Skip to content
This repository has been archived by the owner on Apr 12, 2023. It is now read-only.

consider always including orthologous genes in disease match grid #361

Closed
nlwashington opened this issue May 21, 2014 · 2 comments
Closed

Comments

@nlwashington
Copy link
Collaborator

it might be really useful to show (maybe by optional selection) the orthologs of the known disease-causing gene.

the idea would be in the grid, we would add as fixed columns, the phenotype profiles of the orthologs of the known disease causing genes. this would rely on a call such as #351. it seems we might want to see the top hits in context to the orthologs.

@mellybelly mellybelly added this to the 2014-10 Release milestone Sep 13, 2014
@harryhoch harryhoch modified the milestones: 2015-01 Release, 2014-10 Release Oct 25, 2014
@nlwashington
Copy link
Collaborator Author

so, let's say we're on a disease page. the workflow for the grid would be:

  1. do a search for the similar matches by phenotype search (what's done now).
  2. given the list of orthologs for the gene(s) in the disease-associations, call directly the compare service for any of the genes that were not found in the above search, like .../compare/OMIM:12345/Gene:1+Gene:2+Gene:3...
  3. merge the lists together and sort. (or put the orthologs first, as suggested by zfin.)

@harryhoch
Copy link
Contributor

still undone, see monarch-initiative/phenogrid#136 for further discussion

Sign up for free to subscribe to this conversation on GitHub. Already have an account? Sign in.
Projects
None yet
Development

No branches or pull requests

5 participants