diff --git a/README.md b/README.md
index d4e801f..991ceb8 100644
--- a/README.md
+++ b/README.md
@@ -306,24 +306,22 @@ Add the following snippet to your `~/.tmux.conf`/`~/.config/tmux/tmux.conf` file
 
 ```tmux
 # Smart pane switching with awareness of Vim splits.
-# See: https://github.com/christoomey/vim-tmux-navigator
-is_vim="ps -o state= -o comm= -t '#{pane_tty}' \
-    | grep -iqE '^[^TXZ ]+ +(\\S+\\/)?g?(view|n?vim?x?)(diff)?$'"
-bind-key -n C-h if-shell "$is_vim" 'send-keys C-h'  'select-pane -L'
-bind-key -n C-j if-shell "$is_vim" 'send-keys C-j'  'select-pane -D'
-bind-key -n C-k if-shell "$is_vim" 'send-keys C-k'  'select-pane -U'
-bind-key -n C-l if-shell "$is_vim" 'send-keys C-l'  'select-pane -R'
-
-bind-key -n M-h if-shell "$is_vim" 'send-keys M-h' 'resize-pane -L 3'
-bind-key -n M-j if-shell "$is_vim" 'send-keys M-j' 'resize-pane -D 3'
-bind-key -n M-k if-shell "$is_vim" 'send-keys M-k' 'resize-pane -U 3'
-bind-key -n M-l if-shell "$is_vim" 'send-keys M-l' 'resize-pane -R 3'
+"
+bind-key -n C-h if -F "#{@pane-is-vim}" 'send-keys C-h'  'select-pane -L'
+bind-key -n C-j if -F "#{@pane-is-vim}" 'send-keys C-j'  'select-pane -D'
+bind-key -n C-k if -F "#{@pane-is-vim}" 'send-keys C-k'  'select-pane -U'
+bind-key -n C-l if -F "#{@pane-is-vim}" 'send-keys C-l'  'select-pane -R'
+
+bind-key -n M-h if -F "#{@pane-is-vim}" 'send-keys M-h' 'resize-pane -L 3'
+bind-key -n M-j if -F "#{@pane-is-vim}" 'send-keys M-j' 'resize-pane -D 3'
+bind-key -n M-k if -F "#{@pane-is-vim}" 'send-keys M-k' 'resize-pane -U 3'
+bind-key -n M-l if -F "#{@pane-is-vim}" 'send-keys M-l' 'resize-pane -R 3'
 
 tmux_version='$(tmux -V | sed -En "s/^tmux ([0-9]+(.[0-9]+)?).*/\1/p")'
 if-shell -b '[ "$(echo "$tmux_version < 3.0" | bc)" = 1 ]' \
-    "bind-key -n 'C-\\' if-shell \"$is_vim\" 'send-keys C-\\'  'select-pane -l'"
+    "bind-key -n 'C-\\' if -F \"#{@pane-is-vim}\" 'send-keys C-\\'  'select-pane -l'"
 if-shell -b '[ "$(echo "$tmux_version >= 3.0" | bc)" = 1 ]' \
-    "bind-key -n 'C-\\' if-shell \"$is_vim\" 'send-keys C-\\\\'  'select-pane -l'"
+    "bind-key -n 'C-\\' if -F \"#{@pane-is-vim}\" 'send-keys C-\\\\'  'select-pane -l'"
 
 bind-key -T copy-mode-vi 'C-h' select-pane -L
 bind-key -T copy-mode-vi 'C-j' select-pane -D
@@ -365,7 +363,7 @@ smart_splits.apply_to_config(config, {
   modifiers = {
     move = 'CTRL', -- modifier to use for pane movement, e.g. CTRL+h to move left
     resize = 'META', -- modifier to use for pane resize, e.g. META+h to resize to the left
-  }
+  },
 })
 ```
 
diff --git a/plugin/smart-splits.vim b/autoload/smart_splits.vim
similarity index 76%
rename from plugin/smart-splits.vim
rename to autoload/smart_splits.vim
index 80e4ccf..af1072b 100644
--- a/plugin/smart-splits.vim
+++ b/autoload/smart_splits.vim
@@ -48,7 +48,7 @@ function s:encode_b64(str, size)
   return chunked
 endfunction
 
