diff --git a/src/middleware/methodNotAllowedMiddleware.ts b/src/middleware/methodNotAllowedMiddleware.ts
new file mode 100644
index 0000000..ea0459c
--- /dev/null
+++ b/src/middleware/methodNotAllowedMiddleware.ts
@@ -0,0 +1,7 @@
+import type { Middleware } from './middleware';
+
+export class MethodNotAllowedMiddleware implements Middleware {
+  handle(): Promise<Response> {
+    return Promise.resolve(new Response(undefined, { status: 405 }));
+  }
+}
diff --git a/src/routes/index.ts b/src/routes/index.ts
index 5cdeda3..157adfa 100644
--- a/src/routes/index.ts
+++ b/src/routes/index.ts
@@ -1,5 +1,6 @@
 import latestVersions from '../constants/latestVersions.json' assert { type: 'json' };
 import { cached } from '../middleware/cacheMiddleware';
+import { MethodNotAllowedMiddleware } from '../middleware/methodNotAllowedMiddleware';
 import { NotFoundMiddleware } from '../middleware/notFoundMiddleware';
 import { OptionsMiddleware } from '../middleware/optionsMiddleware';
 import { OriginMiddleware } from '../middleware/originMiddleware';
@@ -52,6 +53,8 @@ export function registerRoutes(router: Router): void {
   ]);
 
   router.get('*', [new NotFoundMiddleware()]);
+
+  router.all('*', [new MethodNotAllowedMiddleware()]);
 }
 
 export * from './router';
diff --git a/src/routes/router.ts b/src/routes/router.ts
index 2f8359a..c9cf507 100644
--- a/src/routes/router.ts
+++ b/src/routes/router.ts
@@ -17,6 +17,14 @@ export class Router {
     return this.itty.fetch(request, ctx);
   }
 
+  all(endpoint: string, middlewares: Middleware[]): void {
+    const middlewareChain = buildMiddlewareChain(middlewares);
+
+    this.itty.all(endpoint, (req, ctx) => {
+      return callMiddlewareChain(middlewareChain, req, ctx);
+    });
+  }
+
   options(endpoint: string, middlewares: Middleware[]): void {
     const middlewareChain = buildMiddlewareChain(middlewares);
 
diff --git a/tests/e2e/file.test.ts b/tests/e2e/file.test.ts
index 2dea723..64ea892 100644
--- a/tests/e2e/file.test.ts
+++ b/tests/e2e/file.test.ts
@@ -172,6 +172,16 @@ describe('File Tests', () => {
     assert.strictEqual(body, '{ hello:');
   });
 
+  it('sends a 405 for anything other than GET or HEAD', async () => {
+    // Doesn't need to be all-inclusive
+    for (const method of ['POST', 'PATCH', 'DELETE', 'PROPFIND']) {
+      const res = await mf.dispatchFetch(`${url}`, {
+        method: method,
+      });
+      assert.strictEqual(res.status, 405, method);
+    }
+  });
+
   // Cleanup Miniflare
   after(async () => mf.dispose());
 });