl.obolibrary.org/obo/MP_0030737>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030740> <http://purl.obolibrary.org/obo/MP_0030738>)
 
@@ -178545,6 +178656,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasExactSynony
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespace> <http://purl.obolibrary.org/obo/MP_0030745> "MPheno.ontology")
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030745> "MP:0030745")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030745> "increased circulating homocitrulline level")
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030745> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030745> <http://purl.obolibrary.org/obo/MP_0030744>)
 
 # Class: <http://purl.obolibrary.org/obo/MP_0030746> (abnormal leucine level)
@@ -178610,6 +178722,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030750> "MP:0030750")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030750> "increased circulating leucine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030750> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0000470> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_25017> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030750> <http://purl.obolibrary.org/obo/MP_0014530>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030750> <http://purl.obolibrary.org/obo/MP_0030747>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030750> <http://purl.obolibrary.org/obo/MP_0030749>)
 
@@ -178627,6 +178740,7 @@ AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#hasOBONamespac
 AnnotationAssertion(<http://www.geneontology.org/formats/oboInOwl#id> <http://purl.obolibrary.org/obo/MP_0030751> "MP:0030751")
 AnnotationAssertion(rdfs:label <http://purl.obolibrary.org/obo/MP_0030751> "decreased circulating leucine level")
 EquivalentClasses(<http://purl.obolibrary.org/obo/MP_0030751> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000051> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/PATO_0001997> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0000052> ObjectIntersectionOf(<http://purl.obolibrary.org/obo/CHEBI_25017> ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/BFO_0000050> <http://purl.obolibrary.org/obo/UBERON_0000178>))) ObjectSomeValuesFrom(<http://purl.obolibrary.org/obo/RO_0002573> <http://purl.obolibrary.org/obo/PATO_0000460>))))
+SubClassOf(<http://purl.obolibrary.org/obo/MP_0030751> <http://purl.obolibrary.org/obo/MP_0014531>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030751> <http://purl.obolibrary.org/obo/MP_0030748>)
 SubClassOf(<http://purl.obolibrary.org/obo/MP_0030751> <http://purl.obolibrary.org/obo/MP_0030749>)