-function s:write(var)
+function smart_splits#write_wezterm_var(var)
   if filewritable('/dev/fd/2') == 1
     let l:success = writefile([a:var], '/dev/fd/2', 'b') == 0
   else
@@ -57,18 +57,6 @@ function s:write(var)
   return l:success
 endfunction
 
-function s:format_var(val)
+function smart_splits#format_wezterm_var(val)
   return printf("\033]1337;SetUserVar=IS_NVIM=%s\007", s:encode_b64(a:val, 0))
 endfunction
-
-let s:are_we_wezterm = luaeval("require('smart-splits.mux.utils').are_we_wezterm()")
-
-if s:are_we_wezterm
-  call s:write(s:format_var("true"))
-  " Set to false if nvim is suspended with ctrl+z
-  autocmd VimSuspend * :call s:write(s:format_var("false"))
-  " Set to true if nvim is resumed after being suspended with ctrl+z
-  autocmd VimResume * :call s:write(s:format_var("true"))
-  " Set to false when nvim exits
-  autocmd VimLeave * :call s:write(s:format_var("false"))
-endif
diff --git a/lua/smart-splits/config.lua b/lua/smart-splits/config.lua
index b8406c7..322a4a7 100644
--- a/lua/smart-splits/config.lua
+++ b/lua/smart-splits/config.lua
@@ -3,7 +3,6 @@ local log = lazy.require_on_exported_call('smart-splits.log') --[[@as SmartSplit
 local types = require('smart-splits.types')
 local AtEdgeBehavior = types.AtEdgeBehavior
 local Multiplexer = types.Multiplexer
-local utils = require('smart-splits.utils')
 local mux_utils = require('smart-splits.mux.utils')
 
 ---@class SmartResizeModeHooks
@@ -108,7 +107,18 @@ function M.set_default_multiplexer()
 end
 
 function M.setup(new_config)
+  local original_mux = config.multiplexer_integration
+
   config = vim.tbl_deep_extend('force', config, new_config or {})
+  -- if the mux setting changed, run startup again
+  if
+    original_mux ~= nil
+    and original_mux ~= false
+    and #tostring(original_mux or '') == 0
+    and original_mux ~= config.multiplexer_integration
+  then
+    mux_utils.startup()
+  end
 
   -- check deprecated settings
   ---@diagnostic disable:undefined-field
diff --git a/lua/smart-splits/mux/tmux.lua b/lua/smart-splits/mux/tmux.lua
index 505474d..e4b9cdb 100644
--- a/lua/smart-splits/mux/tmux.lua
+++ b/lua/smart-splits/mux/tmux.lua
@@ -1,5 +1,6 @@
 local types = require('smart-splits.types')
 local Direction = types.Direction
+local Log = require('smart-splts.log')
 
 local dir_keys_tmux = {
   [Direction.left] = 'L',
@@ -34,7 +35,7 @@ local function tmux_exec(args, as_list)
 end
 
 ---@type SmartSplitsMultiplexer
-local M = {}
+local M = {} ---@diagnostic disable-line: missing-fields
 
 M.type = 'tmux'
 
