diff --git a/MANIFEST.in b/MANIFEST.in
index 4aa67d50..b12dc293 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -3,7 +3,7 @@ include tox.ini
 include unittest.cfg
 include README.rst
 include license.txt
-recursive-include nose2/tests/functional/support *.py *.txt *.cfg *.rst *.json *.egg .coveragerc
+recursive-include nose2/tests/functional/support *.py *.txt *.toml *.cfg *.rst *.json *.egg .coveragerc
 recursive-include docs *.inc *.py *.rst Makefile
 global-exclude __pycache__
 global-exclude *~
diff --git a/docs/changelog.rst b/docs/changelog.rst
index 2d0bd045..6b33dbaa 100644
--- a/docs/changelog.rst
+++ b/docs/changelog.rst
@@ -16,6 +16,13 @@ Unreleased
 * Official support for ``python3.13`` betas. ``nose2`` now tests itself against
   Python 3.13.
 
+* ``nose2`` now supports loading configuration data from the ``tool.nose2``
+  table in ``pyproject.toml``. Thanks to :user:`qequ` for the PR! (:pr:`596`)
+
+  On python 3.11+, ``tomllib`` is used to parse TOML data. On python 3.10 and
+  lower, ``tomli`` must be installed to enable TOML support. Simply
+  ``pip install tomli`` as necessary.
+
 0.14.2 (2024-05-07)
 -------------------
 
diff --git a/nose2/_toml.py b/nose2/_toml.py
new file mode 100644
index 00000000..6577b223
--- /dev/null
+++ b/nose2/_toml.py
@@ -0,0 +1,21 @@
+TOML_ENABLED: bool = False
+
+try:
+    import tomllib as toml
+
+    TOML_ENABLED = True
+except ImportError:
+    try:
+        import tomli as toml
+
+        TOML_ENABLED = False
+    except ImportError:
+        toml = None
+        TOML_ENABLED = False
+
+
+def load_toml(file: str) -> dict:
+    if not TOML_ENABLED:
+        raise RuntimeError("toml library not found. Please install 'tomli'.")
+    with open(file, "rb") as fp:
+        return toml.load(fp)
diff --git a/nose2/main.py b/nose2/main.py
index 3d10d90d..08b3cedb 100644
--- a/nose2/main.py
+++ b/nose2/main.py
@@ -4,6 +4,7 @@
 import unittest
 
 from nose2 import events, loader, plugins, runner, session, util
+from nose2._toml import TOML_ENABLED
 
 log = logging.getLogger(__name__)
 __unittest = True
@@ -242,6 +243,8 @@ def findConfigFiles(self, cfg_args):
         """Find available config files"""
         filenames = cfg_args.config[:]
         proj_opts = ("unittest.cfg", "nose2.cfg")
+        if TOML_ENABLED:
+            proj_opts += ("pyproject.toml",)
         for fn in proj_opts:
             if cfg_args.top_level_directory:
                 fn = os.path.abspath(os.path.join(cfg_args.top_level_directory, fn))
diff --git a/nose2/session.py b/nose2/session.py
index ed171ec3..bfc3e1d3 100644
--- a/nose2/session.py
+++ b/nose2/session.py
@@ -6,6 +6,7 @@
 from configparser import ConfigParser
 
 from nose2 import config, events, util
+from nose2._toml import load_toml
 
 log = logging.getLogger(__name__)
 __unittest = True
@@ -118,7 +119,19 @@ def loadConfigFiles(self, *filenames):
         Loads all names files that exist into ``self.config``.
 
