Increased proportion of HLA DR+ T cells cell confirmation, Add terms

[LCCarmody]

HPO term

HP_0002853	Increased proportion of HLA DR+ T cells

Suggested revision of textual definition

1. There isn't a CL term close to this one. There is only reference to HLA DRA gene. This may require a new term in CL?

2. Needs an 'Abnormal' term and possibly a 'Decreased' term?

#4289

[LCCarmody]

Also, what cell type is this in proportion to? T cell?

[nicolevasilevsky]

For proportion, the logical defs will just be in proportion to cells, so I think the text defs should be the same.

[nicolevasilevsky]

I am not sure if CL would want to add just HLA DR+ T cell. I wonder if we could add a logical def that is something like:

'has_part' some
('proportionality to'
and ('inheres_in' some (T cell and ('has plasma membrane part' some 'HLA-DRA (human)')) and ('part_of' some blood))) and ('towards' some 'cell') and ('has_modifier' some 'abnormal'))

@matentzn would this work?

[nicolevasilevsky]

Maybe we could do this for #5701 too (with CD3)

[matentzn]

It is in theory possible; but quite specific.. How many of these terms are there, and what do you think CL would not create these terms?

[LCCarmody]

Quick google search shows Human CD8+HLA-DR+ Regulatory T Cells, CD3+ CD4+ HLA-DR+ responder T cells (no idea what 'responder T cells' are), CD38+HLA-DR+CD8+ T cells, HLA-DR+ CD38+ (DR+ 38+) CD4+ T. Definitely don't know what the differences are. Some of these may be synonyms with cells already in CL, since HLA-DR is supposed to be the important marker for T cell activation. CL does have terms like activated 'CD8-positive, alpha-beta T cell
^ http://purl.obolibrary.org/obo/CL_0000906'. So maybe we request synonyms?

[pnrobinson]

done