@@ -146,4 +147,28 @@ function M.split_pane(direction, size)
   return ok
 end
 
+function M.on_init()
+  local pane_id = M.current_pane_id()
+  if not pane_id then
+    Log.warn('tmux init: could not detect pane ID!')
+    return
+  end
+  tmux_exec({ 'set-option', '-pt', pane_id, '@pane-is-vim', 1 })
+  if vim.v.shell_error ~= 0 then
+    Log.warn('tmux init: failed to detect pane_id')
+  end
+end
+
+function M.on_exit()
+  local pane_id = M.current_pane_id()
+  if not pane_id then
+    Log.warn('tmux init: could not detect pane ID!')
+    return
+  end
+  tmux_exec({ 'set-option', '-pt', pane_id, '@pane-is-vim', 0 })
+  if vim.v.shell_error ~= 0 then
+    Log.warn('tmux init: failed to detect pane_id')
+  end
+end
+
 return M
diff --git a/lua/smart-splits/mux/utils.lua b/lua/smart-splits/mux/utils.lua
index 4a7c970..0712c1c 100644
--- a/lua/smart-splits/mux/utils.lua
+++ b/lua/smart-splits/mux/utils.lua
@@ -1,16 +1,5 @@
 local M = {}
 
----Check if Neovim is running in Wezterm TUI
----@return boolean
-function M.are_we_wezterm()
-  if M.are_we_gui() then
-    return false
-  end
-  local term = vim.trim((vim.env.TERM_PROGRAM or ''):lower())
-  local wezterm_pane = vim.trim(vim.env.WEZTERM_PANE or '')
-  return term == 'wezterm' or wezterm_pane ~= ''
-end
-
 function M.are_we_tmux()
   if M.are_we_gui() then
     return false
@@ -31,4 +20,30 @@ function M.are_we_gui()
   return current_ui ~= nil and not current_ui.stdin_tty and not current_ui.stdout_tty
 end
 
+---Initialization for mux capabilities.
+---If selected mux has an `on_init` or `on_exit`,
+---call `on_init` and set up autocmds to call `on_init` on `VimResume`
+---and `on_exit` on `VimSuspend` and `VimLeave`.
+function M.startup()
+  local mux = require('smart-splits.mux').get()
+  if not mux then
+    return
+  end
+  if mux.on_init then
+    mux.on_init()
+    vim.api.nvim_create_autocmd('VimResume', {
+      callback = function()
+        mux.on_init()
+      end,
+    })
+  end
+  if mux.on_exit then
+    vim.api.nvim_create_autocmd({ 'VimSuspend', 'VimLeave' }, {
+      callback = function()
+        mux.on_exit()
+      end,
+    })
+  end
+end
+
 return M
diff --git a/lua/smart-splits/mux/wezterm.lua b/lua/smart-splits/mux/wezterm.lua
index a8d30a9..c10f198 100644
--- a/lua/smart-splits/mux/wezterm.lua
+++ b/lua/smart-splits/mux/wezterm.lua
@@ -150,4 +150,16 @@ function M.split_pane(direction, size)
   return ok
 end
 
+function M.on_init()
+  local format_var = vim.fn['smart_splits#format_wezterm_var']
+  local write_var = vim.fn['smart_splits#write_wezterm_var']
+  write_var(format_var('true'))
+end
+
+function M.on_exit()
+  local format_var = vim.fn['smart_splits#format_wezterm_var']
+  local write_var = vim.fn['smart_splits#write_wezterm_var']
+  write_var(format_var('false'))
+end
+
 return M
diff --git a/lua/smart-splits/types.lua b/lua/smart-splits/types.lua
index c4823f7..7649489 100644
--- a/lua/smart-splits/types.lua
+++ b/lua/smart-splits/types.lua
@@ -7,6 +7,8 @@
 ---@field resize_pane fun(direction:SmartSplitsDirection, amount:number):boolean
 ---@field split_pane fun(direction:SmartSplitsDirection,size:number|nil):boolean
 ---@field type SmartSplitsMultiplexerType
+---@field on_init fun()|nil
+---@field on_exit fun()|nil
 
 ---@alias SmartSplitsDirection 'left'|'right'|'up'|'down'
 
diff --git a/plugin/smart-splits.lua b/plugin/smart-splits.lua
index bb46ffb..17766a2 100644
--- a/plugin/smart-splits.lua
+++ b/plugin/smart-splits.lua
@@ -5,3 +5,4 @@ vim.tbl_map(function(cmd)
 end, cmds)
 
 require('smart-splits.config').set_default_multiplexer()
+require('smart-splits.mux.utils').startup()