         """
-        self.config.read(filenames)
+        for filename in filenames:
+            if filename.endswith(".cfg"):
+                self.config.read(filename)
+            elif filename.endswith("pyproject.toml"):
+                if not os.path.exists(filename):
+                    continue
+                toml_config = load_toml(filename)
+                if not isinstance(toml_config.get("tool"), dict):
+                    continue
+                tool_table = toml_config["tool"]
+                if not isinstance(tool_table.get("nose2"), dict):
+                    continue
+                self.config.read_dict(tool_table["nose2"])
 
     def loadPlugins(self, modules=None, exclude=None):
         """Load plugins.
diff --git a/nose2/tests/functional/support/toml/a/pyproject.toml b/nose2/tests/functional/support/toml/a/pyproject.toml
new file mode 100644
index 00000000..c93321f6
--- /dev/null
+++ b/nose2/tests/functional/support/toml/a/pyproject.toml
@@ -0,0 +1,5 @@
+[tool.nose2.a]
+a = 1
+
+[tool.nose2.unittest]
+plugins = "plugin_a"
diff --git a/nose2/tests/functional/support/toml/b/pyproject.toml b/nose2/tests/functional/support/toml/b/pyproject.toml
new file mode 100644
index 00000000..2c23c117
--- /dev/null
+++ b/nose2/tests/functional/support/toml/b/pyproject.toml
@@ -0,0 +1,5 @@
+[tool.nose2.b]
+b = """
+4
+5
+"""
diff --git a/nose2/tests/functional/test_session.py b/nose2/tests/functional/test_session.py
index 3dea9601..9f7061a7 100644
--- a/nose2/tests/functional/test_session.py
+++ b/nose2/tests/functional/test_session.py
@@ -1,6 +1,8 @@
 import sys
+import unittest
 
 from nose2 import session
+from nose2._toml import TOML_ENABLED
 from nose2.tests._common import FunctionalTestCase, support_file
 
 
@@ -53,3 +55,55 @@ def test_session_config_cacheing(self):
         # rather than parsing config file again
         secondaccess = cache_sess.get("a")
         assert secondaccess.as_int("a") == 0
+
+
+class SessionTomlFunctionalTests(FunctionalTestCase):
+    def setUp(self):
+        if not TOML_ENABLED:
+            raise unittest.SkipTest("toml module not available")
+        self.s = session.Session()
+        self.s.loadConfigFiles(
+            support_file("toml", "a", "pyproject.toml"),
+            support_file("toml", "b", "pyproject.toml"),
+        )
+
+    def test_session_can_load_config_files(self):
+        assert self.s.config.has_section("a")
+        assert self.s.config.has_section("b")
+
+    def test_session_holds_plugin_config(self):
+        plug_config = self.s.get("a")
+        assert plug_config
+
+    def test_session_can_load_toml_plugins_from_modules(self):
+        self.s.loadPlugins()
+        assert self.s.plugins
+        plug = self.s.plugins[0]
+        self.assertEqual(plug.a, 1)
+
+    def test_session_config_cacheing(self):
+        """Test caching of config sections works"""
+
+        # Create new session (generic one likely already cached
+        # depending on test order)
+        cache_sess = session.Session()
+        cache_sess.loadConfigFiles(support_file("toml", "a", "pyproject.toml"))
+
+        # First access to given section, should read from config file
+        firstaccess = cache_sess.get("a")
+        assert firstaccess.as_int("a") == 1
+        # Hack cached Config object internals to make the stored value
+        # something different
+        cache_sess.configCache["a"]._mvd["a"] = "0"
+        newitems = []
+        for item in cache_sess.configCache["a"]._items:
+            if item != ("a", "1"):
+                newitems.append(item)
+            else:
+                newitems.append(("a", "0"))
+        cache_sess.configCache["a"]._items = newitems
+
+        # Second access to given section, confirm returns cached value
+        # rather than parsing config file again
+        secondaccess = cache_sess.get("a")
+        assert secondaccess.as_int("a") == 0
diff --git a/tox.ini b/tox.ini
index 371acf02..89ceb7c5 100644
--- a/tox.ini
+++ b/tox.ini
@@ -4,7 +4,9 @@ envlist=py{38,39,310,311,312,313}{,-nocov},pypy,docs,lint
 [testenv]
 passenv = CI
 extras = dev
-deps = !nocov: coverage
+deps =
+    !nocov: coverage
+    py{38,39,310}-toml: tomli
 setenv = PYTHONPATH={toxinidir}
 commands =
     nocov: nose2 -v --pretty-assert {posargs}