diff --git a/doc/api/errors.md b/doc/api/errors.md
index 1866ef333706a6..3abbba99bbd987 100644
--- a/doc/api/errors.md
+++ b/doc/api/errors.md
@@ -717,6 +717,17 @@ Data passed to a Brotli stream was not successfully compressed.
 
 An invalid parameter key was passed during construction of a Brotli stream.
 
+<a id="ERR_NO_TYPESCRIPT"></a>
+
+### `ERR_NO_TYPESCRIPT`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+An attempt was made to use features that require [Native TypeScript support][], but Node.js was not
+compiled with TypeScript support.
+
 <a id="ERR_BUFFER_CONTEXT_NOT_AVAILABLE"></a>
 
 ### `ERR_BUFFER_CONTEXT_NOT_AVAILABLE`
@@ -4128,6 +4139,7 @@ An error occurred trying to allocate memory. This should never happen.
 [ICU]: intl.md#internationalization-support
 [JSON Web Key Elliptic Curve Registry]: https://www.iana.org/assignments/jose/jose.xhtml#web-key-elliptic-curve
 [JSON Web Key Types Registry]: https://www.iana.org/assignments/jose/jose.xhtml#web-key-types
+[Native TypeScript support]: typescript.md#type-stripping
 [Node.js error codes]: #nodejs-error-codes
 [Permission Model]: permissions.md#permission-model
 [RFC 7230 Section 3]: https://tools.ietf.org/html/rfc7230#section-3
diff --git a/lib/internal/errors.js b/lib/internal/errors.js
index 29c0b607746023..8a97384201341f 100644
--- a/lib/internal/errors.js
+++ b/lib/internal/errors.js
@@ -1601,6 +1601,8 @@ E('ERR_NO_CRYPTO',
   'Node.js is not compiled with OpenSSL crypto support', Error);
 E('ERR_NO_ICU',
   '%s is not supported on Node.js compiled without ICU', TypeError);
+E('ERR_NO_TYPESCRIPT',
+  'Node.js is not compiled with TypeScript support', Error);
 E('ERR_OPERATION_FAILED', 'Operation failed: %s', Error, TypeError);
 E('ERR_OUT_OF_RANGE',
   (str, range, input, replaceDefaultBoolean = false) => {
diff --git a/lib/internal/modules/helpers.js b/lib/internal/modules/helpers.js
index 6c13ed3ff5fdd0..172f0fdc02a686 100644
--- a/lib/internal/modules/helpers.js
+++ b/lib/internal/modules/helpers.js
@@ -28,7 +28,7 @@ const assert = require('internal/assert');
 
 const { Buffer } = require('buffer');
 const { getOptionValue } = require('internal/options');
-const { setOwnProperty, getLazy } = require('internal/util');
+const { assertTypeScript, setOwnProperty, getLazy } = require('internal/util');
 const { inspect } = require('internal/util/inspect');
 
 const lazyTmpdir = getLazy(() => require('os').tmpdir());
@@ -327,6 +327,7 @@ const getTypeScriptParsingMode = getLazy(() =>
  * @returns {Function} The TypeScript parser function.
  */
 const loadTypeScriptParser = getLazy(() => {
+  assertTypeScript();
   const amaro = require('internal/deps/amaro/dist/index');
   return amaro.transformSync;
 });
diff --git a/lib/internal/util.js b/lib/internal/util.js
index 65ebef3f4f3e4c..fb09e5331222f4 100644
--- a/lib/internal/util.js
+++ b/lib/internal/util.js
@@ -45,6 +45,7 @@ const {
 const {
   codes: {
     ERR_NO_CRYPTO,
+    ERR_NO_TYPESCRIPT,
     ERR_UNKNOWN_SIGNAL,
   },
   isErrorStackTraceLimitWritable,
@@ -65,6 +66,7 @@ const { getOptionValue } = require('internal/options');
 const { encodings } = internalBinding('string_decoder');
 
 const noCrypto = !process.versions.openssl;
+const noTypeScript = !process.versions.amaro;
 
 const isWindows = process.platform === 'win32';
 const isMacOS = process.platform === 'darwin';
@@ -194,6 +196,11 @@ function assertCrypto() {
     throw new ERR_NO_CRYPTO();
 }
 
+function assertTypeScript() {
+  if (noTypeScript)
+    throw new ERR_NO_TYPESCRIPT();
+}
+
 /**
  * Move the "slow cases" to a separate function to make sure this function gets
  * inlined properly. That prioritizes the common case.
@@ -861,6 +868,7 @@ for (let i = 0; i < encodings.length; ++i)
 module.exports = {
   getLazy,
   assertCrypto,
+  assertTypeScript,
   cachedResult,
   convertToValidSignal,
   createClassWrapper,