diff --git a/chrome/browser/ui/page_info/page_info.cc b/chrome/browser/ui/page_info/page_info.cc
index 818288d636b3..e0e59f3123c2 100644
--- a/chrome/browser/ui/page_info/page_info.cc
+++ b/chrome/browser/ui/page_info/page_info.cc
@@ -448,10 +448,14 @@ void PageInfo::OpenSiteSettingsView() {
   // settings page specific to the current origin of the page. crbug.com/655876
   url::Origin site_origin = url::Origin(site_url());
   std::string link_destination(chrome::kChromeUIContentSettingsURL);
+  // TODO(https://crbug.com/444047): Site Details should work with file:// urls
+  // when this bug is fixed, so add it to the whitelist when that happens.
   if ((base::CommandLine::ForCurrentProcess()->HasSwitch(
            switches::kEnableSiteSettings) ||
        base::FeatureList::IsEnabled(features::kSiteDetails)) &&
-      !site_origin.unique()) {
+      !site_origin.unique() &&
+      (site_url().SchemeIsHTTPOrHTTPS() ||
+       site_url().SchemeIs(content_settings::kExtensionScheme))) {
     std::string origin_string = site_origin.Serialize();
     url::RawCanonOutputT<char> percent_encoded_origin;
     url::EncodeURIComponent(origin_string.c_str(), origin_string.length(),
diff --git a/chrome/browser/ui/views/page_info/page_info_bubble_view_browsertest.cc b/chrome/browser/ui/views/page_info/page_info_bubble_view_browsertest.cc
index 726395fb2983..6da6887730f3 100644
--- a/chrome/browser/ui/views/page_info/page_info_bubble_view_browsertest.cc
+++ b/chrome/browser/ui/views/page_info/page_info_bubble_view_browsertest.cc
@@ -192,6 +192,15 @@ IN_PROC_BROWSER_TEST_F(PageInfoBubbleViewBrowserTest,
             OpenSiteSettingsForUrl(browser(), GURL(url::kAboutBlankURL), true));
 }
 
+// Test opening "Site Details" via Page Info from a file:// URL goes to "Content
+// Settings".
+IN_PROC_BROWSER_TEST_F(PageInfoBubbleViewBrowserTest,
+                       SiteSettingsLinkWithSiteDetailsEnabledAndFileUrl) {
+  GURL url = GURL("file:///Users/homedirname/folder/file.pdf");
+  EXPECT_EQ(GURL(chrome::kChromeUIContentSettingsURL),
+            OpenSiteSettingsForUrl(browser(), url, true));
+}
+
 // Test opening page info bubble that matches SB_THREAT_TYPE_PASSWORD_REUSE
 // threat type.
 IN_PROC_BROWSER_TEST_F(PageInfoBubbleViewBrowserTest,